The article presents the results of the influence of new recipes of feed additives, made on the basis of local resources, on the biochemical parameters of the blood of dairy cows of the Simmental breed in the conditions of Yakutia. Research objectives: 1) study the chemical composition of new recipes for feed additives produced from local resources; 2) determination of the influence of the new formulation of feed additives from local resources on the biochemical parameters of blood in cattle of the Simmental breed. In our experiments, there were no statistically significant changes in the biochemical parameters of blood during the period of the experiments, all the studied blood parameters, both at the beginning and at the end of the experiments, in all groups of animals were within the physiological norms and did not have significant differences between the groups. Consequently, feeding the formulation of feed additives in the composition of Tammi barley, Tuymaada wheat, Pokrovsky and Vilensky oats, dry brewer’s grain, Hongurin zeolite, Hongurinobakt probiotic in the diet of cows and heifers of the Simmental breed contributed to the activation of vital processes in the body, assimilation of feed and improved appetite. It should be noted that the cows of the II experimental group showed a tendency to increase the composition of amino acids. At the beginning of the experiment, the blood lysine content increased by 5.22 mg/% compared with the control and by 5.79 mg /% — with the I experimental group, methionine — by 19.67 mg/% and by 10.02 mg/% respectively. The same pattern is observed for the rest of the amino acid composition at the end of the experiment. The data obtained indicate that the optimization of the feed rations of Simmental cows in terms of the content of vitamins of groups A and C through the use of the formulation of protein-vitamin-mineral feed additives had a positive effect on the hematopoietic function. So, if the content of vitamins A and C at the beginning of the experiment was low, then at the end of the experiment the same indicators returned to normal.