AbstractFluids with enhanced heat transport characteristics are essential for efficient convection heat transportation. Hybrid nanofluids have demonstrated their effectiveness as viable substitutes for conventional heat transport fluids. This study explores the heat and mass exchange occurring within a chemically reactive, unsteady boundary layer flow of a copper oxide‐multi‐walled carbon nanotubes (CuO‐MWCNTs)/ethylene glycol Jeffrey hybrid nanofluid. Additionally, the influence of heat source/sink effects in a hydromagnetic environment is carefully added. The study employs a non‐Newtonian flow model and incorporates the Arrhenius activation energy for analysis. The hybrid nanofluid consists of a base fluid, ethylene glycol, enriched with copper oxide nanoparticles and multi‐walled carbon nanotubes. The governing coupled non‐linear partial differential equations are transformed into ordinary differential equations using similarity transformations, considering appropriate free stream, and wall boundary conditions; then, the Shooting method is employed to solve the resulting ordinary differential equations (ODEs) in MATLAB. The graphical and numerical outcomes are studied for various parameter combinations. The graphs illustrate the numerical results for the CuO‐MWCNTs/ethylene glycol hybrid nanofluid. These results are comprehensively discussed to analyze the influence of different thermo‐fluidic parameters on the Jeffrey hybrid nanofluid's heat, mass, and flow characteristics. The skin friction, Nusselt number, and Sherwood number are provided in a numerical table that displays the alterations of these parameters across various parameter values. As the Jeffrey fluid parameter rises, the Nusselt number and skin friction escalate, while the Sherwood number diminishes. Conversely, as the Deborah number rises, the Nusselt number and skin friction decline, but the Sherwood number increases. A comparative analysis with published results confirms the consistency of the present results.
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