Short-term Loss Research Articles

The role of short-term and long-term water level and wave variability in coastal carbon budgets

SummaryWe investigated soil organic carbon dynamics at three freshwater coastal sites in the Laurentian Great Lakes using a simple carbon budget box model. Long-term carbon budgets (1939–2018) were developed using aerial photography and then compared to short-term carbon export (2018–2019) developed using drone data. This study puts forth a refined coastal carbon budget model that advances previous model iterations by: (1) examining spatial variability in carbon budgets, (2) including a temporally dynamic carbon inventory term, and (3) updating the erosional term. Half of the initial carbon stock of the combined sites was lost in the 80-year study period, which is severely imbalanced with the age of those coastal habitats (400–2000 cal years BP). Major periods of carbon loss corresponded to periods of elevated water level. Short-term loss of carbon during 2018–2019 corresponded to northeasterly extreme wave events during a period of above-average water level.

LOCA analysis of BWR-4/Mark-I nuclear power plant with TRACE

Abstract This study established an RCS-Containment coupled model that integrates the reactor coolant system (RCS) and the containment system by using the TRACE code. The coupled model was used in both short-term and long-term loss of coolant accident (LOCA) analyses. Besides, the RELAP5/CONTAN model that only contains the containment system was also developed for comparison. For short-term analysis, three kinds of LOCA scenarios were investigated: the recirculation line break (RCLB), the main steam line break (MSLB), and the feedwater line break (FWLB). For long-term analysis, the dry-well and suppression pool temperature responses of the RCLB were studied. The analysis results of RELAP5/CONTAN and TRACE models are benchmarked with those of FSAR and RELAP5/GOTHIC models, and it appears that the results of the above four models are consistent in general trends.

Late-in-life neurodegeneration after chronic sleep loss in young adult mice.

Chronic short sleep (CSS) is prevalent in modern societies and has been proposed as a risk factor for Alzheimer’s disease (AD). In support, short-term sleep loss acutely increases levels of amyloid β (Aβ) and tau in wild type (WT) mice and humans, and sleep disturbances predict cognitive decline in older adults. We have shown that CSS induces injury to and loss of locus coeruleus neurons (LCn), neurons with heightened susceptibility in AD. Yet whether CSS during young adulthood drives lasting Aβ and/or tau changes and/or neural injury later in life in the absence of genetic risk for AD has not been established. Here, we examined the impact of CSS exposure in young adult WT mice on late-in-life Aβ and tau changes and neural responses in two AD-vulnerable neuronal groups, LCn and hippocampal CA1 neurons. Twelve months following CSS exposure, CSS-exposed mice evidenced reductions in CA1 neuron counts and volume, spatial memory deficits, CA1 glial activation, and loss of LCn. Aβ 42 and hyperphosphorylated tau were increased in the CA1; however, amyloid plaques and tau tangles were not observed. Collectively the findings demonstrate that CSS exposure in the young adult mouse imparts late-in-life neurodegeneration and persistent derangements in amyloid and tau homeostasis. These findings occur in the absence of a genetic predisposition to neurodegeneration and demonstrate for the first time that CSS can induce lasting, significant neural injury consistent with some, but not all, features of late-onset AD.

Cytomegalovirus Disease, Short-Term Cardiovascular Events and Graft Survival in a Cohort of Kidney Transplant Recipients With High CMV IgG Seroprevalence.

Both cytomegalovirus (CMV) infection and CMV disease have been linked with several long-term indirect effects in kidney transplant recipients. Research questions: We conducted a retrospective study to assess the association between cytomegalovirus disease and risks of death, shortterm cardiovascular events and graft loss in a cohort of renal transplant recipients. The associations between CMV disease and death and cardiovascular events were determined using Cox regression models, while the association between viral disease and graft loss risk was analyzed through a competing risks regression according to the Fine and Gray method. Death with a functioning graft was considered as a competing risk event. A total of 865 consecutive renal transplant recipients were included. The prevalence of seropositive donor/seronegative recipient (D+/R-) group was 89.9% with the remaining patients classified as seropositive recipient (R+). After median follow-up time of 24.4 months, CMV disease was not a risk factor for all-causes mortality (HR = 1.75; 95% CI 0.94-3.25), early cardiovascular events (HR = 0.54; 95% CI 0.16-1.82) or graft loss (subhazard ratio [the HR adjusted for competing risk of death with functioning graft] = 0.99; 95% CI 0.53-1.84). In this cohort with high prevalence of CMV IgG antibodies, we found no association between cytomegalovirus disease and risk of death or graft loss. The relationship between CMV and cardiovascular disease remains to be unraveled and probably corresponds to a multifactorial phenomenon involving individual risk factors and the immune response to infection rather than the virus effect itself.

Tax-Rate Arbitrage: Realization of Long-Term Gains to Enable Short-Term Loss Harvesting

We look at an enhanced loss-harvesting strategy, tax-rate arbitrage, which exploits the differential between short- and long-term tax rates. Our study relies on ATBAT, an After-Tax Back-Testing Analysis Tool that lets us examine tax-managed strategies over numerous historical periods. For the ideal tax-rate arbitrage investor, one who is subject to federal only tax rates, who has a long horizon and a planned liquidation date, and who launches the strategy from all cash, tax-rate arbitrage generated an average of 0.78% in excess after-tax active return at a 10-year horizon relative to a standard loss-harvesting strategy. Other investors with different profiles may benefit from tax-rate arbitrage but typically to a lesser extent.

Changes in Representation of Thalamic Projection Neurons within Prefrontal-Thalamic-Hippocampal Circuitry in a Rat Model of Third Trimester Binge Drinking.

Alcohol exposure (AE) during the third trimester of pregnancy—a period known as the brain growth spurt (BGS)—could result in a diagnosis of a fetal alcohol spectrum disorder (FASD), a hallmark of which is impaired executive functioning (EF). Coordinated activity between prefrontal cortex and hippocampus is necessary for EF and thalamic nucleus reuniens (Re), which is required for prefrontal-hippocampal coordination, is damaged following high-dose AE during the BGS. The current experiment utilized high-dose AE (5.25 g/kg/day) during the BGS (i.e., postnatal days 4–9) of Long-Evans rat pups. AE reduces the number of neurons in Re into adulthood and selectively alters the proportion of Re neurons that simultaneously innervate both medial prefrontal cortex (mPFC) and ventral hippocampus (vHPC). The AE-induced change unique to Re→(mPFC + vHPC) projection neurons (neuron populations that innervate either mPFC or vHPC individually were unchanged) is not mediated by reduction in neuron number. These data are the first to examine mPFC-Re-HPC circuit connectivity in a rodent model of FASD, and suggest that both short-term AE-induced neuron loss and long-term changes in thalamic connectivity may be two distinct (but synergistic) mechanisms by which developmental AE can alter mPFC-Re-vHPC circuitry and impair EF throughout the lifespan.

Evaluating coral reef ecosystem services outcomes from climate change adaptation strategies using integrative system dynamics

Coral reef ecosystems provide a broad spectrum of essential ecological, economic and cultural services for Small Island Developing State (SIDS) communities. However, coral reef communities are increasingly threatened by the adverse impacts of human activities at both global and local scales. This study aims to develop an integrated dynamic assessment framework to evaluate coral reef conditions under different adaptation and climate change scenarios, and their consequential economic impacts in the small island community of Port Resolution on Tanna Island in Vanuatu. Our assessment framework follows a sequential multilayered modelling approach that uses System Dynamics (SD) coupled with Bayesian Network (BN) modelling to deal with the complexity and dynamicity of socioeconomic and environmental systems, and impacts from trans-discipline variables. The BN incorporated existing data and expert knowledge to project the future conditions of coral reefs under different scenario settings, and to parametrise and quantify the SD model where the existing data and information was insufficient. The SD was then used to simulate the dynamic relationship between coral reef condition and the economic benefits derived from its ecosystem services under different climate change (i.e. RCPs) and management scenarios through to 2070. Our findings show that sustainable community-based conservation management strategies are key to preserving the flow of coral reef ecosystem services under RCP 2.6 and 6.0. Importantly, we demonstrate that the implementation of an integrated portfolio of management strategies better protects ecosystem services provided by coral reefs and maximises the total economic benefits achieved over the long-term despite a temporary and short-term economic loss due to high initial capital investments and income reduction due to fishing and tourism restrictions.

Early Tooth Loss after Periodontal Diagnosis: Development and Validation of a Clinical Decision Model.

The aim of this study was to develop and validate a predictive early tooth loss multivariable model for periodontitis patients before periodontal treatment. A total of 544 patients seeking periodontal care at the university dental hospital were enrolled in the study. Teeth extracted after periodontal diagnosis and due to periodontal reasons were recorded. Clinical and sociodemographic variables were analyzed, considering the risk of short-term tooth loss. This study followed the transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD) guidelines for development and validation, with two cohorts considered as follows: 455 patients in the development phase and 99 in the validation phase. As a result, it was possible to compute a predictive model based on tooth type and clinical attachment loss. The model explained 25.3% of the total variability and correctly ranked 98.9% of the cases. The final reduced model area under the curve (AUC) was 0.809 (95% confidence interval (95% CI): 0.629–0.989) for the validation sample and 0.920 (95% CI: 0.891–0.950) for the development cohort. The established model presented adequate prediction potential of early tooth loss due to periodontitis. This model may have clinical and epidemiologic relevance towards the prediction of tooth loss burden.

Risk of short-term biodiversity loss under more persistent precipitation regimes.

Recent findings indicate that atmospheric warming increases the persistence of weather patterns in the mid-latitudes, resulting in sequences of longer dry and wet periods compared to historic averages. The alternation of progressively longer dry and wet extremes could increasingly select for species with a broad environmental tolerance. As a consequence, biodiversity may decline. Here we explore the relationship between the persistence of summer precipitation regimes and plant diversity by subjecting experimental grassland mesocosms to a gradient of dry-wet alternation frequencies whilst keeping the total precipitation constant. The gradient varied the duration of consecutive wet and dry periods, from 1 up to 60days with or without precipitation, over a total of 120days. An alternation of longer dry and wet spells led to a severe loss of species richness (up to -75% relative to the current rainfall pattern in W-Europe) and functional diversity (enhanced dominance of grasses relative to nitrogen (N)-fixers and non-N-fixing forbs). Loss of N-fixers and non-N-fixing forbs in severe treatments was linked to lower baseline competitive success and higher physiological sensitivity to changes in soil moisture compared to grasses. The extent of diversity losses also strongly depended on the timing of the dry and wet periods. Regimes in which long droughts (≥20days) coincided with above-average temperatures showed significantly more physiological plant stress over the experimental period, greater plant mortality, and impoverished communities by the end of the season. Across all regimes, the duration of the longest period below permanent wilting point was an accurate predictor of mortality across the communities, indicating that increasingly persistent precipitation regimes may reduce opportunities for drought stress alleviation. We conclude that without recruitment, which was precluded in this experiment, summer precipitation regimes with longer dry and wet spells will likely diminish plant diversity, at least in the short term.

Subcutaneous transplantation of engineered islet/adipose-derived mesenchymal stem cell sheets in diabetic pigs with total pancreatectomy.

IntroductionIntraportal islet transplantation is a promising therapeutic approach for patients with type 1 diabetes mellitus (T1DM). However, despite being minimally invasive, the method has some limitations, such as short-term graft loss, portal venous thrombosis, and difficulty in collecting adequate amounts of islets. Subcutaneous islet transplantation on adipose-derived mesenchymal stem cell (ADSC) sheets has been suggested to overcome these limitations, and in this study, we have examined its feasibility in T1DM pigs.MethodsInguinal subcutaneous fat was harvested from young pigs and then isolated and cultured adequate ADSCs to prepare sheets. Islets were isolated from the pancreases of mature pigs and seeded on the ADSC sheets. T1DM pigs were generated by total pancreatectomy, and ADSC sheets with transplanted islets were administered subcutaneously to the waist (n = 2). The effects of the islets on the ADSC sheets and on blood glucose levels were evaluated. Insulin secretion was measured by insulin stimulation index.ResultsIslet viability was higher on ADSCs compared to islets alone (91.8 ± 4.3 vs. 81.7 ± 4.1%). The insulin stimulation index revealed higher glucose sensitivity of islets on ADSC sheets compared to islets alone (2.8 ± 2.0 vs. 0.8 ± 0.3). After transplantation, the blood glucose levels of two pigs were within the normal range, and sensitive insulin secretion was confirmed by intravenous glucose tolerance tests. After graftectomy, decreased insulin secretion and hyperglycemia were observed.ConclusionsSubcutaneous islet transplantation using ADSC sheets can regulate the blood glucose levels of T1DM pigs.

Torakolomber Kırıkların Tedavisinde Torakolomber Yaralanma Sınıflaması ve Şiddet Skoru (TLICS) Kullanımının Sonuçları

Aim: To compare short and long term pain intensity changes and long term loss of correction rates in patients who were treated either by kyphoplasty or posterior segmentation due to their TLICS and LSC scores, therefore evaluate the specificity of these classifications. Material and Methods: Medical records of 106 patients operated due to thoracolumbar compression or burst fracture in our clinics between years 2012 to 2015 have been evaluated retrospectively. The patients were evaluated with postoperative radiography (loss of reduction) and visual analogue scale (VAS) in their follow-ups. Results: The average stay on hospital was 6.53 ± 4.51 days in kyphoplasty group. The mean preoperative cobb angle was 10.76±11.67 degrees, which improved to 10.19±10.66 degrees at postoperative 1th month. Beside this, the mean preoperative VAS score was 7.93±0.68 then improved to 4.25±0.77 and 2.75 ± 1.43 at postoperative 6th, 12th month follow-ups respectively. There were 42 patients in instrumentation group. The mean hospitalization was 13.47±10.43 days. The mean preoperative cobb angle was 15.84±10.52 and it improved to 11.86±8.15 degrees at the postoperative 1th-month follow-up. The preoperative VAS scores of the patients improved from 7.71±0.71 to 4.09±0.79 and 4.26±1.23 at 6th and 12th month follow-ups. Conclusion: In long term follow up the kyphoplasty group showed more loss of correction however lesser VAS scores comparing to the instrumentation group. Although evaluating TLICS scores to kyphoplasty patients is still based on case reports in our series it was performed to 64 patients.

Analysis of Wind-wave Effect on Short-term FOWT Power Loss

The paper analyses the effects of wind misalignment, wave oscillatory movement and wind-wave misalignment onto the performance of floating offshore wind turbines (FOWT) and how they affect the power generation. The study focuses on short term prediction to match network requirements for electric energy management avoiding overloads or consumers demand mismatching. The research studies individual as well as combined effects to determine the reduction in power generation due to these effects. The predictive model is based on meteorological data for different marine stations where wind farms are either located or considered for feasible installations. The results of the modelling predict the wind misalignment is more important than wave motion effects. Power loss due to wind-wave misalignment increases with wave height and with misalignment angle. The effects are negligible for wave heights of 0.4 and 1.25 m, with almost null effects for wave height of 2.5 m., with a power reduction less than 4%. The effects, however, are significant for wave heights of 4 and 6 m, especially in this latter case, where power loss varies from 11% for wind-wave misalignment angle of 15° to more than 96% for an angle of 45°. Experimental results match theoretical predictions within 96% accuracy.

Out of Communal Land: Clientelism Through Delegation of Agricultural Tenancy Contracts

Do local institutions influence the nature of political clientelist exchange? We find a positive answer in the context of a village institution prevalent in Java since the Dutch colonial rule, where democratically elected village heads receive usufruct rights over a piece of communal village land (bengkok land) as a compensation for their service in lieu of salary. To formulate how limited-term private ownership of bengkok land promotes clientelism, we model a timely delegation of agricultural tenancy contracts to villagers-cum-voters as an incumbent re-election strategy. Based on a household survey fielded in 2018 across 130 villages in Java, Indonesia, we find that the chances of a bengkok plot being rented out increase by 6 percentage points as the time of the next election becomes closer by one year, and sharecropping is preferred to a fixed-rental contract as the election approaches. The empirical results are statistically significant and remain largely unchanged against a series of robustness checks. We also find suggestive evidence of short-term efficiency loss from clientelist politics over bengkok land.

State Estimation in Mobile Edge Computing With Unreliable Communications

In this letter, we investigate the state estimation problem in Mobile Edge Computing with unreliable communications. A finite-time convergent estimator is proposed, aiming to restore the unmeasurable states within a finite time length. We apply the proposed estimator in two practical scenarios to evaluate its performance. The numerical results show that the proposed estimator is able to quickly make accurate estimations once the interrupted connection resumes. The results also suggest that the effect of short-term data loss is easier to remedy than that of long-term data loss, which shed light on relay deployment and future investigations in this field.

The essence of physical therapy of children 7-10 years with chronic gastritis in the hospital period: problems and prospects

The article substantiates the essence of physical therapy of children 7-10 years old with chronic gastritis in the hospital period: problems and prospects. Chronic gastritis is a chronic polyetiological inflammatory-dystrophic disease of the gastric mucosa with impaired cell regeneration and progressive atrophy of the gastric epithelium.
 The consequences of the disease are damage to the surface layer of the epithelium and glandular apparatus of the gastric mucosa and the development of inflammatory processes in them. Depending on the etiological factor, the inflammatory process may be limited to the superficial epithelium of the mucous membrane or spread to the entire thickness of the glandular apparatus and even the muscular layer.
 The main symptoms of gastritis are pain and dyspeptic disorders. Patients complain of heartburn, belching sour, feeling of pressure, burning, distension in the epigastric region, constipation, rarely - vomiting. Usually dyspeptic disorders appear during the exacerbation of the disease. Appetite usually does not change, however at the expressed frustration of function of a stomach and a duodenum can amplify or decrease - up to full (short-term) loss.
 The analysis of modern approaches to physical therapy of patients with chronic gastritis indicates a lack of attention to this issue. The program of physical therapy for children 7-10 years old with chronic gastritis during the hospital period includes: therapeutic physical training, therapeutic massage, physiotherapy and diet therapy.

Digital entrepreneurs in technology-based spinoffs: an analysis of hybrid value creation in retail public–private partnerships to tackle showrooming

PurposeRetail networks present new challenges in the business-to-business (B2B) collaboration between technology-based spinoffs and traditional businesses. This study aims to explore a public–private partnership (PPP) that leverages advanced digital technologies via spinoffs to tackle the key challenge of showrooming that retail shops are facing. Showrooming is the phenomenon in which shoppers go to the physical stores to gather in-depth product information, and later on, decide to buy the product from online retail competitors.Design/methodology/approachThis research draws on a longitudinal qualitative study of a social context in which digital entrepreneurs are embedded. The empirical setting is a retail network in Italy, Germany and Finland with a particular focus on the process in which a PPP delivers innovation via spinoffs in the context of brick and mortar shops (B&M). The research design enables an understanding of the complexity of the phenomenon from a business and a social perspective.FindingsNew technology to tackle showrooming enables the creation of substantial hybrid value in retail partnerships. Spinoffs are key actors in leveraging digital technologies to create value faster and more tailored compared with large software companies. Spinoff entrepreneurs leverage on specific technologies (e.g. virtual reality and artificial intelligence) available inside organizations’ network (i.e. PPPs). Spinoffs are found to be a fundamental actor in the process of dealing with showrooming because of their time to market. Large software companies usually are not interested in approaching B&M shops because of the high operational costs of product customization for B&M shops.Practical implicationsManagers could use the success factors of the spinoffs in helping their B&M shops to improve both shopper experience and salesperson performance. For managers of B2B retail network, the results are useful towards increasing the involvement of shoppers while they are visiting physical stores, and it also improves salesperson performance. It also leads to the observation that cross-selling is one of the most effective responses to the phenomenon of showrooming. As practical implications for policymakers, the current research supports the view that PPPs should support the creation of spinoffs as a result of longitudinal innovation projects.Social implicationsRetail technologies leveraged from a PPP and commercialized by spinoffs are powerful tools to enable a better quality of salespeople’s life in the working place. At the same time, these new technologies help shop owners increase the retention rates, conversion rates and reduce short-term loss, increasing the likelihood of B&M shops to survive in the condition of extreme competition caused by the showrooming phenomenon.Originality/valueThis research proposes a model of hybrid value creation from networks in digital retail. The model indicates that PPPs create spinoffs to explore showrooming and deliver substantial hybrid value (i.e. business and social) for physical retail shops, mainly because it influences the companies’ growth, employee performance and customer satisfaction. This model expands the field of B2B marketing by identifying factors that enable spinoff creation from retail networks and proposes success factors and research propositions in retail networks.

Perioperative patient-specific factors-based nomograms predict short-term periprosthetic bone loss after total hip arthroplasty

BackgroundAlthough medical intervention of periprosthetic bone loss in the immediate postoperative period was recommended, not all the patients experienced periprosthetic bone loss after total hip arthroplasty (THA). Prediction tools that enrolled all potential risk factors to calculate an individualized prediction of postoperative periprosthetic bone loss were strongly needed for clinical decision-making.MethodsData of the patients who underwent primary unilateral cementless THA between April 2015 and October 2017 in our center were retrospectively collected. Candidate variables included demographic data and bone mineral density (BMD) in spine, hip, and periprosthetic regions that measured 1 week after THA. Outcomes of interest included the risk of postoperative periprosthetic bone loss in Gruen zone 1, 7, and total zones in the 1st postoperative year. Nomograms were presented based on multiple logistic regressions via R language. One thousand Bootstraps were used for internal validation.ResultsFive hundred sixty-three patients met the inclusion criteria were enrolled, and the final analysis was performed in 427 patients (195 male and 232 female) after the exclusion. The mean BMD of Gruen zone 1, 7, and total were decreased by 4.1%, 6.4%, and 1.7% at the 1st year after THA, respectively. 61.1% of the patients (261/427) experienced bone loss in Gruen zone 1 at the 1st postoperative year, while there were 58.1% (248/427) in Gruen zone 7 and 63.0% (269/427) in Gruen zone total. Bias-corrected C-index for risk of postoperative bone loss in Gruen zone 1, 7, and total zones in the 1st postoperative year were 0.700, 0.785, and 0.696, respectively. The most highly influential factors for the postoperative periprosthetic bone loss were primary diagnosis and BMD in the corresponding Gruen zones at the baseline.ConclusionsTo the best of our knowledge, our study represented the first time to use the nomograms in estimating the risk of postoperative periprosthetic bone loss with adequate predictive discrimination and calibration. Those predictive models would help surgeons to identify high-risk patients who may benefit from anti-bone-resorptive treatment in the early postoperative period effectively. It is also beneficial for patients, as they can choose the treatment options based on a reasonable expectation following surgery.

Influence of the Temperature of the Lower Subtropical Stratosphere on Antarctic Polar Vortex Dynamics

Stability of the stratospheric polar vortex in the winter–spring period is one of key factors of the duration and scales of stratospheric ozone depletion in a polar region. The Arctic polar vortex attains its peak intensity in winter, whereas the Antarctic vortex usually strengthens in early spring. As a result, large-scale ozone depletion occurs every year from August to November over the Antarctic, and short-term ozone loss occasionally occurs from January to March over the Arctic. In this work, we analyze the reason for the high strength and stability of the Antarctic polar vortex in the winter–spring period. A good agreement between the seasonal variations in the temperature of the subtropical lower stratosphere and in the zonal wind in the lower subpolar and polar stratosphere in the Southern Hemisphere is shown on the basis of ERA-Interim reanalysis data. The results of numerical simulations with the PlaSim-ICMMG-1.0 model show acceleration of zonal wind in the subpolar region with an increase in the temperature of the subtropical stratosphere. Thus, the winter–spring strengthening of the Antarctic polar vortex occurs due to an increase in the stratospheric equator-to-pole temperature gradient caused by the seasonal increase in the temperature of the lower subtropical stratosphere in this period.

Specific enrichment of hydrocarbonclastic bacteria from diesel-amended soil on biochar particles

Biochar has been proposed as a suitable biostimulant for the remediation of hydrocarbon contamination, and also has the potential to act as a carrier for hydrocarbonoclastic microorganisms which could bioaugment endogenous microbial communities. However, the evidence regarding the biostimulatory effects of biochars on hydrocarbon bioremediation is somewhat equivocal, possibly due to variability of the physicochemical properties of biochar and soil across studies. Here, we use standard biochars with defined properties produced from softwood pellets (SWP) and rice husk (RH) at pyrolysis temperatures of 550 °C or 700 °C to test the effects of biochar amendment on microbial community composition and hydrocarbon degradation in soil microcosms contaminated with diesel oil. Combining this approach for the first time with specific analysis of microbial community composition using amplicon sequence variants (ASVs), we find that oil contamination causes extreme short-term loss of soil microbial diversity, and highly-specific selection of a limited set of genera defined by 13 ASVs. Biochar ameliorates the short-term loss of diversity, and in the longer term (9 weeks), changes community composition in a type-specific manner. The majority of the 13 selected ASVs are further enriched on biochar particles, although SWP biochars perform better than RH biochar in enrichment of putative hydrocarbonoclastic Aquabacterium spp. However, complete degradation of normal (n) alkanes from the aliphatic hydrocarbon fraction is prevented in the presence of biochar amendment, possibly due to their adsorption onto the char surface. Furthermore, we show that putative hydrocarbon degraders released from diesel-amended soil can subsequently be enriched to high levels on SWP biochar particles in growth medium supplemented with diesel oil as the sole carbon source; these include selected ASVs representing the genera Rhodococcus, Aquabacterium, and Cavicella. This work suggests that use of biochar pre-enriched with endogenous, conditionally-rare hydrocarbon degrading bacteria is a promising strategy for bioaugmentation of diesel-contaminated soils.

Sarcopenia during COVID-19 lockdown restrictions: long-term health effects of short-term muscle loss

The COVID-19 pandemic is an extraordinary global emergency that has led to the implementation of unprecedented measures in order to stem the spread of the infection. Internationally, governments are enforcing measures such as travel bans, quarantine, isolation, and social distancing leading to an extended period of time at home. This has resulted in reductions in physical activity and changes in dietary intakes that have the potential to accelerate sarcopenia, a deterioration of muscle mass and function (more likely in older populations), as well as increases in body fat. These changes in body composition are associated with a number of chronic, lifestyle diseases including cardiovascular disease (CVD), diabetes, osteoporosis, frailty, cognitive decline, and depression. Furthermore, CVD, diabetes, and elevated body fat are associated with greater risk of COVID-19 infection and more severe symptomology, underscoring the importance of avoiding the development of such morbidities. Here we review mechanisms of sarcopenia and their relation to the current data on the effects of COVID-19 confinement on physical activity, dietary habits, sleep, and stress as well as extended bed rest due to COVID-19 hospitalization. The potential of these factors to lead to an increased likelihood of muscle loss and chronic disease will be discussed. By offering a number of home-based strategies including resistance exercise, higher protein intakes and supplementation, we can potentially guide public health authorities to avoid a lifestyle disease and rehabilitation crisis post-COVID-19. Such strategies may also serve as useful preventative measures for reducing the likelihood of sarcopenia in general and in the event of future periods of isolation.