Some early reports have indicated that silicate cements are highly irritating to the pulp.'Yet Barker5 has reported that the reactions that took place under silicate were not sufficiently severe to indicate that death of the pulp might result. Shroff6 has considered that the placement of a properly mixed synthetic porcelain did not produce complete pulp necrosis in the common instance, provided that due care was exercised during cavity preparation and that the cavity was not of exceptional depth. Van Huysen and Boyd7 have concurred. More recently, investgators8 using rats' incisors have reported that the effect of silicate cement on the pulp was always severe. Mitchell,9 using the subcutaneous implantation technique in rats, has reported a moderate to severe soft-tissue reaction to silicate cement. Kozam and Burnett,10 using windows cut in rats' incisors, have suggested that if the acidic components in the cement were to affect the pulp significantly, they would have to be in sufficient excess in a deep cavity as to soften the dentin between the cement and the pulp. Mitchell, Buonocore, and Shazer, using monkeys, have reported a mild or minimal reaction to three silicate cements when the cavity floor was thicker than 400 [t, and that the reaction increased as the floor thickness decreased to 50 pt or pulp exposure. Most research in this field has been done by inserting silicate cement into freshly prepared cavities cut in sound teeth of human beings or animals. In actual practice, carious teeth that may have developed dentinal sclerosis and secondary dentin are usually restored, and it is assumed by most that this protects the pulp from the irritating effect of the restorative material. A study by Weider, Schour, and Mohammed'2 has indicated that cavity depth was the most significant factor in determining the amount of secondary dentin formed in rat molars. Less significant were the different filling materials or exposure to the oral fluids. Zander and Pejkol3 had earlier suggested a 3-month interval be allowed prior to placing silicate cement in order to permit irregular dentin formation for pulp protection. It was the purpose of this study to induce and study the development, amount, and morphology of secondary dentin formed beneath deep cavities in deciduous and permanent teeth prepared and left unrestored for 3 months, also to study the modifying effect of the accumulated secondary dentin on pulp irritation due to silicate cement restorations after 1and 2-week periods. As controls, and to evaluate earlier studies in