Sexual Activity Research Articles

A multiplexed real‐time PCR assay for simultaneous quantification of human immunodeficiency virus and Hepatitis B virus for low‐and‐middle‐ income countries

Due to shared routes of transmission, including sexual contact and vertical transmission, HIV-HBV co-infection is common, particularly in sub-Saharan Africa. Measurement of viral load (VL), for both HIV and HBV, plays a critical role for determining their infectious phase and monitoring response to antiviral therapy. Implementation of viral load testing in clinical settings is a significant challenge in resource-limited countries, notably because of cost and availability issues. We designed HIV and HBV primers for conserved regions of the HIV and HBV genomes that were specifically adapted to viral strains circulating in West Africa that are HIV-1 subtype CRF02AG and HBV genotype E. We first validated two monoplex qPCR assays for individual quantification and, then developed a multiplex qPCR for simultaneous quantification of both viruses. HIV RNA and HBV DNA amplification was performed in a single tube using a one-step reverse transcription-PCR reaction with primers and probes targeting both viruses. Performance characteristics such as the quantification range, sensitivity, and specificity of this multiplex qPCR assay were compared to reference qPCR tests for both HIV and HBV viral load quantification. The multiplex assay was validated using clinical samples from co- or mono-infected patients and gave comparable viral load quantification to the HIV and HBV reference test respectively. The multiplex qPCR demonstrated an overall sensitivity of 71.25 % [68.16–74.3] for HBV and 82 % [78.09–85.90] for HIV and an overall specificity of 100 % [94.95–100] for both viruses. Although the overall sensitivities of the HIV and HBV assays were lower than the commercial comparator assays, the sensitivity in the clinical decision range of >1000 copies/mL for HIV was 80 % [71.26–88.73] and >1000 IU/mL for HBV was 100 % [95.51–100] which indicates the test results can be used to guide treatment decisions. This in-house developed multiplex qPCR assay represents a useful diagnostic tool as it can be performed on affordable "open" real-time PCR platforms currently used for HIV or SARS-Cov-2 infection surveillance in Mali.

Self-Esteem among Men Who Have Sex with Men Living with HIV: A Qualitative Study

Background: HIV transmission in males, particularly in Indonesia, is increasing due to increased sexual activity among Men who have Sex with Men (MSM) groups. This is largely due to diminished self-esteem and reluctance to disclose their status, influenced by factors like power, virtue, relevance, and competence. Aims: The study investigates the self-esteem of MSM living with HIV and explores the factors that may influence their self-esteem. Methods: This study employs a descriptive qualitative study. The study used interviews and content analysis techniques to gather data on HIV individuals at the Public Health Center, specifically focusing on MSM. Results: The interview data revealed six themes: individualism, body image dissatisfaction, lack of motivation, lack of peer support, aspiration to be useful, and self-esteem needs. Conclusion: The study reveals that self-esteem in HIV-positive men is influenced by coping strategies, body image dissatisfaction, motivation, and peer support. It suggests helping others and enhancing library resources, regular investigations, and a specialized counseling program to improve self-esteem.

Psychological Problems and Postpartum Coitus Timeline for Dyspareunia

Problem statement. One of the basic needs after the puerperium is over is sexual. Often these needs are not properly met due to various factors. Excessive worry makes the mother feel not ready for this sexual activity. Not a few also when having sex mothers experience pain. Aim of the study. The purpose of this study was to analyze psychological problems and Coitus Postpartum Time Span are affect dyspareunia. Methodology. Non-experimental research design: cross-sectional analytic. The population is post-partum mothers as many as 86 people. Sampling technique nonprobability sampling by taking samples insdental sampling for 3 months at Clinic Pratama Anugrah Surabaya in 2023. Independent variables of psychological problems and coitus time span, dyspareunia dependent variable, questionnaire instrument, data were analyzed multiple linear regression test. Main findings. The results that the majority of mothers who did not have psychological problems (65.4%) experienced mild dyspareunia. Mothers who had sex for less than 40 days postpartum mostly (66.6%) experienced mild dyspareunia. Simultaneous results F (p=0.003) means that there is a significant effect of psychological problems and coitus time on the incidence of dyspareunia. Partially there was an effect (p=0.001) of psychological problems on dyspareunia, but for the time span of coitus it had no effect (p=0.855) on the incidence of dyspareunia. Conclusion. The more the mother has psychological problems related to sexual relations after childbirth, the more mother will experience dyspareunia. The time that is considered most appropriate for sexual intercourse after childbirth does not always affect the incidence of dyspareunia.

Unlocking the psycho-social-dermal axis: A double blinded randomized placebo controlled study unveiling the influence of a novel topical formulation on skin quality, attractiveness, quality of life, and sexual satisfaction.

Improved skin appearance is closely linked to higher self-esteem, favorable first impressions, and enhanced quality of life, with skincare products often being formulated with biostimulatory and regenerative ingredients to both enhance skin health and provide psychological benefits. Certain components, such as phospholipids and botanicals, may not only improve skin quality, but also impact mood, romantic bonding, and sexual attraction. To assess whether a novel topical skin care product formulated with a proprietary combination of proteins, lipids, and botanical derivatives, can potentially result in a robust psycho-social-dermatological benefit via modulation epidermal oxytocin and pheromonal pathways. In this single-center prospective, randomized, controlled, double-blinded study, 40 female subjects were randomly assigned to use of either active novel skincare products, or placebos, for 4-8 weeks. Skin assessments, standardized photography, first impression ratings, and questionnaires on confidence and sexual satisfaction were conducted. Thirty-nine subjects completed the study and demonstrated a statistically significant improvement in skin quality following 4 and 8 weeks of use, with improvements of greater magnitude demonstrated with a longer duration of use. Product users projected a better first impression and appeared on average 3 years younger than their actual age, with 86% of subjects reporting increased confidence. Product users found random people of the opposite sex to be more attractive 88% of the time and reported improvement in sexual satisfaction in 90% of the categories. The use of this novel topical product culminated in statistically significant improvements in skin quality, confidence, sexual relationship satisfaction, perceived attractiveness, and youthfulness, highlighting its potential in anti-aging and mood enhancement.

Sexual bother and sexual activity before and after kidney transplantation

Among patients awaiting kidney transplantation (KT), sexual dysfunction is common owing to end-stage kidney disease, but may improve post-KT. Leveraging a 2-center prospective study, 2422 adult KT candidates and 490 adult KT recipients (May 2014 to December 2023) were identified. Using the Kidney Disease Quality of Life Short Form, participants reported on the negative impact of sexual dysfunction due to end-stage kidney disease (ie, sexual bother) at KT evaluation, admission, and post-KT follow-ups. Using mixed-effect logistic regression models, we estimated odds and trajectories for odds of sexual bother. At evaluation, 46.1% of male and 29.6% of female candidates reported sexual bother; 39.0% and 34.5%, respectively, had been sexually active in the past 4 weeks. At admission, 53.8% male and 27.0% female recipients reported sexual bother; 41.6% and 41.8%, respectively, had been sexually active in the past 4 weeks. The estimated prevalence of sexual bother decreased during the first 3 years post-KT (odds ratio per year: 0.39; 95% CI: 0.25-0.60). Sexual activity increased and peaked 1-year post-KT. At 3 years post-KT, 48.9% of male and 50.0% of female recipients were sexually active. Sexual bother is common pre-KT and improves post-KT, and sexual activity increases post-KT. Sexual health is important and should be considered during KT management.

Association between the regular use of vaginal dilators and/or sexual activity and vaginal morbidity in locally advanced cervical cancer survivors – An EMBRACE-I study report

PurposeTo provide risk estimations for vaginal morbidity with regard to vaginal dilation (summarizing the use of dilators and/or sexual activity) in locally advanced cervical cancer patients (LACC) treated with definitive radiochemotherapy and image-guided adaptive brachytherapy (IGABT) within the prospective, multi-institutional EMBRACE-I study. Material/MethodsPhysician-assessed vaginal morbidity (CTCAEv3.0), use of vaginal dilators and patient-reported sexual activity (EORTC-CX24) were prospectively assessed at baseline and during regular follow-up.Frequency analysis for vaginal dilation was performed in a sub-cohort of patients with ≥3 follow-ups. Regular dilation was defined if reported in ≥50% of follow-ups, no/infrequent dilation if reported in <50%. Actuarial estimates were calculated with Kaplan-Meier method; comparisons evaluated with the log-rank test. Univariate and multivariable Cox proportional hazard regression were used to evaluate risk factors for vaginal stenosis G≥2. ResultsThe EMBRACE-I study included a total of 1416 patients (2008-2015); 882 were evaluated in the present report with a median follow-up of 60 months. Of those, 565 (64%) reported regular dilation. This was associated with a significantly lower 5-year risk of vaginal stenosis G≥2 compared to no/infrequent dilation (23% vs. 37%, p≤0.001). This univariate finding was confirmed by multivariable analysis, after adjusting for other risk factors (HR=0.630, p=0.001).Regular vaginal dilation was also associated with a significantly higher risk for vaginal dryness G≥1 (72% vs. 67%, p=0.028) and bleeding G≥1 (61% vs. 34%, p≤0.001). ConclusionVaginal stenosis represents irreversible fibrotic changes that can cause pain during gynecological examination and dyspareunia in LACC survivors. Regular vaginal dilation (defined as the use of dilators and/or sexual activity) is associated with a significantly lower risk for G≥2 vaginal stenosis, suggesting a potential improvement of vaginal patency. It is also associated with a significantly higher risk for mild G≥1 dryness and bleeding (no higher risk for G≥2), which both can be clinically managed.

Disease-Specific Patient-Reported Quality of Life after Fenestrated/Branched Endovascular Aortic Aneurysm Repair

ObjectivesFenestrated-branched endovascular technology (F/B-EVAR) is increasingly used to repair complex aortic aneurysms. While reintervention, morbidity and mortality after F/B-EVAR have been well-characterized, studies on patient-reported quality of life (QOL) after F/B-EVAR have been limited in their use of non-specific instruments and measures. We report on disease-specific QOL in patients that underwent F/B-EVAR using a validated QOL survey for aortic aneurysms. MethodsProspectively maintained databases were used to contact living patients that underwent F/B-EVAR for pararenal or thoracoabdominal aortic aneurysms at two institutions. Eligible patients (n=286) were asked to complete a disease-specific QOL survey previously validated in patients that underwent repair of an infrarenal abdominal aortic aneurysm. An emotional impact score (EIS) from 0-100 was derived from the survey with higher scores indicating more emotional impact and worse QOL. Respondent behavior change following F/B-EVAR was evaluated in four domains (strenuous activity, travel, heavy lifting, and sexual activity) previously identified by patients to be most impacted by an aortic aneurysm. ResultsIn total, 234 patients (82%) completed surveys. Mean post-operative interval to survey completion was 3.4±2.8 years. Mean EIS was 16 (range 0-91) for all patients surveyed, with higher mean EIS among those within the first year after F/B-EVAR (20 vs 14). Most respondents demonstrated limited adverse emotional impact after F/B-EVAR. However, the 4th quartile of EIS was broad (22-91), indicating that a subset of respondents had significantly worse QOL after repair. While most patients reported no post-procedure change in each of the activity domains, over 40% of patients did report decrease in strenuous activity and heavy lifting after F/B-EVAR. Those with decreased activity after repair had corresponding deficiencies in disease-specific knowledge for the domains of heavy lifting (p<0.001) and sexual activity (p=0.17). ConclusionsThe majority of patients who underwent F/B-EVAR in this cohort had low emotional impact on their QOL after repair. One-quarter of patients did report significant post-procedure anxiety about their aneurysm, with improvement observed beyond one year after repair. Most patients reported unchanged or decreased activity levels following F/B-EVAR, and less aneurysm-specific patient knowledge was associated with decreased activity after repair. These findings are similar to those seen in prior work using this survey instrument in patients that underwent infrarenal aneurysm repair. This work confirms the feasibility of using this survey to evaluate QOL in patients with complex aortic disease. Longitudinal evaluation in these patients may identify those at high-risk for worse QOL after F/B-EVAR.

Male sexual disorder in coronavirus disease 2019 pandemic

Background At the end of 2019, a new coronavirus infection disease, named COVID-19, emerged in China. In this context, couples’ sexual lives could have been significantly altered. Fear of the COVID-19 pandemic implications affects their lives, or the lives of friends and relatives might produce feelings of anxiety and panic. Sometimes, these feelings can degenerate into further negative psychological reactions, including adjustment disorder and depression. Aim To find the relation between COVID-19 pandemic and occurrence of male sexual disorders. Patients and methods In this retrospective study 300 cases with past history of COVID-19 virus infection were included in this study. They were recruited from the Dermatology Outpatient Clinic of Al-Azhar University (Assiut) Hospital. Results There was a statistically significant difference between the prepandemic and postpandemic erectile dysfunction scores (P=0.043). There was a statistically significant difference between prepandemic and postpandemic scores according to premature ejaculation (P=0.022). There was a significant difference among erectile dysfunction and both depression degree (χ 2=90.706, P&lt;0.001) and anxiety degree (χ 2=263.652, P&lt;0.001) likewise, it has been found that there was a significant difference among premature ejaculation and both depression degree (χ 2=109.542, P&lt;0.001) and anxiety degree (χ 2=165.382, P&lt;0.001). Conclusion Significant difference between prepandemic and postpandemic scores according to erectile dysfunction and premature ejaculation. Among erectile dysfunction and both depression degree and anxiety degree likewise, it has been found that there was a significant difference among premature ejaculation and both depression degree and anxiety degree.

Role of Direct Sexual Contact in Human Transmission of Monkeypox Virus, Italy.

The 2022 global mpox outbreak was driven by human-to-human transmission, but modes of transmission by sexual relationship versus sexual contact remain unclear. We evaluated sexual transmission of mpox by using monkeypox virus (MPXV) G2R-mRNA as a marker of ongoing viral replication through in vitro experiments. We analyzed clinical samples of 15 MPXV-positive patients in Italy from different biological regions by using the setup method. The presence of MPXV DNA, MPXV G2R-mRNA, or both in all analyzed lesion swab samples, independent of viral load, confirmed a higher infectivity risk from skin lesions. Positivity for MPXV G2R-mRNA in nasopharyngeal swabs was associated with high MPXV load, whereas positive results for MPXV G2R-mRNA were obtained only in the 2 semen samples with the lowest MPXV loads. Our results suggest that close or skin-to-skin contact during sexual intercourse is the main route of sexual transmission and that semen is a minor driver of infection, regardless of MPXV load.

Late sexual transition: Achievement of developmental tasks and well-being in emerging adulthood

According to the social clock and statistical norms, a transition into sexual activity after age 18 years is considered late. This longitudinal study examines whether late sexual transition is related to delays in the achievement of developmental tasks and lower psychological well-being in emerging adulthood for heterosexual individuals. A sample of 300 participants (61.3% women) was assessed annually from age 15 to 22 years and again at age 25, of which 43 reported sexual intercourse at age 19 or older or remained virgins in emerging adulthood. Results indicate that late sexual transition, particularly for men, is prospectively associated with still being at school, working fewer hours per week, being single and having no kids at age 25. It is also positively associated with depression and anxiety symptoms, interpersonal sensitivity, hostility, lower self-esteem, and lower happiness. This study enriches the understanding of slower developmental trajectories and the associations between late sexual transition and subsequent trajectories in emerging adulthood.

Genitourinary syndrome of menopause: Evaluation of symptoms, using a questionnaire, in a research setting, before and after treatment.

Genitourinary syndrome of menopause (GSM) is a common condition, yet there is no defined, objective, and reproducible intervention with which to make a diagnosis. There are many different treatment options available, but without the correct diagnosis, affected women are unable to access the right therapy. This paper reports on the questionnaire arm of the VAN study (VAginal Health - What's Normal?) which aimed to evaluate the performance and acceptability of the methods of assessment of GSM, described below. To determine the value of the Day-to-Day Impact of Vaginal Aging (DIVA) questionnaire: a multidimensional measure of the impact of vaginal symptoms on functioning and well-being in postmenopausal women, in a prospective, observational, feasibility study. 60 women were recruited to the study (20 premenopausal, asymptomatic women (control group) and 40 peri- and postmenopausal, symptomatic women). All women had a baseline assessment, using three different interventions, in addition to the DIVA questionnaire and symptomatic women were offered treatment, followed by a second assessment undertaken at 16weeks, using the same interventions. This paper focusses on the outcomes for the questionnaire and specifically on the paired data sets, before and after treatment. An improvement in the score for all four sections of DIVA (Activities of daily living, Emotions, Sexual Activity, and Feelings about yourself and your body (female embodiment)) was observed, following any treatment. Additional questions were added to DIVA, to assess patient preference in relation to the different diagnostic interventions. These included a speculum examination as part of the clinical assessment, a smear taken from the lateral vaginal wall to assess the vaginal maturation index, both undertaken by a clinician and a self-administered tampon to collect vaginal secretions, to determine the small molecule metabolite profile, using NMR spectroscopy, and to enable analysis of the vaginal microbiome. The medical standard tampon was the preferred intervention, before and after treatment, for women eligible for treatment. The VAN study demonstrates that DIVA, a previously tested questionnaire, is an easily accessible intervention, to assess the impact of urogenital symptoms on quality-of-life indicators in women in the United Kingdom with GSM and that women prefer to use a tampon themselves, rather than have a clinician performed vaginal speculum examination or a vaginal smear.

Mpox Epidemiology and Risk Factors, Nigeria, 2022.

To investigate epidemiology of and risk factors for laboratory-confirmed mpox during the 2022 outbreak in Nigeria, we enrolled 265 persons with suspected mpox. A total of 163 (61.5%) were confirmed to have mpox; 137 (84.0%) were adults, 112 (68.7%) male, 143 (87.7%) urban/semi-urban dwellers, 12 (7.4%) self-reported gay men, and 3 (1.8%) female sex workers. Significant risk factors for adults were sexual and nonsexual contact with persons who had mpox, as well as risky sexual behavior. For children, risk factors were close contact with an mpox-positive person and prior animal exposure. Odds of being mpox positive were higher for adults with HIV and lower for those co-infected with varicella zoster virus (VZV). No children were HIV-seropositive; odds of being mpox positive were higher for children with VZV infection. Our findings indicate mpox affects primarily adults in Nigeria, partially driven by sexual activity; childhood cases were driven by close contact, animal exposure, and VZV co-infection.

Risky sexual behaviour and its determinants among undergraduate students residing in hostels of Kathmandu Metropolitan City, Nepal: a cross-sectional study

ObjectivesTo assess the prevalence of risky sexual behaviour (RSB) and its associated factors among Nepalese undergraduates residing in hostels of Kathmandu Metropolitan City, Nepal.DesignCross-sectional studySettingHostels operating inside Kathmandu Metropolitan City...

Evaluation of safety, efficacy, and risk factors of different breast reconstruction strategies following polyacrylamide hydrogel removal: A 20-year retrospective cohort study of 436 cases

BackgroundGlobally implemented for breast augmentation, polyacrylamide hydrogel (PAAG) always leads to breast deformity upon its removal. Despite a pressing need for breast reconstruction following PAAG removal to address aesthetic issues, the optimal timing remains controversial. MethodsA retrospective cohort study analyzed patients who underwent PAAG removal between 2003 and 2023. They were categorized into three cohorts: immediate (IBR), delayed (DBR), or no breast reconstruction (NBR) post-PAAG removal. Complication rates, re-operation frequencies, risk factors, and BREAST-Q scores were assessed. ResultsA total of 436 breasts were identified and divided into IBR (n = 126), DBR (n = 48), and NBR (n = 262). Complication rates were 50.0 % (IBR), 31.3 % (DBR), and 26.7 % (NBR) (P < 0.001); reoperation rates were 26.2 % (IBR), 18.8 % (DBR), and 13.0 % (NBR) (P = 0.006). IBR showed significantly shorter complication-free survival than NBR (113.38 ± 8.34 vs. 178.21 ± 6.82 months; log-rank P < 0.001). Cox regression identified injection period, aspiration history, Baker grade II/III/IV, glandular infiltration, and IBR as independent predictors of higher postoperative complications. As for the Breast-Q scores, physical well-being was similar across groups. However, NBR scored significantly lower for postoperative sexual well-being (P < 0.001), psychosocial well-being (P < 0.001), and satisfaction with breasts (P = 0.001) compared to both IBR and DBR. ConclusionsDBR is a safe and effective solution for secondary breast deformities after PAAG removal. Notably, patients with prolonged injection histories, previous aspiration history, Baker Grade II/III/IV, and MRI evidence of gel infiltration into glandular tissues are at a higher risk for postoperative complications. These findings may be beneficial for optimizing strategies to manage patients with PAAG injections in clinical practice.

Sexual differetiation of Rhodiola rosea L. populations in the high-mountain zone of the Ukrainian Carpathians

Background. Individual (morphological) and group parameters (the number of male and female individuals, their sex ratio, and the range of sex ratio displacement) are an important indicator of sexual differentiation of Rhodiola rosea L. populations. To date, indicators of these parameters in natural plant populations have not been studied sufficiently. Therefore, for the analysis of the state of the populations of the species, it is important to study the parameters of their sexual differentiation and the main trends of changes that affect the ability to recover in high-mountain conditions. Methods. In order to obtain data, conventional stationary and route-based research methods were used. To record individuals of different sexes, long-term monitoring plots were used, which were laid in the characteristic habitats of the species’ populations in 2000–2022. The ratio of male and female individuals is determined based on their quantitative distribution per unit area. The sexual potential index that determines the proportion of females and their participation in generative reproduction was used. Results. The main differences in the morphological and quantitative parameters of male and female individuals in high-mountain conditions were determined. It was found that a characteristic feature during long-term research is a decrease in the number of generative individuals of both male and female sexes. In the studied populations, there is a shift in the sex ratio towards males (73 %) and this trend has been maintained over the last dozen of years. Therefore, the number of females compared to males is very small, which affects the sexual potential of populations. Conclusions. The ratio of male and female individuals, the range of its displacement and potential participation in the realization of sexual potential in R. rosea was determined. The present study showed that the general trend in the populations of the species is a decrease in the number of female individuals. Male biased sex ratio has an impact on sexual potential and ability to generative reproduction.

Sexual fulfilment, wellbeing and risk considerations for people with sexual attractions to children

Research focused on understanding the experiences of individuals with sexual attractions to children and their pursuit of sexual fulfilment faces notable limitations, primarily stemming from ethical and legal challenges, and pervasive social stigma. This review paper explores these challenges and outlines the connections between sexual fulfilment, treatment goals and overall wellbeing. We consider the importance of sexual satisfaction in promoting mental and physical health, and its potential role in reducing the risk of sexually abusive behaviors. Recognizing that promoting healthier and more fulfilling lives extends beyond risk mitigation, the paper highlights future research avenues such as exploring the conceptualization and achievement of sexual satisfaction. In examining alternative perspectives, including the potential risk enhancement associated with achieving sexual fulfilment, we also argue the need for an evidence-based approach and robust research agenda to inform and guide interventions. Through these considerations, the paper aims to encourage a more informed and compassionate understanding of sexual fulfilment for people with sexual attractions to children.

Healthy sexuality—not sexual health: for the sexual subject

The aim of this paper is to defend the emerging conceptualization of healthy sexuality (Bianchi in Figurations of Human Subjectivity: A Contribution to Second-Order Psychology. Springer, Berlin, 2020) against the traditional authoritative concept of sexual health as defined by the WHO. Becoming a sexual subject means following a sexual trajectory with episodes of one’s own bodily experiences, genital satisfaction, intimate attachment, acceptance of sexual identity, sexual pleasure, mutual sexual satisfaction and planned parenthood. In each of these episodes, the individual may experience feelings of pressure, fear, shame, pain and/or joy and pleasure. The extent to which the subject has a healthy sexuality depends on whether these feelings/emotions facilitate or inhibit healthy sexuality. The concept of healthy sexuality runs counter not only to quantitative statistical demographic measures of sexual health, but also to the existing arsenal of sexology questionnaires. Qualitative empirical research is being conducted into the facilitators and inhibitors of a healthy sexuality (in the first author’s PhD research).

Behind Prep Decisions: Understanding User Patterns and Discontinuation Factors in Real-World.

This study aimed to characterize the epidemiological aspects of PrEP use and barriers to accessing this prophylaxis. This cross-sectional study was conducted between January 2021 and April 2022, encompassing 140 PrEP users treated at the Testing and Counseling Center (CTA) in Campo Grande, Mato Grosso do Sul. Data on sociodemographic characteristics and factors associated with PrEP discontinuation were obtained using a standardized questionnaire. Most PrEP users were cisgender men (92.00%), predominantly white (51.00%), over 30years of age (56.50%), homosexual-oriented (76.50%), and had a minimum of 12years of education (77.50%). Approximately 60.00% admitted to inconsistent condom use in recent sexual encounters, primarily involving anal intercourse. Approximately 88.00% perceived themselves as at risk of contracting STIs in the upcoming year. Regarding new presentation forms, 54.00% indicated a willingness to use "on-demand PrEP," and 92.00% expressed interest in using "injectable PrEP." After 6months of follow-up, 43.60% (95.00% CI: 35.50-52.00) discontinued PrEP use, primarily due to changes in sexual behavior (38.30%) and difficulties accessing healthcare services (21.28%). This study underscores the need to involve diverse key populations and highlights the significance of PrEP as an ongoing monitoring strategy for HIV/STI prevention in addition to the importance of incorporating new formulations such as daily oral PrEP into the Brazilian National Health System (SUS).

Sexual experience under the influence of alcohol and cannabis consumption.

Substance use affects different areas of life, including the sexual sphere. Drugs and specifically the use of alcohol and cannabis, can influence sexual experience. However, there has been little research and to date none has been carried out in Spain that compares the effect of alcohol and cannabis consumption in the same people on their sexual experience. Therefore, the objective of the study was to analyze and compare the effect of alcohol and cannabis in the same people on their sexual experience. The sample consisted of 483 people who had ever consumed alcohol and cannabis. Participants answered an online questionnaire about alcohol and cannabis use and sexual experience. The results show that despite the fact that when people consume alcohol, they feel more attractive, they feel more attraction towards other people, they are more extroverted, their desire increases and they have longer sexual relations than when they consume cannabis, people who frequently consume when consume cannabis, they have more sensitivity and they are more sexually satisfied than when they consume alcohol. Regarding the sexual experience, although they prefer not to use drugs when they have sex, people who frequently consume prefer to consume more cannabis than alcohol. Therefore, it is concluded that, although alcohol facilitates the sexual encounter, with cannabis people feel more sexually satisfied.

Implantable cardioverter-defibrillator therapies during sexual activities—Rare but fearsome

Implantable cardioverter-defibrillator therapies during sexual activities—Rare but fearsome