We recruited a sample composed of 100 (females=44; males=56) consecutive subjects suffering from psychotic disease. Then we administered them a psychometric protocol composed of International Index of Erectile Function (IIEF-15), Female Sexual Function Index (FSFI) to assess male and female sexuality, Positive and Negative Symptoms Scale (PANSS) and Global Assessment of Functioning (GAF) to evaluate psychotic symptoms and social functioning. Correlation and regression analyses were performed to evaluate our data. As expected, we found a high prevalence of sexual dysfunctions in males (87.5%) and females with psychotic disorder (86.4%), as assessed by sexological psychometric tools. Moreover, we demonstrated in males several correlations between the psychopathology, low global functioning, increase of age and various forms of sexual impairment. In psychotic females, we demonstrated a more specificity of negative symptoms characterizing the dysfunctional sexuality was found. Hence, we found gender specificity of symptoms on sexuality, i.e., negative symptomatology predicts female sexual dysfunction (B=0.44; p=0.04), while positive symptoms predict male sexual dysfunction (B=0.206; p=0.03).