This study examines the flow and thermal properties of water and kerosene hybrid nanofluids in a horizontal microchannel. The effects of nonlinear thermal radiation, heat source coefficient, convective and slip boundary conditions on nanofluids in a microchannel have been studied. The impact of different nanoparticle shape factors on the temperature of nanofluids has also been analysed. The governing partial differential equations have been transformed in to ordinary differential equations using dimensionless terms. In the next step, the corresponding ordinary differential equations have been cracked using the RKF45 numerical approach, and the particles shape factor on dimensionless velocity and energy fields for hybrid nanofluid then reported. The results revealed that the spherical and lamina shape factors for both water and kerosene hybrid nanofluid differ the most, the water-based hybrid nanofluid has a higher velocity than the kerosene-based hybrid nanofluid, the thermal energy of both water and kerosene-based hybrid nanofluid was higher in the lower channel plate than the upper channel plate, flow rate falls near the lower channel wall and increases towards the upper channel wall as Reynolds number increases. Thermal energy and entropy generation decrease as the temperature parameter rises.