Short Recovery Research Articles

A sustainable strategy for targeted extraction of thorium from radioactive waste leachate based on hydrophobic deep eutectic solvent

In this work, the new hydrophobic deep eutectic solvents (HDESs) based on 2-hexyldecanoic acid (HDA) as a hydrogen bond donor (HBD) were used to selectively enrich trace Th from radioactive waste leach solution. These HDESs are characterized by low toxicity, bio-friendliness, low viscosity and sufficient hydrophobicity. Compared with Al, Mg, Ca and RE, HDESs exhibited exceptional selectivity for Th extraction, along with high loading capacity, easy stripping and stable reusability. The mechanism of Th extraction by the HDES is a cation exchange reaction. Based on the thymol (TL):HDA (1:3) HDES, a short flow closed-loop recovery process of Th in the leach solution of radioactive waste residue was developed. After a single-step extraction, the extraction percentage (E%) of Th exceeded 98.0%, while the E% of other elements was less than 0.14%. After stripping, the concentration of Th in the concentrated solution reached 2.16 × 103 mg/L with a purity of 74.2%, which could be directly used for subsequent purification. By adjusting the pH to 4.00, the raffinate was used as a feed solution for RE elements recovery. The HDES-based extraction strategy for Th is simple, safe, efficient and environmentally friendly, providing a new idea for the recovery of radioactive waste residues.

Dendrimer functionalized spinel ferrite for robust sorption of precious metals from strongly acidic medium

The separation of noble metal ions from strongly acidic solutions is considered to be a challenging task due to the significantly low pH of these solutions. Spinel ferrites possess unique physicochemical properties, such as excellent magnetic properties, high specific surface area, high chemical stability, active surface sites, and easy modification or functionalization, making them suitable for various applications. In this study, we have introduced a facile method for synthesizing polyamidoamine (PAMAM) dendrimer-functionalized spinel ferrite (DFSF) with a particle size of approximately 10 nm. The prepared DFSF materials have investigated its ability to adsorb Pt(IV) and Pd(II) anions (PtCl62− and PdCl42−) from strongly acidic solutions. The results indicate that the adsorption kinetics and isotherm studies of synthesized materials have a rapid and high adsorption capacity for Pt(IV) and Pd(II) with simple solid-liquid separation. The data analysis suggests an anion exchange interaction between the adsorbate and the adsorbent, specifically the electrostatic interaction between the protonated amine group (–NH3+) and the noble metal anions (PtCl62–and PdCl42−). The Pseudo second-order rate model fitting suggests that the adsorption of noble metals by DFSF is a function of valence. The excellent superparamagnetic properties (0.346 emu g−1) of DFSF make it a promising candidate for large-scale applications, as it exhibited good reusability with a short recovery time (25 s) and high recovery efficiency through the adsorption-reduction-precipitation route. This study suggests that DFSF can be a potential sorbent for noble metal ions in various applications.

Preparation of ultrafast ammonia sensor based on cross-linked ZnO nanorods coated with poly(3-hexylthiophene)

A gas sensing device was fabricated using poly(3-hexylthiophene) (P3HT)-coated ZnO nanorods, and the ammonia (NH3) gas-sensing properties of the heterojunction device were analyzed. Hexagonal ZnO nanorods were prepared using the hydrothermal method on a ZnO seed layer. The ZnO seed layer was deposited using the sputtering method on a Ti–Pt bilayer interdigital electrode. X-ray diffraction and field emission scanning electron microscopy characterized the crystal structure and morphology of the ZnO–P3HT nanorods heterojunction devices. The gas-sensing properties of the P3HT–ZnO nanorods heterojunction sensor were examined and compared with different concentrations of NH3 gas. The response and recovery times were less than 1.5 s with a NH3 gas concentration of 1 ppm. Comparison with sensors of other materials indicated that P3HT was the reason for the short response and recovery times. Plausible mechanisms explaining the enhanced NH3 selectivity of the P3HT–ZnO nanorods heterojunction structure are discussed.

Sodium-doped InP/ZnSeS/ZnS quantum dots as a saturable absorber for passive Q-switched fiber lasers

In this work, sodium-doped InP/ZnSeS/ZnS (InP–Na) QDs was fabricated by thermal injection method for the first time. The nonlinear optical properties were first demonstrated by realizing a modulation depth of 7.85% and saturable intensity of 2.2 MW cm−2 by two-detector method. The Q-switching operations were carried out by integrating InP–Na QDs as saturable absorber (SA) in a fiber laser ring cavity system. Q-switched laser pulses with a pulse width of 139 ns were generated. The ability of effective pulse width compression can be attributed to the short exciton recovery time of SA, as confirmed by transient absorption and time-resolved photoluminescence. This is the first demonstration of Na-doped InP/ZnSeS/ZnS QDs and using it as SA for generating ultrafast laser pulses. Therefore, this study extends the research scope of InP-based QDs in optical communications, nonlinear photonics and ultrafast photonics.

Muscle magnetic resonance imaging of a large cohort of distal hereditary motor neuropathies reveals characteristic features useful for diagnosis

Distal motor neuropathies (dHMN) are an heterogenous group of diseases characterized by progressive muscle weakness affecting predominantly the distal muscles of the lower and upper limbs. Our aim was to study the imaging features and pattern of muscle involvement in muscle magnetic resonance imaging (MRI) in dHMN patients of suspected genetic origin (dHMN). We conducted a retrospective study collecting clinical, genetic and muscle imaging data. Muscle MRI included T1-weighted and T2 weighted Short Tau Inversion Recovery images (STIR-T2w) sequences. Muscle replacement by fat was quantified using the Mercuri score. Identification of selective patterns of involvement was performed using hierarchical clustering. Eighty-four patients with diagnosis of dHMN were studied. Fat replacement was predominant in the distal lower leg muscles (82/84 cases), although also affected thigh and pelvis muscles. Asymmetric involvement was present in 29% of patients. The superficial posterior compartment of the leg, including the soleus and gastrocnemius muscles, was the most affected area (77/84). We observed a reticular pattern of fatty replacement progressing towards what is commonly known as “muscle islands” in 79.8%. Hyperintensities in STIR-T2w were observed in 78.6% patients mainly in distal leg muscles. Besides features common to all individuals, we identified and describe a pattern of muscle fat replacement characteristic of BICD2, HSPB1 and DYNC1H1 patients. We conclude that muscle MRI of patients with suspected dHMN reveals common features helpful in diagnosis process.

NO Gas Sensor Based on Ti-Doped ZnO Thin Films Prepared by SILAR Method

In this study, Ti-doped ZnO films with flower-rod-like nanostructures were synthesized by the SILAR method for enhanced NO gas sensing applications. The stoichiometric ratio of Ti in the host ZnO lattice was confirmed by atomic absorption and energy-dispersive X-ray spectroscopies. All the synthesized films exhibited a pure wurtzite hexagonal structure that seemed to deteriorate at high Ti doping contents as it was manifested by the measured X-ray diffraction patterns. Scanning electron microscopy images of ZnO revealed the coexistence of porous flower- and rod-like structures, and became finer, denser and more compact with Ti doping. By UV-Vis measurements, the transmittance of the synthesized pure ZnO thin film in the visible region (~75%) increased by about 10% with Ti doping, and the energy bandgap seemed to decrease up to a some limit of Ti content. Among the fabricated sensors (based on pure ZnO, 1% Ti-doped, 3% Ti-doped and 5% Ti-doped ZnO films), the best sensing performance was observed for the 1% Ti-doped ZnO film. At first, this was associated with its high density of oxygen vacancies present on the surface of the film and ionized oxygen vacancies present in the ZnO lattice (confirmed respectively by X-ray photoelectron and photoluminescence spectroscopies). Nonetheless, this may be also due to its increased crystallinity (confirmed by X-ray diffraction and photoluminescence spectroscopy), high area-to-volume ratio (confirmed by scanning electron microscopy images), high specific surface area (confirmed by Brunauer-Emmett-Teller measurements) as well as high mobility and carrier concentration (confirmed by Hall measurements). The sensor was highly selective to NO gas and showed notable stability as well as very short response and recovery times which makes it eligible for the early detection of any indoor or outdoor NO gas leakages. Keywords : SILAR, Ti-doped ZnO, Structural properties, Optical properties, Electrical properties, Gas sensor. Acknowledgement This research was supported by the research grant 021220FD2201 “Development of highly sensitive MOS based nano-film gas sensors” from Nazarbayev University. Figure 1

The Evolving Role of Cryosurgery in Breast Cancer Management: A Comprehensive Review.

Breast cancer is the most commonly diagnosed type of cancer, accounting for approximately one in eight cancer diagnoses worldwide. In 2020, there were approximately 2.3 million new cases of breast cancer globally, resulting in around 685,000 deaths. Consequently, there is an ongoing need to develop innovative therapeutic approaches that can improve both clinical outcomes and patient quality of life. The use of ultra-low cryogenic temperatures, facilitated by cryogenic media such as liquid nitrogen, has revolutionized the biomedical field and opened up new possibilities for advanced clinical treatments, including cryosurgery. Cryosurgery has demonstrated its feasibility as a minimally invasive technique for destroying breast tumors and eliciting a significant antitumor immune response in the host. This feature sets cryosurgery apart from other ablative techniques. It has been shown to be well tolerated and effective, offering several advantages such as simplicity, the avoidance of general anesthesia, minimal pain, low morbidity, short recovery time, cost-effectiveness, and notably, improved aesthetic outcomes. The reviewed studies indicate that cryosurgery holds promise in the management of early-stage breast cancer and metastatic disease, especially in triple-negative and Her2-positive molecular subtypes in conjunction with checkpoint inhibitors and anti-Her2 antibodies, respectively. Furthermore, the effectiveness of cryosurgery in the management of ductal carcinoma in situ should be investigated as an alternative modality to surgery or surveillance. The minimally invasive nature of cryosurgery has the potential to significantly enhance the quality of life for patients.

Magnetic resonance imaging features of invasive breast cancer association with the tumour stromal ratio.

To assess the association between breast cancer tumour stroma and magnetic resonance imaging (MRI) features. A total of 84 patients with treatment-naïve invasive breast cancer were enrolled into this retrospective study. The tumour stroma ratio (TSR) was estimated from the amount of tumour stroma in the pathology specimen of the breast tumour. The MRI images of the patients were analysed based on Breast Imaging Reporting and Data Systems (ACR-BIRADS) for qualitative features which include T2- weighted, diffusion-weighted images (DWI) and dynamic contrast-enhanced (DCE) for kinetic features. The mean signal intensity (SI) of Short Tau Inversion Recovery (STIR), with the ratio of STIR of the lesion and pectoralis muscle (L/M ratio) and apparent diffusion coefficient (ADC) value, were measured for the quantitative features. Correlation tests were performed to assess the relationship between TSR and MRI features. There was a significant correlation between the margin of mass, enhancement pattern, and STIR signal intensity of breast cancer and TSR. There were 54.76% (n = 46) in the low stromal group and 45.24% (n = 38) in the high stromal group. A significant association were seen between the margin of the mass and TSR (p = 0.034) between the L/M ratio (p <0.001), and between STIR SI of the lesion and TSR (p<0.001). The median L/M ratio was significantly higher in the high TSR group as compared to the lower TSR group (p < 0.001). Breast cancer with high stroma had spiculated margins, lower STIR signal intensity, and a heterogeneous pattern of enhancement. Hence, in this preliminary study, certain MRI features showed a potential to predict TSR.

A DFT and QTAIM insight into ethylene oxide adsorption on the surfaces of pure and metal-decorated inorganic fullerene-like nanoclusters

In this industrial era, the use of low-dimensional nanomaterials as gas sensors for environmental monitoring has received enormous interest. To develop an effective sensing method for ethylene oxide (EO), DFT computations are conducted using method ωB97X-D and B3LYP with 6-31G(d,p) basis set to evaluate the adsorption behavior of ethylene oxide gas on the surfaces of pristine, as well as Scandium and Titanium decorated B12N12, Al12N12, and Al12P12 nanocages. Several properties like structural, physical, and electronic are studied methodically to better understand the sensing behavior. Scandium-decorated aluminum phosphate and boron nitride nanocages were shown to perform better in terms of adsorption properties. The short recovery time observed in this study is beneficial for the repetitive use of the gas sensor. The Natural Bond Orbital and molecular electrostatic potential analysis demonstrated a substantial quantity of charge transfer from adsorbate to adsorbents. The bandgap alternation after adsorption shows an influence of adsorption on electronic properties. The interactions of adsorbate and adsorbents are further studied using the ultraviolet–visible predicted spectrum, and quantum theory of atoms in molecules all of which yielded promising findings.

Outpatient percutaneous image-guided microwave ablation with monitored anesthesia care: An exploratory study

PurposeTo evaluate the feasibility, safety, and periprocedural perception of pain for a combination approach of moderate and deep sedation for image-guided percutaneous microwave ablation of both primary and secondary malignant lesions. MethodsThis was a retrospective study of 33 image-guided percutaneous microwave ablation procedures performed on 33 patients in an outpatient-based interventional radiology center. We used a combination of midazolam, fentanyl, propofol, and/or ketamine to achieve mild to moderate sedation for the procedure, and also to achieve deeper sedation as needed for the ablation portion. ResultsTechnical success was achieved in all image-guided percutaneous microwave ablation procedures. Mean procedural time was 49.4 min. There were no major complications. Intraprocedural pain was absent in all patients. All 33 patients were deemed fit for discharge within 30 min following the procedure. ConclusionThe combination approach of moderate and deep sedation for anesthesia during image-guided percutaneous microwave ablation is an advantageous option. This approach has a strong safety profile, good technical success, short procedure times, low levels of intraprocedural and post-procedural pain, and short recovery from anesthesia.

A DFT Study of Volatile Organic Compounds Detection on Pristine and Pt-Decorated SnS Monolayers.

Real-time monitoring of volatile organic compounds (VOCs) is crucial for both industrial production and daily life. However, the non-reactive nature of VOCs and their low concentrations pose a significant challenge for developing sensors. In this study, we investigated the adsorption behaviors of typical VOCs (C2H4, C2H6, and C6H6), on pristine and Pt-decorated SnS monolayers using density functional theory (DFT) calculations. Pristine SnS monolayers have limited charge transfer and long adsorption distances to VOC molecules, resulting in VOC insensitivity. The introduction of Pt atoms promotes charge transfer, creates new energy levels, and increases the overlap of the density of states, thereby enhancing electron excitation and improving gas sensitivity. Pt-decorated SnS monolayers exhibited high sensitivities of 241,921.7%, 35.7%, and 74.3% towards C2H4, C2H6, and C6H6, respectively. These values are 142,306.9, 23.8, and 82.6 times higher than those of pristine SnS monolayers, respectively. Moreover, the moderate adsorption energies of adsorbing C2H6 and C6H6 molecules ensure that Pt-decorated SnS monolayers possess good reversibility with a short recovery time at 298 K. When heated to 498 K, C2H4 molecules desorbs from the surface of Pt-decorated SnS monolayer in 162.33 s. Our results indicate that Pt-decorated SnS monolayers could be superior candidates for sensing VOCs with high selectivity, sensitivity, and reversibility.

Physisorption Behaviors of Organochlorine Pesticides on the InP3 Monolayer from Theoretical Insight.

Dichlorodiphenyltrichloroethane (DDT), hexachlorocyclohexane (BHC), aldrin, and chlordimeform are ubiquitous organochlorine pesticide (OCP) residues in the environment, which pose a great threat to human health and ecosystems due to their high toxicity and easy accumulation. Based on the density functional theory (DFT) calculations, a two-dimensional InP3 monolayer was selected as a sensing material to study the sensitivity detection and adsorption behaviors toward BHC, aldrin, chlordimeform, and DDT. The calculation results show that four pesticide molecules are adsorbed on the InP3 surface by physical interaction. The identified response values (69.1, -43.1%) for DDT and chlordimeform reveal the potential of the InP3 monolayer as a sensing material for the detection of these two pesticides, accompanied by the achievement of cyclic utilization by heating to 498 K. The most satisfactory result is the adsorption of BHC, owing to the admirable sensing response (62.7%) and short recovery time (1.8 s) at room temperature, which makes InP3 a promising pesticide sensor for BHC. However, the InP3 surface is unsuitable for aldrin sensing due to poor response (-1.9%). Our work gives theoretical insight into the good sensitivity and recycling of the InP3 monolayer as a new pesticide sensor to detect DDT, BHC, and chlordimeform, which further broadens the application prospect of the InP3 nanosheet into the sensitive detection of organochlorine pesticides in the ecological environment.

A wearable 3D pressure sensor based on electrostatic self-assembly MXene/chitosan sponge and insulating PVP spacer

It has been shown that flexible pressure sensors may be used in many different contexts, including human-machine interaction, intelligent robots, and health monitoring. In this work, we create a 3D sponge piezoresistive pressure sensor using MXene, chitosan, polyurethane sponge, and polyvinyl pyrrolidone (MXene/CS/PU sponge/PVP), with the well-conductive MXene nanosheet serving as the force sensitive material. In particular, the mechanical strength and endurance of the sensor are enhanced by electrostatic self-assembly between the negatively charged MXene nanosheets and the positively charged CS/PU composite sponge skeleton. The insulating PVP nanowires (PVP-NWs) also decreases the device’s initial current, increasing the sensor’s sensitivity. These characteristics allow the pressure sensor to simultaneously have a high sensitivity (50.27 kPa−1 for pressure below 7 kPa and 13.3 kPa−1 for pressure between 7 and 16 kPa), a quick response time (160 ms), a short recovery time (130 ms), and excellent cycling stability (5000 cycles). Moreover, the sensor exhibits a waterproof performance, where the force-sensitive layer still works normally after cleaning. In practice, the sensor could detect a variety of human actions as well as the distribution of spatial pressure due to the above superior device performance.

Analysis of muscle magnetic resonance imaging of a large cohort of patient with VCP-mediated disease reveals characteristic features useful for diagnosis

BackgroundThe diagnosis of patients with mutations in the VCP gene can be complicated due to their broad phenotypic spectrum including myopathy, motor neuron disease and peripheral neuropathy. Muscle MRI guides the diagnosis in neuromuscular diseases (NMDs); however, comprehensive muscle MRI features for VCP patients have not been reported so far.MethodsWe collected muscle MRIs of 80 of the 255 patients who participated in the “VCP International Study” and reviewed the T1-weighted (T1w) and short tau inversion recovery (STIR) sequences. We identified a series of potential diagnostic MRI based characteristics useful for the diagnosis of VCP disease and validated them in 1089 MRIs from patients with other genetically confirmed NMDs.ResultsFat replacement of at least one muscle was identified in all symptomatic patients. The most common finding was the existence of patchy areas of fat replacement. Although there was a wide variability of muscles affected, we observed a common pattern characterized by the involvement of periscapular, paraspinal, gluteal and quadriceps muscles. STIR signal was enhanced in 67% of the patients, either in the muscle itself or in the surrounding fascia. We identified 10 diagnostic characteristics based on the pattern identified that allowed us to distinguish VCP disease from other neuromuscular diseases with high accuracy.ConclusionsPatients with mutations in the VCP gene had common features on muscle MRI that are helpful for diagnosis purposes, including the presence of patchy fat replacement and a prominent involvement of the periscapular, paraspinal, abdominal and thigh muscles.

Effects of 36-hour recovery on marksmanship and hormone concentrations during strenuous winter military survival training

ObjectivesSurvival training can provide a unique setting for scientific examination of human stress responses and physical performance in a realistic operational military context. The aim of the present study was to observe effects of a 36-h recovery period on serum hormone concentrations, salivary cortisol, and marksmanship during 10-day winter military survival training in north of the Arctic Circle.Design and methodsSixty-eight male soldiers were randomly divided into two groups; EXP (n = 26) and CON (n = 42). While CON performed the whole exercise phase in the field, EXP had 36-h recovery period between days 6 and 8. Several hormones were measured during the study to investigate recovery.ResultsSubjective physical and mental demand as well as catabolic hormone levels increased and anabolic hormones decreased in CON (p < 0.05), whereas in EXP, recovery period attenuated negative effects of survival training. Prone shooting performance decreased (87.5 ± 6.5 vs. 76.3 ± 8.8, points out of 100, p < 0.05) between days 6 and 8 in CON while EXP was able to maintain shooting performance throughout the study.ConclusionA short recovery during a strenuous training can prevent the degradation in psychophysiological state and shooting performance in soldiers, which can be crucial for survival in demanding operational winter environment. In the present study, 36-h rest period during the field training seems to enhance recovery but the duration of the period was inadequate for full recovery from the accumulated operative stress. In conclusion, appropriate recovery periods should be implemented in order to optimize occupational performance during high operative stress.

Capacitive humidity sensor based on zirconium phosphate nanoplates film with wide sensing range and high response

Humidity sensing material is a key component of humidity sensor. In this short communication, we synthesized zirconium phosphate (ZrP) nanoplates and investigated their capacitive humidity sensing performance. The results show that the ZrP humidity sensor exhibits a wide response range (10.9–91.5 % relative humidity (RH)), high response (2409 at 91.5 % RH), short recovery time (9 s), and good repeatability at the optimal working frequency of 100 Hz and room temperature of 25 °C. In addition, the humidity sensing mechanism of the ZrP humidity sensor is analyzed by combining the characterization, dielectric constant and impedance testing results.

Chronic ammonia toxicity disturbed energy homeostasis and damaged the hepatopancreas of swimming crab Portunus trituberculatus

Ammonia is toxic to aquatic animals and its chronic effects on the swimming crab Portunus trituberculatus is still not fully understood. Therefore, we conducted this study to detect the responses of energy metabolism of crabs to chronic high environmental ammonia (HEA) exposure by exposing them to HEA (5 and 15 mg·L−1) for 15 d and subsequently recovering in natural seawater for 7 d. Then we analyzed the glucose and lactate content, ATPases activities and the expression of the genes involved in energy homeostasis. Besides, glutamic pyruvic transaminase (GPT), glutamic oxaloacetic transaminase (GOT), alkaline phosphatase (AKP) activity and histological changes were assayed to determine the HEA-induced hepatopancreas damage. Results showed a HEA dose- and exposure time-dependent mortality and hepatopancreas damage. This was accompanied by a loss of energy homeostasis as indicated by the significant increase of AMP/ATP ratio and genes expression involved in AMPK pathway (P < 0.05). While indices such as HMGCR expression, glucose content and ion related ATPases demonstrated the energy dishomeostasis might be related with the inhibitory effect of chronic HEA on energy regulatory capacity especially when HEA approached 15 mg·L−1. In summary, chronic HEA can seriously damage hepatopancreas structure and function of energy metabolism in P. trituberculatus, and this deleterious effect could even not be completely repaired in a short recovery time.

Facile transformation of graphene oxide nanospheres based on AAO template

In this paper, a facile one-step drop method is developed to convert reduced graphene oxide into graphene oxide nanoparticles. An aqueous solution of reduced graphene oxide is poured through the pores of anodic aluminum oxide templates to form graphene oxide nanospheres at low temperature (120 ​°C) and low pressure (0.8 ​bar) preparation conditions. Electrochemical exfoliation of graphite and reduced graphene oxide nanospheres (not hollow) were adopted to fabricate reduced graphene oxide within the pores of an anodic aluminum oxide template. The prepared reduced graphene oxide nanospheres show uniform diameters (∼42.5 ​nm) and a low O/C ratio (8%). Graphene nanospheres achieve higher sensitivity to CO2 gas in air (at room temperature) compared to graphene oxide nanosheets (i.e., in contrast to carbon dioxide gas sensors in graphene sheets). Its sensitivity increased to 35% by shaping the nanosheets to nanospheres of reduced graphene oxide which is attributed to a surface area expansion of 7.4 ​× ​105 times. Moreover, graphene oxide, reduced graphene oxide, and reduced graphene oxide nanospheres show a fast response time of 0.19 ​s, 0.24 ​s, and 0.31 ​s, and short recovery times of 1.14 ​s, 1.17 ​s, and 1.22 ​s, respectively, with higher sensitivity of reduced graphene oxide nanospheres.

Is Dissection and Preservation of Adherent Popliteal Vessels From a Posterior Soft Tissue Mass Associated With a Higher Proportion of Local Recurrence in Patients With a Distal Femoral Osteosarcoma?

Is Dissection and Preservation of Adherent Popliteal Vessels From a Posterior Soft Tissue Mass Associated With a Higher Proportion of Local Recurrence in Patients With a Distal Femoral Osteosarcoma?

Quantitative evaluation of primary lower extremity lymphedema staging using MRI: a preliminary study.

The staging of primary lower extremity lymphedema (LEL) is difficult yet vital in clinical work, and magnetic resonance imaging (MRI) can be used for quantitative assessment of primary LEL due to its high resolution for soft tissues. In this study, we evaluated the value of MRI-based soft tissue area measurements for staging primary LEL. A total of 90 consecutive patients with clinically diagnosed primary lower limb lymphoedema from January 2017 to December 2019 in Beijing Shijitan Hospital were enrolled retrospectively. Short time inversion recovery (STIR) sequence was applied to measure the total, muscle, bone, and subcutaneous areas in the upper 1/3 level of the bilateral lower calf. The difference between the affected and unaffected calf regarding the subcutaneous area was obtained, and (subcutaneous area)/(bone area) and (subcutaneous area)/(muscle area) were calculated. According to the International Society of Lymphology (ISL) clinical staging standard established in 2020, all patients were divided into stages I, II, and III, accordingly. Statistical analysis was performed to determine the validity of MRI measurements in staging LEL. There were 33 patients classified as stage I clinically, 44 patients as stage II, and 13 patients as stage III. There were significant differences in total, subcutaneous, the difference in subcutaneous area of limbs, subcutaneous/bone (S/B), and subcutaneous/muscle (S/M) between stage I and II as well as between stage I and III (P<0.001), but not between stage II and III (P=0.706, 0.329, and 0.229, respectively). A positive correlation was detected between the clinical stage and difference in subcutaneous area of limbs (rho =0.752, P<0.001), S/B (rho =0.747, P<0.001), S/M (rho =0.709, P<0.001), and subcutaneous (rho =0.723, P<0.001). For staging primary LEL, receiver operating characteristic (ROC) curves indicated that the difference in subcutaneous area of limbs had the best discrimination ability among parameters [area under the ROC curve (AUC) =0.950; 95% confidence interval (CI): 0.875-0.987; sensitivity: 95.45%; specificity: 84.85%], followed by S/B (AUC =0.930; 95% CI: 0.848-0.975; sensitivity: 77.27%; specificity: 93.94%) and S/M (AUC =0.895; 95% CI: 0.804-0.953; sensitivity: 77.27%; specificity: 90.91%). The ROC curves indicated that subcutaneous area (AUC =0.927; 95% CI: 0.844-0.974; sensitivity: 84.09%, specificity: 90.91%) and total (AUC =0.852; 95% CI: 0.753-0.923; sensitivity: 70.45%; specificity: 90.91%) also had discrimination ability between stage I and II. The measurement of the soft tissue area of the calf may be used as an auxiliary method for staging primary LEL. For patients with unilateral primary LEL, the difference in subcutaneous area of limbs could be a specific indicator to distinguish clinical stage I from II.