Climate projections simulated by the Brazilian Earth System Model (BESM2.5) under RCP4.5 and RCP8.5 climate scenarios are analyzed based on future changes of surface air temperature (SAT) and precipitation with respect to the historical reference period 1971–2000. Since BESM2.5 is the only climate model developed in a South American country, this study gives a particular emphasis to South American future climate projections. Regarding the surface air temperature, BESM2.5 projects a steady warming throughout the 21st century, with the highest warming over eastern Amazonia, northern Chile and central South America for both scenarios. The SAT changes range between 2 °C and 3–4 °C for RCP4.5 and RCP8.5, respectively. On the other hand, projected precipitation varies over different regions of South America, with decreasing and increasing trends over the Amazon and southern South America, respectively. Interestingly, this study shows contrasting results with respect to extreme precipitation indicators, projecting enhanced extreme events with higher numbers of both consecutive dry days and days in which the precipitation exceeds 20 mm over the southeastern region. The model projects a meridional dipole pattern in the precipitation, with decreasing precipitation and longer dry spells over Northeast Brazil and the East Amazon region and increasing precipitation and shorter dry spells over Northwest South America and West Amazon, that is driven by future changes in the SLP that imposes a meridional gradient over these regions, causing the increase of westerlies that are likely to increase the moisture transport from the Pacific Ocean into western South America and the weakening of the easterlies that transport moisture over eastern South America and East Amazon.