Significant ST Segment Depression Research Articles

Interpreting results of exercise studies after acute myocardial infarction altered by thrombolytic therapy, coronary angioplasty or bypass

Numerous studies have assessed the ability of exercise modalities to predict patient outcome after acute myocardial infarction (AMI). Implicit in the use of these prior data to assess the prognosis of patients currently undergoing exercise studies is the assumption that patients selected for exercise assessment are similar over time and that the data generated in the past are therefore applicable to the current patient populations. This study retrospectively assessed the clinical, exercise, and rest and exercise radionuclide angiographic data in 791 consecutive patients referred for exercise radionuclide angiography within 1 month after AMI during a 5-year period to determine if the clinical and exercise characteristics of patients referred for exercise evaluation after infarction have changed significantly over time. Most parameters examined demonstrated significant increasing trends, including thrombolytic therapy at the time of AMI, revascularization procedure between AMI and exercise assessment, age, β-blocker usage, Q-wave AMI, inferior infarction, exercise double product, exercise capacity, significant ST-segment depression with exercise, peak ejection fraction, and change in ejection fraction with exercise. These data indicate that the characteristics of patients selected to undergo exercise after AMI in a large referral center have changed significantly over time. If these data are applicable to other referral centers and to other exercise testing modalities, previously published results regarding exercise assessment after AMI will need to be reconfirmed in patients currently selected for testing, since these results may no longer be applicable in this current era of aggressive medical and interventional management.

Prevention of creatine kinase-MB release in coronary artery disease and pacing-induced myocardial ischemia by isosorbide dinitrate spray

The effect of isosorbide dinitrate (ISDN) spray on release of the isoenzyme creatine kinase-MB (CK-MB) after myocardial ischemia induced by atrial pacing was evaluated in 8 patients with coronary artery disease. Atrial pacing to ischemia (ST-segment depression of ≥1.5 mm for ≥80 ms) resulted in elevation of CK-MB levels in plasma drawn from the coronary sinus, from 1.8 ± 1.5 to 6.8 ± 7.0 ng/ ml (p < 0.001) at 30 minutes after onset of ischemia. When atrial pacing was repeated at the same rate after 1 squirt of ISDN spray, 1.25 mg, the CK-MB levels were not altered despite significant ischemic ST-segment depression. It is concluded that ISDN prevents the process responsible for myocardial release of CK-MB, being either micronecroses or a reversible consequence of ischemia.

Long-term cardiorespiratory effects of amelioration of renal anaemia by erythropoietin

The long-term cardiorespiratory effects of recombinant human erythropoietin treatment were investigated in ten haemodialysis patients by means of maximum exercise testing, lung function tests, echocardiography, chest X-ray, and rheological assessment over 12 months. There were significant rises in exercise time (mean [SD] 13·2 [5·5] to 20·0 [6·2] min), maximum oxygen consumption (19·1 [7·0] to 25·0 [6·7] ml.min-1.kg-1), and anaerobic threshold (11·7 [3·6] to 15·4 [4·8] ml.min-1.kg-1) after 2 months of erythropoietin treatment. The improvements were maintained but not augmented on repeat testing after 4, 8, and 12 months of therapy. Carbon monoxide treatment rose from 15·5 (2·9) to 18·6 (3·7) ml.min-1.mm Hg-1. There was a substantial reduction in exercise-induced cardiac ischaemia (eight patients had significant ST segment depression before erythropoietin, only one after 2 months' treatment, and none after 12 months' treatment), despite a significant rise in whole blood viscosity. Left ventricular mass, as estimated by echocardiography, progressively decreased from 354 (169) g to 251 (95) g after 12 months' treatment, and four patients showed a reduction in cardiothoracic ratio on chest X-ray.

ECG Response to Water and Land Based Exercise in Patients with Cardiovascular

The purpose of this study was to compare the ECG response during land, based (LB) and. water based (WB) exercise rehabilitation of cardiac patients. Thirty-seven patients (JOURNAL/jcrh/04.02/00008483-199001000-00001/ENTITY_OV0335/v/2017-08-08T011905Z/r/image-png age = 55.6 ± 5.0 yrs; 19 Myocardial Infarction; 4 Coronary Bypass Surgery; 5 Angina; 5 Silent Ischemia; 4 Other) completed a maximal exercise test (GXT) (X HRmax= 132 ± 23 bpm; JOURNAL/jcrh/04.02/00008483-199001000-00001/ENTITY_OV0335/v/2017-08-08T011905Z/r/image-png BPmax = 170/85 ± 21/19 mmHg;JOURNAL/jcrh/04.02/00008483-199001000-00001/ENTITY_OV0335/v/2017-08-08T011905Z/r/image-png functional capacity = 9 Mets) and participated in both the LB and WB exercise programs. Both LB and WB were designed to use varying arm and leg exercises eliciting a heart rate response of 70–85% of attained HR max for 40–50 minutes, excluding warm-up and cool down. The ECG was continuously monitored by telemetry during LB and WB, and evaluated for arrhythmias and ST changes. The mean exercise HR was 98 ± 15 bpm and 104 ±17 bpm during LB and swimming WB respectively, which was not significantly different (P > 0.05). Significant ST segment depression was present in 14 subjects during the GXT (38%) and in seven subjects (19%) during both LB and WB (Chi-Square = 4.7; P > 0.05). Ectopy was present in nine (24%) subjects during the GXT and in 14 (38%) and two (5%) subjects during LB and WB respectively (Chi-Square = 11.3; P

Improvement of ST Segment Depression by Gradual Recruitment of Collateral Circulation

The purpose of the present study was to document that the coronary collateral vessels do not open immediately upon the occurrence of myocardial ischemia. A multistage bicycle exercise was performed to determine a maximal tolerable work load until the onset of angina and significant ST segment depression in 10 patients with well-developed collateral circulation. On a different day, exercise with the maximal tolerable work load was repeated for a comparable exercise duration. In 2 of the 10 patients, anginal pain was gradually alleviated despite the continuation of exercise with fixed work load. The extent of ST segment depression at 3 min of exercise with fixed work load was 0.20 +/- 0.10 (SD) mV, significantly (p less than 0.05) greater than 0.16 +/- 0.08 mV at the end of exercise with fixed work load. In contrast, the rate-pressure product was smaller at 3 min than at the end of exercise with fixed work load (20,900 +/- 5,500 vs. 22,700 +/- 5,700 mm Hg.beats/min; p less than 0.05). In 5 patients without well-developed collateral circulation, the extent of ST depression changed in parallel with changes in rate-pressure product during exercise with fixed work load. Thus, it is concluded that the delayed collateral opening plays a critical role in the pathogenesis of myocardial ischemia in patients with a totally occluded coronary artery.

New Exercise Parameter for the Identification of Severe Coronary Artery Disease

Exercise testing remains one of the most useful noninvasive diagnostic tests for identification of the patient with coronary artery disease. Significant ST segment depression,1 chronotropic incompetence,2 hypotensive systolic blood pressure response,3 and angina at low workload4 have all been shown to be of diagnostic and prognostic value in patients with severe coronary artery disease. However, the sensitivity of these criteria varies considerably, and their diagnostic value can be further limited in the presence of LVH,5 electrocardiographic conduction abnormalities such as LBBB,6 arrhythmia such as atrial fibrillation,7 and in patients receiving medical therapy such as digitalis8 or beta adrenergic blockers.

Left main coronary artery disease: radionuclide angiographic function versus anatomic correlates with visual and quantitative angiographic methods

The results of exercise radionuclide angiography in 29 patients with significant left main coronary artery stenosis were examined to correlate functional left ventricular performance with anatomic severity of left main coronary artery stenosis. Change in ejection fraction, regional wall motion, and peak ejection fraction were widely variable; none of these parameters correlated with severity of left main stenosis as assessed by visual or quantitative angiographic methods. Twenty-five patients (86%) had two or more of the following indicators of ischemia with exercise: chest pain, significant ST-segment depression, systolic hypotension, definite decrease in ejection fraction, or definite decline in regional wall motion. However, four patients (14%) had only mild abnormalities in ejection fraction and regional wall motion, although they did have hemodynamic and electrocardiographic evidence of severe ischemia. Exercise radionuclide angiography yields heterogeneous results in patients with significant left main coronary artery stenosis. Anatomically severe left main coronary artery stenosis is not always associated with mechanical evidence of severe ischemia.

Assessment of silent and symptomatic ischemia in daily activity by an ambulatory ventricular function monitor.

We have assessed the sequential changes in left ventricular function and ECG in 39 patients with coronary artery disease (CAD) using an ambulatory ventricular function monitor. Following radionuclide ventriculography, the instrument detectors were placed over the region of the left ventricle and lung, and beat-to-beat left ventricular time activity curve and modified V5 ECG data were continuously monitored for up to 6 hours (mean 2.5 hours), while the patient performed various daily activities. Thirty-six episodes of transient ejection fraction (EF) decrease (6-18%) were recorded in 16 patients, 12 were symptomatic and 24 asymptomatic. ST segment changes were recorded in 6 of the 12 symptomatic and 5 of the 24 asymptomatic episodes. In 10 of the 12 symptomatic episodes, EF began to drop 30 to 90 seconds before the onset of the symptoms. Of 14 episodes of significant ST segment depression in five patients, 11 were associated with a significant EF decrease. We conclude that the combination of left ventricular function and ECG monitoring is a promising means for determining incidence of silent and symptomatic ischemia and for severity of ischemia in patients with CAD.

The effects of physical training in post-myocardial infarction patients with exercise-induced silent ischaemia

To assess the clinical significance of monitoring during physical training in post-myocardial infarction (MI) patients with asymptomatic exercise-induced ischaemia, we studied 232 patients who were survivors of first recent acute MI and consecutively admitted to the same CCU, who underwent an exercise test (ET) and coronary angiography within two months of the acute event. We selected the 97 patients with multivessel disease. Among them, 60 showed a negative ET and no angina; 37 showed a positive ET with significant ST segment depression, 32 of them had no angina. The 37 patients with positive ET repeated the stress test within a week. In eight of them, the two ETs differed because ischaemia was induced once with and once without precipitation of angina, while the workload (WL) and double product (DP) at the ischaemic threshold of 0.1 mV ST segment depression were not different. During a four-week training period, seven of the asymptomatic patients complained of effort angina and three of angina at rest. To assess training effects, we selected 60 non-consecutive patients with asymptomatic (38) and symptomatic (22) exercise-induced ischaemia. All the symptomatic and 25 asymptomatic patients followed a four-week physical training programme based on the ischaemic threshold. The remaining 13 asymptomatic patients did not undergo physical training. The pre-training period ergometric patterns were comparable between painful and pain-free patients. Training resulted in a similar increase in the WL at the ischaemic threshold (+45% in asymptomatic and +47% in symptomatic patients, both P less than 0.05), without any difference in the DP threshold.(ABSTRACT TRUNCATED AT 250 WORDS)

Exercise testing after myocardial infarction: Relative values of the low level predischarge and the postdischarge exercise test

This study was undertaken to compare the relative values of the low level predischarge exercise test and the postdischarge (6 weeks) symptom-limited test in 518 consecutive patients admitted with an acute myocardial infarction. Of the patients who did not develop significant ST segment depression or angina during the predischarge test, the symptom-limited test also remained negative in 91.5 and 91.9% of the patients, respectively. Similar results were obtained with ST segment elevation and the systolic blood pressure response during the two exercise tests with only 2.1 and 11.4% changing from normal to abnormal, respectively. Discriminant function analysis was done to predict the occurrence of coronary events (unstable angina, reinfarction, cardiac failure, cardiac death) with use of the data from the exercise tests together with other clinical and investigational data. The jackknife method correctly classified 71.9 and 71.4% of the patients with the data from the predischarge exercise test and symptom-limited test, respectively. Combining the data from the two tests improved the overall predictive accuracy to only 75.0%. It is concluded that the routine performance of a symptom-limited test 6 to 8 weeks after infarction does not reveal any significant additional information in those patients who have undergone a predischarge low level exercise test. Thus the 6 to 8 week test should be restricted to selected patients after myocardial infarction.

Effects of Exercise-Induced Ischemia on Isovolumic Relaxation Period: An Echopolycardiographic Study

The time course of the isovolumic relaxation period (IRP), evaluated by the echopolycardiographic method, has been assessed in 20 patients with angiographically demonstrated coronary artery disease (CAD) and in 14 age-matched healthy subjects (N), at rest and during supine bicycle exercise. During the stress test all CAD showed significant ST segment depression ( > 0.1 mV). IRP decreased in both groups, but the decrease was significantly (p < 0.05) higher in CAD compared to controls. Moreover, CAD showed a greater duration of both the preejection period and ejection time during exercise. Because timing of ejection is an important determinant of the rate of relaxation, the results of this study suggest that a delayed and longer ventricular ejection could play a role in the abnormal shortening of IRP during exercise-induced ischemia.

Early precordial ST-segment depression due to isolated acute right or left circumflex coronary artery occlusion

Prolonged chest pain (at least 30 minutes) and ST-segment elevation on the admission electrocardiogram are frequently used as the sole eligibility criteria for patient enrollment into randomized studies of thrombolytic therapy during acute myocardial infarction (AMI). 1,2 The rationale for using these criteria is that in most patients with acute ST-segment elevation, “transmural” AMI and pathologic Q waves will develop if the patient is treated conventionally. 3 Conversely, patients presenting with AMI characterized by electrocardiographic ST-segment depression are usually excluded from participation in acute thrombolytic trials, ostensibly because such ST-segment depression is a marker of “subendocardial ischemia” or non-Q-wave AMI, and thus is not indicative of a totally occluded infarct-related artery. 4 We report 2 patients with 1-vessel coronary artery disease who had significant precordial ST-segment depression associated with isolated acute occlusion of a dominant right coronary artery and circumflex coronary artery, respectively.

Value of the treadmill exercise test in asymptomatic and minimally symptomatic patients with chronic severe aortic regurgitation

The value of the graded treadmill exercise test was assessed in 19 asymptomatic and minimally symptomatic (13 NYHA class I and 6 NYHA class II) male patients with chronic severe aortic regurgitation. It was observed that, in 2 patients who showed significant ST segment depression at peak exercise, the total exercise duration was significantly shorter ( P < 0.001) than in the patients not showing such changes. During left ventricular and aortic root angiography (in both patients) and selective left coronary angiography (in one of them), ST segment changes similar to those seen during exercise testing were observed. The mean rise in left ventricular end-diastolic pressure after injection of contrast material was significantly more ( P < 0.001) in these 2 patients compared to the other 17 patients. Both patients had normal resting M-mode echocardiographic parameters. It is concluded that ST segment depression on exercise testing and reduced exercise capacity are indicants of exercise-induced left ventricular dysfunction in asymptomatic and minimally symptomatic patients with chronic severe aortic regurgitation. Furthermore, it is suggested that this simple and cheap test can be used for serial evaluation of such patients in the absence of the facility of radionuclide cineangiography.

Ambulatory heart rate and ST-segment depression during painful and silent myocardial ischemia in chronic stable angina pectoris

The relation between heart rate and ischemic ST-segment depression was studied in 70 patients with documented obstructive coronary artery disease (CAD) and reproducible effort angina. Symptom-limited treadmill exercise testing was performed before and after a 2-week placebo period and 24-hour FM ambulatory electrocardiographic monitoring at the end of the placebo period. The means (± standard deviation) of the basal and placebo values for exercise time, heart rate and maximal ST-segment depression were: 6.4 ± 2.6 minutes vs 6.9 ± 2.8 minutes (difference not significant [NS]), 125 ± 17 beats/min vs 125 ± 19 beats/min (NS) and 2.3 ± 0.8 mm vs 2.1 ± 0.8 (NS), respectively. Ambulatory monitoring revealed 205 episodes of significant ST-segment depression (J + 80 ms; 49 episodes with more than 1 mm, 83 with more than 2 mm, 39 with more than 3 mm and 34 with more than 4 mm). Of all episodes of ST-segment depression, 130 (64%) were asymptomatic. The episodes lasted for 3 to 110 minutes. The maximal 24-hour ambulatory heart rate and ST-segment depression during ischemic episodes were expressed as a percentage of those seen during exercise-induced ischemia. When all ambulatory ischemic episodes (both symptomatic and asymptomatic) were compared with exercise-induced ischemic changes in the individual patient, there was little difference in heart rate (91 ± 15% vs 90 ± 18%, NS) but there was a greater magnitude of ST-segment depression (122 ± 57% vs 104 ± 52%, p < 0.05). When the symptomatic and asymptomatic ambulatory episodes were compared, the variables of heart rate, duration of the episodes and diurnal variation were not significantly different. The magnitude of ST-segment depression was greater during the symptomatic episodes than during the asymptomatic episodes (p < 0.05). Since heart rate reflects myocardial oxygen demand, the variation in magnitude of ST depression between these 2 types of episode suggests different mechanisms of ischemia. Changes in myocardial perfusion secondary to transient impairment in coronary flow cannot be ruled out in the genesis of silent myocardial ischemia during daily life in patients with chronic stable angina.

Myocardial ischemia during daily activities and stress

Twenty-four-hour, 2-channel Holter monitoring during daily activities was performed in 210 patients; during the same day a Bruce protocol treadmill test was also performed and the electrocardiogram was recorded using the same Holter system. Significant ST-segment depression was observed during daily activities in 97 patients, while similar changes were recorded during the treadmill test in 122 patients. Thus, 77% of patients with ST depression during the provocation of the treadmill test had ischemic episodes during their everyday life. On the other hand, 3 patients with proven significant coronary artery disease had spontaneous ischemic episodes during daily activities, but had a negative stress test. The ischemic changes during daily activity developed at a lower heart rate than during stress testing (94 beats/ min vs 109 beats/min, respectively, p < 0.05). A total of 351 ischemic episodes were recorded during daily activities, 241 (69%) of these were asymptomatic. In 46 patients all episodes were asymptomatic, in 15 all were symptomatic, while in 36 both symptomatic and silent episodes were detected. The mean duration of the symptomatic episodes was 13.7 minutes and that of the asymptomatic ones was 14.9 minutes (difference not significant). The degree of ST depression in these 2 groups was also similar. Because of more advanced symptomatology in 143 patients, coronary arteriography was performed; 43 had normal and 100 had pathologic coronary arteries. In this selected group, the sensitivity of Holter monitoring during daily activity was 87% and during stress 97%; the specificity during daily activity was 95% and during stress 88%. These data support the use of Holter monitoring for evaluating ischemic changes during daily activity and suggest its potential application for judging efficacy of antianginal therapy.

Character of transient ischemia in angina pectoris

There is growing interest in the possible therapeutic and prognostic significance of silent myocardial ischemia in coronary artery disease (CAD) and its detection by ambulatory electrocardiographic (ECG) monitoring. In 100 apparently healthy normal subjects (20 with angiographically normal coronary arteries), Holter monitoring revealed significant ST-segment depression in only 2 (both over 40 years, one with positive treadmill test, the other with risk factor for CAD). No significant ECG changes were found in those with normal coronary vessels. In 30 patients with documented CAD, significant ST-segment depression during 1,934 episodes over 446 days of monitoring over 18 months was found. Only 24% of the episodes were associated with angina. Asymptomatic and symptomatic episodes were associated with comparable changes in perfusion detected by positron emission tomography. Heart rate increases >10 beats/mm preceding the onset of the ST-segment changes occurred in only 23% of the episodes. There was considerable variability in the ST-segment changes in the same patient monitored serially over long periods of time. The data indicate that it is extremely uncommon for patients without CAD to exhibit silent myocardial ischemia, whereas patients with stable angina exhibit frequent, variable and often asymptomatic ECG evidence of myocardial ischemia rarely triggered by increases in heart rate. These findings are likely to be of therapeutic and prognostic significance.

Clinical evaluation of transient myocardial ischemia during daily life

Ambulatory ST-segment monitoring has been introduced in an attempt to obtain an objective measure of transient myocardial ischemia during daily life. Serial observations conducted out of the hospital have produced a picture of the nature and activity of ischemic heart disease that differs markedly from that obtained by conventional assessment. Episodes of transient ischemia appear to be more frequent and prolonged than is suggested by the occurrence of chest pain. Furthermore, only a minority of episodes are associated with tachycardia, and most occur at heart rates well below those achieved during exercise testing. This suggests that mechanisms other than an excessive increase in myocardial oxygen demand may be responsible for the many episodes occurring outside the hospital. Accurate interpretation of this new information depends on the reliability of transient ST-segment depression as a marker of ischemia. In 100 normal volunteers, episodes of significant ST-segment depression similar to that observed in patients with angina were rare (2 percent). Positron emission tomography with rubidium-82 was used to study regional myocardial perfusion during transient ST-segment depression with and without pain in patients with angina and coronary disease. All episodes of painless ST-segment depression and 97 percent of episodes with angina were accompanied by tomographic evidence of ischemia. This much broader view of ischemic heart disease, revealed by studies performed out of the hospital during patients' ordinary daily activities, has important implications for the objective assessment of symptoms, the relief of ischemia, and the prevention of myocardial damage.

Myocardial ischemia induced by prostacyclin and iloprost

Vasodilators of resistive vessels may induce ischemia in patients with coronary artery disease. To evaluate this possibility during prostacyclin (PGI2; scalar doses up to 10 ng/kg/min) and prostacyclin analog (iloprost; scalar doses up to 6 ng/kg/min) infusions, we studied 33 patients with angina pectoris and proved coronary artery disease. Patients were also submitted to dipyridamole (0.15 mg/kg/min for 4 minutes) and exercise stress testing (starting at 25 W and increasing 25 W every 2 minutes). In a preliminary study the hemodynamic and side effects of iloprost were studied in seven healthy subjects. At an iloprost dose of 4 to 6 ng/kg/min, these subjects had a significant decrease in mean arterial pressure and total peripheral and pulmonary vascular resistances. Side effects were limited to facial flushing and slight headache and were readily reversible. PGI2 induced typical chest pain and significant ST segment depression in six patients with severe coronary artery disease (three with left main and three with triple vessel disease) and poor exercise tolerance (means +/- SD = 362 +/- 99 seconds). All six patients had had angina during the dipyridamole infusion. Similar findings were observed after iloprost infusion in four of these. Aminophylline (125 mg iv) completely relieved chest pain. Although the rate-pressure products occasionally rose during PGI2 and iloprost infusions, there were no significant changes between ischemic (11.3 +/- 2.3 and 10.6 +/- 1.4 X 10(-3) U) and preischemic (10.8 +/- 1.5 and 10.7 +/- 1.4 X 10(-3) U) rates of infusion. Our data indicate that PGI2 and iloprost may induce ischemia independently of changes in oxygen demand, and suggest that these drugs dilate small coronary vessels. This may result in decreased subendocardial perfusion pressure and/or "coronary steal."

Side effects of prostacyclin in patients with angina pectoris and coronary artery disease.

Although the exposure of human subjects to prostacyclin (PGI2) infusion has been broad, no systematic approaches have been made in order to investigate the dose-related side effects in patients with angina pectoris and coronary artery disease (CAD). We studied 25 patients with typical chest pain and overt CAD. All patients underwent a cycloergometer stress testing (25 W increments at 2-min intervals). PGI2 was infused in scalar doses up to 10 ng/kg/min. During the infusion 25 patients (100%) had facial flushing, 7 (28%) moderate headache and one (4%) had nausea. In addition, 4 patients experienced the typical chest pain and had significant (greater than or equal to 0.1 mV) ST segment depression at 8.10 ng/kg/min infusion rates. These patients had lower tolerance to exercise (6.7 +/- 1.7 vs. 8.8 +/- 1.9 min; p less than 0.05) and coronary artery lesions more severe than those observed in patients without drug-induced angina pectoris. Our data therefore indicate that PGI2 at therapeutic doses may induce myocardial ischemia in patients with angina pectoris, low tolerance to exercise and severe CAD. In patients with mild to moderate degree of CAD, PGI2 was found to be well tolerated. These findings suggest that patients with angina pectoris and low tolerance to exercise should be excluded from clinical studies directed at elucidating the effectiveness of PGI2 in cardiovascular disorders.

Coronary angiography during exercise-induced angina with ECG changes

Coronary angiography was performed at rest and during bicycle exercise immediately after the onset of angina and significant ST segment elevation or depression in the ECG. Of 11 patients, six showed significant reduction of coronary lumen diameter at the site of organic stenosis; mean values of stenosis (range) before and during exercise were 55% (25% to 88%) and 98% (89% to 100%), respectively. Five patients did not have any diameter change of the organic lesion; mean values of stenosis (range) before and during exercise were 84% (74% to 89%) and 84% (73% to 92%), respectively. Excluding the areas of these stenoses, diameters of left main coronary artery, proximal, middle, and distal left anterior descending, circumflex, and right coronary artery segments were measured before and during exercise. Diameter in each coronary artery segment during exercise was not significantly changed from that before exercise, both in the groups with and without diameter reduction. Exercise provoked a localized worsening of coronary artery stenosis without changing the diameter in the remaining artery. These findings suggest that the worsening of stenosis might be caused by a regional abnormality of the coronary artery that is not necessarily related to the degree of organic stenosis.