In manufacturing industries, monitoring and diagnosis of multivariate process out-of-control condition become more challenging. Process monitoring refers to the identification of process status either it is running within a statistically in-control or out-of-control condition, whereas process diagnosis refers to the identification of the source variables of out-of-control process. In order to achieve these requirements, the application of an appropriate statistical process control framework is necessary for rapidly and accurately identifying the signs and source out-of-contol condition with minimum false alarm. In this research, a framework namely, an Integrated Multivariate Exponentially Weighted Moving Average with Artificial Neural Network was investigated in monitoring-diagnosis of multivariate process mean shifts in manufacturing audio video device component. Based on two-stages monitoring-diagnosis technique, the proposed framework has resulted in efficient performance.