Short-term Gain Research Articles

The Manifestation and Solution of Time Dilemma of Teachers of Ideological and Political Theory Courses in Colleges

Ideological and political education activities are promoted in a certain period of time. The teachers of ideological and political theory courses in colleges and universities are also in a certain period of time and are subject to time constraints. Due to the contradictions between the delay of value revelation and the unilinearity of natural time, conflicts between the regularity of institutional time and the rheology of life time, and incompatibility between the idleness of virtual time and the tightness of classroom time, ideological and political theory teachers are currently stuck in a certain time dilemma, which is mainly manifested in: Teachers of ideological and political theory courses in colleges and universities have a low sense of short-term gain, and the pressure of ideological and political education time preemption increases sharply, and the countdown of institutional time increases the pressure. In order to help ideological and political theory teachers to face the time dilemma, it is necessary to improve the time quality of ideological and political theory teachers, perfect the evaluation system of ideological and political education, put ideological and political education on life time.

Supplementation of cyanidin-3-O-β-glucoside-rich haskap (Lonicera caerulea L.) berry extract attenuates hepatic lipid dysregulation in diet-induced obese mice

Haskap (Lonicera caerulea L.) berry is enriched in anthocyanins, primarily cyanidin-3-O-β-glucoside (C3G). It remains unknown whether C3G counteracts metabolic alterations of the pathogenesis of obesity. In this study, mice were fed high-fat high-sucrose (HFHS) diet supplemented either with C3G-rich extract (HFHS + CE) or berry powder with low C3G (HFHS + BP). Mice fed HFHS + CE displayed short-term protection against weight gain, independent of food intake. HFHS + CE mice had lower hepatic diacylglycerols and triacylglycerols content and reduced expression of key lipogenic transcription factors. These metabolic changes also translated into improved glucose tolerance and insulin sensitivity. 16S rRNA sequencing revealed altered gut microbiota composition in the HFHS + CE group. In summary, we demonstrate that C3G enrichment in the HFHS diet attenuates short-term weight gain, decreases hepatic lipid content by suppressing key lipogenic gene expression and improves glucose homeostasis during obesity development, supporting the therapeutic utility of C3G as a bioactive phytonutrient to manage obesity-related complications.

Management of children with obesity at local hospital and impact of COVID-19 pandemic.

This study investigated the status of children with obesity before and after the COVID-19 pandemic, and the effects of lifestyle guidance on weight loss among children in Japan. We analysed the data of patients who visited our hospital after check-ups for obesity and evaluated the efficacy of lifestyle guidance. The patients were divided into groups A, B, and C (year 2011, 2019, and 2021, respectively). There were no differences in body weight, obesity index (OI), blood pressure, or alanine transaminase (ALT) levels between the groups; however, aspartate transaminase (AST) level was the highest in Group C. In Group C, only OI increased between the primary and secondary screenings; however, OI and body mass index (BMI) improved during the second screening and more children in the weight loss group followed lifestyle guidance. OI/BMI did not change over the past decade; however, short-term weight gain was significant owing to the COVID-19 pandemic, and simple guidance was effective in reducing weight. Future challenges include identifying methods to achieve long-term weight loss.

Paediatric cataract surgery with 27G vitrectomy instrumentation: the Ghent University Hospital Experience.

To describe a cohort of paediatric patients who underwent unilateral or bilateral lens extractions at Ghent University hospital using the Dutch Ophthalmic Research Center (D.O.R.C.) ultra-short 27G vitrectomy system. Retrospective analysis of the medical and surgical records of all children that underwent lens extraction between September 2016 and September 2020 using the D.O.R.C. ultra-short 27G vitrectomy system. Seventy-two eyes of 52 patients were included. The most important aetiologies in this study were of secondary (25.5%), developmental (13.7%), or genetic (13.7%) nature. No definitive cause could be established in more than a quarter of cases (27.5%) despite extensive work-up, them being deemed idiopathic. The remainder of cases (19.6%) was not assigned a final aetiologic designation at the time of the study due to contradicting or missing diagnostic data. This study could not identify any cataract cases related to infection or trauma. Surgical complications rate was 61.1% of which posterior capsule opacification was the most frequent with a rate of 25%. A significant short-term postoperative best-corrected visual acuity gain (≤ -0.2 LogMAR) was observed in 60.5% of eyes for which usable acuity data were available (n = 38). Many different instruments and techniques have been described and used in the context of paediatric lens extractions, each with its advantages and disadvantages. This study illustrates that an ultra-short 27G vitrectomy system can be used to perform paediatric lens extractions with good surgical outcomes. Further studies and comparative trials are needed to ascertain this further.

The #ObGynInternChallenge: Reach, Adoption, Implementation, and Effectiveness of a Microlearning SMS-Distributed Curriculum.

While many medical schools have implemented bootcamps or specialized curricula to prepare medical students for residency, these programs are neither universal nor consistent in their content. The authors created an electronic, multimodal, short messaging service (SMS)-distributed curriculum, called the #ObGynInternChallenge, to improve learners' medical knowledge, based on the Council on Resident Education in Obstetrics and Gynecology educational objectives. The curriculum was open to all fourth-year medical students who matched into obstetrics and gynecology (Ob/Gyn). Daily messages were delivered to participants' mobile devices via SMS for 25 consecutive weekdays, May 3-June 4, 2021. Each day's message included an introduction with key facts, an infographic, a website link with a podcast and additional reference materials, and at least one question. The authors assessed its reach, adoption, implementation, and effectiveness. For reach and adoption, total enrollment for the curriculum was 1,057 (72.0%) of 1,469 filled Ob/Gyn residency positions in the 2021 Match. The total cost of the intervention was $2,503.20 or $2.37 per participant. For implementation, all participants who signed up for the course received the daily messages, and 858/1,057 (81.2%) completed the course. Participants felt the curriculum was an excellent resource for studying (391/426, 91.8%) and the course was enjoyable to use (395/424, 93.2%). For effectiveness, mean score improvement was 11.6% (pre-test: 62.4%, post-test: 74.0%; P < .001). In the multivariate linear regression analysis, high podcast ( P = .02) and website use ( P = .002) were associated with greater score improvement. High social media use was associated with less improvement ( P = .02). This study suggests promise for a low-cost, largely satisfying SMS-distributed curriculum in terms of offering some benefit for short-term knowledge gain. Next steps include expanding such a curriculum to meet standard learning objectives for all fourth-year medical students entering residency.

Conservation and Conflict in the Cockpit Country, Jamaica, 1962-2022.

Cockpit Country in west central Jamaica is a unique karst landscape. Based on a wide range of published and online sources, this article examines threats to the area’s biodiversity and attempts to conserve it, from Jamaica’s independence in 1962 to the declaration of the Cockpit Country Protected Area in 2022. It focusses on several stakeholders – the government, international organisations, environmental groups, and Cockpit communities –, and argues that their interplay made conservation of the area a far from straightforward trajectory. It will show that by the late 1980s, international organisations increasingly used mainstream conservation approaches in their work to protect the Cockpit Country and that local environmental groups gradually also came to embrace mainstream conservation. But it will also highlight that Cockpit communities have had a more ambivalent attitude towards conservation of the area than local environmental groups and international organisations, and that a focus on short-term gain has made the government a reluctant and even obstructive stakeholder in the preservation of the area’s biodiversity.

Biomimicry in Building Architecture

Biomimicry— design inspired by the functional genius of nature— is a concept becoming more and more prevalent in fields of material science, architecture, and other sciences. Yet, the construction industry does not understand how to build with biomimetic materials, nor understand their biological precedents. Much of this has to do with the familiar use of traditional, high-carbon materials, and lack of collaboration between contractors and biologists. Thus, this study offers a comprehensive exploration of how well biomimetics is translated into the material and structural qualities of buildings. Furthermore, this study aims to provide insight on how to fill the gap between novel technologies and commercial building development. As a result of this effort, architects and engineers will understand how to leverage nature to make buildings more sustainable. In the first part of this document, biomimicry is contextualized and the scope of this investigation is explained. The second part transitions into a detailed exploration of biological models, processes, and their material feasibility in today’s industry. Lastly, this study evaluates evidence from part two to compare how well biomimetic precedents are optimized based on available research. Evidence suggests that a paradigm shift towards system thinking is paramount to the integration of nature’s genius into a sustainable built environment. Lay Summary Copying nature's patterns, forms, and processes in new building technology is one way to achieve more efficient material and energy use. However, there are two key obstacles to sustainable building: lack of collaboration between industries, and short-term gain. This investigation explores how we can overcome these obstacles to bring more innovative solutions into the built environment. Key ideas about the green building are discussed, then existing research is explained. In the end, evidence is evaluated to demonstrate the potential for developing natural models in the real world. To see the complete thesis, please visit https://scholar.colorado.edu/concern/undergraduate_honors_theses/nk322f51x.

PD-1 signaling serves a dual role in suppressing T cell activation but also in protecting from activation-induced cell death

Abstract PD1/PDL1 interactions exert potent inhibitory effects on T cell responses. Inhibition of this pathway results in greater T cell responses and is increasingly used in cancer immunotherapy but the long-term effects of PD1 inhibition on T cell activation responses remain unclear. We hypothesized that these gains in proliferation and activation on T cells over time may result in greater T cell loss due to apoptosis via activation induced cell death (AICD). We investigated this using both mouse and human T cell models of activation. T cells from wild-type or PD1−/− mice were activated in vitro by a variety of stimuli. We observed significantly increased total T cell numbers, as well as expression of Ki67 and CD69 in the PD-1 −/−T cells compared to controls. However, we identified that this increase was accompanied by increased cell death and apoptosis at later time points. Using in vivo adoptive transfer models (allogeneic &amp; xenogeneic) in which PD-1 −/−murine cells, or human T cells given in tandem with PD-1 checkpoint blockade we assessed PD-1 inhibition in vivo on T cell activation, proliferation, and apoptosis. We observed early expansion and activation of murine PD-1 −/−cells in the allogeneic environment compared to controls. Furthermore, human T cells transplanted into immunodeficient mice given anti-PD1 also had greater activation and proliferation. Yet, this was followed by a sharper contraction and increased apoptosis identified through decreased cell numbers and increased Annexin V staining. These data suggest PD-1 regulates T cell activation as a means of protection, but when this balance is manipulated, T cells experience a “short term gain” for a “long term loss” in which cells undergo greater early activation at the cost of AICD. Supported by National Institute of Health grant numbers NIH RO1 HL140921 (WJM), National Institute of Health grant numbers NIH RO1 CA214048 (WJM).

No-till is more of sustaining the soil than a climate change mitigation option

No-till is often referred to as a climate change mitigation option, possibly with a stronger conviction, than as a practice to manage soil organic C (SOC) content. We conducted a global meta-analysis to evaluate the effect of no-till (NT) on SOC concentration (SOCc, g C kg−1 soil) and stock (SOCs, Mg C ha−1 land) across climate, soil texture, cropping systems, and no-till duration to appraise the priority-setting. Compared to conventional tillage, NT favoured a significant rise (ΔSOCc) of 38% in the 0–5 cm soil layer and a much lesser 6% increase in the 5–10 cm layer and no change beyond 10 cm. The temperate climate had nearly twice ΔSOCc in the 0–5 cm layer compared to other climates, while the tropical climate favoured sub-surface accumulation. Coarse- and medium-textured soils and the inclusion of legumes in crop rotation facilitated larger positive ΔSOCs under NT. The microbial biomass C was the most abundant C pool, with 61% and 23% increases under NT in 0–5 and 5–10 cm layers. A large ΔSOCc in aggregates also characterized the top 0–5 cm layer. The difference in SOCs was realized to a maximum 30 cm depth (5.4 Mg ha−1 or 14%) in favour of NT, although varying with the duration of its adoption. The contribution of NT in mitigating global anthropogenic greenhouse gas emissions is meagre, although it can substantially offset emissions from agriculture (17–58%). The benefit of NT in improving SOC is primarily restricted to the surface layer, which is potentially exposed, and therefore an increase could be short-lived. Nevertheless, a short-term gain in SOC is likely to enhance soil quality and crop productivity. Thus, NT may be promoted as a sustainable agricultural management practice rather than emphasizing its role as a potential climate change mitigation option.

Predictive value of pigment epithelial detachment markers for visual acuity outcomes in neovascular age-related macular degeneration

BackgroundTo determine the predictive value of quantitative morphological parameters for pigment epithelial detachment (PED) of neovascular age-related macular degeneration (nAMD) patients.MethodsOne eye from each of 159 patients with nAMD were studied. Polypoidal choroidal vasculopathy (PCV) group included 77 eyes, and non-PCV group 82. Patients received conbercept 0.05 ml (0.5 mg) in a 3 + ProReNata (PRN) treatment regimen. Correlations between retinal morphologic parameters at baseline and best-corrected visual acuity (BCVA) gain at 3 or 12 months after treatment (structure–function correlations) were assessed. Optical coherence tomography (OCT) scans were used to assess retinal morphologic features including intraretinal cystoid fluid (IRC), subretinal fluid (SRF), PED or PED type (PEDT), and vitreomacular adhesion (VMA). Greatest height (PEDH) and width of PED (PEDW), and volume of PED (PEDV) at baseline were also measured.ResultsFor non-PCV group, BCVA gain from 3 or 12 months after treatment was negatively correlated with PEDV at baseline (r = -0.329, -0.312, P = 0.027, 0.037). BCVA gain at 12 months after treatment was negatively correlated with PEDW at baseline (r = -0.305, P = 0.044). For PCV group, there were no correlations with PEDV, PEDH, PEDW, and PEDT in BCVA gain between baseline and 3 or 12 months after treatment (P > 0.05). SRF, IRC, VMA at baseline did not correlate with short-term and long-term BCVA gain in patients with nAMD (P > 0.05).ConclusionFor patients with non-PCV, PEDV at baseline was negatively correlated with short-term and long-term BCVA gain, and PEDW was negatively correlated with long-term BCVA gain. On the contrary, quantitative morphological parameters for PED at baseline had no correlation with BCVA gain in patients with PCV.

The Influence of the Pandemic on Decisions Occuring During the Last Few Years

The notion that present value of cash flows is often improperly estimated in financial models concerning capital improvements and abandonments is a fundamental problem in decision analysis in management and associated decisions and affects estimation of and valuation of intellectual property. Previous studies indicate the usefulness of estimation theory in financial in financial accounting. During the Covid Pandemic of the past few years decisions by governmental and health authorities in the United States and the World were often dictatated during the Pandemic by short-term political influences which included disinformation by some who wished to rake advantage of the misuse of the health Pandemic for political gain and/or financial power and short-term financial gain. Previously this was show to be true as the media with the aid of self-promotional activities by many who were attempting this kind of gain. Furthermore the Pandemic in the United States and other nations is receding in drfamatic ways and many restrictions of the Endemic era are nolonger in use. This was the result of Mask restrictions and increasing but not universal vaccine programs many states and nations.

Simulation of silvicultural treatments based on real 3D forest data from mobile laser scanning point clouds

Forest management has a direct influence on the structure and stability of forests. In this study, we used the 3D data from mobile laser scanning in real forest stands dominated by European beech (Fagus sylvatica L.) to simulate different silvicultural treatments and assess their impact on the structural complexity and short-term economic return. For the structural assessment, we used the box-dimension (Db), a holistic measure of structural complexity in forest. The expected net revenues of the silvicultural treatments were used as a proxy for short-term economic gain. We simulated six different treatments in 19 different real-world forest stands. The results showed that each treatment had a negative impact on the structural complexity of the stands but with varying severity. The treatments with the smallest effect on stand structural complexity showed the highest net revenue, indicating no trade-offs if a forest owner strives for small stand structural changes and high economic return. The approach used here allows quantifying the structural and economic consequences of different treatments in forest stands prior to the actual application in the real world. This holds large potential for decision making according to the forest owner's objective.

Economic benefits of conservation biocontrol: A spatially explicit bioeconomic model for insect pest management in agricultural landscapes

Spatially explicit population dynamic models have been successfully used to explore management scenarios in terms of pest suppression across a wide range of systems. However, the economic implications of pest management, particularly in the case of biological control and non-crop management strategies, have not been well considered. A bioeconomic spatially explicit simulation model was developed, that integrates models of pest population dynamics, pest movement and economics of management. The utility of the model is demonstrated here usingNysius vinitor, a pest of grain crops in Australia. The model estimates the short- and long-term economic benefits of three pest management strategies: (1) in-field pesticide spray; (2) pest suppression through weed management in non-crop habitat; and (3) bolstering biocontrol through revegetation with, or maintenance of, native vegetation. Across all management types, high yield and low relative management cost resulted in a greater chance of a gross profit. The impacts of the pests themselves were shown to be non-linear, with an intermediate level of pest pressure maximizing the economic gain from management. Pest dispersal capacity influenced the profitability of management of non-crop vegetation, with lower pest dispersal resulting in a greater likelihood of benefit, as benefits from non-crop management are localized (e.g., increased beneficial insect populations). In an intensively cropped landscape, pesticide management was most profitable over the short-term. Once a 10-year horizon was reached, then the profitability of revegetation was greater and continued to increase. While weeding requirements are low, it is likely to always be profitable in the long-term to maintain or restore native vegetation in good condition to control this pest in an intensively cropped landscape. Using pesticide alongside revegetation gave some short-term gain, but the negative impact of pesticide on beneficials outweighed the benefit and in the long-term it is less profitable. These results do not hold in a low production landscape, due to increased pest pressure and costs of managing non-crop habitat. In summary, when quantified over a 10–20 year time horizon, revegetation or conserving native remnants in good (i.e., non-weedy) condition could be economically more beneficial to control an insect pest than ongoing pesticide use, in intensively cropped landscapes.

Regional industrial growth and biopharma patent networks: empirical insights from the UK

The COVID-19 pandemic has once again brought the significance of biopharmaceutical and medical technology sectors to the spotlight. Seeing that some of the most critical medical breakthroughs such as the speedy mRNA vaccine development were results of cross-border patenting collaboration, we have proposed in a previous work a new method to identify the cross-border collaborative regional centres in the patent networks, using a clustering comparison approach based on adjusted mutual information (AMI). In this paper, we focus on the UK industrial landscape. We use the UK bioscience and health technology sector statistics from 2015 to 2020 and look into the regional growth of each postcode area. We compare the top growth regions with the cross-border collaborative centres identified using AMI comparison at the postcode area level, and find that both long-term and short-term AMI gains show an increase in the correlation with regional annual growth rates of firm numbers in the studied sectors from 2016 to 2020, and the increase is more consistent with the short-term AMI gain. We also found that areas more central in the long-term cross-regional R&D collaboration demonstrate a stronger association with more developed industrial settings indicated by more firms and, potentially more employment and turnover in the field. However, AMI gains are found to have negative correlations with the industrial growths as a sign of possible trade-offs of being central.

Studies of charging up in THGEMs

The time-dependent variation of detector response in MPGDs, especially THGEMs, is a challenging problem that has been attributed to the charging up and charging down processes of insulating materials present in these detector. Experimental studies of stabilization of gain with time due to these phenomena under various experimental conditions are presented in this paper. Effects of sources with varying irradiation rates on the gain saturation process have been studied. Low-rate source shows two-step gain stabilization phenomena, one short-term saturated gain, another long-term saturated gain, whereas high-rate source shows a single-step gain saturation. While this two-step stabilization has been attributed to the charging up of the rim by earlier studies, its effect seems to be subdued for high-rate irradiation according to the observations presented here.

Preferences for Weight Gain Compared With Other Antiretroviral Therapy Side Effects in People Living With HIV: A Discrete Choice Experiment.

Antiretroviral (ARV) side effects are a critical determinant of adherence among people living with HIV (PLWH). Integrase strand transfer inhibitors (INSTIs), a commonly used ARV, have been reported to cause weight gain. We determined the relative importance of weight gain compared with other side effects from the perspective of PLWH. Melbourne Sexual Health Centre and the Alfred Hospital in Victoria, Australia. We conducted a discrete choice experiment survey to explore PLWH's preferences for 8 short-term side effects (eg, weight gain and depression) and 4 long-term side effects (eg, long-term weight gain and risks of heart attack). We sent an anonymous survey link through short message service (SMS) and postcards to PLWH attending both centers between July and August 2021. The choice data were analyzed using random parameter logit (RPL) and latent class (LCM) models. Three hundred thirty-five respondents were included: most were male (88.1%). In the RPL analyses, weight gain was the second most important attribute after depression for short-term side effects and the third most important attribute after risk of heart attack and kidney problem for long-term side effects. In the LCM analyses, 23.9% were most sensitive to short-term weight gain, whereas 16.0% were most sensitive to long-term weight gain. Weight gain was the second most important short-term side effect and the third most important long-term side effect in a cohort of Australian PLWH. However, weight gain was the most important side effect of ARV for a significant minority.

Living in relationship with the Ocean to transform governance in the UN Ocean Decade.

Humanity’s relationship with the Ocean needs to be transformed to effectively address the multitude of governance crises facing the Ocean, including overfishing, climate change, pollution, and habitat destruction. Earth law, including Rights of Nature, provides a pathway to center humanity as a part of Nature and transform our relationship from one of dominion and separateness towards holism and mutual enhancement. Within the Earth law framework, an Ocean-centered approach views humanity as interconnected with the Ocean, recognizes societies’ collective duty and reciprocal responsibility to protect and conserve the Ocean, and puts aside short-term gain to respect and protect future generations of all life and the Ocean’s capacity to regenerate and sustain natural cycles. This Essay presents Ocean-centered governance as an approach to help achieve the 10 challenges for collective impact put forward as part of the UN Decade of Ocean Science for Sustainable Development and therefore living in a harmonious relationship with the Ocean.

Household debt: An institutionalist perspective and empirical assessment

The paper deals with the empirical evidence on household borrowing behavior from an institutionalist perspective. Assuming close interconnections between the availability of credit and consumerist culture, we estimate the effects of precedence of consumption, status consumption, and “investment”-minded buying driven by debt pattern. We rely on official statistics on household debt, disposable income and spending since the early 2000s to 2020. The institution of precedence of consumption is measured through data on loans drawn by households, outstanding loans, loan payments, household consumption and disposable income. Corresponding metrics illustrate that debt-financed consumption has become a widespread scheme. Financialization rate is measured separately for retail sector and housing market. Households are becoming more dependent on loan payments, as we estimated for different income groups using the paymentto-income ratios. In case with car loans, these metrics serve as indirect evidence for the embeddedness of conspicuous motive. Evidence on housing loans suggests that “investment”-minded buying can hardly result in a short-term gain. Research findings show that the pattern of precedence of consumption feeds the socially induced motives of conspicuous waste and speculation. Causality can go the other way too. The novelty of our approach is that we integrate the discourse of financialization into the institutionalist perspective and combine the theoretical constructs of precedence of consumption, conspicuous waste and speculative motive, seen as the factors of debt dependence. We contribute to applied studies by introducing factual data on household debt and providing evidence of interplay between these factors. The research is relevant socially and economically in view of the connection between unsustainable household debt and consumerist culture.

PLIS: A metabolomic response monitor to a lifestyle intervention study in older adults.

The response to lifestyle intervention studies is often heterogeneous, especially in older adults. Subtle responses that may represent a health gain for individuals are not always detected by classical health variables, stressing the need for novel biomarkers that detect intermediate changes in metabolic, inflammatory, and immunity-related health. Here, our aim was to develop and validate a molecular multivariate biomarker maximally sensitive to the individual effect of a lifestyle intervention; the Personalized Lifestyle Intervention Status (PLIS). We used 1 H-NMR fasting blood metabolite measurements from before and after the 13-week combined physical and nutritional Growing Old TOgether (GOTO) lifestyle intervention study in combination with a fivefold cross-validation and a bootstrapping method to train a separate PLIS score for men and women. The PLIS scores consisted of 14 and four metabolites for females and males, respectively. Performance of the PLIS score in tracking health gain was illustrated by association of the sex-specific PLIS scores with several classical metabolic health markers, such as BMI, trunk fat%, fasting HDL cholesterol, and fasting insulin, the primary outcome of the GOTO study. We also showed that the baseline PLIS score indicated which participants respond positively to the intervention. Finally, we explored PLIS in an independent physical activity lifestyle intervention study, showing similar, albeit remarkably weaker, associations of PLIS with classical metabolic health markers. To conclude, we found that the sex-specific PLIS score was able to track the individual short-term metabolic health gain of the GOTO lifestyle intervention study. The methodology used to train the PLIS score potentially provides a useful instrument to track personal responses and predict the participant's health benefit in lifestyle interventions similar to the GOTO study.

Safety and Efficacy of Pediatric Growth Hormone Therapy: Results From the Full KIGS Cohort.

The Kabi/Pfizer International Growth Database (KIGS) is a large, international database (1987-2012) of children treated with recombinant human growth hormone (rhGH) in real-world settings. This work aimed to evaluate the safety and efficacy of rhGH from the full KIGS cohort. Data were collected by investigators from children with growth disorders treated with rhGH (Genotropin [somatropin]; Pfizer). Safety was evaluated in all treated patients, and efficacy in those treated for 1 year or more. A subgroup included patients treated for 5 years or more (≥ 2 years prepubertal) who had reached near-adult height (NAH). Main outcomes included adverse events (AEs), serious AEs (SAEs), and height growth. The full KIGS cohort (N = 83 803 [58% male]) was treated for idiopathic GH deficiency (IGHD; 46.9%), organic GHD (10.0%), small for gestational age (SGA; 9.5%), Turner syndrome (TS; 9.2%), idiopathic short stature (ISS; 8.2%), and others (16.2%). Median rhGH treatment duration was 2.7 years and observation 3.1 years. SAEs occurred in 3.7% of patients and death in 0.4%. The most common SAEs were recurrence of craniopharyngioma (n = 151), neoplasm (n = 99), and cancer (n = 91); and scoliosis (n = 91). Median first-year delta height-SD score (SDS) (Prader) in prepubertal patients was 0.66 (IGHD), 0.55 (ISS), 0.58 (TS), and 0.71 (SGA). Median gains in NAH-SDS were 1.79 (IGHD), 1.37 (ISS), and 1.34 (SGA) for boys, and 2.07 (IGHD), 1.62 (ISS), 1.07 (TS), and 1.57 (SGA) for girls. Data from KIGS, the largest and longest running international database of rhGH-treated children, show that rhGH is safe and increases short-term height gain and adult height across GHD and non-GHD conditions.