To assess postoperative pain and bacterial reduction following the use of XP-endo Shaper versus conventional rotary files in preparation of oval canals with necrotic pulps. This superiority, parallel, randomized, double blinded clinical trial was conducted in the clinic of the Endodontic Department, Faculty of Dentistry, Cairo University, Egypt. Sixty single-canalled mandibular premolars with necrotic pulps were randomly assigned into two equal groups. Canals were instrumented using XP-endo Shaper files in the intervention group and iRaCe rotary files in the control group. Bacterial samples were taken before and after canal instrumentation. Incidence and severity of postoperative pain was assessed using a modified VAS after 6, 12, 24h and daily for 5days. A culture method was used to assess the number of bacterial colony forming units. Incidence of analgesic intake as well as flare-ups was recorded. Data were analysed using chi-square, Fisher Exact, Mann-Whitney, Independent t-test, and Spearman's correlation for pain and bacterial counts. The XP-endo Shaper compared with the iRaCe group was associated with a significantly lower incidence of postoperative pain at 6, 12, and 24h (P=0.039, 0.047, and 0.026, respectively), and severity of postoperative pain at 6h (mean difference: 1.33, 95% CI: 0.307-2.352, P=0.02), 12h (mean difference: 1.1, 95% CI: 0.26-1.936, P=0.007), 24h (mean difference: 0.94, 95% CI: 0.178-1.701, P=0.008) and 48h (mean difference: 0.97, 95% CI: 0.192-1.747, P=0.038). There was a significant decrease in bacterial count following canal instrumentation in both groups (P<0.001) with no significant difference between them (mean difference: 0.83×105 , 95% CI: 0.336×105 -1.996×105 , P=0.56). A weak correlation existed between postoperative pain severity and bacterial counts (P=0.54). There was no significant difference in analgesic intake between the two groups (P=0.085). Flare-ups occurred in 3.3% of teeth in the iRaCe group, while no flare-ups occurred in the XP-endo Shaper group. XP-endo Shaper was associated with a significantly lower frequency of postoperative pain for up to 24h, and lower severity of postoperative pain for up to 48h compared with iRaCe files. Both systems were equally effective in bacterial reduction from oval root canals with necrotic pulps.