Significant Changes In Heart Research Articles

Chick edema factor: some tissue distribution data and toxicologic effects in the rat and chick.

SummaryUnsaponifiable matter isolated from a toxic fat and containing an estimated 10 ppm chick edema factor (CEF) was force-fed daily to adult rats at levels of 2.0 cc and 1.0 cc/kg body weight/day in 2 studies of 14 and 6 days, respectively. Feed consumption, body weight, and digestibility were depressed. Heart and spleen weights were unaffected, kidney weights seemed to be slightly increased, and adrenal and liver weights were significantly increased. In the chick, typical hydropericardium,. ascites, and subcutaneous edema were observed. There were no significant changes in heart or spleen weights. Liver weights were significantly increased. The rat was as sensitive as the chick to CEF according to increase in liver weight. Of the 8 or 9 CEF components shown to be in this unsap, 2 (Nos. 4 and 7) were found to be absorbed and located in the liver, while the other components were not detected. In place of Nos. 4 and 7, there were 2 new peaks in the feces with slightly increased retention times. This sugg...

5-Hydroxytryptamine, 5-hydroxytryptophan decarboxylase and monoamine oxidase in hearts of normal, thyroid-fed and propylthiouracil-fed male and female rats.

Male and female Wistar rats (125–175 g) were fed for 21 days ad lib. diets of a meal containing 0.15% strong desiccated thyroid, 0.15% prophylthiouracil (PTU), or meal alone. 5-Hydroxytryptamine (5-HT) contents, and 5-Hydroxytryptophan decarboxylase (5-HTPD) and monoamine oxidase (MAO) activities of the hearts of these animals were determined. Normal male rats possessed significantly greater heart MAO activities than normal females; these animals showed no significant sex difference in heart 5-HT or 5-HTPD. Thyroid feeding of the males lowered heart 5-HTPD but did not alter heart 5-HT or MAO significantly. Thyroid-fed females showed decreased heart 5-HT and 5-HTPD and increased MAO. PTU-fed males showed elevated heart 5- HTPD, lowered MAO, and unchanged 5-HT. PTU feeding of the females produced no significant change in heart 5-HT or MAO but increased heart 5-HTPD.