Image quality is a well understood concept for human viewing applications, particularly in the multimedia space, but increasingly in an automotive context as well. The rise in prominence of autonomous driving and computer vision brings to the fore research in the area of the impact of image quality in camera perception for tasks such as recognition, localization and reconstruction. While the definition of “image quality” for computer vision may be ill-defined, what is clear is that the configuration of the image signal processing pipeline is the key factor in controlling the image quality for computer vision. This paper is partly review and partly positional with demonstration of several preliminary results promising for future research. As such, we give an overview of what is an Image Signal Processor (ISP) pipeline, describe some typical automotive computer vision problems, and give a brief introduction to the impact of image signal processing parameters on the performance of computer vision, via some empirical results. This paper provides a discussion on the merits of automatically tuning the ISP parameters using computer vision performance indicators as a cost metric, and thus bypassing the need to explicitly define what “image quality” means for computer vision. Due to lack of datasets for performing ISP tuning experiments, we apply proxy algorithms like sharpening before the vision algorithm processing. We performed these experiments with a classical algorithm namely AKAZE and a machine learning algorithm for pedestrian detection. We obtain encouraging results, such as an improvement of 14% accuracy for pedestrian detection by tuning sharpening technique parameters. We hope that this encourages creation of such datasets for more systematic evaluation of these topics.