Numerous natural products having a 2,2-dimethylchromene (2,2-dimethylbenzopyrane) structural element present interesting biological activities that may, therefore, be considered as privileged pharmacophore. Nine aliphatic and aromatic amides were synthesized from the 5-amino-7-methoxy-2,2-dimethyl-2 H-chromene synthon. The antibacterial, antifungal, antileishmanial and cytotoxic activities of all amidochromenes were evaluated. No antibacterial or antifungal activity was observed. Nevertheless, three aromatic amides compounds shown significant antileishmanial activity with an excellent selectivity index.