Sialoadenectomized Rats Research Articles

Reproductive ability among sialoadenectomized rats of the Harvard caries-resistant strain

Sialoadenectomized male and female rats of the Harvard caries-resistant strain bred sufficiently well to permit carrying the strain through several generations. This procedure is being followed to determine whether a more exact and earlier selection of breeders can be made and thereby further increase the caries-resistance of this strain and reduce the variability among the offspring.

Studies on the oral administration of saliva-parotin-A. II. Effects on the epiphyseal growth of tibia in rats.

The effect of the oral administration of saliva-parotin-A to rats was studied in comparing with that of subcutaneous injection of the substance. Sialoadenectomized and sham operated male rats of Donryu strain (28 days old) were orally administered with 0.6 and 3.0mg per 100g of body weight of saliva-parotin-A for 3 weeks and subcutaneously with 0.03mg per 100g of body weight. The morphologicaleffects upon tibial epiphysis and adrenal cortex were examined. The reduction of the width of cartilage plate and atrophic pattern of primary spongiosa were found in the tibial epiphysis in control non-injected rats 3 weeks after the sialoadenectomy. Subcutaneous injection of saliva-parotin-A retarded the subsequent involution to the sialoadenectomy, and the oral administration of salivaparotin-A also could retard the epiphyseal involution with the dose of 3mg per 100g of body weight, corresponding the 100 times dosage to the subcutaneous injection. No effect on the involution was recognized in rats with the oral administration of 0.6mg. In the adrenal cortex, a kind of stressful picture was observed after the sialoadenectomy or subcutaneous injection of saliva-parotin-A. In the rats received 3mg of saliva-parotin-A orally, however, such changes were neither observed in adrenal of the sialoadenectomized rats nor in the sham operated ones.

The incidence of caries in sialoadenectomized rats drinking water containing human saliva.

The incidence of caries in sialoadenectomized rats drinking water containing human saliva.

The effect of fluorides on dental caries in rats after sialoadenectomy

One hundred twenty-five rats of a caries-susceptible strain were used to study the mechanism by which a posteruptive influence of fluoride administration upon dental caries incidence is mediated. Intact and sialoadenectomized rats had similar reductions in dental caries incidence when the drinking water contained 15 ppm of fluoride. A still greater dental caries reduction in sialoadenectomized rats was observed when 30 ppm of fluoride was ingested in the drinking water. Comparable reductions in dental caries incidence were not observed when the same amounts of fluoride were injected subcutaneously. This posteruptive fluoride influence appears to result from a contact of the fluoride solution with the external surfaces of the teeth.