Priapism is a painful and pathological erection caused by various abnormalities in erectile hemodynamics [1]. There are several aetiologies of which the common long-term risk is to cause sequelae erectile dysfunction in 50 to 60% [1, 2, 3]. In Mali, the main cause of priapism is sickle cell anemia. Our objective is to study the socio-demographic, clinical and therapeutic aspects of priapism at the Fousseyni Daou hospital in Kayes. This was a cross-sectional and descriptive study involving a series of 21 patients. It lasted 56 months (April 2016 to February 2020); performed in the urology department of the Fousseyni DAOU hospital in Kayes. The inclusion criteria for the study were: records of patients who presented with priapism during the study period. Records of patients with intermittent priapism were excluded. Treatment consisted of a transglandular caverno-cancellous shunt type Ebbehoj to local anesthesia associated with drug treatment. The main reasons for seeing patients are pain and being in a state of priapism. The age group of 8 to 20 years was 52% and 71.4% of our patients presented sickle cell traits including SS phenotype: 19%, SC: 19% and AS phenotype: 33.3%. 42.9% of our patients presented a lack of erection after an episode of priapism. Delays of more than a week were observed in 3 patients. Prevention of these priapisms involves regular monitoring of sickle cell patients.