Significant Extension Research Articles

Repairing Regular Expressions for Extraction

While synthesizing and repairing regular expressions (regexes) based on Programming-by-Examples (PBE) methods have seen rapid progress in recent years, all existing works only support synthesizing or repairing regexes for membership testing, and the support for extraction is still an open problem. This paper fills the void by proposing the first PBE-based method for synthesizing and repairing regexes for extraction. Our work supports regexes that have real-world extensions such as backreferences and lookarounds. The extensions significantly affect the PBE-based synthesis and repair problem. In fact, we show that there are unsolvable instances of the problem if the synthesized regexes are not allowed to use the extensions, i.e., there is no regex without the extensions that correctly classify the given set of examples, whereas every problem instance is solvable if the extensions are allowed. This is in stark contrast to the case for the membership where every instance is guaranteed to have a solution expressible by a pure regex without the extensions. The main contribution of the paper is an algorithm to solve the PBE-based synthesis and repair problem for extraction. Our algorithm builds on existing methods for synthesizing and repairing regexes for membership testing, i.e., the enumerative search algorithms with SMT constraint solving. However, significant extensions are needed because the SMT constraints in the previous works are based on a non-deterministic semantics of regexes. Non-deterministic semantics is sound for membership but not for extraction, because which substrings are extracted depends on the deterministic behavior of actual regex engines. To address the issue, we propose a new SMT constraint generation method that respects the deterministic behavior of regex engines. For this, we first define a novel formal semantics of an actual regex engine as a deterministic big-step operational semantics, and use it as a basis to design the new SMT constraint generation method. The key idea to simulate the determinism in the formal semantics and the constraints is to consider continuations of regex matching and use them for disambiguation. We also propose two new search space pruning techniques called approximation-by-pure-regex and approximation-by-backreferences that make use of the extraction information in the examples. We have implemented the synthesis and repair algorithm in a tool called R3 (Repairing Regex for extRaction) and evaluated it on 50 regexes that contain real-world extensions. Our evaluation shows the effectiveness of the algorithm and that our new pruning techniques substantially prune the search space.

A compact 9–23 GHzlow noise amplifier with bandwidth extension techniques in 0.18‐μmSiGe BiCMOS

AbstractIn this paper, a novel wideband low noise amplifier (LNA) operating in the 9–23 GHz frequency range is presented. The proposed LNA design utilizes a combination technique consisting of pole‐tuning technique, shunt resistive‐capacitor negative feedback, and gate‐capacitive peaking technique to achieve significant bandwidth extension while maintaining acceptable overall performance. For verification, a one‐stage triple‐stacked LNA using the combination technique is designed and implemented in a 0.18‐μm SiGe BiCMOS heterojunction bipolar transistor (HBT) process. The fabricated prototype demonstrates a peak gain of 13.8 dB at 19.5 GHz, minimum noise figure of 3.1 dB at 14 GHz, 3‐dB bandwidth of 14 GHz, and a fractional bandwidth of 87.5%, while consuming a dc power of 39.6 mW. Moreover, the chip occupies a small silicon area of 0.39 mm2including all testing pads with a core size of only 0.192 mm2.

A phase 0/Ia study of BI 907828 concentrations in brain tissue and a nonrandomized, open-label, dose escalation study of BI 907828 in combination with radiotherapy in patients with newly diagnosed glioblastoma (GBM).

TPS2081 Background: Murine double minute 2 (MDM2) directly regulates the stability of the tumor suppressor p53, and dysregulation of this pathway can critically disrupt cellular response to genomic stress and lead to cell death. BI 907828 is a highly potent inhibitor of the MDM2-p53 interface that triggers accumulation of p53 and subsequent apoptosis in multiple GBM patient-derived xenografts (PDXs) with wild-type p53. Moreover, the combination of BI 907828 and radiotherapy provides significant survival extension in multiple orthotopic GBM PDXs. Methods: An integrated Phase 0/1 trial design is being used to evaluate the potential for BI 907828 to achieve a therapeutic concentration in brain tumor tissue and to test the safety of the combination with radiation. The co-primary endpoints for the Phase 0 study are i) measured total concentration of BI 907828 and ii) calculated unbound concentration of BI 907828 in contrast and non-contrast enhancing regions of tumor. Key inclusion criteria for the Phase 0 study are patients at least 18 years of age, ECOG performance status of 0 or 1, histologic or radiologic new diagnosis of GBM, and planned surgical resection. The first approximately 6 patients enrolled in the Phase 0 will be treated at the starting dose of 30 mg, and the future patients enrolled will be dosed at higher levels (45 mg or 60 mg) provided there are no safety concerns. If dose-limiting toxicities (DLTs) are encountered, then a Bayesian Logistic Regression Model (BLRM) with overdose control will be used to guide the dose level decisions for the additional patients. Multiple, image-registered tumor samples and intra-operative plasma samples will be analyzed for BI 907828 by LC-MS/MS. Intra-tumoral variation in BI 907828 will be correlated with pharmacodynamic effects of MDM2 inhibition (elevation of p53, p21, MDM2, GDF15, PUMA). Those patients completing the Phase 0 study and who meet additional eligibility criteria can enroll on the Phase 1a portion of the study. The pathologic inclusion criteria are TP53 wild-type, IDH1/2 wild-type, MGMT unmethylated GBM. Co-primary endpoints for the Phase 1a trial are i) occurrence of DLTs during and within 21 days after completion of radiation therapy, and ii) occurrence of adverse events throughout the treatment period. Tolerability of inter-patient dose-escalation of BI 907828 (30, 45, 60 mg) combined with radiation therapy (60 Gy in 30 fractions) will be evaluated with dose-escalation guided by a two-parameter BLRM with overdose control. Patients will remain on BI 907828 monotherapy following completion of radiotherapy until progression. To date, two patients have enrolled on the Phase 0 study, and one patient went on to enroll on the Phase 1a portion of the study. Clinical trial information: NCT05376800 .

CARD9: Ex-vivo Heart Perfusion Using Organ Care System for Cardiac Transplantation: A Single Center Experience in the United States

Background: The Organ Care System (OCS) (Transmedics, Andover, MA) for ex vivo organ perfusion of the heart has enabled significant extension of ex situ intervals. OCS can minimize cold ischemic time, allowing for an expansion of the limited donor pool to include extended distances. As the use of OCS for donor recovery after brain death (DBD) in the United States is lacking, we report our initial experience. Methods: We reviewed consecutive DBD heart transplant (HT) patients at our center from May 2022 (FDA approval) to January 2023. Patients were stratified into two groups: OCS (N=10) vs. Conventional cold storage (Control, N=16). The indication for OCS use was an expected ischemic time >4 hours. Results: Baseline characteristics were similar (Table 1). The OCS group displayed a significantly greater distance traveled for heart recovery (OCS, 764±352 vs Control, 207±176 miles, p <0.001), in addition to mean total preservation time (6.2±0.9 vs 2.6±0.6, p<0.001) (Figure 1). No patients in the OCS group required new veno-arterial extracorporeal membrane oxygenation support (0% vs 7.7%, p=0.32). Primary graft dysfunction was comparable in both groups (OCS 10% vs Control 18.7%, p=0.55). Mortality was lower in the OCS group, with 100% in-hospital survival compared to 93.7% in conventional group (p=0.21). Conclusion: Our short-term results of the use of OCS for DBD recovery were favorable. Given our mean preservation time of approximately 7 hours and distance traveled of >700 miles, OCS can safely augment the number and viability of available organs without compromising the outcome.Figure 1. Total preservation time and cold ischemic time in OCS and conventional procurement groups

Call for Papers: Special Issue on Modulation of the Immune System to Improve Tissue Regeneration Strategies.

Tissue Engineering Part AVol. 29, No. 11-12 Call for PapersFree AccessCall for Papers: Special Issue on Modulation of the Immune System to Improve Tissue Regeneration StrategiesManuscript Submission Deadline: September 1, 2023Guest Editors: Laura Bracaglia and Themis KyriakidesGuest Editors: Laura BracagliaE-mail Address: laura.bracaglia@villanova.eduSearch for more papers by this author and Themis KyriakidesE-mail Address: themis.kyriakides@yale.eduSearch for more papers by this authorPublished Online:13 Jun 2023https://doi.org/10.1089/ten.tea.2023.29045.cfpAboutSectionsPDF/EPUB Permissions & CitationsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail We want this issue to comprise research that not only investigates the interaction between the immune system and tissue regeneration, but also aims to inhibit, promote, alter or monitor that interaction to enhance remodeling and tissue growth. This interaction is important in many thematic areas in tissue engineering, and we think the issue should encompass many anatomical regions and physiological conditions.This prominent special issue will consider articles from the full breadth of evidence: from original research papers and reviews, to perspectives, profiles, commentaries, and exemplary front matter. The special issue will publish as a collection featured in Tissue Engineering, Part A.Areas of interest include, but are not limited to: Macrophage response to tissue engineered constructs or strategiesImmune response to tissue engineered constructs or strategiesProtection of tissue engineered constructs from unwanted immune destructionImmune activating biomaterials in wound response strategiesTissue regeneration with support from immune cells and signalsDiscovery of immune system and tissue regeneration interactionsWe also encourage submission of papers that have been published in conference proceedings, with the requirement that the authors have made significant extensions as compared to the already published version of the study.Questions or pre-submission queries? Please contact Guest Editor Laura Bracaglia, PhD laura.bracaglia@villanova.eduPlease upload your submissions under the manuscript category: Modulation of the Immune SystemVisit the Instructions for Authors:www.liebertpub.com/TEASubmit your paper for peer review online:https://mc.manuscriptcentral.com/TEAFiguresReferencesRelatedDetails Volume 29Issue 11-12Jun 2023 InformationCopyright 2023, Mary Ann Liebert, Inc., publishersTo cite this article:Guest Editors: Laura Bracaglia and Themis Kyriakides.Call for Papers: Special Issue on Modulation of the Immune System to Improve Tissue Regeneration Strategies.Tissue Engineering Part A.Jun 2023.307-307.http://doi.org/10.1089/ten.tea.2023.29045.cfpPublished in Volume: 29 Issue 11-12: June 13, 2023PDF download

Call for Papers: Special Issue on Modulation of the Immune System to Improve Tissue Regeneration Strategies

Tissue Engineering Part B: ReviewsVol. 29, No. 3 Call for PapersFree AccessCall for Papers: Special Issue on Modulation of the Immune System to Improve Tissue Regeneration StrategiesManuscript Submission Deadline: September 1, 2023Guest Editors: Laura Bracaglia and Themis KyriakidesGuest Editors: Laura BracagliaE-mail Address: laura.bracaglia@villanova.eduSearch for more papers by this author and Themis KyriakidesE-mail Address: themis.kyriakides@yale.eduSearch for more papers by this authorPublished Online:7 Jun 2023https://doi.org/10.1089/ten.teb.2023.29018.cfpAboutSectionsPDF/EPUB Permissions & CitationsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail We want this issue to comprise research that not only investigates the interaction between the immune system and tissue regeneration, but also aims to inhibit, promote, alter or monitor that interaction to enhance remodeling and tissue growth. This interaction is important in many thematic areas in tissue engineering, and we think the issue should encompass many anatomical regions and physiological conditions.This prominent special issue will consider articles from the full breadth of evidence: from original research papers and reviews, to perspectives, profiles, commentaries, and exemplary front matter. The special issue will publish as a collection featured in Tissue Engineering, Part A.Areas of interest include, but are not limited to: Macrophage response to tissue engineered constructs or strategiesImmune response to tissue engineered constructs or strategiesProtection of tissue engineered constructs from unwanted immune destructionImmune activating biomaterials in wound response strategiesTissue regeneration with support from immune cells and signalsDiscovery of immune system and tissue regeneration interactionsWe also encourage submission of papers that have been published in conference proceedings, with the requirement that the authors have made significant extensions as compared to the already published version of the study.Questions or pre-submission queries? Please contact Guest Editor Laura Bracaglia, PhD laura.bracaglia@villanova.eduPlease upload your submissions under the manuscript category: Modulation of the Immune SystemVisit the Instructions for Authors:www.liebertpub.com/TEBSubmit your paper for peer review online:https://mc.manuscriptcentral.com/TEBFiguresReferencesRelatedDetails Volume 29Issue 3Jun 2023 InformationCopyright 2023, Mary Ann Liebert, Inc., publishersTo cite this article:Guest Editors: Laura Bracaglia and Themis Kyriakides.Call for Papers: Special Issue on Modulation of the Immune System to Improve Tissue Regeneration Strategies.Tissue Engineering Part B: Reviews.Jun 2023.189-189.http://doi.org/10.1089/ten.teb.2023.29018.cfpPublished in Volume: 29 Issue 3: June 7, 2023PDF download

Implementation of the Maximum Bandwidth Ratio of Satellite Radio Communication Systems under the Conditions for Intramodal Dispersion of Transionospheric Radio Channels

The problem of significant extension of the band of the transionospheric radio channel to the maximum possible values is solved to improve the efficiency of satellite communication systems. Hardware and software are created to suppress the group delay dispersion using methods of data mining for experimental diagnostics of a transionospheric communication line. Algorithms and tools for intelligent sensory diagnostics of wideband radio channels with adaptation to dispersion variability are developed. In the absence of adaptation, it is possible to create radio channels of undistorted transmission with a bandwidth ratio of no greater than 4.5%, while adaptation to dispersion variability makes it possible to increase the bandwidth ratio to 11.5%. The greatest bandwidth ratio (20–25%) for dispersion-free transmission can be achieved with the aid of adaptive inverse filtering of the channel frequency response in combination with such intelligent methods as equalization with error, machine learning of channel equalizer, and big data processing.

Call for Papers: Special Issue on Modulation of the Immune System to Improve Tissue Regeneration Strategies.

Tissue Engineering Part C: MethodsVol. 29, No. 6 Call for PapersFree AccessCall for Papers: Special Issue on Modulation of the Immune System to Improve Tissue Regeneration StrategiesManuscript Submission Deadline: September 1, 2023Guest Editors: Laura Bracaglia and Themis KyriakidesGuest Editors: Laura BracagliaE-mail Address: laura.bracaglia@villanova.eduSearch for more papers by this author and Themis KyriakidesE-mail Address: themis.kyriakides@yale.eduSearch for more papers by this authorPublished Online:15 Jun 2023https://doi.org/10.1089/ten.tec.2023.29038.cfpAboutSectionsPDF/EPUB Permissions & CitationsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail We want this issue to comprise research that not only investigates the interaction between the immune system and tissue regeneration, but also aims to inhibit, promote, alter or monitor that interaction to enhance remodeling and tissue growth. This interaction is important in many thematic areas in tissue engineering, and we think the issue should encompass many anatomical regions and physiological conditions.This prominent special issue will consider articles from the full breadth of evidence: from original research papers and reviews, to perspectives, profiles, commentaries, and exemplary front matter. The special issue will publish as a collection featured in Tissue Engineering, Part A.Areas of interest include, but are not limited to: Macrophage response to tissue engineered constructs or strategiesImmune response to tissue engineered constructs or strategiesProtection of tissue engineered constructs from unwanted immune destructionImmune activating biomaterials in wound response strategiesTissue regeneration with support from immune cells and signalsDiscovery of immune system and tissue regeneration interactionsWe also encourage submission of papers that have been published in conference proceedings, with the requirement that the authors have made significant extensions as compared to the already published version of the study.Questions or pre-submission queries? Please contact Guest Editor Laura Bracaglia, PhD laura.bracaglia@villanova.eduPlease upload your submissions under the manuscript category: Modulation of the Immune SystemVisit the Instructions for Authors:www.liebertpub.com/TECSubmit your paper for peer review online:https://mc.manuscriptcentral.com/TECFiguresReferencesRelatedDetails Volume 29Issue 6Jun 2023 InformationCopyright 2023, Mary Ann Liebert, Inc., publishersTo cite this article:Guest Editors: Laura Bracaglia and Themis Kyriakides.Call for Papers: Special Issue on Modulation of the Immune System to Improve Tissue Regeneration Strategies.Tissue Engineering Part C: Methods.Jun 2023.229-229.http://doi.org/10.1089/ten.tec.2023.29038.cfpPublished in Volume: 29 Issue 6: June 15, 2023PDF download

Skeleton-Enhanced Discontinuous Galerkin Method for 3-D Nonlinear Semiconductor Modeling

We present a mesh skeleton-enhanced discontinuous Galerkin (DG) method, i.e., hybridizable DG, to solve the 3-D highly nonlinear semiconductor drift-diffusion model. This skeleton-enhanced DG algorithm is a remedy but a significant extension of the classical DG method, where only the degrees of freedom on the skeleton are involved as a globally coupled problem, thus reducing the global dimension from 3-D to 2-D and 2-D to 1-D. Furthermore, high-order nodal basis functions over tetrahedra are easily obtained, and meticulous mesh designs are circumvented for complex semiconductor modeling. Rigorous analytical solutions demonstrate that the convergence rate achieves an optimal order of <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\emph{p}+1$</tex-math> </inline-formula> in the <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\bm{L}^{\bm{2}}$</tex-math> </inline-formula> -norm. Then, we also apply our algorithm to solve semiconductor devices, including a bipolar transistor and a trigate fin-shaped field-effect transistor. Compared with the conventional finite volume and finite element solvers, the proposed algorithm exhibits superior stability, convergence, and efficiency.

Revision of the genus Calofulcinia Giglio-Tos (Mantodea: Nanomantidae: Fulciniinae) in Australia.

The genus Calofulcinia comprises several species of small, cryptic mantis, three of which have been described from Australia. The genus is infrequently recorded and is thus very poorly known, and even basic questions of species delimitation and distribution have remained virtually unknown since the descriptions of these taxa. We here redescribe and figure the three known Australian species of Calofulcinia in full and provide a detailed key to Australian species. We record significant range extensions for all three species, and provide the first detailed behavioural and ecological records for the genus. In addition, we group the Australian species into a Robust Group (C. paraoxypila) and a Gracile Group (C. australis and C. oxynota), we detail the occurrence of colour polymorphism within the genus, and finally we discuss the apparent microhabitat specificity of Calofulcinia spp. (mosses and lichens) and their preference for cool, moist environments with reference to our changing climate.

Analysis of experimental spectra of phosphine in the Tetradecad range near 2.3 μm using ab initio calculations

Due to its major interest for the chemistry of planetary atmospheres and exobiology, accurate spectroscopy data of phosphine are required for the search of signatures of this molecule in astronomical observations. In this work, high resolution infrared laboratory spectra of phosphine were analyzed for the first time in the full Tetradecad region (3769–4763 cm−1) involving 26 rotationally resolved bands. Overall, 3242 lines were assigned in spectra previously recorded by Fourier transform spectroscopy at temperatures 200 K and 296 K, using a combined theoretical model based on ab initio calculations. The total nuclear motion Hamiltonian of PH3 including ab initio potential energy surface, was reduced to an effective Hamiltonian using the high-order contact transformation method adapted to vibrational polyads of the AB3 symmetric top molecules, followed by empirical optimization of the parameters. At this step, the experimental line positions were reproduced with a standard deviation of 0.0026 cm−1 that provided unambiguous identification of observed transitions. The effective dipole transition moments of the bands were obtained by fitting to the intensities obtained from variational calculations using the ab initio dipole moment surface. The assigned lines were used to newly determine 1609 experimental vibration-rotational levels up to Jmax = 18 with energy in the range 3896–6037 cm−1 that represents significant extension towards higher energies compared to previous works. Transitions for all 26 sublevels of the Tetradecad were identified but with noticeably fewer transitions for fourfold excited bands because of their weaker intensity. At the final step, pressure-broadened half widths were attached to each transition and a composite line list adopting ab initio intensities and empirical line positions corrected to the accuracy of about 0.001 cm−1 for strong and medium transitions was validated against experimental spectra available in the literature.

Call for Papers: Special Issue on Modulation of the Immune System to Improve Tissue Regeneration Strategies.

Tissue Engineering Part AAhead of Print Call for PapersFree AccessCall for Papers: Special Issue on Modulation of the Immune System to Improve Tissue Regeneration StrategiesManuscript Submission Deadline: September 1, 2023Guest Editors: Laura Bracaglia and Themis KyriakidesGuest Editors: Laura BracagliaE-mail Address: laura.bracaglia@villanova.eduSearch for more papers by this author and Themis KyriakidesE-mail Address: themis.kyriakides@yale.eduSearch for more papers by this authorPublished Online:24 May 2023https://doi.org/10.1089/tea.2023.29045.cfpAboutSectionsPDF/EPUB Permissions & CitationsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail We want this issue to comprise research that not only investigates the interaction between the immune system and tissue regeneration, but also aims to inhibit, promote, alter or monitor that interaction to enhance remodeling and tissue growth. This interaction is important in many thematic areas in tissue engineering, and we think the issue should encompass many anatomical regions and physiological conditions.This prominent special issue will consider articles from the full breadth of evidence: from original research papers and reviews, to perspectives, profiles, commentaries, and exemplary front matter. The special issue will publish as a collection featured in Tissue Engineering, Part A.Areas of interest include, but are not limited to: Macrophage response to tissue engineered constructs or strategiesImmune response to tissue engineered constructs or strategiesProtection of tissue engineered constructs from unwanted immune destructionImmune activating biomaterials in wound response strategiesTissue regeneration with support from immune cells and signalsDiscovery of immune system and tissue regeneration interactionsWe also encourage submission of papers that have been published in conference proceedings, with the requirement that the authors have made significant extensions as compared to the already published version of the study.Questions or pre-submission queries? Please contact Guest Editor Laura Bracaglia, PhD laura.bracaglia@villanova.eduPlease upload your submissions under the manuscript category: Modulation of the Immune SystemVisit the Instructions for Authors:www.liebertpub.com/TEASubmit your paper for peer review online:https://mc.manuscriptcentral.com/TEAFiguresReferencesRelatedDetails Volume 0Issue 0 InformationCopyright 2023, Mary Ann Liebert, Inc., publishersTo cite this article:Guest Editors: Laura Bracaglia and Themis Kyriakides.Call for Papers: Special Issue on Modulation of the Immune System to Improve Tissue Regeneration Strategies.Tissue Engineering Part A.ahead of printhttp://doi.org/10.1089/tea.2023.29045.cfpOnline Ahead of Print:May 24, 2023PDF download

Call for Papers: Special Issue on Modulation of the Immune System to Improve Tissue Regeneration Strategies.

Tissue Engineering Part C: MethodsAhead of Print Call for PapersFree AccessCall for Papers: Special Issue on Modulation of the Immune System to Improve Tissue Regeneration StrategiesManuscript Submission Deadline: September 1, 2023Guest Editors: Laura Bracaglia and Themis KyriakidesGuest Editors: Laura BracagliaE-mail Address: laura.bracaglia@villanova.eduSearch for more papers by this author and Themis KyriakidesE-mail Address: themis.kyriakides@yale.eduSearch for more papers by this authorPublished Online:24 May 2023https://doi.org/10.1089/tec.2023.29038.cfpAboutSectionsPDF/EPUB Permissions & CitationsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail We want this issue to comprise research that not only investigates the interaction between the immune system and tissue regeneration, but also aims to inhibit, promote, alter or monitor that interaction to enhance remodeling and tissue growth. This interaction is important in many thematic areas in tissue engineering, and we think the issue should encompass many anatomical regions and physiological conditions.This prominent special issue will consider articles from the full breadth of evidence: from original research papers and reviews, to perspectives, profiles, commentaries, and exemplary front matter. The special issue will publish as a collection featured in Tissue Engineering, Part A.Areas of interest include, but are not limited to: Macrophage response to tissue engineered constructs or strategiesImmune response to tissue engineered constructs or strategiesProtection of tissue engineered constructs from unwanted immune destructionImmune activating biomaterials in wound response strategiesTissue regeneration with support from immune cells and signalsDiscovery of immune system and tissue regeneration interactionsWe also encourage submission of papers that have been published in conference proceedings, with the requirement that the authors have made significant extensions as compared to the already published version of the study.Questions or pre-submission queries? Please contact Guest Editor Laura Bracaglia, PhD laura.bracaglia@villanova.eduPlease upload your submissions under the manuscript category: Modulation of the Immune SystemVisit the Instructions for Authors:www.liebertpub.com/TECSubmit your paper for peer review online:https://mc.manuscriptcentral.com/TECFiguresReferencesRelatedDetails Volume 0Issue 0 InformationCopyright 2023, Mary Ann Liebert, Inc., publishersTo cite this article:Guest Editors: Laura Bracaglia and Themis Kyriakides.Call for Papers: Special Issue on Modulation of the Immune System to Improve Tissue Regeneration Strategies.Tissue Engineering Part C: Methods.ahead of printhttp://doi.org/10.1089/tec.2023.29038.cfpOnline Ahead of Print:May 24, 2023PDF download

Call for Papers: Special Issue on Modulation of the Immune System to Improve Tissue Regeneration Strategies.

Tissue Engineering Part B: ReviewsAhead of Print Call for PapersFree AccessCall for Papers: Special Issue on Modulation of the Immune System to Improve Tissue Regeneration StrategiesManuscript Submission Deadline: September 1, 2023Guest Editors: Laura Bracaglia and Themis KyriakidesGuest Editors: Laura BracagliaE-mail Address: laura.bracaglia@villanova.eduSearch for more papers by this author and Themis KyriakidesE-mail Address: themis.kyriakides@yale.eduSearch for more papers by this authorPublished Online:24 May 2023https://doi.org/10.1089/teb.2023.29018.cfpAboutSectionsPDF/EPUB Permissions & CitationsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail We want this issue to comprise research that not only investigates the interaction between the immune system and tissue regeneration, but also aims to inhibit, promote, alter or monitor that interaction to enhance remodeling and tissue growth. This interaction is important in many thematic areas in tissue engineering, and we think the issue should encompass many anatomical regions and physiological conditions.This prominent special issue will consider articles from the full breadth of evidence: from original research papers and reviews, to perspectives, profiles, commentaries, and exemplary front matter. The special issue will publish as a collection featured in Tissue Engineering, Part A.Areas of interest include, but are not limited to: Macrophage response to tissue engineered constructs or strategiesImmune response to tissue engineered constructs or strategiesProtection of tissue engineered constructs from unwanted immune destructionImmune activating biomaterials in wound response strategiesTissue regeneration with support from immune cells and signalsDiscovery of immune system and tissue regeneration interactionsWe also encourage submission of papers that have been published in conference proceedings, with the requirement that the authors have made significant extensions as compared to the already published version of the study.Questions or pre-submission queries? Please contact Guest Editor Laura Bracaglia, PhD laura.bracaglia@villanova.eduPlease upload your submissions under the manuscript category: Modulation of the Immune SystemVisit the Instructions for Authors:www.liebertpub.com/TEBSubmit your paper for peer review online:https://mc.manuscriptcentral.com/TEBFiguresReferencesRelatedDetails Volume 0Issue 0 InformationCopyright 2023, Mary Ann Liebert, Inc., publishersTo cite this article:Guest Editors: Laura Bracaglia and Themis Kyriakides.Call for Papers: Special Issue on Modulation of the Immune System to Improve Tissue Regeneration Strategies.Tissue Engineering Part B: Reviews.ahead of printhttp://doi.org/10.1089/teb.2023.29018.cfpOnline Ahead of Print:May 24, 2023PDF download

A scaling methodology for high-power magnetically shielded Hall thrusters

The past two decades have seen an increasing interest in Hall thrusters in space propulsion, thanks to their favorable performance characteristics with respect to a wide variety of missions of current and future interest and to the significant extension in operational life potential achievable with magnetic shielding. Nevertheless, the physics underlying their behavior is complex and not yet fully understood, limiting the practical applications of models based on first principles due to their inability to self-consistently predict the device performance. Fortunately, modern Hall thrusters were developed through a lengthy process of gradual refinement, and thus they represent convenient reference devices to design new thrusters using appropriately defined scaling criteria. The objective of this work is to propose a new scaling methodology, especially intended for magnetically shielded high-power Hall thrusters. To this purpose, a novel phenomenological model for shielded thrusters is presented and discussed. This model includes free coefficients, whose values are chosen based on the agreement with the empirical data collected in a specially created high-power Hall thruster database. The proposed methodology features a new reference thruster and aims at keeping unchanged its main plasma intensive parameters in a scaling transformation. The possibility of creating performance maps at constant discharge power, which show how the scaling results vary with the channel dimensions, is also proposed as a preliminary design tool.

A revision of Delevea Reichardt, 1976: a Southern African endemic water beetle genus including the largest known extant myxophagans (Coleoptera: Myxophaga: Torridincolidae).

The Southern African endemic torridincolid water beetle genus Delevea Reichardt, 1976 is revised, based largely on recently collected material from the Republic of South Africa. Significant range extensions are provided for the two previously described species, Delevea bertrandi Reichardt, 1976 and D. namibiensis Endrödy-Younga, 1997, these taxa apparently being endemic to the Fynbos Biome in the Western Cape Province and semi-arid, summer rainfall, areas of the Great Escarpment in Namibia and South Africa, respectively. In addition, two new species, Delevea madiba sp. nov. and D. namaqua sp. nov. are described from winter rainfall areas of Namaqualand in the Northern Cape Province. Both species are currently only known from their type locality and, at up to 2.85 mm in adult body length, D. namaqua sp. nov. is the largest described extant species of the suborder Myxophaga.

Transorbital neuroendoscopy-assisted resection of a giant optic pathway glioma in a neonate.

Congenital giant orbital tumors in infancy are relatively rare, especially when the tumors are associated with significant intracranial extension. We describe the use of a transorbital neuroendoscopy-assisted resection of such a lesion. While this approach is increasingly gaining popularity for certain anterior and middle skullbase lesions in adults, this report represents the youngest patient reported on where this minimally invasive approach has been successfully used to resect the intracranial tumor. This surgical approach obviated the need for a separate craniotomy, with the additional benefit of minimizing blood loss.

An Evidence Theoretic Approach for Traffic Signal Intrusion Detection

The increasing attacks on traffic signals worldwide indicate the importance of intrusion detection. The existing traffic signal Intrusion Detection Systems (IDSs) that rely on inputs from connected vehicles and image analysis techniques can only detect intrusions created by spoofed vehicles. However, these approaches fail to detect intrusion from attacks on in-road sensors, traffic controllers, and signals. In this paper, we proposed an IDS based on detecting anomalies associated with flow rate, phase time, and vehicle speed, which is a significant extension of our previous work using additional traffic parameters and statistical tools. We theoretically modelled our system using the Dempster–Shafer decision theory, considering the instantaneous observations of traffic parameters and their relevant historical normal traffic data. We also used Shannon’s entropy to determine the uncertainty associated with the observations. To validate our work, we developed a simulation model based on the traffic simulator called SUMO using many real scenarios and the data recorded by the Victorian Transportation Authority, Australia. The scenarios for abnormal traffic conditions were generated considering attacks such as jamming, Sybil, and false data injection attacks. The results show that the overall detection accuracy of our proposed system is 79.3% with fewer false alarms.

First Record of the Northern Wolffish Anarhichas denticulatus Krøyer, 1845 (Anarhichadidae: Zoarcoidei: Perciformes) in the Siberian Arctic: Further Evidence of Atlantification?

A single specimen of the northern wolffish Anarhichas denticulatus Krøyer, 1845, 393 mm in length, was documented for the first time in the Siberian Arctic (Laptev Sea, Russia). Species identification was confirmed by an integrative taxonomic approach that included examination of external morphology and DNA barcoding using the COI mtDNA gene. This species is widely distributed in the North Atlantic, but records in the Arctic Ocean are limited to the Canadian and US coasts. This record might represent a significant range extension of about 7500 km for the species and may be associated with the eastward transport of a pelagic juvenile specimen from the Northeastern Atlantic to the Laptev Sea by the North Atlantic current, consistent with the hypothesis of Atlantification of the Arctic Ocean. X-ray images of the Laptev Sea specimen and photographs showing ontogenetic variations of species’ coloration are provided for reference. The Laptev Sea specimen had a more elongated shape, longer preorbital distance, and longer pectoral, dorsal, and anal fins, as well as a larger eye and wider caudal fin compared to North Atlantic samples. The size differences are likely associated with conditions experienced as a juvenile during the pelagic stage of the lifecycle.

Multi-view Ensemble Clustering via Low-rank and Sparse Decomposition: From Matrix to Tensor

As a significant extension of classical clustering methods, ensemble clustering first generates multiple basic clusterings and then fuses them into one consensus partition by solving a problem concerning graph partition with respect to the co-association matrix. Although the collaborative cluster structure among basic clusterings can be well discovered by ensemble clustering, most advanced ensemble clustering utilizes the self-representation strategy with the constraint of low-rank to explore a shared consensus representation matrix in multiple views. However, they still encounter two challenges: (1) high computational cost caused by both the matrix inversion operation and singular value decomposition of large-scale square matrices; (2) less considerable attention on high-order correlation attributed to the pursue of the two-dimensional pair-wise relationship matrix. In this article, based on low-rank and sparse decomposition from both matrix and tensor perspectives, we propose two novel multi-view ensemble clustering methods, which tangibly decrease computational complexity. Specifically, our first method utilizes low-rank and sparse matrix decomposition to learn one common co-association matrix, while our last method constructs all co-association matrices into one third-order tensor to investigate the high-order correlation among multiple views by low-rank and sparse tensor decomposition. We adopt the alternating direction method of multipliers to solve two convex models by dividing them into several subproblems with closed-form solution. Experimental results on ten real-world datasets prove the effectiveness and efficiency of the proposed two multi-view ensemble clustering methods by comparing them with other advanced ensemble clustering methods.