A method for determining the content of one element in the multi-component samples is proposed. In the known methods of X-ray fluorescent analysis, the standard composition samples are used, or the fundamental parameters method is applied to determine the intensity of the analytical line of the defined element from the content in order to account for the inter-nutrient influences. A distinctive feature of the method in determining the content of one element in the material proposed by the current study does not require the use of standard samples and does not require the measurements of other elements that are part of the sample being analyzed to account for the inter-nutrient influences. This approach is most convenient and economical when it comes to determining the content of one or more elements in the multi-component materials on the simple single-channel X-ray spectrometers and analyzers. The possibility of implementing such solution is based on using the measured intensity of the analytical line of the defined element in the single-element sample and in the material under study and calculating the content of the defined element with the record absorption factor of the - the relationship of absorbent properties of filler to the absorption properties of the defined element. The calculation of the absorption factor is carried out using a program to compute the theoretical intensity considering all the influencing factors. Experimental testing of the proposed method was performed using the standard samples of steel and brass composition. A theoretical assessment of the effectiveness of the method in determining niobium in zirconium as well as harmful impurities in organic materials has been conducted. Keywords : X-ray fluorescent analysis, definition of one element, multi-component samples, steel and alloys, organic materials, absorption factor (Russian) DOI: http://dx.doi.org/10.15826/analitika.2019.23.4.006 B.D. Kalinin “Pretsizion Tekhnologies” Co. Lt, u l. Altai, 12, St. Petersburg, 196066, Russian Federation