Journal Of Sexual Medicine Research Articles

Is Metabolic Syndrome the Main Threat to Human Health in the Twenty-First Century?

Series Editor: Marja-Riitta Taskinen See page 2276 Solid evidence has confirmed that the Metabolic Syndrome is associated with an increased risk of both type 2 diabetes and cardiovascular disease (CVD). Recognizing the full blown global epidemics of type 2 diabetes and obesity, the prevalence of the metabolic syndrome is rapidly growing and portends a daunting wave of CVD—a threat to human health in this century. Metabolic syndrome is …

Pathological Gamblers Demonstrate Frontal Lobe Impairment Consistent With That of Methamphetamine-Dependent Individuals

Using tests that are frequently administered by neuropsychologists, the authors investigated whether pathological gambling is associated with frontal lobe abnormalities. The sample comprised 10 pathological gamblers, 25 methamphetamine-dependent subjects, and 19 matched comparison subjects. The pathological gamblers and methamphetamine-dependent subjects performed significantly less well than comparison subjects, and the gamblers' test scores were comparable to those of the methamphetamine-dependent participants. The overall magnitude of the effect size was large. These findings demonstrate that the severity of frontal lobe dysfunction in pathological gambling is similar to that observed in methamphetamine-dependent individuals on frequently used clinical measures.

SEXUAL MEDICINE HISTORY: The Birth and Development of Sexual Medicine: Reflections of My Personal Journey

The phrase "sexual medicine" has become commonplace, as there is now the International Society for Sexual Medicine, the British Society for Sexual Medicine, the European Academy for Sexual Medicine, and the Journal of Sexual Medicine. The historic origin of the phrase "sexual medicine" is somewhat obscure. The goal of this report is to provide my own individual journey as a physician to recall the use of the phrase "sexual medicine." Literature review, personal historic recall. Gorm Wagner has identified an early publication/journal article [corrected] in the German language from 1908 that includes [corrected] "Sexualmedizin" in its title [corrected] Later journals between 1914 and 1933 are entitled "Sexualwissenschaft (Sexual Science)," but do not specifically use the term "Sexual Medicine" [corrected] I have no recollection of having heard the term "sexual medicine" before a meeting in 1970 on nonconsummation. I met Dr. Eric Trimmer, editor of "Medical News," who discussed with me the idea of introducing a new journal devoted to sexual issues. I suggested the title "British Journal of Sexual Medicine." The term "sexual medicine" was preferred because it encompassed both organic and psychological issues of sexual function and its problems. The British Journal of Sexual Medicine was published in 1973 to 1985. Other titles using Sexual Medicine appeared in other texts over the years. From my perspective, including a search of the literature in the English language published in or before 1970 that failed to find any reference to sexual medicine, I conclude that the phase "sexual medicine" was popularized in the 1970s.

Controversies in Sexual Medicine: Penile Rehabilitation Should Become the Norm for Radical Prostatectomy Patients

ABSTRACT Introduction The Journal of Sexual Medicine (JSM) held a debate at the annual fall meeting of the Sexual Medicine Society of North America (SMSNA). The motion was “Penile Rehabilitation Should Become the Norm for Radical Prostatectomy Patients.” At the suggestion of several SMSNA members, it was requested that this debate might be of interest to JSM readers in the form of a published controversy. Methods Two debate speakers with expertise and/or strong opinions in the area of penile rehabilitation submitted their literature-review, evidence-based opinions on the topic. Main Outcome Measure Literature review of laboratory basic science and clinical research studies on penile rehabilitation. Results Penile rehabilitation involves prophylactic procedures designed to improve oxygen delivery to penile erectile tissues, aimed at preserving erectile tissue health and minimizing erectile tissue damage that otherwise occurs during the period of neural recovery to the autonomic cavernosal nerve following radical prostatectomy. There are several studies in the sexual medicine literature on penile rehabilitation after radical prostatectomy, and the positive results appear to support this concept, the rationale, and mechanism. The use of prophylactic penile rehabilitation programs has not been fully elucidated, nor have the results been replicated in large multicenter placebo-controlled trials. Conclusion Penile rehabilitation may be performed along with counseling with the couple, vacuum erection therapy, and vacuum erection device therapy if it is the patient and partner's preference, provided that it is undertaken in a safe and effective manner and is monitored closely.

Management of erectile dysfunction after radical prostatectomy in 2007

As radical prostatectomy (RP) remains a commonly used procedure in the treatment of clinically localized prostate cancer, we critically analyzed the evidence suggesting the role of pharmacological prophylaxis and treatment of erectile dysfunction (ED) after surgery. Systematic literature review using Medline and Cancerlit from January 1997 to December 2006. Abstracts published in the journals European Urology, The Journal of Urology, The International Journal of Impotence Research and The Journal of Sexual Medicine as official proceedings of internationally known scientific Societies held in the same time period were also assessed. Patient selection and surgical technique (i.e., preservation of neurovascular bundles) are the major determinants of post-operative erectile function. Pharmacological treatment of post-operative ED, using either oral or local approaches, is effective and safe. Moreover, recent studies have shown that pharmacological prophylaxis early after RP can significantly improve the rate of erectile function recovery after surgery. Use of on-demand treatments for treatment of ED in patients subjected to RP has been shown to be highly effective, especially in case of properly selected young patients treated with a bilateral nerve-sparing approach by experienced surgeons. In this context, pharmacological prophylaxis may potentially have a significant expanding role in future strategies aimed at preserving post-operative erectile function.

NERI Symposium at 2006 Sexual Medicine Society of North America Meeting

The Journal of Sexual Medicine (JSM) held a debate at the annual fall meeting of the Sexual Medicine Society of North America (SMSNA). The motion was “Penile Rehabilitation Should Become the Norm for Radical Prostatectomy Patients.” At the suggestion of several SMSNA members, it was requested that this debate might be of interest to JSM readers in the form of a published controversy.Two debate speakers with expertise and/or strong opinions in the area of penile rehabilitation submitted their literature-review, evidence-based opinions on the topic.Literature review of laboratory basic science and clinical research studies on penile rehabilitation.Penile rehabilitation involves prophylactic procedures designed to improve oxygen delivery to penile erectile tissues, aimed at preserving erectile tissue health and minimizing erectile tissue damage that otherwise occurs during the period of neural recovery to the autonomic cavernosal nerve following radical prostatectomy. There are several studies in the sexual medicine literature on penile rehabilitation after radical prostatectomy, and the positive results appear to support this concept, the rationale, and mechanism. The use of prophylactic penile rehabilitation programs has not been fully elucidated, nor have the results been replicated in large multicenter placebo-controlled trials.Penile rehabilitation may be performed along with counseling with the couple, vacuum erection therapy, and vacuum erection device therapy if it is the patient and partner's preference, provided that it is undertaken in a safe and effective manner and is monitored closely. Mulhall JP, and Morgentaler A. Penile rehabilitation should become the norm for radical prostatectomy patients.

EDITORIAL: Addressing Both Genders in Sexual Medicine Diagnosis and Treatment

The Journal of Sexual Medicine (JSM) was developed on the premise that the sexual health of men and women is equally important. For men with sexual dysfunction, there are currently multiple pharmaceutical products approved by various government regulation agencies around the world [1]. The first, intracavernosal alprostadil, was approved in 1996, a decade ago. Presently, the list of pharmaceutical options for men with sexual health concerns includes two versions of intracavernosal alprostadil, intraurethral alprostadil, three different oral phosphodiesterase type 5 agents [2–4], and sublingual apomorphine for a total of seven pharmaceutical applications.

EDITORIAL: Finding Strength in Diversity with The Journal of Sexual Medicine as the Common Bond

Diversity creates strength, as any school admissions officer will tell you, but only when there is a common bond behind that diversity. That diversity among people has come to mean race and religion; however, it can mean so much more. I recently attended my 35th college reunion. My friends had been from different countries and studied different subjects. Thirty‐five years later, we still come from different locations and work in different fields, but we have the common connection of our 4 years of university life, no matter what we experienced before or after.

STATE-OF-THE-ART LECTURES SUMMARIES

Journal Article State-Of-The-Art Lectures Summaries Get access The Journal of Sexual Medicine, Volume 3, Issue Supplement_5, September 2006, Pages 344–353, https://doi.org/10.1111/j.1743-6109.2006.00313_2.x Published: 01 September 2006

UNMODERATED POSTER PRESENTATIONS ABSTRACTS

Journal Article Unmoderated Poster Presentations Abstracts Get access The Journal of Sexual Medicine, Volume 3, Issue Supplement_5, September 2006, Pages 438–451, https://doi.org/10.1111/j.1743-6109.2006.00311_3.x Published: 01 September 2006

DEBATES SUMMARIES

Journal Article Debates Summaries Get access The Journal of Sexual Medicine, Volume 3, Issue Supplement_5, September 2006, Pages 366–370, https://doi.org/10.1111/j.1743-6109.2006.00313_4.x Published: 01 September 2006

EDITORIAL: The Power of the Written Word

In the March 2006 issue of The Journal of Sexual Medicine (JSM), the editorial focused on the power of a simple change in words to alter the meaning and therefore attitude and support for sexual medicine healthcare and research by insurers and government agencies.

What’s in a Word? Addiction Versus Dependence in DSM-V

What’s in a Word? Addiction Versus Dependence in DSM-V

Prevalence, Characteristics and Implications of Premature Ejaculation/Rapid Ejaculation

Premature ejaculation/rapid ejaculation is a common but incompletely understood male sexual dysfunction. The purposes of this review are to 1) raise awareness of the prevalence and characteristics of PE/RE, its impact on the male and his partner, and the lack of approved medications indicated for its treatment, 2) encourage dialogue about PE/RE between physicians and patients, and 3) stimulate the development of appropriate new therapies. A MEDLINE search was performed to retrieve articles relating to PE/RE pathophysiology, etiology, impact, diagnosis and treatment. Sexual medicine journals not indexed in MEDLINE, sexual medicine texts and congress abstracts were also reviewed. No universally accepted definition, licensed treatment, validated screening instrument or diagnostic criteria have been established for PE/RE, and its pathophysiology and etiology are incompletely understood. Additional barriers are the reluctance of patients and physicians to talk about PE/RE and the lack of knowledge regarding available treatments. Current pharmacological treatments include off label uses of antidepressants, topical anesthetics or phosphodiesterase-5 inhibitors. All are associated with drawbacks that limit their efficacy. Psychological counseling and behavioral therapy have a valuable role, although resources for this modality are limited. Prevalence rates of 20% to 30% and negative effects on the quality of life of men and their partners illustrate the need for improved, standardized methods of PE/RE diagnosis, assessment and treatment. Medications indicated specifically for PE/RE and effective on an as needed basis are required. Behavioral therapies should emphasize pleasure, arousal, control, confidence and satisfaction, and they may have the best success when coupled with pharmacological approaches.

EDITORIAL: The Journal of Sexual Medicine Celebrates 2006 and Recognizes the Relevance of History

Welcome to 2006! On behalf of the editorial team, the editorial board, the contributors, and the publishers of The Journal of Sexual Medicine (JSM), I would like to wish the members of the International Society for Sexual Medicine (ISSM) and the five regional affiliate societies and all our readers a healthy, joyful, untroubled, and flourishing New Year! We hope that the coming year will not be fraught with the natural and man‐made disasters that plagued this past year. We are all grateful and appreciative of your steadfast and resolute support, encouragement, and cooperation despite the tragedies occurring throughout the world. The JSM is an awesome collaboration.

Serotonin

Back to table of contents Previous article Next article Images in NeuroscienceFull AccessSerotoninAhmad R. Hariri, PH.D., and Sarah M. Brown, B.A., Ahmad R. HaririSearch for more papers by this author, PH.D., and Sarah M. BrownSearch for more papers by this author, B.A., Pittsburgh, PennsylvaniaPublished Online:1 Jan 2006https://doi.org/10.1176/appi.ajp.163.1.12AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail Neural transmission at the serotonin synapse plays a central role in the regulation of human mood and temperament. The serotonin transporter protein is one of the critical elements in determining synaptic concentrations of serotonin. There is mounting evidence that genetic variance in the promoter region of the serotonin transporter protein gene (SLC6A4) is associated with differences in human mood, temperament, and response to stress, suggesting this may be an important genetic variant for human behavior. The regulatory variant (called 5-HTTLPR) in the promoter region of SLC6A4 has two common variants (alleles), both normal, the short (S) and long (L). In Caucasians, the genotype frequencies are approximately 36% L/L, 48% L/S, and 16% S/S. The S allele has been associated with a nearly 50% reduction in expression of the serotonin transporter protein, as well as vulnerability for mood disorders (both anxiety and depression) and inadequate response to SSRIs. However, studies have suggested that the neural mechanisms underlying these associations are complex and can be influenced by environmental conditions. Understanding the mechanisms of these associations will allow a more specific appreciation of normal and pathological mood regulation in humans. We have looked at the effects of the S allele on amygdala activation to emotional stimuli. The human amygdala shows activation in response to threatening environmental stimuli, like angry and fearful faces. The figure shows that right amygdala activation is relatively greater in those normal volunteers who have the S allele in comparison to L allele homozygotes when responding to the same threatening faces. These data illustrate the observation that normal heritable variation in serotonin signaling associated with 5-HTTLPR can result in increased amygdala response to provocative stimuli. Evidence suggests that only in the face of environmental duress does this genetically driven variation in amygdala reactivity lead S allele individuals to be more likely to develop pathologic features and illness. This genetic variant, even though associated with increases in amygdala responsivity, does not inevitably result in psychiatric illness, only in the propensity to a pathological response in certain environmental circumstances.Address reprint requests to Dr. Tamminga, UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd., #NC5.914, Dallas, TX 75390-9070; [email protected] (e-mail). FiguresReferencesCited byDetailsCited byLeadership Seen by Neuroscience1 February 2022 | International Journal of Applied Research in Business and Management, Vol. 3, No. 1Effects of paroxetine on intravaginal ejaculatory latency time in Egyptian patients with lifelong premature ejaculation as a function of serotonin transporter polymorphism29 September 2016 | International Journal of Impotence Research, Vol. 29, No. 1European Journal of Pharmacology, Vol. 753, Vol. 4Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene–environment study21 April 2009 | Molecular Psychiatry, Vol. 15, No. 8Revista Internacional de Andrología, Vol. 8, No. 1International Journal of Neuropsychopharmacology, Vol. 12, No. 8The Journal of Sexual Medicine, Vol. 6, No. 1Neurochemical Research, Vol. 33, No. 4British Journal of Clinical Pharmacology, Vol. 65, No. 5Journal of Neural Transmission, Vol. 114, No. 6The Journal for Nurse Practitioners, Vol. 3, No. 2Monographs of the Society for Research in Child Development, Vol. 72, No. 2 Volume 163Issue 1 January 2006Pages 12-12 Metrics PDF download History Published online 1 January 2006 Published in print 1 January 2006

Potency after Radical Prostatectomy: From New Techniques to Better Results

Introduction and objectives Radical prostatectomy remains a commonly used procedure in the treatment of clinically localized prostate cancer. We critically analyzed current and future evidence-based strategies for preventing and managing postoperative erectile dysfunction (ED). Methods We conducted a systematic literature review using MEDLINE and CancerLit for the period from January 1997 through August 2005. We also assessed abstracts published in European Urology, the Journal of Urology, the International Journal of Impotence Research, and the Journal of Sexual Medicine, as well as official proceedings of internationally recognized scientific societies, during the same period. Results Patient selection and surgical technique are the major determinants of postoperative erectile function. Novel surgical approaches have been associated with increasing success in terms of restoring of erectile and urinary function after surgery. Pathophysiology of ED after radical prostatectomy includes chronic cavernosal hypoxia and apoptosis of corporeal smooth muscle cells, which might play a role in the development of cavernous arteriogenic and veno-occlusive dysfunction following radical prostatectomy. Recent evidence suggests that both pharmacological prophylaxis and treatment of postoperative ED are effective and safe. Conclusion In the hands of experienced high-volume surgeons, properly selected patients undergoing nerve-sparing radical prostatectomy should be able to achieve unassisted or medically assisted full erections in the postoperative period.

LETTERS TO THE EDITOR: Persistent Sexual Arousal Syndrome

I was diagnosed with persistent sexual arousal syndrome (PSAS) around a year and a half ago. As part of a PSAS Yahoo support group (consisting of about 54 women), I took Dr. Leiblum's survey around a year ago over the Internet. I recently received a copy of the published manuscript in The Journal of Sexual Medicine and, although I am pleased that Dr. Leiblum and coworkers performed the “survey,” for the exposure value, I find numerous flaws in the “results” of the survey, especially because women were included who only met at least ONE criterion for PSAS. I would like to make two comments.

EDITORIAL: Inaugural Supplement of The Journal of Sexual Medicine on Women's Sexual Health Concerns: Postmenopausal Female Sexual Dysfunction Roundtable

This is the initial industry‐sponsored supplement of The Journal of Sexual Medicine (JSM) dedicated to a woman's sexual health concern. In keeping with the theme of publishing the highest‐quality, innovative articles in a journal of basic science and clinical research in the field of sexual medicine, the JSM embarks on a new tradition with this publication. This relevant, clinically useful, and evidence‐based supplement entitled “Postmenopausal Female Sexual Dysfunction Roundtable” may very well be the first‐ever supplement exclusively devoted to women's sexual function and dysfunction.

Assessment of performance in orthopaedic training

The reliable measurement of performance is a problem faced by training authorities worldwide. At a recent international orthopaedic conference, none of a group of experienced orthopaedic educators could report significant progress on this issue. The current Record of In Training Assessment (RITA)