Silver Nanoparticles In Treatment Research Articles

Effect of Folic Acid Conjugated Silver Nanoparticles in Treatment of RA Like Adjuvant Arthritis in Rats

Objective: Nano medicine has become one of the promising research areas, opening new horizons in disease diagnosis and treatment. Recent years have witnessed a surge in the development of Nano medicine for combating rheumatoid arthritis (RA), the most common autoimmune arthritis. RA is characterized by progressive inflammation and persistent synovitis, leading to joint destruction, functional incapability, and ultimately disability. Although there has been a tremendous evolution in disease assessment and treatment, many patients still fail to attain remission. Therefore, developing new drugs that specifically target inflamed joints and simultaneously attenuate other possible damages to healthy tissues is indispensable. This study was done to evaluate the potential of folic acid conjugated silver nanoparticles (FA-AgNPs) as RA therapy. Methods: In the CFA-arthritic rat model, FA-AgNPs & methotrexate were administered for 8 consecutive weeks. Therapeutic efficacy was evaluated by measuring paw volume, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), tumor necrosis factor (TNF-α), and interleukin-6 (IL-6) levels. For safety concerns, complete blood picture (CBC), liver and renal function tests were evaluated. Joints histological assessment was also carried out. Results: FA-AgNPs significantly reduced paw volume, paw weight, ESR, CRP, RF, TNF-α, and IL-6 levels compared with arthritic non-treated rats, demonstrating good anti-inflammatory activity. Likewise, histology of tarsal joints depicted comparatively lesser inflammatory cellular infiltration and diminished cartilage erosions. Methotrexate displayed comparable results. In contrast to methotrexate, FA-AgNPs showed normal CBC & significantly improved liver and renal function tests. Conclusion: FA-AgNPs exhibited substantial anti-arthritic activity. This notable anti-arthritic potential of FA-AgNPs was as good as the current standard treatment of methotrexate (MTX) with higher biosafety.

Comparison of Hydrocolloid Dressings and Silver Nanoparticles in Treatment of Pressure Ulcers in Patients with Spinal Cord Injuries: A Randomized Clinical Trial.

Introduction: There are numerous dressings used to treat pressure ulcers (PUs), depending on their advantages to achieve optimum patient outcomes. This study aimed to compare hydrocolloid dressings and silver nanoparticles in treating PUs among patients with spinal cord injury (SCI). Methods: This randomized clinical trial was conducted on 70 patients with SCI in Iran. Participants were randomly divided into two equal groups (n=35) receiving silver nanoparticle dressing and hydrocolloid dressing, respectively. The groups were evaluated in four assessment periods using the Bates-Jensen Wound Assessment Tool (BWAT). Data analysis was performed using SPSS software version 13, repeated measures ANOVA, non-parametric tests, and chi-square. Results: Chi-square test was used to investigate the difference between the scores before the intervention, the results of which were not statistically significant. In repetitive measurements, the results of the analysis of variance showed that the average assessment score in both groups decreased and both dressings were effective in the treatment process. Although PU improvement status in the group that received silver nanoparticles was better, between-group analysis of variance did not show any statistically significant difference between the two groups. Conclusion: Our results indicated that silver nanoparticles and hydrocolloid dressings can be used interchangeably in the treatment of PUs.

The effectiveness of biogenic silver nanoparticles in the treatment of caprine mastitis induced by Staphylococcus aureus

The aim of the present study is to determine the efficiency of silver nanoparticles in mastitis treatment induced by Staphylococcus aureus, 20 lactating goats were infected intramammaryinoculated with 1.5×108 cfu/ml of virulence Staphylococcus aureus isolated from milk of caprine mastitis and at 48hr post inoculation, the animals were divided randomly into four groups equally, 1st group left without treatment as control positive, 2nd group treated intramammaryinfusion with 5 ml Silver nanoparticle after 2h from infection daily for 3 consecutive days, 3rd group treated intramammaryinfusion with 5 ml Silver nanoparticle after 72h from infection daily for 3 consecutive days, 4th group treated intramammaryinfusion with 5 ml Silver nanoparticle mixed with gentamycin after 72h from infection daily for 3 consecutive days. The silver nanoparticles used in this study were created using a green method from Bacillus clausii. The Scanning electron microscope was spherical and homogeneous form, with a size range of 25 to 45 nm. Results showed severe clinical signs of the mammary gland with heavy bacterial isolation in 1st control groups at 3, 6-, 9-, 14- and 21-days post infection, while animals that were intramammary treated with Silver nanoparticle alone or combination with gentamycin showed a disappearance in clinical signs of the mammary gland and bacterial isolation, it was concluded that Silver nanoparticle had a strong action against mastitis caused by Staphylococcus aureus.

Effect of systemic administration of silver nanoparticles in treatment of experimental periodontitis in albino rats

ABSTRACTIntroduction: Periodontal disease is one of the main dental diseases that affectmillions of people around the world. Modern nanotechnology progression andrenovations through nanodentistry providing a suitable solution for the treatment of manydental illnesses including periodontal disease. Aim: Histological and ultrastructuralevaluation of the effect of silver nanoparticles in treatment of periodontitis in albinorats. Materials and methods: A total of 18 adults male albino rats with body weightranging from 150 to 180 gm were used and divided into three groups group 1: served ascontrol, group 2: used for induction of experimental periodontitis using wiring aroundthe cervix of mandibular central incisors for two weeks, and group 3: after induction ofexperimental periodontitis as in group 2 they were subjected to intraperitoneal injectionwith silver nanoparticles for the treatment of periodontitis three times per week for fourweeks. Results: Histological and ultrastructural investigation revealed that periodontalligament around ligated mandibular incisors showed marked improvement in thedegenerated fibers after injection with silver nanoparticles in group 3 compared togroup 2 as the fibers regained their association in strong bundles and they regained theirattachment to regenerated bone and tooth surface. Conclusions: Marked regenerationof the periodontium of periodontally affected ligated mandibular incisors reflected thatsilver nanoparticles have a great anti-inflammatory effect

Applications of Gold and Silver Nanoparticles in the Treatment of Acne Vulgaris: A Systematic Review.

Current treatments for acne are often accompanied by undesirable side effects and contribute to antibiotic resistance. Gold and silver nanoparticles are an emerging treatment method with potentially fewer adverse effects. To evaluate current literature discussing the various uses of gold and silver nanoparticles in the potential treatment of acne vulgaris. A search of PubMed, EMBASE, and SCOPUS databases was conducted through April 22, 2020 to identify studies using gold or silver nanoparticles in the treatment of acne vulgaris. 16 original articles were identified in the systematic review including clinical studies, case reports, and in vitro publications. The available evidence found gold nanoparticles to be effective when combined with phototherapy to target overactive sebaceous glands and bacteria, or to mediate localized, targeted drug release. Silver nanoparticles have primarily been studied for their antibacterial properties. This review found gold and silver nanoparticles to be a promising treatment for acne vulgaris. Further randomized controlled studies are needed to determine clinical efficacy and the role of gold and silver nanoparticles in the treatment algorithm for acne. J Drugs Dermatol. 2021;20(6):666-670. doi:10.36849/JDD.5762.

In vivo efficacy of biocompatible silver nanoparticles cream for empirical wound healing

Wound healing is a complicated process that begins at the onset of injury and a continued process till complete healing. The emergence of nanotechnology has provided a new therapeutic modality to silver nanoparticles in treatment of wounds. However, the safety of these silver nanoparticles in the process of wound healing is yet to be elucidated; nevertheless, biocompatibility is the primary concern. Biosynthesis of silver nanoparticles was synthesized using aqueous clove extract and silver nitrate solution under microwave and the obtained particles size were 30–60 nm and roughly spherical in shape. The present study focused on the efficacy of biocompatible silver nanoparticles in vivo wound healing process. Consequently, this study supported the incorporation of biosynthesized silver nanoparticles in wound dressings as a cream formulation for improved healthcare.

Characterization and Antitumor Activity of Chitosan/Poly (Vinyl Alcohol) Blend Doped with Gold and Silver Nanoparticles in Treatment of Prostatic Cancer Model

Characterization and Antitumor Activity of Chitosan/Poly (Vinyl Alcohol) Blend Doped with Gold and Silver Nanoparticles in Treatment of Prostatic Cancer Model

SILVER NANOPARTICLES IN THE SOLUTION OF THE PROBLEM OF DRUG RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS

The goal — a scientific evaluation of the effectiveness and safety of NHS in the treatment of experimental drug-resistant tuberculosis. Materials and methods. Used silver nanoparticles obtained by an electrochemical method. With a size of 5-60 nm, 120-270 kontsentratsiey- 1 mcm² and the size of the stabilizer shell — 2-5 nm. 750 crops studied Inhibitory activity of the silver nanoparticles in an isolated form and as part of a nanocomposite with chemotherapy in concentrations of 5; 25 and 50 mcg/ml. Defines the minimum inhibitory concentration of bactericidal nanoparticles composed of a nanocomposite with isoniazid. To evaluate the morphometry M.tuberculosis used atomic force microscopy. Toxicology nanopreparations studied 83 non-linear white mice and 146 white rats. Chemotherapeutic Activity nanopreparations determined on an experimental model of tuberculosis in 65 white male mice imbrednoy line BALB/c. Infectivity dose amount 5х106 colony forming units injected into the sinus venosus animal eyes. Isoniazid, nanoparticles and nanocomposite began administered 14 days after infection by intramuscular injection daily. Treatment efficacy was determined by comparing the evaluation criteria in the experimental and control groups of animals. Evaluated the following indicators: survival index, body mass index and weight of target organ, lesions index, index smear and inoculation of affected organs. Conducted pathological examination. Results. When using isoniazid, which had resistant pathogens, with silver nanoparticles full and significant inhibition of the growth of the M.tuberculosis observed in 49,2% of cases. When the concentration of the nanoparticles 5 mcg/ml in the composite bactericidal activity reached 91,3%. The minimum inhibitory concentration of silver nanoperticles in combination with isoniazid was 2,5 mcg/ml, the minimum bactericidal — 5 mcg /ml. There have been changes in the M.tuberculosis morphometry under the influence of the nanocomposite according to atomic force microscopy. In the studied doses of isolated silver nanoparticles do not affect the basic biometrics, laboratory and functional parameters of the animals, and do not increase the toxicological parameters of isoniazid. All criteria studied the effectiveness of treatment of experimental tuberculosis had significantly priority performance using nanocomposite. Pathological studies have confirmed these results. Conclusions. Of the study provides a scientific rationale for the effectiveness of the experimental use of silver nanoparticles in treatment of drug-resistant tuberculosis. The most effective dose of silver nanoparticles in the composite in the treatment of experimental tuberculosis is 25 mcg / kg.

Use of Silver Nanoparticles in Treatment of Socially Significant Diseases

The effects of colloidal silver are determined by concentration, sizes and stability of the finely-divided nanoparticles. Studies of silver-based drugs acting against antibiotic-resistant microorganisms are of significant scientific and practical interest. Silver does not effect on the infection, but directly on the cell structure. The main disadvantages of the current nanosilver-based compositions include low aggregative stability, polydispersity and oxidation of silver nanoparticles during prolonged storage. The main attention should be paid to the preservation of activity and bioavailability of the active substance, and ideally the increase in efficiency through synergy with other components of the formulation. Scientists of different special fields should focus not only on the development of new technologies for production of new nanomedicines, but on the possible health and environmental side effects