Enhancement of detection efficiency of low temperature detectors (LTDs) is quite important for biomolecular mass spectrometry. One solution to realize efficient analysing tools is to produce large-scale array detectors. In this case the wiring configuration in cryostats gets much more complex. For the purpose of detecting macromolecules efficiently, we are developing spectrometer systems with 100 pixel array superconducting tunnel junction detectors (STJs), infrared-blocking filters, and cryogen-free cryostats. Considering thermal leakage and signal attenuation through signal wires at each stage of a cryostat, the optimal combination of wiring cables and infrared-blocking filters was determined. Furthermore, from the point of view of cryostat handling, an easy exchange of detectors and simple maintenance are necessary for practical use of the spectrometers. In this study, the configuration of a cryogen-free cryostat and its cooling performance is presented.