Simple Tool Research Articles

Gamma-enhancement of reflected light images as a routine method for assessment of compositional heterogeneity in common low-reflectance Fe-bearing minerals

Abstract Incorporation of impurity elements into minerals impacts on their physical properties (e.g., reflectance, hardness, and electrical conductivity) but the quantitative relationships between these features and compositional variation remain inadequately constrained. Prior work has shown that gamma-enhancement of reflected light images represents a simple yet powerful tool to assess the compositional heterogeneity of single pyrite crystals as it can enhance subtle differences in reflectance between distinct domains with different minor element concentrations. This study extends the gamma correction method to several other common Fe-bearing minerals, magnetite, garnet, wolframite, and tetrahedrite-tennantite, which all have far lower reflectance than pyrite. Gamma-enhanced optical images reveal clear variations in reflectance that are either systematic with increased minor element concentration as the change in gray value on backscatter electron (BSE) images (in the case of magnetite, garnet, and tetrahedrite-tennantite) or contrasting (as in pyrite), yielding a convincing linkage between reflectance variation and compositional heterogeneity. Reflectance variation is an expression of the distribution of the average effective number of free electrons on the mineral surface that can re-emit light when excited by visible light. Gamma-enhanced images can reveal compositional heterogeneity in minerals such as wolframite where small atomic mass differences between substituting elements (Mn and Fe, in the case of wolframite) are virtually impossible to observe as a variation of gray values on BSE images. Results also demonstrate that Fe-rich domains in these minerals can be expected to have higher reflectance than Fe-poor domains whenever Fe is a major constituent. The greater reflectance is attributed to Fe ions having a greater effective number of free electrons than many other elements (e.g., Co, Ni, Si, Ca, Al, Mg, Mn, and As). The research highlights the utility of gamma correction as an inexpensive tool for routine evaluation of compositional heterogeneity in common Fe-bearing minerals, potentially obviating the necessity of a microbeam platform to correlate textures and composition.

Green Neighbourhood Sustainability Index – A measure of the balance between anthropogenic pressure and ecological relevance

Peri-urban landscapes grow more urbanised due to suburbanisation. This, in turn, makes them environmentally and culturally susceptible to changes. Keen demand for residential areas threatens the sustainability of the peri-urban landscape. Green spaces are at particular risk of conversion. Recently, researchers focused on the function of green sites in urban environments. What is more, research on green spaces involves mainly their mapping and analysis of spatiotemporal changes. Nevertheless, there is a research gap in the multi-criteria research on the hypothetical sustainability of green spaces and the identification of areas that are the most at risk of conversion. Therefore, the present study is an attempt to develop a simple technique tool for objective measurement of the sustainability of green spaces in peri-urban areas. To this end, we developed the Green Neighbourhood Sustainability Index (GNSI), with which one can assess the sustainability of the landscape and green spaces using spatial data and GIS technology. The GNSI was then put to the test in the peri-urban zone of Kraków (Poland). The research shows that as the area of agricultural land increases, the sustainability of nearby green spaces decreases. Forest land, on the other hand, improves sustainability. The structure of land use types in the peri-urban zone of Kraków is well balanced. It is both desirable and good for landscape sustainability and harmony. The GNSI can be among the aids used by decision-makers to take science-informed strategic spatial planning decisions to ensure the sustainability of green spaces and the proper functioning of the ecosystem in peri-urban areas, especially in post-socialist transformation countries.

Nomogram for predicting surgical site infections in elderly patients after open lumbar spine surgery: A retrospective study.

The aim of this study is to develop a nomogram to assess the risk of surgical site infection in elderly patients undergoing open lumbar spine surgery and explore related risk factors. We reviewed the records of 578 elderly patients who had undergone open lumbar spine surgery. The clinical parameters were subjected to lasso regression and logistic regression analyses. Subsequently, a nomogram was constructed to predict the risk of postoperative surgical site infection and validated using bootstrap resampling. A total of 578 patients were included in the analysis, of which 17 were diagnosed as postoperative surgical site infection. Following the final logistic regression analysis, obesity, hypoalbuminemia and drinking history were identified as independent risk factors and subsequently incorporated into the nomogram. The nomogram demonstrated excellent discrimination, with an area under the receiver-operating characteristic curve of 0.879 (95% CI 0.769 ~ 0.989) after internal validation. The calibration curve exhibited a high level of consistency. Decision curve analysis revealed that this nomogram had greater clinical value when the risk threshold for surgical site infection occurrence was >1% and <89%. We had developed a nomogram for predicting the risk of postoperative surgical site infection in elderly patients who had undergone open lumbar spine surgery. Validation using bootstrap resampling demonstrated excellent discrimination and calibration, indicating that the nomogram may hold potential clinical utility as a simple predictive tool for healthcare professionals.

The Prognostic Value of Serum Calcium Levels in Elderly Dilated Cardiomyopathy Patients.

It is unclear whether serum calcium on admission is associated with clinical outcomes in dilated cardiomyopathy (DCM). In this study, we conducted a retrospective study spanning a decade to investigate the prognostic value of baseline calcium in elderly patients with DCM. A total of 1,089 consecutive elderly patients (age ≥60 years) diagnosed with DCM were retrospectively enrolled from January 2010 to December 2019. Univariate and multivariate analyses were performed to investigate the association of serum calcium with their clinical outcomes. In this study, the average age of the subjects was 68.36 ± 6.31 years. Receiver operating characteristic (ROC) curve analysis showed that serum calcium level had a great sensitivity and specificity for predicting in-hospital death, with an AUC of 0.732. Kaplan-Meier survival analysis showed that patients with a serum calcium >8.62 mg/dL had a better prognosis than those with a serum calcium ≤8.62 mg/dL (log-rank χ2 40.84, p < 0.001). After adjusting for several common risk factors, a serum calcium ≤8.62 mg/dL was related to a higher risk of long-term mortality (HR: 1.449; 95% CI: 1.115~1.882; p = 0.005). Serum calcium level could be served as a simple and affordable tool to evaluate patients' prognosis in DCM.

Development and validation of a simplified risk prediction model for preterm birth: a prospective cohort study in rural Ethiopia

Preterm birth is one of the most common obstetric complications in low- and middle-income countries, where access to advanced diagnostic tests and imaging is limited. Therefore, we developed and validated a simplified risk prediction tool to predict preterm birth based on easily applicable and routinely collected characteristics of pregnant women in the primary care setting. We used a logistic regression model to develop a model based on the data collected from 481 pregnant women. Model accuracy was evaluated through discrimination (measured by the area under the Receiver Operating Characteristic curve; AUC) and calibration (via calibration graphs and the Hosmer–Lemeshow goodness of fit test). Internal validation was performed using a bootstrapping technique. A simplified risk score was developed, and the cut-off point was determined using the “Youden index” to classify pregnant women into high or low risk for preterm birth. The incidence of preterm birth was 19.5% (95% CI:16.2, 23.3) of pregnancies. The final prediction model incorporated mid-upper arm circumference, gravidity, history of abortion, antenatal care, comorbidity, intimate partner violence, and anemia as predictors of preeclampsia. The AUC of the model was 0.687 (95% CI: 0.62, 0.75). The calibration plot demonstrated a good calibration with a p-value of 0.713 for the Hosmer–Lemeshow goodness of fit test. The model can identify pregnant women at high risk of preterm birth. It is applicable in daily clinical practice and could contribute to the improvement of the health of women and newborns in primary care settings with limited resources. Healthcare providers in rural areas could use this prediction model to improve clinical decision-making and reduce obstetrics complications.

A cross-sectional study of breastfed infants referred for tongue tie assessment and frenotomy in one Canadian health region.

Tongue tie (TT) is a condition that can cause infant feeding difficulties due to restricted tongue movement. When TT presents as a significant barrier to breastfeeding, a frenotomy may be recommended. Universally accepted diagnostic criteria for TT are lacking and wide prevalence estimates are reported. New referral processes and a Frenotomy Assessment Tool were implemented in one Canadian health region to connect breastfeeding dyads with a provider for TT evaluation and frenotomy. To determine the proportion of babies with TT as well as the frequency of frenotomy. This cross-sectional study included infants who initiated breastfeeding at birth and were referred for TT evaluation over a 14-month period. Data were collected retrospectively by chart review and analyzed using SPSS. Factors associated with frenotomy were examined using logistic regression. Two hundred and forty-one babies were referred. Ninety-two percent (n = 222) were diagnosed with TT and 66.0% (n = 159) underwent frenotomy. In the multivariate model, nipple pain/trauma, inability to latch, inability to elevate tongue, and dimpling of tongue on extension were associated with frenotomy (P < 0.05). Most referrals in our region resulted in a diagnosis of TT; however, the number of referrals was lower than expected, and of these two-thirds underwent frenotomy. TT is a relatively common finding among breastfed infants. Future research should examine whether a simplified assessment tool containing the four items associated with frenotomy in our multivariate model can identify breastfed infants with TT who require frenotomy.

Evaluating Anterior and Posterior Oral Tongue Contributions to Pressure Generation: A Comparison Between Regular and Effortful Saliva Swallows.

This study determined the contributions of the anterior and posterior tongue regions in tongue pressure generation during regular saliva swallows (SSs) and effortful swallows (ESs) completed under two different instructions. The association between tongue pressure and perceived effort to swallow was also examined. Forty healthy adults without swallowing disorders participated in this study, divided into two age groups: 20 younger (Mage = 21.95 years, SD = 4.43) and 20 older (Mage = 70.10 years, SD = 4.30). Simultaneous data acquisition involved submental surface electromyography, tongue manometry, and a visual analog scale across swallowing conditions (SS, ES with tongue emphasis, and ES with pharyngeal squeezing). The main outcome measures were tongue pressure during swallowing and perceived effort to swallow. Overall tongue pressure during ESs with tongue emphasis and with pharyngeal squeezing was greater than that during SSs (R2 = .78, p < .001). Moreover, tongue pressure during the ES with tongue emphasis was greater than that during the ES with pharyngeal squeezing (t = 25.63, p < .001). The posterior tongue region generated more pressure during SSs (R2 = .64, p < .001) and the ES with tongue emphasis (R2 = .55, p < .001) than the anterior tongue. Finally, a positive correlation was found between perceived effort and tongue pressure during swallowing (r = .75, 95% CI [0.72, 0.77]). Tongue pressure generation was affected by the type of instruction used to elicit ESs, and the posterior tongue showed relatively greater pressure contributions than the anterior tongue for ESs with tongue emphasis and SSs. Furthermore, age-related declines in pressure generation during swallowing were not evidenced in this study, underscoring the ability of healthy older individuals to appropriately modulate lingual pressure during ESs. Last, our results showed that the visual analog scale is a simple tool for rating swallowing effort during ESs, supporting its potential clinical use to train ESs.

Role of detailed psychological evaluation and treatment in pulmonary rehabilitation programs for patients with chronic obstructive pulmonary disease.

Psychological co-morbidities are common in chronic obstructive pulmonary disease (COPD) but remain overlooked. Psychosocial interventions are deemed to promote mental health and optimize management. This study aimed to determine the role of detailed psychological evaluation and treatment in the comprehensive management of COPD. COPD patients after screening with the general health questionnaire-12 (GHQ-12) for psychological co-morbidity were divided into three groups (26 patients each): i) group A [GHQ-12 score<3, received pulmonary rehabilitation (PR) and standard medical management]; ii and iii) group B and C (GHQ-12 score>3, in addition, received management by a psychiatrist and counseling by a pulmonologist, respectively). At baseline and 8 weeks of follow-up, all participants were evaluated for respiratory [forced expiratory volume in the first second (FEV1), six-minute walk distance (6-MWD), St. George's respiratory questionnaire (SGRQ), modified medical research council (mMRC) dyspnea scale], and psychological [GHQ-12, patient distress thermometer (PDT), coping strategy checklist (CSCL), World Health Organization-quality of life-brief (WHOQOL-Bref-26), and depression anxiety stress scales (DASS)] parameters. Psychological distress (GHQ-12>3) decreased significantly at follow-up, with 11.5% and 53.8% of patients having psychological distress in groups B and C, respectively, versus baseline (p<0.001). mMRC score, SGRQ score, FEV1 and 6-MWD significantly improved in all three groups. Improvement in mMRC and SGRQ was maximal in group B when compared with the other groups. PDT, CSCL, and WHO-QOL-Bref-26 scores improved significantly at follow-up in all three groups, with maximum improvement in group B, followed by group C, and then group A. The DASS score also improved maximally in group B. Patients should be screened for psychological co-morbidities using simple screening tools. PR plays an important role in improving the psychology of COPD patients. However, results are better with directed psycho-educative sessions by non-experts and best with definitive treatment by psychiatrists.

Effectiveness of Screening Models in Improving the Quality of Cenrana River Water as a Drinking Water

The objective of this study is to assess the quality of the Cenrana River water as a potential drinking water source for a community in the Cenrana watershed Wajo, as well as to evaluate the effectiveness of a basic water purification system in improving its condition. Cenrana River is located in the Maros Regency and Bone Regency, South Sulawesi Province, Indonesia. The study was conducted at the Laboratory of Material Testing, Faculty of Engineering Universitas Negeri Makassar, and the Makassar Health Laboratory Center. Water samples are taken in the Walanae River located in Bone Regency and tested in the abovementioned laboratory. This type of research is experimental, which involves assembling a simple clarification tool in the material testing laboratory, and then raw water is purified with the device. Water samples, both raw water and purified water, are tested at the Makassar Health Laboratory Center. The data analysis used is qualitative descriptive, which compares the results of laboratory tests of raw water that have not been clarified and the results of laboratory tests of water that have been purified with the parameters of clean water standard criteria based on the regulation by the Ministry of Health of the Republic of Indonesia. The results showed that although the water had been cleaned through two filters, several parameters tended to increase from the previous year's test results with one filter, such as the No2 content from 0.017 to 0.034, No3 from 0.01 to 0.39, dissolved solids from 152 to 156, Fe from 0.01 to 0.17, Mn from 0.01 to 0.15, SO4 from 14.39 to 15, 54, and Ammonia from 0.05 to 0.29 even though it still meets the standards of the Ministry of Health of the Republic of Indonesia. In addition, the raw water coliform content also increased from an average of 6,600/100 ml in 2016 to 20,050/100 ml in 2019. This means that there is a tendency for Cenrana River water pollution may increase every year.

Solvent-free parallel artificial liquid membrane extraction for drugs of abuse in plasma samples using LC-MS/MS

BackgroundParallel artificial liquid membrane extraction (PALME) is a 96-well plate setup variant of liquid-phase microextraction. Basic or acidic analytes are extracted in neutral form from the sample, through a supported liquid membrane (SLM), and into aqueous acceptor. PALME is already considered a green extraction technique, but in the current conceptual work, we sought to make it even greener by replacing the use of organic solvents with essential oils (EO). PALME was combined with LC-MS/MS for analysis of plasma samples and multiple drugs of abuse with toxicological relevance (amphetamines, phenethylamines, synthetic cathinones, designer benzodiazepines, ayahuasca alkaloids, lysergic acid diethylamide, and ketamine). ResultsFourteen EO were compared to organic solvents frequently used in PALME. The EO termed smart & sassy yielded the best analyte recovery for all drugs studied and was thus selected as SLM. Then, factorial screening and Box-Behnken were employed to optimize the technique. The extraction time, concentration of base, sample volume, and percentage of trioctylamine significantly impacted analyte recovery. The optimum values were defined as 120 min, 10 mmol/L of NaOH, 150 μL, and 0%, respectively. Once optimized, validation parameters were 1–100 ng mL-1 as linear range, accuracy ±16.4%, precision >83%, 1 ng mL-1 as limit of quantitation, 0.1–0.75 ng mL-1 as limit of detection, matrix effect <20%, and recovery 20–106%. Additionally, EO purchased from different production batches were tested and achieved acceptable reproducibility. Data were in compliance with requirements set by internationally accepted validation guidelines and the applicability of the technique was proven using authentic samples. SignificanceIn this study, the use of an EO provided a solvent-free sample preparation technique suited to extract different classes of drugs of abuse from plasma samples, dismissing the use of hazardous organic solvents. The method also provided excellent sample clean-up, thus being a simple and efficient tool for toxicological applications that is in agreement with the principles of sustainable chemistry.

APPLICATION OF FRACTAL GEOMETRY TO STUDY STRUCTURAL CHANGES OF GAS FLOWS

Due to insufficiently efficient gas drying at processing units for gathering and preparing well products, a sufficient amount of liquid may remain in the transported flows. During the transportation products from gas condensate fields from platforms to onshore gathering points, complications arise due to precipitation of the liquid phase or, conversely, gas separation in the moving flow. In this regard, the selection of an adequate transportation mode and pipe-line diameter is of great scientific interest. The presence of a liquid phase, on the one hand, can change the structural forms of flow through the pipeline, and on the other hand, liquid can accumulate in low sections of the route and thereby reduce the capacity of the pipeline. The liquid phase also accelerates corrosion processes on the inner surface of the pipeline. In connection with the above, early diagnosis of the presence of a liquid phase in gas flows transported through main pipelines remains relevant today and requires the development of appropriate criteria. In this work, based on real measurements in sections of the main gas pipeline, was studied the dynamics of the gas flow’s main thermodynamic parameters (flow temperature and pressure). Based on the conducted research, was identified a stable relationship between the presence of liquid in the gas flow and the fractal dimension of time series for temperature, flow and pressure. The result is a relatively simple tool for diagnosing the presence of liquid in transported flows. Keywords: gas pipeline, gas-liquid flows, structural forms of flow, fractal dimension.

Sensitivity of human-induced vibrations and comfort analysis to partially rigid STS joints in timber-to-timber composite floors

The study of floors vibration serviceability represents a well-known challenging task and has a critical role in comfort analysis, assessment and optimization of pedestrian systems in general. To this aim, several consolidated and/or simplified tools are available in the literature to address the most important aspects. In practice, however, most of assumptions for the analysis and verification are based on the use of rough mechanical models of joints and connections, which have indeed a primary role especially for composite floors. In this paper, the attention is given to timber-to-timber floors with inclined self-tapping screws (STS). A parametric Finite-Element (FE) numerical investigation is carried out by taking into account conventional walking features and a case-study timber-to-timber composite beam, well representative of a one-way wooden floor. A major advantage for structural and pedestrian modelling stages is taken from previous literature efforts, while large attention is spent for structural analysis and vibration serviceability assessment tasks, as a function of the STS mechanical parameters (first of all the secant stiffness). Comparative linear modal and non-linear time history analyses are carried out and addressed towards limit mechanical configurations for STS joints, in terms of vibration frequency considerations, as well as structural response and comfort assessment, based on classical performance indicators. The parametric numerical results are further discussed based on simplified methods provided by selected design standards. A critical analysis of major effects due to partial joint rigidity and floor performance classification is presented, both in terms of expected structural safety and comfort levels for similar systems.

The significance of G8 and other geriatric assessments in urologic cancer management: A comprehensive review.

In urologic oncology, which often involves older patients, it is important to consider how to manage their care appropriately. Geriatric assessment (GA) is a method that can address the specific needs of older cancer patients. The GA encompasses various assessment domains, but these domains exhibit variations across the literature. Some of the common items include functional ability, nutrition, comorbidities, cognitive ability, psychosocial disorders, polypharmacy, social and financial support, falls/imbalance, and vision/hearing. Despite the diversity of domains, there is limited consensus on reliable measurement methods. This review discusses the role of GA in managing urologic cancer in unique scenarios, such as those necessitating temporary or permanent urinary catheters or stomas due to urinary diversion. A comprehensive GA is time and human-resource-intensive in real-world clinical practice. Hence, simpler tools such as the Geriatric-8 (G8), capable of identifying high-risk patients requiring a detailed GA, are also under investigation in various contexts. Therefore, we conducted a systematic literature review on the G8. Our findings indicate that patients with low G8 scores encounter difficulties with stoma self-care after urinary diversion and have higher risks of urinary tract infections and ileus after radical cystectomy. The utilization of G8 as a screening tool for urologic cancer patients may facilitate the delivery of appropriate and personalized treatment and care.

Characterization of train kinematics and source wavelets from near-field seismic data

SUMMARY Train traffic is a powerful source of seismic waves, with many applications for passive seismic imaging. Seismic signals were recorded a few metres away from the railway track. These records display harmonious waveforms below 15 Hz for trains driving at speeds of around 100 km hr−1. The sensors record an apparent wavelet emitted by the interaction of the axle on a few of the closest sleepers. From this, we build a simple modelling tool using shifted wavelets to simulate a train signal. The relationship involves the varying train speed, the distances between each axle, and the wavelet emitted by each axle. We propose a nonlinear deconvolution method to invert this relationship. We use a local minimization algorithm with gradients derived by the adjoint state method, and use a frequency continuation technique. A linearized picking-based inversion initializes the nonlinear inversion. On real data, we apply this automatic workflow to 300 train passages, with an excellent match between the best simulation and the data. We identify the trains decelerating as they enter a train station. We also identify the train type based on inverted wheel spacing with centimetric accuracy. The inverted wavelets are consistent with the assumption that trains emit seismic waves by bending the rail above sleepers, although the theory does not explain why the inverted wavelet is not zero phase. This automated kinematic inversion algorithm may allow for contactless railway monitoring, and be used for source characterization for subsurface monitoring below railway tracks.

Noninvasive Evaluation of Tumoral PD-L1 Using a Novel 99mTc-Labeled Nanobody Tracer with Rapid Renal Clearance.

The expression level of PD-L1 in tumor tissue is considered one of the effective biomarkers to guide PD-1/PD-L1 therapy. Quantifying whole-body PD-L1 expression by SPECT imaging may help in selecting patients that potentially respond to PD-1/PD-L1 therapy. Nanobody is the smallest antibody fragment with antigen-binding ability that is well suited for radionuclide imaging. Nevertheless, high retention of radioactivity in the kidney may limit its clinical translation. The present study aimed to screen, design, and prepare a nanobody-based SPECT probe with rapid renal clearance to evaluate the PD-L1 expression level in vivo noninvasively. A phage library was constructed by immunizing alpaca with recombinant human PD-L1 protein, and 17 anti-PD-L1 nanobodies were screened by the phage display technique. After sequence alignment and flow cytometry analysis, APN09 was selected as the candidate nanobody, and a GGGC chelator was attached to its C-terminus for 99mTc labeling to prepare a SPECT imaging probe. The affinity and specificity of 99mTc-APN09 were evaluated by protein and cell-binding experiments, and SPECT imaging and biodistribution were performed in a mouse model with bilateral transplantation of A549 and A549PD-L1 tumors. The ability of 99mTc-APN09 to quantify the PD-L1 expression level in vivo was validated in tumor models with different PD-L1 expression levels. 99mTc-APN09 had a radiochemical purity higher than 99% and a binding equilibrium dissociation constant of 21.44 ± 1.65 nM with hPD-L1, showing high affinity. SPECT imaging results showed that 99mTc-APN09 could efficiently detect PD-L1-positive tumors within 0.5 h, and the quantitative results of SPECT were well correlated with the expression level of PD-L1 in cell lines. SPECT imaging and biodistribution results also showed that 99mTc-APN09 was rapidly cleared from the kidney in 2 h postinjection. 99mTc-APN09 was a simple and stable tool for visualizing PD-L1 expression in the whole body. In addition, due to its significant reduction in renal retention, it has better prospects for clinical translation.

Visual associative learning to detect early episodic memory deficits and distinguish Alzheimer's disease from other types of dementia.

We investigated how well a visual associative learning task discriminates Alzheimer's disease (AD) dementia from other types of dementia and how it relates to AD pathology. 3,599 patients (63.9 ± 8.9 years old, 41% female) from the Amsterdam Dementia Cohort completed two sets of the Visual Association Test (VAT) in a single test session and underwent magnetic resonance imaging. We performed receiver operating curve analysis to investigate the VAT's discriminatory ability between AD dementia and other diagnoses and compared it to that of other episodic memory tests. We tested associations between VAT performance and medial temporal lobe atrophy (MTA), and amyloid status (n = 2,769, 77%). Patients with AD dementia performed worse on the VAT than all other patients. The VAT discriminated well between AD and other types of dementia (area under the curve range 0.70-0.86), better than other episodic memory tests. Six-hundred forty patients (17.8%) learned all associations on VAT-A, but not on VAT-B, and they were more likely to have higher MTA scores (odds ratios range 1.63 (MTA 0.5) through 5.13 for MTA ≥ 3, all p < .001) and to be amyloid positive (odds ratio = 3.38, 95%CI = [2.71, 4.22], p < .001) than patients who learned all associations on both sets. Performance on the VAT, especially on a second set administered immediately after the first, discriminates AD from other types of dementia and is associated with MTA and amyloid positivity. The VAT might be a useful, simple tool to assess early episodic memory deficits in the presence of AD pathology.

The Use of Financial Tools in Small-Scale Irrigated Crops to Assess Socioeconomic Sustainability: A Case Study in Tocantins-Araguaia Basin, Brazil

To expand financial knowledge and promote the socioeconomic sustainability of agricultural production systems, this work applied financial instruments to small-scale irrigated crops, making use of agricultural projects from the Bom Sucesso/Santa Cruz Settlement, located in the Tocantins-Araguaia basin, Brazil. The economic viability indicators of two irrigated okra production systems (furrow and drip) were calculated using the following indicators: Net Present Value, Modified Internal Rate of Return, Cost–Benefit Index, Discounted Payback, and Average Cost of Production. And a risk assessment through sensitivity analysis, a tornado chart, and Monte Carlo simulation was performed in a simplified financial model. The economic viability results showed that both irrigated systems were economically viable, although the okra drip system had lower indicators and reduced financial resilience, with a 58% probability of success, while the furrow system’s was 89%. The crops’ financial return was mainly influenced by okra’s sale price and productivity, followed by harvesting and planting costs. The financial tools applied in this study demonstrated some key factors to assess socioeconomic sustainability, such as the necessity to increase producers’ organizational capacity and to achieve technical improvements, which could result in market power, competitive sale prices, lower input costs, and greater productivity. The applied instruments increased financial management and have the potential to the build economic and social strength in the area of small-scale irrigated crops, and they can be replicated using simplified tools for producers, companies, and policy makers.

Integrating circularity into Life Cycle Assessment: Circularity with a life cycle perspective

With the current efforts on striving towards sustainable development both Life Cycle Assessment (LCA) and circularity have become extremely popular, worldwide. Both are addressing sustainability aspects, yet typically applied separately. LCA counts with dedicated tools and databases, while circularity is commonly calculated with simple tools or even just formulas in excel, ignoring the supply chain. This paper presents a combination of LCA and circularity. The Material Circularity Indicator (MCI) and the Circularity Index (CI) are incorporated into openLCA, and the LCA database Ecoinvent is adapted to trace circularity throughout. This allows to track circularity variables across supply chains and apply circularity indicators in LCA models. Results show that the LCA database mostly presents linear systems, with most datasets having a circularity values close to full linearity. Furthermore, investigations over the cradle-to-grave datasets of a Lithium-ion battery show that the amount of virgin material extracted from earth is actually 43 times bigger than the weight of the battery, and that the overall waste produced is 92 times the weight of the battery. Such high values are overlooked in common circularity indicator calculations. This comprehensive framework aims to contribute to the ongoing dialogue surrounding sustainable practices and circular economy integration within LCA.

Application of the screening method for estimating COVID-19 vaccine effectiveness using routine surveillance data: Germany's experience during the COVID-19 pandemic, July 2021 to March 2023.

The screening method represents a simple, quick, and practical tool for estimating vaccine effectiveness (VE) using routine disease surveillance and vaccine coverage data, even if these data cannot be linked. In Germany, where notification data, laboratory testing data, and vaccine coverage data cannot be linked due to strict data protection requirements, the screening method was used to assess COVID-19 VE continuously between July 2021 and March 2023. During this period, when Delta and Omicron variants circulated, VE estimates were produced in real-time for different age groups and clinical outcomes. Here we describe the country's overall positive experience using the screening method, including its strengths and limitations, and provide practical guidance regarding a few issues, such as case definition stringency, testing behaviour, and data stratification, that require careful consideration during data analysis and the interpretation of the results.

Comprehensive Spinal Tuberculosis Score: A Clinical Guide for the Management of Thoracolumbar Spinal Tuberculosis.

A newly proposed scoring tool was designed to assist in the clinical management of adult thoracolumbar spinal tuberculosis (TB). To formulate a comprehensive yet simple scoring tool to guide decision-making in the management of adult thoracolumbar spinal TB. Spine surgeons have differing consensus in defining the threshold grade for clinico-radiological parameters when deciding between operative or conservative treatment for adult thoracolumbar spinal TB. Currently, the void in decision-making from the lack of well-defined guidelines is compensated by the surgeon's experience in treating these patients. To the best of our knowledge, no scoring system holistically integrates multiple facets of spinal TB to guide clinical decision-making. The RAND/University of California, Los Angeles appropriateness method was employed among an expert panel of 10 spine surgeons from four apex tertiary care centers. Vital characteristics that independently influenced treatment decisions in spinal TB were identified, and a scoring tool was formulated. Points were assigned for each component based on their severity. The cutoff scores to guide clinical management were determined from the receiver operating characteristic curve based on the retrospective records of 151 patients treated operatively or non-operatively with improved functional outcomes at the 1-year follow-up. The components of the comprehensive spinal TB score (CSTS) are pain, kyphosis angle, vertebral destruction, and neurological status. A score classification of <5.5, 5.5-6.5, and >6.5 was established to guide the patient toward conservative, conservative/ operative, and operative management, respectively. The CSTS was designed to reflect the essential indicators of mechanical stability, neurological stability, and disease process stabilization in spinal TB. The scoring tool is devised to be practical and serve as a common language in the spine community to facilitate discussions and decision-making in thoracolumbar spinal TB. The validity, reliability, and reproducibility of this tool must be assessed through multicenter long-term studies.