Similar Principles Research Articles

Renewed Theories and Discourses of 21st Century; City Planning and Housing Design COVID-19 and Beyond, Sustainable, and Green Design

This research delves into the future housing theories of the 21st century, focusing on recent transformations in both urban planning and housing projects and models. Despite the world's anticipation of a vast sustainable transformation since the late 20th century, the first quarter of the 21st century was confronted with an unexpected event: humanity found itself amidst a pandemic that significantly transformed the world. The post-COVID-19 era has guided significant and enduring changes in various aspects from urban planning to living styles, working patterns, housing models, and typologies. This research presents renewed perspectives, based on theoretical dialogues, and discourses that aim to understand the transformation period with recent events specifically housing. The research also includes the perspective of housing in the past aims to contribute to comprehension of this new era and aid in shaping future urban and housing planning strategies. The theoretical basis is to investigate new methods and techniques in urban, and housing planning that have addressed climate-related issues since the 1980s and the subsequent pandemic period. According to the findings obtained in the research, COVID-19 and sustainability initially considered different phenomena, pandemic is essentially triggered and contributed to sustainable city planning, and housing design. While the public perception often distinguishes between COVID-19 and drivability as distinct design concepts, the research reveals a nuanced reality. Despite apparent differences, it is discerning that similar ideas and design principles aim for a healthier housing concept in airier, and greener areas both in terms of housing planning, and models. This intricates a close conceptual relationship between pandemic-induced design adaptations and sustainable concepts underscores the complexity of contemporary urban and housing planning paradigms.

"Synthetic Map": A Graphic Organizer Inspired by Artificial Neural Network Paradigms for Learning Organic Synthesis.

Organic Chemistry is widely recognized as a challenging subject, with the design of syntheses and retrosyntheses identified as particularly difficult tasks. Inspired by the success of artificial neural networks in machine learning, we propose a framework that leverages similar principles to enhance the teaching and learning of organic synthesis. In this paper, we introduce a novel teaching tool, the "Synthetic Map", that attempts to visually recreate an expert's mental map and conceptual understanding of organic synthesis built over years of experience. The educational benefits of the Synthetic Map were evaluated through its implementation in an Organic Chemistry course of a Pharmacy degree over two years. The new tool promoted students' learning by providing a mental organizer fostering a deeper understanding of the subject and empowering students to design and execute effective synthetic strategies.

Simple synthesis of MoSSe heterojunction nanosphere for ultrafast kinetics and high-performance sodium-ion battery

Sodium-ion batteries (SIBs) are expected to be an effective solution for energy storage to be applied to various electronic devices due to their cost-effective performance and similar working principles to lithium-ion batteries (LIBs). However, the electrochemical performances of SIBs are currently hindered by the challenges posed by the large size and slow diffusion kinetics of Na+. Chalcogenide heterojunctions have great potential in SIBs anode materials. Therefore, this study presents a MoSSe heterojunction with a three-dimensional flower-like spherical structure. This heterojunction exhibits enhanced Na+ adsorption and storage capabilities, a high rate of Na+ diffusion, and improved structural stability. These excellent structures and characteristics are highly beneficial for Na+ storage, demonstrating superior stability, and large capacity. Consequently, the designed MoSSe exhibits long cycling stability at 5.0 A g−1 (195.2 mAh g−1 after 2000 cycles) and exceptional capacity at 0.1 A g−1 (413.1 mAh g−1). This work demonstrates that heterojunctions can become excellent electrode materials for SIBs to achieve stable sodium energy storage.

Tectonic Physical Simulation Experiments: Evolution from Qualitative Exploration to Quantitative Analysis and Future Prospects

This review synthesizes the historical development, research methodologies, and current scientific issues of tectonic physical simulation experiments, while also looking forward to future research directions in the field. Since the early 19th century when James Hall first simulated fold formation, the field has undergone a transition from qualitative studies to quantitative analysis. We analyze key research and technological advancements across the early exploration, mid-term development, and late maturation stages, with a particular focus on the introduction and application of the similarity principles, as well as the incorporation of Particle Image Velocimetry (PIV) technology. Despite significant progress, challenges remain in the selection of experimental materials, precise application of similarity principles, and experimental precision. Future research should explore new materials, interdisciplinary collaboration, and the application of big data technology to enhance the accuracy and reliability of simulation experiments.

Framework for scaling-up extraction processes in nutraceutical beverages: A simulation, techno-economic, and environmental analysis approach

The nutraceutical beverages market has increased in recent years, motivated by the increasing trend of consumers choosing food and beverages beneficial to health, mostly after the COVID-19 pandemic. Several researchers have proposed different formulations, where the combination of plants has been tested at the laboratory and pilot scales to maximize the desirable features of the beverages, including antioxidant capacity, anticarcinogens, and anti-inflammatory properties. Developing these products requires scaling-up from these scales to the industry one and, hence, identifying the criteria and/or parameters affecting process yield due to the transport phenomena associated with the scale increment. This work proposes a framework for scaling up solid-liquid extraction in a nutraceutical beverage process using available pilot plant data, combining brute-force and empirical scaling approaches. This framework provides an alternative for industries that have acquired equipment without considering the principles of similarity between the larger scale and the laboratory stage. Operating conditions are tuned to reach the product quality at the pilot level and the maximum beverage's antioxidant capacity. A techno-economic analysis of the production process and an environmental evaluation were performed, providing the basis for an effective scaling-up to the industry level. The scaling-up proved to be feasible, as the net present value of the process is $2018,000 with a payback time of 4.83 years; the major source of solid waste is the raw materials with a carbon footprint less than 0.205 MT eCO2 due this process operates with temperatures lower than 100 °C. The circular economy indicators in this project were circular material usage rate and Waste Stream Recycling Rate. The Circular Material Usage Rate ranged from 16.7 % to 66.7 % depending on the composition of the cocoa husk in the raw material, and the Waste Stream Recycling Rate (%) ranged from 4.4 % to 5 % destined for composting development. The framework is designed to be applicable to other food production processes that encounter equipment constraints. It facilitates the evaluation of process yield and enables the simulation and analysis of economic profitability and environmental impact using circular economy indicators at an industrial/commercial scale.

Benefit-Sharing by Design: A Call to Action for Human Genomics Research.

The ethical standards for the responsible conduct of human research have come a long way; however, concerns surrounding equity remain in human genetics and genomics research. Addressing these concerns will help society realize the full potential of human genomics research. One outstanding concern is the fair and equitable sharing of benefits from research on human participants. Several international bodies have recognized that benefit-sharing can be an effective tool for ethical research conduct, but international laws, including the Convention on Biological Diversity and its Nagoya Protocol on Access and Benefit-Sharing, explicitly exclude human genetic and genomic resources. These agreements face significant challenges that must be considered and anticipated if similar principles are applied in human genomics research. We propose that benefit-sharing from human genomics research can be a bottom-up effort and embedded into the existing research process. We propose the development of a "benefit-sharing by design" framework to address concerns of fairness and equity in the use of human genomic resources and samples and to learn from the aspirations and decade of implementation of the Nagoya Protocol.

Exhaustive local chemical space exploration using a transformer model

How many near-neighbors does a molecule have? This fundamental question in chemistry is crucial for molecular optimization problems under the similarity principle assumption. Generative models can sample molecules from a vast chemical space but lack explicit knowledge about molecular similarity. Therefore, these models need guidance from reinforcement learning to sample a relevant similar chemical space. However, they still miss a mechanism to measure the coverage of a specific region of the chemical space. To overcome these limitations, a source-target molecular transformer model, regularized via a similarity kernel function, is proposed. Trained on a largest dataset of ≥200 billion molecular pairs, the model enforces a direct relationship between generating a target molecule and its similarity to a source molecule. Results indicate that the regularization term significantly improves the correlation between generation probability and molecular similarity, enabling exhaustive exploration of molecule near-neighborhoods.

Pharmacokinetic/pharmacodynamic analysis of vancomycin in patients with Enterococcus faecium bacteraemia: a retrospective cohort study

ObjectivesThe trough concentration of vancomycin and the area under the concentration–time curve (AUC)/minimum inhibitory concentration (MIC) ratio are crucial in determining vancomycin efficacy against methicillin-resistant Staphylococcus aureus. However, the use...

Experimental Study on Explosion Characteristics and Consequences for Homogeneous and Inhomogeneous Methane-Air Mixtures within a Kitchen

ABSTRACT Owing to the effect of a non-uniform concentration distribution, natural gas leakage explosion accidents usually cause different degrees of damage inside residential kitchens. According to the similarity principle, a reduced-scale experiment setup of a kitchen was established. Uniform and non-uniform explosion experiments for methane-air mixtures with concentrations of 7.7%, 9.5%, and 11.2% were performed. The flame propagation behavior and pressure evolution characteristics were analyzed for homogeneous and inhomogeneous methane-air mixtures. In addition, two dimensionless coefficients, namely macroscopic and directional non-uniformity coefficients, were introduced to quantify the uneven distribution of gas concentration within the kitchen. Furthermore, the flame development process and pressure evolvement characteristics were compared between homogeneous and inhomogeneous methane-air mixtures in a fuel-lean, chemical equivalence concentration and fuel-rich state. The results show that the macroscopic non-uniformity coefficients are 0.0998, 0.0653, and 0.0571 on the fuel-lean, chemical equivalence concentration and fuel-rich conditions, respectively. It indicates that the greatest non-uniformity of methane concentration distribution within the kitchen is represented on the fuel-lean condition. The concentration gradient could obviously reduce the explosion overpressure in the fuel-lean condition, whereas it would not significantly decrease the explosion overpressure in the chemical equivalence concentration or fuel-rich condition. It means that the greater the non-uniformity coefficient is, the more significant the effect on the overpressure peak is.

Balancing Plk1 activity levels: The secret of synchrony between the cell and the centrosome cycle.

The accuracy of cell division requires precise regulation of the cellular machinery governing DNA/genome duplication, ensuring its equal distribution among the daughter cells. The control of the centrosome cycle is crucial for the formation of a bipolar spindle, ensuring error-free segregation of the genome. The cell and centrosome cycles operate in close synchrony along similar principles. Both require a single duplication round in every cell cycle, and both are controlled by the activity of key protein kinases. Nevertheless, our comprehension of the precise cellular mechanisms and critical regulators synchronizing these two cycles remains poorly defined. Here, we present our hypothesis that the spatiotemporal regulation of a dynamic equilibrium of mitotic kinases activities forms a molecular clock that governs the synchronous progression of both the cell and the centrosome cycles.

Enhanced Electrohydrogenation of Cis,Cis-Muconic Acid to Trans-3-Hexenedioic Acid Using Hybrid Metal/Carbon Fiber Cathodes

Organic electrosynthesis is a long-known technique for diverse product development and efficient synthesis. With the recent rise of biomass as an alternative carbon and energy source, electrochemistry is further gaining popularity due to its inherently green and environmentally benign operating conditions. Electrochemical hydrogenation (ECH) reactions are particularly attractive for biomass conversion due to their ability to abstract hydrogen from water, tolerate biogenic impurities, and utilize Earth-abundant base metal electrodes. Moreover, the rate and selectivity of the reaction can be tubed by controlling the electrode material, operating potential/current density, and reactor design. However, the implementation of this decarbonized technology for chemical production is still hampered by low productivity and, as a result, unfavorable economics. cis,cis-Muconic acid (ccMA), a bioderived C6 diunsaturated diacid platform molecule, can be converted into commodity chemicals like caprolactam, adipic acid (AA), and terephthalic acid, with AA being of particular interest for the synthesis of nylon 6,6.1 Apart from various drop-in chemicals, ccMA can also be electrochemically upgraded to trans-3-hexenedioic acid (t3HDA), a potential bio-advantaged substitute for AA as the additional C=C bond in t3HDA can be leveraged to synthesize performance-advantaged polyamides.2,3 In this work, we investigated the electrohydrogenation of ccMA to t3HDA over Pb cathodes. We demonstrate that the reaction follows a radical-based pathway involving sequential electron transfer and hydrogen addition in solution to selectively produce t3HDA (100% selectivity). Next, we contacted the cathode with carbon felts (CF) to increase productivity. CF are often used in fuel cells and H2O2 electrolyzers due to their excellent conductivity, porosity for enhanced turbulence, and ability to tune the gas-liquid-solid three-phase interface. Following similar principles, we placed a CF (3mm. thickness) in contact with the Pb cathode to lower the charge transfer resistance (~3Ω) at the interface. The surface functionalities of carbon allowed us to further tune the hydrophobicity/hydrophilicity of our hybrid electrode. Molecular dynamics (MD) calculations provided critical insights into the role of surface functionalities and guided the optimal functionalization of CF’s surface. Combining reactor configuration with fine-tuning of the electrode’s microenvironment, we were able to achieve a 50x increase in t3HDA productivity reaching up to 20 g/cm2/day at a current density of 200 mA/cm2. We further replaced the kinetically sluggish oxygen-evolution reaction with the glucose oxidation reaction at the anode, allowing us to operate the electrolyzer at a lower cell potential.Overall, ECH represents a valuable alternative to thermochemical transformations for biomass upgrading. This work provides critical insights into reactor modifications for the scaled-up synthesis of bio-derived performance monomers via hybrid microbial electrosynthesis (HMES).

“Component flow” conditions and its effects on enhancing production of continental medium-to-high maturity shale oil

Based on the production curves, changes in hydrocarbon composition and quantities over time, and production systems from key trial production wells in lacustrine shale oil areas in China, fine fraction cutting experiments and molecular dynamics numerical simulations were conducted to investigate the effects of changes in shale oil composition on macroscopic fluidity. The concept of “component flow” for shale oil was proposed, and the formation mechanism and conditions of component flow were discussed. The research reveals findings in four aspects. First, a miscible state of light, medium and heavy hydrocarbons form within micropores/nanopores of underground shale according to similarity and intermiscibility principles, which make components with poor fluidity suspended as molecular aggregates in light and medium hydrocarbon solvents, such as heavy hydrocarbons, thereby decreasing shale oil viscosity and enhancing fluidity and outflows. Second, small-molecule aromatic hydrocarbons act as carriers for component flow, and the higher the content of gaseous and light hydrocarbons, the more conducive it is to inhibit the formation of larger aggregates of heavy components such as resin and asphalt, thus increasing their plastic deformation ability and bringing about better component flow efficiency. Third, higher formation temperatures reduce the viscosity of heavy hydrocarbon components, such as wax, thereby improving their fluidity. Fourth, preservation conditions, formation energy, and production system play important roles in controlling the content of light hydrocarbon components, outflow rate, and forming stable “component flow”, which are crucial factors for the optimal compatibility and maximum flow rate of multi-component hydrocarbons in shale oil. The component flow of underground shale oil is significant for improving single-well production and the cumulative ultimate recovery of shale oil.

High-Entropy Prussian Blue Analogues as High-Capacity Cathode Material for Potassium Ion Batteries

Potassium ion batteries, due to their similar electrochemical principles to lithium-ion batteries and the abundance of metal sources, are considered one of the alternatives to lithium-ion batteries. The development of new cathode materials has always been a research focus in this field. Among them, Prussian blue materials, with their three-dimensional open and flexible metal framework structure, can efficiently and reversibly store potassium ions. However, Prussian blue cathode materials still face issues such as poor reversibility and low capacity, which limit their application scope. This study investigates the preparation of high-entropy Prussian blue analogues materials to enhance electrochemical performance. The doping of five different transition metals (Fe2⁺, Co2⁺, Cu2+, Ni2+, and Mn2+) sharing the same nitrogen coordination sites results in a configurational entropy greater than 1.5 R for the material. HEPB-1 cathode material (K1.75Mn0.26Fe0.01Ni0.01Cu0.08Co0.09 [Fe(CN)6]0.66·0.83H2O) shows better electrochemical performance, with the initial discharge capacity of 86.69 and 74.51 mAh g−1 (capacity retention is 75.2% after 100 cycles) at 20 and 100 mA g−1, respectively. The research results have provided new insights for the further development and application of potassium ion batteries.

Model experimental study on the mechanism of collapse induced by leakage of underground pipeline

The evolution and mechanism of ground collapse caused by underground water pipeline leakage have become increasingly significant as more urban areas experience collapses. Based on the principle of similarity, and considering the engineering context of road collapses in Anqing City, Anhui Province, this study designed a 3 m × 2 m × 2 m rupture-collapse model test device. Digital Image Correlation (DIC) technology was employed to investigate the erosion process and collapse mechanisms caused by underground pipeline leakage. The results indicate that groundwater seepage provides the driving force for collapses, combined with the migration space provided by defects, collectively triggering the collapses. When groundwater seepage is minimal, the cohesive forces between soil particles maintain soil stability. As groundwater seepage increases, the soil particle framework is eroded, leading to soil structure destabilization and collapse initiation. The depth of collapse significantly influences stress evolution: stress evolution intensity beneath and above the collapse pit is positively correlated with the distance from the collapse pit bottom, but negatively correlated with the distance from the defect. The research provides insights for the early warning and management of ground collapse.

Warisan Mafqud dan Orang Mati Bersama Menurut Imam Mazhab dan Hukum Islam di Indonesia

This study aims to examine the legal implications for inheritance rights for parties involved in cases of mafqud (missing persons) and individuals who die together according to Islamic law and the Compilation of Islamic Law (KHI) in Indonesia. The research employs a normative legal study method with an Islamic law approach. The findings indicate that Islamic law provides specific provisions for mafqud cases, considering an individual deceased after a certain period, while in cases of individuals dying together, inheritance distribution is based on confirmation of the order of death. KHI follows a similar principle and involves religious courts in resolving inheritance disputes to ensure fairness. The discussion emphasizes the importance of consistent application of legal provisions and the crucial role of religious courts in addressing uncertainty and conflicts in inheritance distribution.

Numerical Simulation of the Behavior of Caisson Based on Physical Modeling

Stiffened caissons are a new kind of offshore platform foundation which has been widely used in recent years. Stiffeners are employed to avoid buckling during the installation process. However, they also create a significant challenge in terms of understating the soil-flow patterns and corresponding installation resistance prediction. Although centrifuge and in situ tests can simulate the caisson installation process very well, their high costs prevent their widespread application. Model tests have been widely used in research on caisson behavior during installation, as they are convenient and cost less compared to centrifuge and prototype tests. However, the quantitative conclusions of the resulting predictions of installation resistance have some uncertainties because it is quite hard to strictly follow the similarity principle in 1 g model tests. Therefore, it is important to establish a method to calibrate the data from model tests, providing better estimates of caisson behavior in field tests. In our research, large deformation finite element (LDFE) analyses were conducted to provide insights into differences in the outcomes of caisson installation approaches between prototype tests and 1 g model tests. Prior to carrying out parametric studies, validations were conducted with good results. The results show that normalized soil strength significantly influences the behavior of caissons of various dimensions in 1 g model tests. In uniform clay, caissons exhibit consistent installation behavior; otherwise, they show significant differences. Based on systematic research, this paper reveals the mechanisms of the difference between model tests and prototype tests with different sizes of caissons and identifies the factors influencing these differences.

Carnap and Wittgenstein: Tolerance, Arbitrariness, and Truth

This article discusses the relationship between Ludwig Wittgenstein’s and Rudolf Carnap’s philosophies of logic during the time of Wittgenstein’s interactions with the Vienna Circle and up to 1934 when the German edition of Carnap’s The Logical Syntax of Language was published. Whilst Section 1 focuses on the relationship between Carnap and Wittgenstein’s Tractatus, including Wittgenstein’s accusation of plagiarism against Carnap in 1932, Section 2 discusses the relationship between Carnap’s principle of tolerance and Wittgenstein’s similar principle of the arbitrariness of grammar. I argue that, although Carnap’s claim in Logical Syntax to ‘go beyond’ Wittgenstein has certain justification in relation to the Tractatus, so does Wittgenstein’s priority claim. The relationship between Carnap’s philosophy of logic and the Tractatus is thus more complicated than is often recognized. If the reference point is Wittgenstein in the early 1930s, however, Carnap cannot be described as going beyond him, and by 1934, Wittgenstein had advanced further than Carnap would ever venture. Despite evidence that Carnap knew about Wittgenstein’s principle of the arbitrariness of syntax well before his first articulations of his principle of tolerance, the extent of the influence of Wittgenstein’s principle on Carnap remains unclear. What can be established with certainty is that Wittgenstein’s principle predates Carnap’s and that Carnap resisted acknowledging him despite being urged to do so. Arguably, Wittgenstein’s account of syntax as both arbitrary and non-arbitrary is also superior in clarity to Carnap’s misleading claim about a ‘complete freedom’ implied by the principle of tolerance, because such a freedom only exists for idle syntactical systems that are not put to work. In Section 3, I discuss the relationship between Carnap’s notion of expediency and Wittgenstein’s account of the correctness or truth of logical accounts. As my discussion of Wittgenstein’s account brings out, Carnap’s rejection of truth in logic for expediency as the goal of logical clarifications does not follow from the principle of tolerance and is not justified by it. It remains unclear what justifies Carnap’s rejection of truth as the goal of logical clarification. Again, Wittgenstein’s account seems preferable, given the vacuity of the claim that expediency constitutes the basis of choice between different logical languages and clarifications.

Evolution features and a prediction model of casing perforation erosion during multi-staged horizontal well fracturing

Large-displacement high-intensity sanding hydraulic fracturing operations often cause casing perforation erosion and thus temporary plugging failures, exacerbate the unevenness of fracture initiation and expansion, and induce casing damage. In order to clarify the dynamic evolution of perforation erosion and predict perforation diameter, the effects of different types of proppants, the viscosity of sand-carrying liquids, and large sand-passing quantities on perforation erosion rate were experimentally explored in the study. The evolution of perforation erosion and the particle size distribution of quartz sand and ceramsite were analyzed in the experiment and a prediction model for perforation erosion under various fracturing parameters was established. Compared to ceramsite, quartz sand had the more significant effect on perforation erosion and the more serious particle abrasion and fragmentation under the same sand-passing quantity. Increasing the viscosity of the sand-carrying liquid slowed down perforation erosion and made the edge of perforation entrance more uniform. As the sand-passing quantity through the perforation increased, perforation erosion in the initial stage was concentrated at the perforation edge. Then, the inner wall of the perforation was also eroded, but the average erosion rate was reduced. A prediction model of perforation erosion considering multiple fracturing parameters was established based on the principle of fluid similarity. The errors between predicted values and downhole eagle-eye observation values were less than 15 %. The model provides an important basis for the optimization of fracturing parameters and downhole casing strength design.

Energy storage mechanism and modeling method of underground aquifer to meet the demand of large-capacity new energy consumption

With the increasing scale of new energy, the ability to rationally utilize new energy power abandonment has become key to improving the operational efficiency of new power systems in the future. Existing new energy power abandonment consumption methods have problems such as limited consumption capacity and large-scale applications. Therefore, to consume the large-scale power abandonment of new energy and enable it to be stored for a long time, this study proposed a method in which electro-thermal conversion devices are used to convert electric energy into thermal energy, and the energy is stored in an underground aquifer. A finite element numerical analysis model was constructed to analyze and calculate this process. A multi-physical field coupling numerical analysis model, considering the seepage of groundwater and the heat transfer of the heat exchangers and porous media, was constructed by combining the distribution characteristics of power abandonment and a theoretical analysis of the heat transfer principle of an aquifer. A scaled test platform was constructed based on the similarity principle to verify the accuracy of the numerical analysis model. The results of the numerical analysis and simulated test showed that the energy storage system could store power abandonment in the form of thermal energy in the aquifer. At the same time, the annual energy loss of the system is only 14.89%, indicating that the system has long-term storage capabilities. In addition, a comparative analysis of the consumption effects of energy storage systems of different sizes showed that an aquifer energy storage system can be configured according to the capacity of power abandonment. Thus, a large-capacity new energy consumption space can be constructed to realize the complete consumption of power abandonment.

The San Francisco Health Systems Collaborative: Public Health and Health Care Delivery Systems’ Response to the Covid-19 Pandemic

The Covid-19 pandemic challenged health care delivery systems worldwide. Many acute care hospitals in communities that experienced surges in cases and hospitalizations had to make decisions such as rationing scarce resources. Hospitals serving low-income communities, communities of color, and those in other historically marginalized or vulnerable groups reported the greatest operational impacts of surges. However, cross-institutional collaborations within jurisdictions offer unique opportunities to prevent or mitigate health disparities in resource utilization and access to care. In January 2020, in response to the emerging coronavirus epidemic, the San Francisco Department of Public Health (SFDPH) and local hospital and health systems partners convened to align and coordinate medical surge planning and response. Adopting a governance structure of mutual accountability and transparency, the San Francisco Health Systems Collaborative guided local medical and public health response in the areas of medical surge, vaccination administration, testing, and therapeutics. Four principles guided the collaborative response: (1) shared priorities, (2) clear governance and accountability, (3) data transparency, and (4) operational coordination. High-level priorities established included protecting vulnerable people, protecting health care workers, and maintaining health system capacity. The governance structure consisted of three layers: local hospital and health systems’ CEOs coordinating with SFDPH executives; hospital chief medical and nursing officers coordinating high-level surge capacity assessments and mitigation plans; and local clinical operational managers working with public health response operational leaders to coordinate scarce resource utilization. Fluctuating with the tempo of the disease indicators and medical surge, governance and coordination were maintained through a tiered meeting and reporting system. Data visibility and transparency were key principles facilitating operational decision-making and executive-level coordination of resources, including identifying additional surge bed capacity for use systemwide, as well as ensuring efficient and equitable vaccine distribution through implementation of five mass-vaccination sites with prioritized access for vulnerable communities. Applying these four principles of shared priorities, accountability, transparency, and operational coordination and pragmatism helped the public health and individual hospital systems make contributions to the overall response that were aligned with their unique strengths and resources. Publication here represents the first official public use of the name San Francisco Health Systems Collaborative (which had served as the term used internally to refer to the group) and the first time codifying this structure. Through this coordination, San Francisco achieved one of the lowest Covid-19 death rates and had one of the highest vaccination and booster rates, compared with rates across California or the United States. Similar principles and implementation methods can be adopted by other health jurisdictions for future emergency outbreak response.