Simple Patch Research Articles

The Open-Book Technique With Sliced Biceps Tendon Autograft Augmentation in the Reconstruction of the Subscapularis in Shoulder Arthroplasty

Postoperative insufficiency of the subscapularis can diminish clinical outcome after shoulder arthroplasty. Poor tendon tissue quality and prior surgery can impair the possibility of reconstruction and healing, as well as the postoperative range of motion and strength. Patch augmentation has been investigated for soft tissue augmentation in the glenohumeral joint utilizing different graft materials. Recently, the surgical technique using compressed biceps tendon autograft was introduced for the subscapularis augmentation following shoulder arthroplasty. However, the viable cell potential after mechanical compression remains uncertain. Therefore, we propose an augmentation technique of the subscapularis tendon using a sliced autograft of the long head of the biceps tendon. This technique can offer a simple, replicable, and cost-effective autologous tendon patch augmentation after subscapularis tenotomy in the setting of total shoulder arthroplasty.

A Wideband High-Gain All-Metal Antenna under Quad Resonances Realized by Folding a Simple Patch

This paper presents a novel wideband antenna with a simple structure comprising an integrated microstrip patch antenna (MPA) and three shorted microstrip patch antennas (SMPAs). These four radiators constitute an antenna that operates under quad resonances and achieves a wide frequency bandwidth. Since all units are electrically connected, the antenna can be easily fabricated by folding a single metallic strip to realize an all-metal antenna structure, leading to enhanced resistance to extreme environmental conditions and lower power loss. An antenna prototype was used to validate the proposed concept. The measurement results indicated that the proposed handmade structure, which employed probe excitation with overall electrical dimensions of 0.29λ × 0.27λ × 0.11λ, can acquire an impedance frequency bandwidth of 67% for <i>S</i><sub>11</sub> ≤ -10 dB from 1.6–3.2 GHz and achieve a maximum boresight gain of up to 10 dB. The wide frequency bandwidth, high gain, and simple structure make this antenna a promising candidate for wideband mobile systems.

A Mg Battery-Integrated Bioelectronic Patch Provides Efficient Electrochemical Stimulations for Wound Healing.

Bioelectronic patches hold promise for patient-comfort wound healing providing simplified clinical operation. Currently, they face paramount challenges in establishing long-term effective electronic interfaces with targeted cells and tissues due to the inconsistent energy output and high bio interface impedance. Here a new electrochemical stimulation technology is reported, using a simple wound patch, which integrates the efficient generation and delivery of stimulation. This is realized by employing a hydrogel bioelectronic interface as an active component in an integrated power source (i.e., Mg battery). The Mg battery enhances fibroblast functions (proliferation, migration, and growth factor secretion) and regulates macrophage phenotype (promoting regenerative polarization and down-regulating pro-inflammatory cytokines), by providing an electric field and the ability to control the cellular microenvironment through chemical release. This bioelectronic patch shows an effective and accelerated wound closure by guiding epithelial migration, mediating immune response, and promoting vasculogenesis. This new electrochemical-mediated therapy may provide a new avenue for user-friendly wound management as well as a platform for fundamental insights into cell stimulation.

Long-term Survival of Bladder Augmentation is Influenced by its Shape and Mucosal Lining

IntroductionBladder augmentation in the UK has been largely by enterocystoplasty or ureterocystoplasty (UC). Ileocystoplasty can be simple patch placement (SPP), or formation of an ileal cup (IC). Urothelium is the “right” mucosa, whereas intestinal mucosa exhibits absorption, mucus production, malignancy. On videourodynamics it can be shown that SPP fills with a poor conformation (irregular shape), while IC was good, and UC adequate.Our aim was to measure the long-term outcomes of augmentation, comparing UC (“right” mucosa and adequate conformation), to SPP (“wrong” mucosa and poor conformation) to IC (“wrong mucosa” and good conformation). MethodsSingle-centre retrospective review. Patients were identified from operative logs for the period 2005 to 2022. Registered as an audit (CARMS 31503). Data collected included: demographics, dates: operation, redo-surgery, imaging, stones (renal/bladder) and any intervention. Data were given as numbers (%), median (range) analysed by Fisher exact test where P < 0.05 was taken as significant. ResultsThere were 168 bladder augmentations: UC (n = 24), SPP (n = 72), and IC (n = 72). Follow-up was no different for IC 4.23 (0.05–11.50) vs SPP 4.43 (0.15–13) yrs, but was longer for UC at 6.2 (4.1–8.9) yrs. Age at augmentation was 6.7 (2.5–17.1) vs 8.1 (2–17) vs 11.6 (5.9–17) yrs respectively (UC vs IC vs SPP, P = 0.0001).Revision surgery was required in 3/24 (12.5 %) UC, 6/72 (8.3 %) SPP, and 0/72 (0 %) IC. IC had fewer redos than SPP, P = 0.028. Long-term survival was significantly better for IC (100 % at 10 years, vs UC 85 % at 10 years and SPP 96 % at 5 yrs and 75 % at 10 yrs, log-rank P < 0.05).Imaging follow-up was available in SPP (n = 56) IC (n = 62), UC (n = 24) with renal stones identified in 7/56 (%) SPP, 2/62 (%) IC, and 0 in UC. Bladder stones were present in SPP 5/56 (8.9 %) vs IC 2/62 (3.2 %), NS. Stone-free survival was 100 % at 10yrs in UC, 95 % in IC, and 62 % in SPP, P = 0.028.Combining bladder failure leading to reaugmentation and bladder stones requiring surgery, allows comparison between SPP and IC: In SPP bladder stones and augment failure occurred in 15.3 %, vs 2.8 % in IC. There is a 6.3-fold increase in bladder stones and augment redo with SPP [irregular filling bladder (poor conformation) and the “wrong” mucosa] vs IC (good confirmation, but “wrong” mucosa). ConclusionAugmentation survival is influenced by conformation and presence of the “right” mucosa. UC is only possible in 14 % of cases, and an IC is preferable to SPP when an enterocystoplasty is needed.

Olfactory and gustatory chemical sensor systems in the African turquoise killifish: Insights from morphology

Smell and taste are extensively studied in fish species as essential for finding food and selecting mates while avoiding toxic substances and predators. Depending on the evolutionary position and adaptation, a discrete variation in the morphology of these sense organs has been reported in numerous teleost species. Here, for the first time, we approach the phenotypic characterization of the olfactory epithelium and taste buds in the African turquoise killifish (Nothobranchius furzeri), a model organism known for its short lifespan and use in ageing research. Our observations indicate that the olfactory epithelium of N. furzeri is organized as a simple patch, lacking the complex folding into a rosette, with an average size of approximately 600 µm in length, 300 µm in width, and 70 µm in thickness. Three main cytotypes, including olfactory receptor neurons (CalbindinD28K), supporting cells (β-tubulin IV), and basal cells (Ki67), were identified across the epithelium. Further, we determined the taste buds’ distribution and quantification between anterior (skin, lips, oral cavity) and posterior (gills, pharynx, oesophagus) systems. We identified the key cytotypes by using immunohistochemical markers, i.e. CalbindinD28K, doublecortin, and neuropeptide Y (NPY) for gustatory receptor cells, glial fibrillary acidic protein (GFAP) for supporting cells, and Ki67, a marker of cellular proliferation for basal cells. Altogether, these results indicate that N. furzeri is a microsmatic species with unique taste and olfactory features and possesses a well-developed posterior taste system compared to the anterior. This study provides fundamental insights into the chemosensory biology of N. furzeri, facilitating future investigations into nutrient-sensing mechanisms and their roles in development, survival, and ageing.

The use of a simple and affordable skin patch for measurement of transcutaneous bilirubin levels in neonates during phototherapy.

Transcutaneous bilirubin (TcB) measurements during and after phototherapy for hyperbilirubinemia must be performed on unexposed skin. There are commercially made skin patches for this purpose, but they are relatively unavailable in low-resource settings. We devised a simple cotton patch and tested its use for TcB during phototherapy. Measurements were taken in healthy neonates born at a gestational age of ≥35 weeks who were undergoing phototherapy for hyperbilirubinemia in western India before, 12 h after the start, and 12 h after the end of phototherapy. Total serum bilirubin (TSB) was measured using the diazo method in a clinical laboratory. TcB measurements were performed using a Dräger Jaundice Meter JM-105 placed over the sternum on two skin areas that were protected during and after treatment by a commercial (Philips BilEclipse) or self-made patch comprised of cotton gauze and wool. In total, 47 neonates were included in our study. Before phototherapy, TSB and TcB values had a strong correlation (Pearson, r = 0.88), with a mean difference of -1.35 mg/dl. Correlations with TSB were good and equivalent for TcB values measured on skin covered by the commercial and self-made patches during (0.78 and 0.70, respectively) and after (0.57 and 0.58, respectively) phototherapy. TcB values measured on skin covered by the two patches correlated well both during and after phototherapy, with r = 0.82 and 0.90, respectively, and mean (95% confidence interval) differences of -1.21 and -0.32 mg/dl, respectively. Reliable TcB measurements taken during and after phototherapy can be achieved on skin covered with a simple and affordable cotton skin patch.

A Simple Egg Membrane Patch Bridging Method for Repairing Tympanic Membrane Perforation

Objective: To analyze the clinical effect of a simple egg membrane patch bridging method in repairing tympanic membrane perforation. Methods: A total of 93 tympanic membrane perforation patients admitted to the hospital between September 2022 and October 2023 were selected and divided into two groups according to the random number table method. The control group implemented the conventional treatment (n = 46 cases), and the patch group adopted the simple egg membrane patch bridging method (n = 47 cases). The healing rate of the tympanic membrane, the air-bone gap, the air conduction hearing threshold, the dry ear rate, and the incidence of complications in both groups were compared before and after treatment. Results: The healing rate of the tympanic membrane in the patch group was significantly higher than that of the control group (95.75% vs. 76.09%), with P &lt; 0.05; there was no difference in the air-bone gap and air conduction hearing threshold levels between the two groups before treatment (P &gt; 0.05), and the hearing indexes of the patch group were significantly lower than those of the control group 3 months after treatment (P &lt; 0.05); the dry ear rate in the patch group was significantly higher than that of the control group after treatment (85.11% vs. 67.39%), and the total incidence of complications was also significantly lower than that of the control group (6.38% vs. 21.74%), with P &lt; 0.05. Conclusion: The simple egg membrane patch bridging method is effective in repairing tympanic membrane perforation, which can effectively improve patients’ hearing levels and reduce the occurrence of post-treatment complications. Thus, it is worth popularizing and applying in the clinic.

Wideband circularly polarized reconfigurable metasurface antenna for 5G applications

Abstract A framework of a metasurface (MTS) – based wideband circularly polarized (CP) reconfigurable antenna for fifth generation (5G) wireless systems operating in the sub-6 GHz mid-frequency range is presented in this article. The proposed structure contains a simple patch antenna, which serves as the primary source, a shorting pin, two ring slots, and a metasurface superstrate. The shorting pin and two ring slots produce perturbation resulting in circular polarization with a narrow axial ratio (AR) bandwidth. A metasurface (MTS) superstrate composed of 4 × 4 rectangular patches stacked over the primary source antenna generates additional resonances that significantly improve the −10 dB impedance and 3 dB axial ratio (AR) bandwidth. Two PIN diodes are employed to alter the circular polarization between left-hand circular polarization (LHCP) and right-hand circular polarization (RHCP). The prototype is made using an FR-4 epoxy substrate and has an overall size of 50 mm × 35 mm × 4.2 mm. The antenna has a −10 dB bandwidth of 44 % (4.0–6.2) and a 3 dB axial ratio bandwidth of 28 % (4.2–5.6). It also has a 3 dB beam width of 74° and 85° in the E and H planes, a gain of 7.1 dBi, cross-polar isolation of more than 15 dB, and a unidirectional radiation pattern. The simulated and measured results confirm that the implemented antenna is promising for sub-6 GHz 5G communication systems, particularly cognitive radio, wireless body area networks (WBAN), and satellite communication systems.

Capillary-osmotic wearable patch based on lateral flow assay for sweat potassium analysis

This paper reports a simple, disposable, and wearable patch inspired by lateral flow assay (LFA) that can continuously and non-invasively sample sweat for colorimetric sensing of potassium (K+). K+ is an important biomarker for healthy cardiovascular and neuromuscular functions of the body. Current techniques for K+ sensing in sweat commonly use ion-selective electrodes that require complex fabrication steps, signal drift issues, and active perspiration for continuous operation. Here, the sensor uses passive osmotic-capillary principles to collect sweat from the skin without the need of external power for sampling. A skin-mounted hydrogel patch equilibrated with glucose and glycerin solutions can extract fluid from the skin at rest because of the high osmotic strength of the hydrogel compared to sweat. The gel delivers fluid to a commercial colorimetric assay via a paper strip. The assay contains the reagent dipicrylamine which is selective to K+. On-body human trials prove that these patches function with low sweat volumes (∼2–3 µL) and measure K+ concentration in sweat extracted both during exercise and rest. The sweat potassium concentration is independent of the sweat rate and its magnitude matches that of blood. Such economical patches could open opportunities for at-home or in-field point-of-care (POC) diagnostics.

Synthesis of Non-Uniform Spiral Antenna with Low Peak Sidelobe Level Using Enhanced Harris Hawks Optimization Algorithm

In this paper, to obtain antenna arrays with grating lobes suppression capability in wideband and achieve a low peak sidelobe level (PSLL), two non-uniform spiral antenna arrays and an enhanced Harris Hawks optimization (EHHO) algorithm are proposed. By controlling the parameters of the spiral line and sampling equidistant on the spiral line, the sampling points that make up the non-uniform array can be arranged in the plane uniformly and non-uniformly. The simulation results indicate that, because of this special arrangement, the non-uniform arrays obtain the capability of grating lobe suppression in wideband or wide spacing arrangement when compared to the classic uniform array. In addition, to obtain lower PSLL, the Harris Hawks optimization (HHO) algorithm is used for array synthesis because of its diversity of search methods. By employing the step-type taper distribution strategy and the migration strategy, the algorithm’s search ability is enhanced, and the simulation results indicate the EHHO algorithm obtains a better solution in terms of the PSLL than other algorithms. A simple patch antenna is designed to build the non-uniform spiral arrays synthesized by the EHHO algorithm. The calculation and simulation results validate the superior performance of the proposed algorithm.

Polarization conversion metasurface enabled broadband circularly polarized patch antenna

AbstractAssembling polarization conversion metasurface (PCM) and a simple patch antenna to realize a circularly polarized (CP) antenna with over 10% fractional bandwidth (BW) is a challenging task. A kind of PCM composed of S‐ring and grating structure that converts linearly polarized (LP) wave into CP wave in a broadband frequency from 8.74 to 12 GHz can address the challenge. The universality of the PCM in realizing antenna polarization conversion is verified by using a standard LP horn antenna. Then, we design a broadband LP rectangular patch antenna to demonstrate that the present PCM can be integrated with small antenna devices to achieve CP antenna. A broadband CP patch antenna with a 12.4% −10 dB BW and 11.3% 3 dB axial ratioBW is obtained. The antenna gain reaches 8.1 dB with the enhancement gain of 4.1 dB. The findings are very attractive for wireless communication, radar monitoring, and satellite systems because the proposed antenna has excellent broadband CP performances, simple structure, and easy fabrication.

Formulation, in vitro and in vivo evaluation of olanzapine nanoparticles dissolving microneedles for transdermal delivery

Olanzapine (OLZ) is classified as a typical antipsychotic drug utilized for the treatment of schizophrenia. Its oral bioavailability is 60% due to its low solubility and pre-systemic metabolism. Hence, the present work aims to formulate and evaluate OLZ nanoparticles dissolving microneedles (MNs) for transdermal delivery to overcome the problems associated with drug administration orally. OLZ nanoparticles were prepared by the nanoprecipitation method. The optimized OLZ nanoparticle formula was utilized for the fabrication of dissolving MNs by loading OLZ nanodispersion into polydimethylsiloxane (PDMS) micromould cavities, followed by casting the polymeric solution of polyvinylpyrrolidone(PVP-K30) and polyvinyl alcohol (PVA) to form MN matrix. The results revealed that the optimized OLZ nanoparticle formula (NP-5) exhibited particle size 115.76±5.45 nm, entrapment efficiency 78.4±5.46, and zeta potential -19.01±1.6 mV. The results of MNs revealed that MN-4 exhibits a high drug content of 98.52%, and ex vivo permeation through rabbit skin exhibited that MN-4 permeates more effectively than a simple patch by approximately 5.16 fold. In vivo pharmacokinetics study revealed that the area under curve AUC 0-∞ of MN-4 was 6054.56±376 ng. h/ml as compared with AUC0-∞ of marketed OLZ tablet was 3975.77±373 ng. h/ml. It can be concluded that the dissolving MN-4 patch is considered a promising formula to overcome the problems associated with drug administration orally and could improve drug bioavailability, in addition to the ease of administering the medication to schizophrenic patients.

A comprehensive end-to-end computer vision framework for restoration and recognition of low-quality engineering drawings

The digitization of engineering drawings is crucial for efficient reuse, distribution, and archiving. Existing computer vision approaches for digitizing engineering drawings typically assume the input drawings have high quality. However, in reality, engineering drawings are often blurred and distorted due to improper scanning, storage, and transmission, which may jeopardize the effectiveness of existing approaches. This paper focuses on restoring and recognizing low-quality engineering drawings, where an end-to-end framework is proposed to improve the quality of the drawings and identify the graphical symbols on them. The framework uses K-means clustering to classify different engineering drawing patches into simple and complex texture patches based on their gray level co-occurrence matrix statistics. Computer vision operations and a modified Enhanced Super-Resolution Generative Adversarial Network (ESRGAN) model are then used to improve the quality of the two types of patches, respectively. A modified Faster Region-based Convolutional Neural Network (Faster R-CNN) model is used to recognize the quality-enhanced graphical symbols. Additionally, a multi-stage task-driven collaborative learning strategy is proposed to train the modified ESRGAN and Faster R-CNN models to improve the resolution of engineering drawings in the direction that facilitates graphical symbol recognition, rather than human visual perception. A synthetic data generation method is also proposed to construct quality-degraded samples for training the framework. Experiments on real-world electrical diagrams show that the proposed framework achieves an accuracy of 98.98% and a recall of 99.33%, demonstrating its superiority over previous approaches. Moreover, the framework is integrated into a widely-used power system software application to showcase its practicality. The reference codes and data can be found at https://github.com/Lattle-y/AI-recognition-for-lq-ed.git Future work will focus on improving the generalizability of the proposed framework to different quality degradation scenarios and extrapolating the application to different engineering domains.

Sinus of Valsalva Aneurysm: Different Modes of Presentation and Techniques of Repair.

A sinus of valsalva aneurysm (SVA) is an asymmetrical dilatation of the aortic root located between the aortic valve anulus and the sino-tubular junction. Congenital weakness of the elastic lamina in the aortic media layer or trauma and infection as acquired events are the most principal causes of SVA. Presentation may be acute when rupture has occurred or SVA may be discovered fortuitously on echocardiography or CT scan when patients are examined because of unspecific chest pains, dyspnea or arrhythmias. Although endovascular treatment has been performed successfully in individual cases, surgical closure of the aneurysm aiming at preservation of the aortic valve whenever possible is the established procedure. This short report emphasizes the fact that individual treatment is required when SVA need to be operated, depending on the presentation, the location and the size of the finding. Surgery may consist of simple patch closure, bilateral tunnel closure (entry and exit) or more radical operation like Bentall in case the whole aortic root should be addressed. Overall results are excellent, independently of the clinical presentation (acute or elective) with a mortality approaching zero.

MICROSTRIP PATCH ANTENNA DESIGN WITH ENHANCED RADIATION EFFICIENCY FOR 5G 60 GHZ MILLIMETER-WAVE SYSTEMS

In this paper, a wideband, high-gain microstrip patch antenna design for 60 GHz applications is presented. The chosen substrate material is Rogers RT 5880, with a thickness of 1.6 mm, a relative permittivity of 2.2, and a loss tangent of 0.0009. Initially, a simple rectangular patch antenna is designed. To address the challenges of low gain and low radiation efficiency, two rectangular parasitic elements are introduced. These parasitic elements interact with the main radiator, resulting in improved gain and radiation efficiency. In the final step, an extended ground plane structure is adopted to further enhance return loss, radiation efficiency, and gain. The proposed antenna achieves a high gain of 13.10 dBi and a maximum radiation efficiency of 90% with a compact size of 13.6 × 10.6 mm2. For bandwidth calculations, given that the 60 GHz frequency band is known for its challenging propagation environment, the -15 dB criteria is chosen instead of the commonly used -10 dB criterion. According to this -15 dB criterion, the antenna exhibits wideband behavior spanning from 55 to 65 GHz, offering an impressive impedance bandwidth of 10 GHz. This design demonstrates significant potential for 60 GHz applications.

Multifunctional Siloxene-Decorated Laser-Inscribed Graphene Patch for Sweat Ion Analysis and Electrocardiogram Monitoring.

Potentiometric detection in complex biological fluids enables continuous electrolyte monitoring for personal healthcare; however, the commercialization of ion-selective electrode-based devices has been limited by the rapid loss of potential stability caused by electrode surface inactivation and biofouling. Here, we describe a simple multifunctional hybrid patch incorporating an Au nanoparticle/siloxene-based solid contact (SC) supported by a substrate made of laser-inscribed graphene on poly(dimethylsiloxane) for the noninvasive detection of sweat Na+ and K+. These SC nanocomposites prevent the formation of a water layer during ion-to-electron transfer, preserving 3 and 5 μV/h potential drift for the Na+ and K+ ion-selective electrodes, respectively, after 13 h of exposure. The lamellar structure of the siloxene sheets increases the SC area. In addition, the electroplated Au nanoparticles, which have a large surface area and excellent conductivity, further increased the electric double-layer capacitance at the interface between the ion-selective membranes and solid-state contacts, thus facilitating ion-to-electron transduction and ultimately improving the detection stability of Na+ and K+. Furthermore, the integrated temperature and electrocardiogram sensors in the flexible patch assist in monitoring body temperature and electrocardiogram signals, respectively. Featuring both electrochemical ion-selective and physical sensors, this patch offers immense potential for the self-monitoring of health.

A Multibranch Deep Neural Network for the Superresolution of Solar Magnetograms

The existing superresolution (SR) models for solar magnetograms are mostly borrowed from the SR models for natural images. They are less effective for processing solar magnetograms with a very large dynamic range and very rich image features. In this paper, a multibranch superresolution (MBSR) model is specially designed for solar magnetograms. First, we split a low-resolution magnetogram into a group of overlapping image patches, and classify them into three categories according to magnetic flux intensity, namely simple, medium, and complex. Then, image patches of each category are fed into the corresponding branch of the MBSR network, the lightweight branch for simple image patches and the heavyweight one for complex image patches. The advantage of such a strategy is twofold. On the one hand, active regions are allocated more computational resources to train a heavyweight branch more fully, while quiet regions are allocated fewer computational resources to train a lightweight branch for saving computational resources. On the other hand, a lightweight network with a simple nonlinear function is preferable to simple regions, while a heavyweight one may be underfitting. Additionally, to verify the effectiveness of the proposed model, a magnetic field structure similarity metric is proposed to measure the artifacts of the generated high-resolution (HR) magnetograms. Experimental results show that the proposed MBSR model generates HR magnetograms highly consistent with the HMI ones, and achieves the best performance over five objective metrics, including peak signal-to-noise ratio and structure similarity, etc.

A simple low-cost flexible plasmonic patch based on spiky gold nanostars for ultra-sensitive SERS sensing.

Recently, transparent and flexible surface-enhanced Raman scattering (SERS) substrates have received great interest for direct point-of-care detection of analytes on irregular nonplanar surfaces. In this study, we proposed a simple cost-effective strategy to develop a flexible SERS patch utilizing multibranched sharp spiked gold nanostars (GNS) decorated on a commercially available adhesive Scotch Tape for achieving ultra-high SERS sensitivity. The experimental SERS measurements were correlated with theoretical finite element modeling (FEM), which indicates that the GNS having a 2.5 nm branch tip diameter (GNS-4) exhibits the strongest SERS enhancement. Using rhodamine 6G (R6G) as a model analyte, the SERS performance of the flexible SERS patch exhibited a minimum detection limit of R6G as low as 1 pM. The enhancement factor of the SERS patch with GNS-4 was calculated as 6.2 × 108, which indicates that our flexible SERS substrate has the potential to achieve ultra-high sensitivity. The reproducibility was tested with 30 different spots showing a relative standard deviation (RSD) of SERS intensity of about 5.4%, indicating good reproducibility of the SERS platform. To illustrate the usefulness of the flexible SERS sensor patch, we investigated the detection of a carcinogenic compound crystal violet (CV) on fish scales, which is often used as an effective antifungal agent in the aquaculture industry. The results realized the trace detection of CV with the minimum detection limit as low as 1 pM. We believe that our transparent, and flexible SERS patch based on GNS-4 has potential as a versatile, low-cost platform for real-world SERS sensing applications on nonplanar surfaces.

Overview of Antihypertensive Transdermal Drug Delivery System

In order to boost bioavailability and enhance patient compliance, this review focuses on the antihypertensive action of transdermal patches. Using a transdermal method for administering medication (TDDS), it is possible to administer a systemic medicament via a simple skin patch. Among the most prevalent human diseases is hypertension. There is a strong correlation between hypertension and cardiovascular mortality and morbidity. The evolution of skin science, innovation, and experience that led to these patches began with the earliest written records of human history and continues to this day through with a combination of trial and error, clinical observation, and research evidence. Because it’s a long-term condition, treatment will take a while

Design And Simulation of a Hexagonal High-Gain MIMO Patch Antenna For 5G Applications

View of the technological evolution and the problems encountered by the world, researchers are obliged to find solutions, particularly researchers in the field of antennas. This article has been devoted to the design and study of a hexagonal dual-band MIMO patch antenna for Satellite and 5G applications. Several parameters have been studied, we can quote among other things the gain, the bandwidth, the radiation diagram, the directivity, and the distribution of the electric field E. To achieve these studies and find optimal solutions, several designs have been made like the design of a simple hexagonal patch antenna, and, in the end, the proposed antenna is a MIMO with a hexagonal shape and 2 feeding ports. The proposed antenna operates at 25 GHz as the central frequency. The obtained ECC (envelope correlation coefficient) value is less than 0.006 for the entire operating bandwidth, which satisfies the standard value criteria of less than 0.5 and indicates minimal isolation between the antenna arrays. The values of the gain and the maximum directivity of the antenna obtained are respectively 8.12 dB and 8.37 dB, which gives us an efficiency of the antenna at 97.01% with high isolation &gt; 25 dB. The results are found to be sufficient for the device to be used for mm-wave 5G MIMO applications. Additional MIMO performance metrics, such as the channel capacity loss (CCL), diversity gain (DG), and total active reflection coefficient (TARC), are evaluated. All this work has been done using HFSS 15 as software.