Abstract
The time course of the isovolumic relaxation period (IRP), evaluated by the echopolycardiographic method, has been assessed in 20 patients with angiographically demonstrated coronary artery disease (CAD) and in 14 age-matched healthy subjects (N), at rest and during supine bicycle exercise. During the stress test all CAD showed significant ST segment depression ( > 0.1 mV). IRP decreased in both groups, but the decrease was significantly (p < 0.05) higher in CAD compared to controls. Moreover, CAD showed a greater duration of both the preejection period and ejection time during exercise. Because timing of ejection is an important determinant of the rate of relaxation, the results of this study suggest that a delayed and longer ventricular ejection could play a role in the abnormal shortening of IRP during exercise-induced ischemia.
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