Similar Intensity Research Articles

AVDNet: Joint coronary artery and vein segmentation with topological consistency

Coronary CT angiography (CCTA) is an effective and non-invasive method for coronary artery disease diagnosis. Extracting an accurate coronary artery tree from CCTA image is essential for centerline extraction, plaque detection, and stenosis quantification. In practice, data quality varies. Sometimes, the arteries and veins have similar intensities and locate closely, which may confuse segmentation algorithms, even deep learning based ones, to obtain accurate arteries. However, it is not always feasible to re-scan the patient for better image quality. In this paper, we propose an artery and vein disentanglement network (AVDNet) for robust and accurate segmentation by incorporating the coronary vein into the segmentation task. This is the first work to segment coronary artery and vein at the same time. The AVDNet consists of an image based vessel recognition network (IVRN) and a topology based vessel refinement network (TVRN). IVRN learns to segment the arteries and veins, while TVRN learns to correct the segmentation errors based on topology consistency. We also design a novel inverse distance weighted dice (IDD) loss function to recover more thin vessel branches and preserve the vascular boundaries. Extensive experiments are conducted on a multi-center dataset of 700 patients. Quantitative and qualitative results demonstrate the effectiveness of the proposed method by comparing it with state-of-the-art methods and different variants. Prediction results of the AVDNet on the Automated Segmentation of Coronary Artery Challenge dataset are avaliabel at https://github.com/WennyJJ/Coronary-Artery-Vein-Segmentation for follow-up research.

The influence of illumination regimes on the structure of ant (Hymenoptera, Formicidae) community composition in urban habitats

The reliance on visual cues can vary among ant species living in different habitats, and is mostly influenced by the level of ambient illumination and the morphological adaptations of ant species that can determine their period of daily activity. Thus, different illumination regimes might affect ant community composition in habitats with different ambient illumination intensities. Despite this, in the literature, information is scarce about the effects of ambient illumination on ant activity. In the present study, we investigated the effect of ambient illumination intensity on the activity of ant species and their community composition under herbaceous and woody plants in 24 localities from Kyiv and Kyiv region, Ukraine. Our results showed that the ambient illumination properties of the habitat type affect the presence of ant species and the activity of their workers. In open habitats, the maximum ambient illumination had a negative effect, whereas in closed, woody habitats the maximum ambient illumination and tree circumference generally had a positive effect on the number of non-dendrobiotic ant individuals found on individual plants. The dendrobiotic species were less affected by the maximum illumination intensity. Although, in closed habitats, the effect of the previous variables and their interaction had species-specific aspects. Based on the former, we can tell that more structured forest habitats can provide broader illumination intensity ranges, allowing more ant species to coexist. However, similar illumination intensity ranges can lead to overlaps in the activity of ant species under the same illumination conditions, especially in open habitats. The outcomes of these interactions are highly influenced by larger trees that besides lowering illumination intensities, can enhance ant worker activity and promote species coexistence.

Reactivity of aged biochars to the degradation of adsorbed p-nitrophenol: Role of intensity and species of persistent free radicals

Persistent free radicals (PFRs) in biochar have been found to the transformation of organic contaminants in environment. However, there remains insufficient comprehension on the relationship of biochar aging with interfacial reactivity of PFRs to the degradation of phenolic compound in geochemical process. Herein, we studied both sorption and degradation of p-nitrophenol (PNP) on fresh and aged biochars via H2O2 aging under anoxic condition. With increasing aging extent, the enhancive proportion of O-centered radicals was observed progressively as indicated by increased g factors. The aging of PS350 annihilated the presence of PFRs in aged biochars of low-temperature, weakening PFR intensity. But, the aging of PS650 supplied more O-centered radicals for aged biochars of high-temperature, enhancing PFR intensity. This caused the decreased degradation on 5%PS350 and 15%PS350 (37.7–79.6% decline), whereas the increased degradation on 5%PS650 and 15%PS650 (33.3–55.8% increase). At similar intensity and species of PFRs, more adsorbed amount on fresh and aged biochars produced more degradation of PNP. Nevertheless, when PFR intensity of PS650 was much lower than that of PS350, despite high sorption capacity of PS650, the degradation amount of PS350 and PS650 was comparable. The results indicated that the reactivity of C-centered radicals of PS650 was stronger than that of O-centered radicals of PS350 in anoxic system. Overall, the interfacial reactivity of biochars was simultaneously regulated by the sorption capacity of biochars and intensity and species of PFRs. This work provides a deep perspective to the impact of biochar aging on the interfacial reactivity of PRFs to phenolic compound, which will be beneficial to accurately predict the fate of organic contaminant in carbon-rich environment.

Eu2O3 doped silicoborate glasses for scintillation material application: Luminescence ability and X-ray imaging

The glass samples were prepared by melt quenching method and changing Eu2O3 concentrations following component of xEu2O3 - 40Na2O - 7.5Gd2O3 - 5SiO2 - (47.5-x)B2O3 (x = 0, 1, 2, 3 mol %). Density and molar volume tend to increase with increasing Eu2O3 concentrations, corresponding to the larger non-bridging oxygen. Fourier transform infrared spectra (FTIR) results point out that the majority BO3 borate group. The absorption spectra were represented in the length of UV-Vis and NIR region. The phonon energy of 3Eu:7.5Gd was 1280.54 cm−1, related to the borate glass host. The photoluminescence and X-ray-induced luminescence spectra of 3Eu:7.5Gd glass showed similar highest intensity at 613 nm (5D0→7F2). The photoluminescence quantum yield (PLQY) of 3Eu:7.5Gd glass shows the highest value at 85.70 %. The scintillation efficiency of 3Eu:7.5Gd glass was 17.51 % of bismuth germanate (BGO) crystal. The decay time owing to Eu3+ emission is 2.054 ms for 2Eu:7.5Gd glass. The highest energy transfer efficiency was 2 mol % of Eu2O3 concentrations (ηET = 70 %). The CIE chromaticity coordinates of the glasses are placed in the reddish-orange area (0.65, 0.35). The spatial resolution of X-ray imaging study was 10 lp/mm. These results suggest that 3 mol % of Eu2O3 doped silicoborate glass is capable of being a scintillator applied in the X-ray imaging system.

Factors Associated with the Downshear Reformation of Tropical Cyclones

Abstract The conditions associated with tropical cyclones undergoing downshear reformation are explored for the North Atlantic basin from 1998 to 2020. These storms were compared to analog tropical cyclones with similar intensity, vertical wind shear, and maximum potential intensity, but did not undergo downshear reformation. Storm-centered, shear-relative composites were generated using ERA5 and GridSat-B1 data. Downshear reformation predominately occurs for tropical cyclones of tropical storm intensity embedded in moderate vertical wind shear. A comparison between composites suggests that reformed storms are characterized by greater low-level and midtropospheric relative humidity downshear, larger surface latent heat fluxes downshear and left of shear, and larger low-level equivalent potential temperatures and CAPE right of shear. These factors increase thermodynamic favorability, building a reservoir of potential energy and decreasing dry air entrainment, promoting sustained convection downshear, and favoring the development of a new center. Significance Statement The development of a new low-level circulation center in tropical cyclones that replaces the original center, called downshear reformation, can affect the structure and intensity of storms, representing a challenge in forecasting tropical cyclones. While there have been a handful of case studies on downshear reformation, this study aims to more comprehensively understand the conditions that favor downshear reformation by comparing a large set of North Atlantic tropical cyclones that underwent reformation with a similar set of tropical cyclones that did not undergo reformation. Tropical cyclones that undergo reformation have a moister environment, larger surface evaporation, and higher low-level instability in specific regions that help sustain deep, downshear convection that favors the development of a new center.

Role of Insole Material in Treatment of Plantar Fasciitis: A Randomized Clinical Trial

Category: Hindfoot; Other Introduction/Purpose: Plantar fasciitis (PF), a leading cause of persistent heel pain, results in almost a million physician visits annually. Conservative treatment is often the first line of management with insoles being frequently prescribed. While multiple studies have compared insoles based on the degree of customization to foot contour, the literature is lacking in data comparing insoles based on their material. In this randomized clinical trial, we compared the early effects of foam, polyurethane, and carbon fiber insoles in the treatment of PF, using a robust set of PROMS. Methods: A randomized clinical trial was designed at the foot and ankle research center of a tertiary care hospital in Massachusetts. Adult patients diagnosed with PF who had not received injectable or surgical treatment for it were included. Participants who consented were randomly allocated one of the three prefabricated insoles – carbon fiber insole (Group 1, n=13), polyurethane insole (Group 2, n=13), or foam insole (Group 3, n=9) for regular use. Their response was recorded using PROMIS 3a (for pain intensity), PROMIS 4a (for pain interference), FAOS (Foot and Ankle Outcome Score), and VAS for pain at baseline (T0), two (T2), six (T6) and twelve weeks (T12). A per-proto analysis was undertaken using Kruskal Wallis and Friedman tests. P< 0.05 was set as the level of significance. Results: Among groups 1, 2 and 3, the mean age of participants was 51.9±13.2, 51±12.5, and 47.9±13.5 years respectively and baseline weight varied as 211.6±32.7 lbs, 193.6±59.3 lbs, and 180.7±33 lbs respectively (p>0.05 for both). The group-wise distribution of participants based on sex and laterality of the affected foot showed no difference. Participants in each group reported similar intensity of the pain (VAS) at baseline and at all follow-up time points (p>0.05). A comparison of outcomes between baseline and subsequent timepoints showed significant improvement in quality of life (FAOS) at T12 (p=0.047) for carbon fibre insole users (Figure 1), significant pain relief on PROMIS Pain intensity and Pain Interference questionnaires for foam insoles at T3 and T12 (p=0.0003, 0.036 respectively). Conclusion: Carbon fiber insoles offered slightly better pain relief as early as six weeks into treatment and improved quality of life after twelve weeks of use. A possible link between the material of insole used and effective treatment of PF may exist. Conducting further analyses on the position of the foot during gait while using insoles and designing the insoles based on patient-specific criteria should be considered for future research.

Muscle activation patterns during active external rotation after reverse total shoulder arthroplasty: an electrophysiological study of the teres minor and associated musculature

Preoperative teres minor insufficiency has been identified as a risk factor for poor restoration of external rotation (ER) after reverse total shoulder arthroplasty (RTSA). However, there has been little investigation regarding muscle activation patterns generating ER. This prospective study sought to determine the timing and activation levels of the shoulder girdle musculature during ER in well-functioning RTSAs with an intact teres minor using a lateralized design. Patients who underwent RTSA ≥1 year previously with functional ER, an American Shoulder and Elbow Surgeons (ASES) score >70, superior rotator cuff deficiency, and an intact teres minor were identified. Electrophysiological and kinematic analyses were performed during ER in the modified neutral position (arm at side with 90° of elbow flexion) and in abduction (AB) (shoulder abducted 90° with 90° of elbow flexion). Dynamometer-recorded torque and position were pattern matched to electromyography during ER. The root-mean-square and integrated electromyography (in microvolts × milliseconds with standard deviation [SD]), as well as median frequency (MF) (in hertz with SD), were calculated to determine muscle recruitment. Pair-wise t test analysis compared muscle activation (P<.05 indicated significance). After an a priori power analysis, 16 patients were recruited. The average ASES score, visual analog scale pain score, and ASES subscore for ER in AB ("comb hair") were 87.7, 0.5, and 2.75 of 3, respectively. In AB, muscle activation began with the upper trapezius, middle trapezius, and latissimus dorsi, followed by the anterior deltoid activating to neutral. With ER beyond neutral, the teres major (9.6 μV × ms; SD, 9.2 μV × ms) initiated ER, followed by the teres minor (14.1 μV × ms; SD, 18.2 μV × ms) and posterior deltoid (11.1 μV × ms; SD, 9.3 μV × ms). MF analysis indicated equal contributions of the teres major (1.1 Hz; SD, 0.5 Hz), teres minor (1.2 Hz; SD, 0.4 Hz), and posterior deltoid (1.1 Hz; SD, 0.4 Hz) in ER beyond neutral. In the modified neutral position, the upper trapezius and middle trapezius were not recruited to the same level as in AB. For ER beyond neutral, the teres major (9.5 μV × ms [SD, 9 μV × ms]; MF, 1.1 Hz [SD, 0.5 Hz]), teres minor (11.4 μV × ms [SD, 15.1 μV × ms]; MF, 1.1 Hz [SD, 0.5 Hz]), and posterior deltoid (8.5 μV × ms [SD, 8 μV × ms]; MF, 1.2 Hz [SD, 0.3 Hz]) were activated in similar sequence and intensity as AB. No differences in muscle activation duration or intensity were noted among the teres major, teres minor, and posterior deltoid (P>.05). Active ER after RTSA is complex and is not governed by a single muscle-tendon unit. This study establishes a sequence, duration, and intensity of muscle activation for ER in well-functioning RTSAs. In both tested positions, the teres major, teres minor, and posterior deltoid function equally and sequentially to power ER.

HAU-Net: Hybrid CNN-transformer for breast ultrasound image segmentation

Breast cancer is a significant health concern that remains one of the leading causes of mortality in women worldwide. Convolutional Neural Networks (CNNs) have been shown to be effective in ultrasound breast image segmentation. Yet, because of the lack of long-distance dependence, the segmentation performance of CNNs is limited in addressing challenges typical of segmentation of ultrasound breast lesions, such as similar intensity distributions, the presence of irregular objects, and blurred boundaries. In order to overcome these issues, several studies have combined transformers and CNNs, to compensate for the shortcomings of CNNs with the ability of transformers to exploit long-distance dependence. Most of these studies limited themselves to rigidly plug transformer blocks into the CNN, lacking consistency in the process of feature extraction and therefore leading to poor performances in segmenting challenging medical images. In this paper, we propose HAU-Net(hierarchical attention-guided U-Net), a hybrid CNN-transformer framework that benefits from both the long-range dependency of transformers and the local detail representation of CNNs. To incorporate global context information, we introduce a L-G transformer block nested into the skip connections of the U shape architecture network. In addition, to further improve the segmentation performance, we added a cross attention block (CAB) module on the decoder side to allow different layers to interact. Extensive experimental results on three public datasets indicate that the proposed HAU-Net can achieve better performance than other state-of-the-art methods for breast lesions segmentation, with Dice coefficient of 83.11% for BUSI, 88.73% for UDIAT, and 89.48% for BLUI respectively.

Myocardial Tissue Characterization in Patients with Hypertensive Crisis, Positive Troponin, and Unobstructed Coronary Arteries: A Cardiovascular Magnetic Resonance-Based Study.

Hypertensive crisis can present with cardiac troponin elevation and unobstructed coronary arteries. We used cardiac magnetic resonance (CMR) imaging to characterize the myocardial tissue in patients with hypertensive crisis, elevated cardiac troponin, and unobstructed coronary arteries. Patients with hypertensive crisis and elevated cardiac troponin with coronary artery stenosis <50% were enrolled. Patients with troponin-negative hypertensive crisis served as controls. All participants underwent CMR imaging at 1.5 Tesla. Imaging biomarkers and tissue characteristics were compared between the groups. There were 19 patients (63% male) with elevated troponin and 24 (33% male) troponin-negative controls. The troponin-positive group was older (57 ± 11 years vs. 47 ± 14 years, p = 0.015). The groups had similar T2-weighted signal intensity ratios and native T1 times. T2 relaxation times were longer in the troponin-positive group, and the difference remained significant after excluding infarct-pattern late gadolinium enhancement (LGE) from the analysis. Extracellular volume (ECV) was higher in the troponin-positive group (25 ± 4 ms vs. 22 ± 3 ms, p = 0.008) and correlated strongly with T2 relaxation time (rs = 0.701, p = 0.022). Late gadolinium enhancement was 32% more prevalent in the troponin-positive group (82% vs. 50%, p = 0.050), with 29% having infarct-pattern LGE. T2 relaxation time was independently associated with troponin positivity (OR 2.1, p = 0.043), and both T2 relaxation time and ECV predicted troponin positivity (C-statistics: 0.71, p = 0.009; and 0.77, p = 0.006). Left ventricular end-diastolic and left atrial volumes were the strongest predictors of troponin positivity (C-statistics: 0.80, p = 0.001; and 0.82, p < 0.001). The increased T2 relaxation time and ECV and their significant correlation in the troponin-positive group suggest myocardial injury with oedema, while the non-ischaemic LGE could be due to myocardial fibrosis or acute necrosis. These CMR imaging biomarkers provide important clinical indices for risk stratification and prognostication in patients with hypertensive crisis.

Pain experience in eating disorders: The mediating role of depression, alexithymia and interoceptive awareness.

Evidence suggests reduced sensitivity to pain due to high pain threshold in anorexia and bulimia nervosa and a possible role of depression, alexithymia and interoceptive awareness on pain experience. This study examined whether self-report and real-time evoked pain experience were mediated by depression, alexithymia and interoceptive awareness in a comprehensive sample of patients with eating disorders (ED). 145 participants (90 ED, 55 healthy controls (HC)) underwent a real-time evoked examination of pain and completed self-report questionnaires for pain (Pain Detect Questionnaire (PD-Q), PD-Q VAS, Leeds Assessment of Neuropathic Symptoms and Signs), depression (BDI-II), interoceptive awareness Multidimensional Assessment of Interoceptive Awareness (MAIA), and alexithymia (TAS-20). Three mediation models, with ED diagnosis as independent variable, and BDI, MAIA and TAS-20 as mediators, were tested. Participants with ED and HC exhibited similar pain type and intensity (self-report and real-time). Eating disorders diagnosis was associated with lower self-report pain intensity and non-neuropathic like pain experience (model 1-2). Depressive symptoms partially (model 1-2) or fully (model 3) mediated the association between ED diagnosis and pain experience, alone (model 1) or via alexithymia (model 3). Interoceptive awareness did not influence pain symptomatology. ED diagnosis is associated with non-neuropathic and lower pain experience. However, concurrent depression and alexithymia are associated with higher pain symptoms and neuropathic features. These results could inform clinicians about the influence of psychopathology on pain experience in ED.

Comparison Of Hemodynamic Responses To Isometric And Aerobic Exercise At Similar Intensities In Normotensive Men

Comparison Of Hemodynamic Responses To Isometric And Aerobic Exercise At Similar Intensities In Normotensive Men

The Quagmire of Arrested Development in Tropical Cyclones

Abstract The 48-h intensity forecasts for Hurricane Pamela (2021) from numerical weather prediction models, statistical–dynamical aids, and forecasters were a major forecast bust with Pamela making landfall as a minor rather than major hurricane. From the satellite presentation, Pamela exhibited a symmetric pattern referred to as central cold cover (CCC) in the subjective Dvorak intensity technique. Per the technique, the CCC pattern is accompanied by arrested development in intensity despite the seemingly favorable convective signature. To understand forecast uncertainty during occurrences, central cold cover frequency from 2011 to 2021 is documented. From these cases, composites of longwave infrared brightness temperatures from geostationary satellites for CCC cases are presented, and the surrounding tropical cyclone large-scale environment is quantified and compared with other tropical cyclones at similar latitudes and intensities. These composites show that central cold cover has a consistent presentation, but varies in the preceding hours for storms that eventually intensify or weaken. And, the synoptic-scale environment surrounding the tropical cyclone thermodynamically supports the vigorous deep convection associated with CCC. Finally, intensity forecast errors from numerical weather prediction models and statistical–dynamical aids are examined in comparison to similar tropical cyclones. This work shows that guidance struggles during CCC cases with intensity errors from these models being in the lowest percentiles of performance, particularly for 24- and 36-h forecasts. Significance Statement The appearance of symmetric cold clouds near the center of developing tropical cyclones is most often associated with future intensification. This simple relationship is widely used by statistical tropical cyclone intensity forecast models. Here, we reexamine and confirm that one subjectively determined nighttime cold cyclone cloud pattern termed the “central cold cover” pattern in Vern Dvorak’s seminal technique for estimating tropical cyclone intensity from infrared satellite images is indeed related to slow or arrested development, and represents a failure mode for these simple forecast models.

Autotetraploid Origin of Chinese Cherry Revealed by Chromosomal Karyotype and In Situ Hybridization of Seedling Progenies.

Polyploidy is considered a driving force in plant evolution and diversification. Chinese cherry [Cerasus pseudocerasus (Lindl.) G.Don], an economically important fruit crop native to China, has evolved at the tetraploid level, with a few pentaploid and hexaploid populations. However, its auto- or allo-polyploid origin remains unclear. To address this issue, we analyzed the ploidy levels and rDNA chromosomal distribution in self- and open-pollinated seedling progenies of tetraploid and hexaploid Chinese cherry. Genomic in situ hybridization (GISH) analysis was conducted to reveal the genomic relationships between Chinese cherry and diploid relatives from the genus Cerasus. Both self- and open-pollinated progenies of tetraploid Chinese cherry exhibited tetraploids, pentaploids, and hexaploids, with tetraploids being the most predominant. In the seedling progenies of hexaploid Chinese cherry, the majority of hexaploids and a few pentaploids were observed. A small number of aneuploids were also observed in the seedling progenies. Chromosome 1, characterized by distinct length characteristics, could be considered the representative chromosome of Chinese cherry. The basic Chinese cherry genome carried two 5S rDNA signals with similar intensity, and polyploids had the expected multiples of this copy number. The 5S rDNA sites were located at the per-centromeric regions of the short arm on chromosomes 4 and 5. Three 45S rDNA sites were detected on chr. 3, 4 and 7 in the haploid complement of Chinese cherry. Tetraploids exhibited 12 signals, while pentaploids and hexaploids showed fewer numbers than expected multiples. Based on the GISH signals, Chinese cherry demonstrated relatively close relationships with C. campanulata and C. conradinae, while being distantly related to another fruiting cherry, C. avium. In combination with the above results, our findings suggested that Chinese cherry likely originated from autotetraploidy.

Immunofluorescence Staining for IgG Subclass: Cause for Discrepancy in the Detection of IgG1

Immunofluorescence (IF) staining for IgG subclasses plays an important role in the classification of kidney disease. However, widely used IgG subclass-specific antibodies are now commercially unavailable. Thus, we compared alternative antibodies for performing IgG subclass staining. A total of 21 cases were stained by 3 different methods: direct IF using fluorescein isothiocyanate (FITC)-conjugated polyclonal antibodies against IgG1-4 (commercially unavailable method), direct IF using FITC-conjugated monoclonal antibodies (clones HP-6091, 6014, 6050, and 6025), indirect IF using monoclonal antibodies (clones HP-6069, 6002, 6050, and 6025), and FITC-conjugated polyclonal secondary antibody. For cases with discrepancy in IgG1 staining, additional direct IF using FITC-conjugated monoclonal antibody (clone 4E3) was performed. Of 21 cases, 11 (52%) had no staining for IgG1 by direct IF using the clone HP-6091 despite≥1+ staining by the direct IF using polyclonal antibodies. Similarly, direct IF for IgG1 using the clone 4E3 had negative result in all 10 cases with available tissue. However, indirect IF for IgG1 using the clone HP-6069 had similar staining intensity (within 1 order of magnitude) as direct IF using the polyclonal antibodies (10 of 10). Results of IF for IgG2, IgG3, and IgG4 were similar in most cases. The choice of antibodies influences the result of IgG subclass staining, especially for anti-IgG1 antibodies, in which 2 monoclonal antibodies (HP6091 and 4E3) appear less sensitive. Although this may be due to unaccounted variables and requires confirmation, our results may partially explain the difference in IgG1 staining in the literature and underscore the need for careful validation.

A Novel Densenet-324 Densely Connected Convolution Neural Network for Medical Crop Classification using Remote Sensing Hyperspectral Satellite Images

In the past few decades, importance of the medicinal Crops is extending to a large extent due to its benefits in treating life-threatening diseases. Medicinal Crop has excellent medicinal properties on its roots, stem, and leaves to prevent human and animal health. Particularly detection and identification of the Crop classes are effectively carried out using hyperspectral images as discrimination of the target feature or objects is simple and it contains rich information containing the spatial and temporal details of underlying the land cover. However, Crop classification using machine learning architectures concerning spectral characteristics obtained on the anatomical features and morphological features. Extracted features towards classification lead to several challenges such as large spatial and temporal variability and spectral signatures similarity between different objects. A further hyperspectral image poses several difficulties with changes in illumination, environment, and atmospheric aspects. To tackle those non-trivial challenges, DenseNet-324 Densely Connected convolution neural network architecture has been designed in this work to discriminate the crop and medical Crop effectively in the interested areas. Initially, the Hyperspectral image is pre-processed against a large number of noises through the employment of the noise removal technique and bad line replacement techniques. Pre-processed image is explored to image segmentation using the global thresholding method to segment it into various regions based on spatial pieces of information on grouping the neighboring similar pixels intensity or textures. Further regions of the image are processed using principle component analysis to extract spectral features of the image. That extracted feature is employed to ant colony optimization technique to obtain the optimal features. Computed optimal features are classified using Convolution Neural Network with a hyper parameter setup. The convolution Layer of the CNN architecture process spatial, temporal, and spectral feature and generates the feature map in various context, generated feature map is max pooled in the pooling layer and classified into crops and medicinal Crop in the SoftMax layer. Experimental analysis of the proposed architecture is carried out on the Indiana Pines dataset using cross-fold validation to analyze the representation ability to discriminate the features with large variance between the different classes. From the results, it is confirmed that the proposed architecture exhibits higher performance in classification accuracy of 98.43% in classifying the Crop species compared with conventional approaches.

Analyzes In Silico Indicate the lncRNAs MIR31HG and LINC00939 as Possible Epigenetic Inhibitors of the Osteogenic Differentiation in PDLCs.

Chromatin conformation, DNA methylation pattern, transcriptional profile, and non-coding RNAs (ncRNAs) interactions constitute an epigenetic pattern that influences the cellular phenotypic commitment and impacts the clinical outcomes in regenerative therapies. Here, we investigated the epigenetic landscape of the SP7 transcriptor factor (SP7) and Distal-Less Homeobox 4 (DLX4) osteoblastic transcription factors (TFs), in human periodontal ligament mesenchymal cells (PDLCs) with low (l-PDLCs) and high (h-PDLCs) osteogenic potential. Chromatin accessibility (ATAC-seq), genome DNA methylation (Methylome), and RNA sequencing (RNA-seq) assays were performed in l- and h-PDLCs, cultured at 10 days in non-induced (DMEM) and osteogenic (OM) medium in vitro. Data were processed in HOMER, Genome Studio, and edgeR programs, and metadata was analyzed by online bioinformatics tools and in R and Python environments. ATAC-seq analyses showed the TFs genomic regions are more accessible in l-PDLCs than in h-PDLCs. In Methylome analyses, the TFs presented similar average methylation intensities (AMIs), without differently methylated probes (DMPs) between l- and h-PDLCs; in addition, there were no differences in the expression profiles of TFs signaling pathways. Interestingly, we identified the long non-coding RNAs (lncRNAs), MIR31HG and LINC00939, as upregulated in l-PDLCs, in both DMEM and OM. In the following analysis, the web-based prediction tool LncRRIsearch predicted RNA:RNA base-pairing interactions between SP7, DLX4, MIR31HG, and LINC00939 transcripts. The machine learning program TriplexFPP predicted DNA:RNA triplex-forming potential for the SP7 DNA site and for one of the LINC00939 transcripts (ENST00000502479). PCR data confirmed the upregulation of MIR31HG and LINC00939 transcripts in l-PDLCs (× h-PDLCs) in both DMEM and OM (p < 0.05); conversely, SP7 and DLX4 were downregulated, confirming those results observed in the RNA-Seq analysis. Together, these results indicate the lncRNAs MIR31HG and LINC00939 as possible epigenetic inhibitors of the osteogenic differentiation in PDLCs by (post)transcriptional and translational repression of the SP7 and DLX4 TFs.

Process-Oriented Diagnosis of Tropical Cyclones in Reanalyses Using a Moist Static Energy Variance Budget

Abstract Global models are frequently used for tropical cyclone (TC) prediction and climate projections but have biases in their representation of TCs that are not fully understood. The objective of this work is to assess how well and how robustly physical processes that are important for TC development are represented in modern reanalysis products and to consider whether reanalyses can serve as an observationally constrained reference against which model representation of these physical processes can be evaluated. Differences in the representation of large-scale environmental variables relevant to TC development do not readily explain the spread in TC climatologies across climate models, as found in prior work, or across reanalysis datasets, as shown here. This motivates the use of process-oriented diagnostics that focus on how convection, moisture, clouds, and related processes are coupled and can be used to identify areas to target for model improvement. Using the column-integrated moist static energy (MSE) variance budget, we analyze radiative and surface flux feedbacks across five different reanalyses. We construct an intensity-bin composite of the MSE variance budget to compare storms of similar intensity. Our results point to some fundamental differences across reanalyses in how they represent MSE variance and surface flux and radiative feedbacks in TCs, which could contribute to differences across reanalyses in how they represent TCs, but other factors also likely contribute. Any future work that evaluates these diagnostics in GCMs against reanalyses should do so cautiously, and efforts should be undertaken to provide a true observational estimate of these processes.

Post-COVID-19 Symptoms in Adults with Asthma-Systematic Review.

Research on the longer-term sequelae of COVID-19 in patients with asthma is limited. To assess the frequency and severity of long-term symptoms of COVID-19 in the population of asthma patients. A systematic review of the published literature was conducted in accordance with the recommendations of the PRISMA statement. EMBASE, MEDLINE/PubMed, Web of Science, CINAHL, and Scopus Scholar were searched for terms related to asthma and post or long COVID-19, and for systematic reviews related to specific questions within our review, up to June 2022. Data from 9 references publications included in the review were extracted. A total of 1466 adult asthmatic patients with COVID-19 infection were described in all the publications mentioned above. Of the long-term symptoms reported after COVID-19, patients indicated: lower respiratory symptoms, fatigue, cognitive symptoms, psychological problems, and other such as skin rashes, gastrointestinal disorders, tachycardia, palpitations, ocular disorders, ageusia/hypogeusia, anosmia/hyposmia, and poor sleep quality. These symptoms in similar intensity were observed in the comparison groups without a diagnosis of asthma. The published data neither confirm nor deny that long-term COVID-19 symptoms in patients with asthma diagnosis are different in strength and frequency from patients without asthma diagnosis. To indicate associations between asthma and COVID-19 infection and severity, as well as the frequency of long-term symptoms of COVID-19, more longitudinal research is needed in chronic asthma patients with different phenotypes, intensity of treatment, and degree of asthma control.

Experimental investigation on two-dimensional aerodynamic admittances of rectangular cylinders in various turbulent flows

This paper conducts an experimental investigation of two-dimensional aerodynamic admittances (2D AAFs) for rectangular 5:1 cylinders within various turbulent flow fields. The determination of 2D AAF is achieved by removing the influence of the three-dimensional effect (3D effect) from the traditional AAF, wherein the traditional AAF can be straightly derived based on the ratio of the one-dimensional fluctuating force spectrum to the one-dimensional turbulent wind spectrum. In line with prior research, the values of traditional AAFs show variations in response to the 3D effect in different turbulent flow fields. Moreover, within homo-turbulence conditions, or more specifically, under similar turbulence intensity, the traditional AAFs differ depending on the turbulent integral scale to the model characteristic width ratios (dimensionless turbulent integral scale). Compared to the traditional AAF, the 2D AAF effectively cuts down on the discrepancies arising from the dimensionless turbulent integral scale. In cases where different dimensionless turbulent integral scales are present but the turbulence intensity remains constant, the 2D AAFs are almost consistent. Nevertheless, it can be observed that the 2D AAF of the rectangular 5:1 cylinder is still affected by turbulence intensity. For different turbulence intensities, the 2D AAFs have certain changes. When there is less turbulence intensity, it frequently approaches the quasi-steady value, and as the turbulence intensity increases, it gradually approaches the Sears function.

Long-term effects of resistance exercise with and without vascular occlusion on TNF-α, IL-6 and IL-15 secretion in non-athletic women

Abstract Resistance training is associated with reduced risk of low-grade inflammation related diseases. This study aimed to consider the effect of two methods of resistance training with and without vascular occlusion on changes in some serum cytokines in young non-athlete women. Thirty non-athlete women (20 to 30 years of age) were randomly divided into three groups (n=10 in each): resistance training without vascular occlusion (traditional), resistance training with vascular occlusion, and a control group. Resistance training was conducted three sessions for 8 weeks. In the vascular occlusion group, prior to the main exercise, the proximal part of both thighs was closed with a rubber tourniquet and the resistance exercise was performed with an intensity of 20–30% 1-repetition maximum (1RM) until fatigue. In the group without vascular occlusion, the same exercise were performed with similar intensity (with 70–80% 1RM until fatigue). Serum interleukin (IL)-15, IL-6, and tumour necrosis factor-alpha (TNF-α) were measured by ELISA method. One-way ANOVA was employed to compare the changes in the studied variables. The results show that serum levels of IL-6 and TNF-α and IL-15 do not have a significant change in groups with and without obstruction (P&gt;0.05). Numerous studies have evaluated the positive effects of vascular occlusion on muscle hypertrophy and strength during rehabilitation. According to the results of the present study, it seems that the use of vascular occlusion exercise has less effect on inflammatory or IL-15.