This paper presents the first data on the flora of silica-scaled chrysophytes (orders Synurales and Paraphysomonadales) in the delta of the Mekong River (Vietnam). A total of 15 taxa have been identified: nine from the genus Mallomonas, one from Synura, and five from Paraphysomonas. Six taxa are reported for the first time from Vietnam. At most sites, 1–2 species per station are recorded. The maximum diversity (12 taxa) is revealed at the station with salinity >1 g/L. Based on previous floristic studies of silica-scaled chrysophytes in Vietnam, the number of taxa known from the country has been increased to 66. Our studies have expanded the list of species which have tolerance to salinity of about 1 g/L.