Previously, we have shown that satiety and metabolites increased for a short period after high-fat-modified sham feeding. The aim of the study was to assess possible metabolic effects due to oral stimulation with a high-fat sham-fed ‘meal’, in comparison to a high-fat fed meal and to water, in the postprandial state. Fourteen healthy women aged 18–40 years, BMI 22.5±3 kg/m 2 , were fed in energy balance during 4 days with a carbohydrate/protein/fat of 50/15/35 energy-% menu. On the fourth day, the subjects were given 1 out of 3 test lunches, 5 h after a high-fat breakfast, in random order: a high-fat Modified Sham Fed (MSF) lunch, the same lunch to be eaten (E), or water (W) during their 36-h stay in the respiration chamber. Substrate oxidation, 24-h energy expenditure (EE), and appetite profile were measured. Oral fat stimulation by MSF increased EE (W–MSF–E: 6.3±0.8–6.9±1.0–6.8±0.7 kJ/min, p <0.04), plasma non-esterified fatty acid concentrations (W–MSF–E: 432±108–418±146–282±72 μmol/l, p <0.01), and attenuated the decrease in plasma triacylglycerol (W–MSF–E: 1092±548–1116±493–1350±352 μmol/l, p <0.05) and the increase in glycerol (W–MSF–E: 87±29–74±34–67±18 μmol/l, p <0.05) concentrations up to 1 h after the MSF meal. Over a longer period of time, i.e. 24-h, oral fat stimulation had no effect on substrate oxidation, diet-induced thermogenesis, or total EE. In addition to the previously observed metabolic effects of oral stimulation with fat, energy expenditure is stimulated up to 1 h after the MSF meal.