Sexual Activity Research Articles

The association between lifestyle factors and the composition of the vaginal microbiota: a review.

The vaginal microbiota offers valuable insights into women's sexual health and the risk of developing sexually transmitted infections (STIs) and bacterial vaginosis. Despite the public health implications of changes in the vaginal environment, existing data on this topic remain sparse. Following the PRISMA statement guidelines, we consulted five bibliographic databases, focusing on five main daily habits and behaviors. We included only studies published up to October 2023, investigating the influence of personal hygiene, sexual behaviors, hormonal contraception, smoking, alcohol consumption, and psychosocial stress on the vaginal microbiota using next-generation sequencing. Based on our inclusion criteria, we incorporated 37 studies into this review. Hormonal contraception and personal hygiene were found to promote eubiosis of the vaginal microbiota. In contrast, sexual behaviors, smoking, alcohol consumption, and psychosocial stress were associated with an increased susceptibility to bacterial vaginosis, STIs, and severe pelvic inflammatory diseases due to a modified vaginal microbiota. Black ethnicity emerged as a confounding factor, with this population showing unstable vaginal microbiota. Oral contraception and a stable male sexual partner were found to favor Lactobacillus colonization, acting as a protective factor. Conversely, non-hormonal contraception and unprotected or non-penile/vaginal sexual activity increased the incidence of vaginal inflammation and bacterial vaginosis by disturbing the vaginal microbiota and reducing Lactobacillus abundance. Daily habits and lifestyle can influence the composition of the vaginal microbiota, thereby affecting vaginal health. Disturbances in the vaginal microbiota could be associated factors for STIs and vaginosis. Therefore, prioritizing more appropriate management of the vaginal microbiota is crucial.

“Tell me I’m okay”: A cross-sectional quality-of-life assessment of patients in a breast cancer survivorship program.

213 Background: The number of breast cancer survivors is increasing due to improvements in care and an aging population, leading to an increased need for care that addresses the physical and psychological needs of patients after completion of active treatment. The Sunnybrook Breast Cancer Survivorship Program was established to provide comprehensive evidence-based survivorship care and facilitate the transition to family doctors. Despite rising interest in dedicated survivorship care, there is little consensus regarding which individuals are likely to suffer the most long-term impacts of breast cancer treatment. Factors as varied as age, ethnicity, socioeconomic status, and treatment type can influence Quality-of-Life (QoL) outcomes. This cross-sectional assessment uses mixed methods to evaluate QoL trends in the patient cohort. Methods: Current patients of the Sunnybrook Breast Cancer Survivorship Program were asked to complete a baseline information form, as well as the EORTC QLQ-30 and BR-45, two validated measures of QoL for breast cancer patients and survivors. QoL, functional, and symptom domains were calculated from these responses accordingly and analyzed statistically. Patients reported their most bothersome QoL concerns through an open-ended questionnaire, which was analyzed and organized thematically. 99 patients have been recruited to date, of a planned 200. Results: We find that sexual health is of importance for this population, with 50 (50.5%) participants reporting sexual activity. Patients under 50 have poorer sexual functioning scores (p<0.01) as well as more issues with body image (p<0.05) than older survivors. Both married and under-50 patients are significantly more likely to have poorer outlooks on the future (p<0.05; p<0.01). Younger patients also tended to have worse role functioning, cognitive functioning, emotional functioning, and social functioning scores, though these differences were not statistically significant. Thematic analysis of qualitative data showed that patients’ chief concerns were the impact that ongoing side effects had on their daily functioning, impact of treatment on body image, disruptions to work and personal relationships, and strong anxiety about potential recurrence. Conclusions: While it is understood that younger BC survivors face unique challenges, our findings indicate that these obstacles persist into older age groups. In addition to physical side effects, such concerns as body image issues, social strain, and emotional functioning can drive QoL scores for these patients. Notably, many patients endorsed strong anxiety regarding potential recurrence that affected QoL, and identified dedicated survivorship follow-up as an ameliorating factor. Further research should be conducted into the unique needs of under-50 survivors, as well as the role of recurrence anxiety in impacting QoL.

A Critical Examination of Toni Morrison’s Sula from Psychological Perspective

The article investigates the connection between sexuality, repression, and power. This study explores how power influences sexuality, forming specific discourses, while also examining how sexuality produces power. The scholar applies Foucauldian discourse in interpreting Toni Morrison's novel Sula in order to examine sexuality and repression. It also explores the impact of power and sexuality within the Bottom community and the behaviors of the characters. In this book, there are characters that battle for the cause of justice. The novel has a repressive theme illustrating the conflicts of its characters. The woman utilizes sexual behavior to assert power and challenge male dominance. The way the characters engage in sexual activities reflects the society they are a part of. It provides insight into the African American community's struggle against racism and sexism. In this manner, power influences everything just as it shapes the novel. The research paper has been written based on both primary and secondary materials from both electronic and print sources. The writing is analytical and critical in terms of theme discussion and theory application. Since the research has been based on the qualitative research design, the dialogues among the characters of the novel have been the basis of analysis.

The effect of protecting women against economic shocks to fight HIV in Cameroon, Africa: The POWER randomised controlled trial.

Women in sub-Saharan Africa are disproportionately affected by the HIV epidemic. Young women are twice as likely to be living with HIV as men of the same age and account for 64% of new HIV infections among young people. Many studies suggest that financial needs, alongside biological susceptibility, are a leading cause of the gender disparity in HIV acquisition. New robust evidence suggests women adopt risky sexual behaviours to cope with economic shocks, the sudden decreases in household's income or consumption power, enhancing our understanding of the link between poverty and HIV. We investigated if health insurance protects against economic shocks, reducing the need for vulnerable women to engage in risky sexual behaviours and reducing HIV and sexually transmitted infection (STI) incidence. We conducted a randomised controlled trial to test the effectiveness of a formal shock coping strategy to prevent HIV among women at high risk of HIV (registration number: ISRCTN 22516548). Between June and August 2021, we recruited 1,508 adolescent girls and women over age 15 years who were involved in transactional sex (n = 753) or commercial sex (n = 755), using snowball sampling. Participants were randomly assigned (1:1) to receive free health insurance for themselves and their economic dependents for 12 months either at the beginning of the study (intervention; n = 579; commercial sex n = 289, transactional sex n = 290) from November 2021 or at the end of the study 12 months later (control; n = 568; commercial sex n = 290, transactional sex n = 278). We collected data on socioeconomic characteristics of participants. Primary outcomes included incidence of HIV and STIs and were measured at baseline, 6 months after randomisation, and 12 months after randomisation. We found that study participants who engaged in transactional sex and were assigned to the intervention group were less likely to become infected with HIV post-intervention (combined result of 6 months post-intervention or 12 months post-intervention, depending on the follow-up data available; odds ratio (OR) = 0.109 (95% confidence interval (CI) [0.014, 0.870]); p = 0.036). There was no evidence of a reduction in HIV incidence among women and girls involved in commercial sex. There was also no effect on STI acquisition among both strata of high-risk sexual activity. The main limitations of this study were the challenges of collecting reliable STI incidence data and the low incidence of HIV in women and girls involved in commercial sex, which might have prevented detection of study effects. The study provides to our knowledge the first evidence of the effectiveness of a formal shock coping strategy for HIV prevention among women who engage in transactional sex in Africa, reinforcing the importance of structural interventions to prevent HIV. The trial was registered with the ISRCTN Registry: ISRCTN 22516548. Registered on 31 July 2021.

Tyramine Derivatives as Versatile Pharmacophores With Potent Biological Properties: Sex Hormone-Binding Globulin Inhibition, Colon Cancer Antimigration, and Antimicrobial Activity.

Guided by the idea that the presence of a heterocyclic aromatic core and tyramine moiety, under the umbrella of a single molecular scaffold could bring interesting biological properties, herein we present synthesis, characterization, with two crystal structures reported, and biological evaluation of some tyramine derivates. Cytotoxic and antimigratory potential was addressed by using a colorectal cancer cell line as a model system. Although possessing no cytotoxic effects, two compounds have shown strong antimigratory potential in low doses, with no effect on healthy MRC-5 cells. Evaluation of their antimicrobial activities suggested prominent antimicrobial activity, where Compound 4 outperformed streptomycin against Escherichia coli and Proteus mirabilis. Hormone-dependent types of cancer, such as prostate, ovary, and breast, are highly dependent on human sex hormone-binding globulin (SHBG) blood levels. A molecular docking study has shown that 1 has high affinity to bind and therefore compete with natural steroids for the SHBG steroid-binding site. DNA-binding study have shown that 4 interacts with CT-DNA in a groove-binding mode. In silico ADME/T study revealed that all compounds have suitable physicochemical properties for oral bioavailability and druglikeness, while toxicity tests for 1, 4, and 6 suggested potential for mutagenicity (4, 6), hepatotoxicity (6), and skin sensation (1).

In search of the genetic variants of human sex ratio at birth: was Fisher wrong about sex ratio evolution?

The human sex ratio (fraction of males) at birth is close to 0.5 at the population level, an observation commonly explained by Fisher's principle. However, past human studies yielded conflicting results regarding the existence of sex ratio-influencing mutations-a prerequisite to Fisher's principle, raising the question of whether the nearly even population sex ratio is instead dictated by the random X/Y chromosome segregation in male meiosis. Here we show that, because a person's offspring sex ratio (OSR) has an enormous measurement error, a gigantic sample is required to detect OSR-influencing genetic variants. Conducting a UK Biobank-based genome-wide association study that is more powerful than previous studies, we detect an OSR-associated genetic variant, which awaits verification in independent samples. Given the abysmal precision in measuring OSR, it is unsurprising that the estimated heritability of OSR is effectively zero. We further show that OSR's estimated heritability would remain virtually zero even if OSR is as genetically variable as the highly heritable human standing height. These analyses, along with simulations of human sex ratio evolution under selection, demonstrate the compatibility of the observed genetic architecture of human OSR with Fisher's principle and render it plausible that multiple OSR-influencing genetic variants segregate among humans.

Sex Education Among Recent High School Graduates

Abstract Introduction Sexuality education varies considerably from abstinence-only to comprehensive sex education and can influence knowledge, attitudes, and behaviors about sexuality. We examined the relations among types of sex education, sex-positive and purity culture attitudes, and sexual and reproductive health knowledge among a group of diverse high school graduates. Methods This study captured the sexuality knowledge and attitudes pursuant to the type of sex education received among a sample of 1005 high school graduates. Data were collected in the summer of 2023. We used ANOVAs, MANOVA, and linear regressions to examine relations among sex education type, sexual and reproductive health knowledge, sex-positive and purity culture beliefs, and participants’ self-reported readiness for their sexual lives. Results Participants who reported receiving abstinence-only sex education endorsed more purity culture beliefs and fewer sex-positive beliefs than those who experienced comprehensive sex education. Sexual and reproductive health knowledge was poor. Participants who experienced comprehensive sex education rated that education as better preparing them for a healthy sexual life compared to those who had abstinence-only education. Conclusions Findings reveal the relation of sex education type on attitudes toward sexuality and self-reported readiness for adults’ sexual lives. Policy Implications Policymakers, educators, and others who work with young people should champion sex-positive, comprehensive sex education. More work is needed to ensure sex education yields an informed public who can navigate their sexual lives effectively.

Transdermal Carboxytherapy for Treating Vulvovaginal Atrophy: A Pilot Study

Objective: Genitourinary syndrome of menopause (GSM) is a prevalent disorder that can negatively impact the overall health, sexual function, and quality of life of affected women; however, available data do not support specific treatment protocols. A novel product enables the noninvasive transdermal administration of carboxytherapy with a topical gel (CO2Lift®, Lumisque, Inc.; Weston, FL). The following randomized, placebo-controlled pilot study assessed the safety and efficacy of the transdermal carboxytherapy gel for treating GSM-related vulvovaginal changes. Methods: Menopausal or postmenopausal women 40 to 70 years old with signs or symptoms of vulvovaginal atrophy and Female Sexual Dysfunction were randomized to receive topical carboxytherapy gel (n=40) or placebo gel (n=10) in a randomized, double-blind fashion. The assigned treatments were placed into the vagina and on the vulva for 45 minutes before removal. Treatment was applied daily for 5 days, stopped for 2 days, then continued for 5 additional days. Subjects completed four validated pre- and posttreatment questionnaires to assess female sexual function, sexual health, and genital self-image. Additionally, control (n=10) and treatment subjects (n=10) were randomized to undergo 3 mm pre- and posttreatment punch biopsies of vulva and vaginal tissue. Results: Overall, carboxytherapy-treated subjects achieved significant improvements in Female Sexual Function Index scores with strong positive correlations between sexual desire and arousal, arousal and sexual satisfaction, and sexual satisfaction and desire. The Day-to-Day Impact of Vaginal Aging Questionnaire results demonstrated a significant difference in mean pre- and posttreatment values for each assessment among subjects receiving topical carboxytherapy. Biopsy improvements included hyperplasia of the keratinized squamous epithelium, discrete hyperplasia of the basal layer and neovascularization, and increased thickness of mucous squamous epithelium. There were no adverse events. Conclusion: Transdermal carboxytherapy represents a safe, noninvasive means of treating the genitourinary syndrome of menopause symptoms and is suitable for home use. Additional research on this treatment is warranted.

Measuring non-events: infertility estimation using cross-sectional, population-based data from four countries in sub-Saharan Africa.

Does the prevalence of 12-month infertility in Burkina Faso, Côte d'Ivoire, Kenya, and Uganda differ between women trying to conceive and the broader population of women exposed to unprotected sex, and how are prevalence estimates affected by model assumptions and adjustments? Estimates of 12-month infertility among tryers ranged from 8% in Burkina Faso to 30% in Côte d'Ivoire, increasing substantially among a larger population of women exposed to unprotected intercourse. While having a child is a fundamental human experience, the extent to which women and couples experience infertility is a neglected area of research, particularly in sub-Saharan Africa. Existing estimates of infertility in this region vary widely from 2% to 32%, however, potential impacts of variability in study populations and model assumptions have not been well-examined. We used cross-sectional nationally representative survey data from Burkina Faso, Côte d'Ivoire, Kenya, and Uganda. We employed a multi-stage cluster random sampling design with probability proportional to the size selection of clusters within each country to produce representative samples of women aged 15-49. Samples ranged from 3864 in Côte d'Ivoire to 9489 in Kenya. We created two analytic samples in each country-tryers and a broader sample of women exposed to unprotected sex-exploring differences in population characteristics and estimating the period prevalence of 12-month infertility using the current duration (CD) approach. We also examined the impact of several model assumptions within each of the two analytic samples, including adjustments for recent injectable contraceptive use, unrecognized pregnancy, infertility treatment, underreported contraceptive use, and sexual activity. Employing the CD approach among tryers produced an overall 12-month infertility prevalence of 7.9% (95% CI 6.6-12.7) in Burkina Faso, 29.6% (95% CI 15.3-100.0) in Côte d'Ivoire, 24.5% (95% CI 16.5-34.6) in Kenya, and 14.7% (95% CI 8.1-22.4) in Uganda. Results among women exposed to unprotected intercourse indicated much higher levels of infertility, ranging from 22.4% (95% CI 18.6-30.8) in Uganda to 63.7% (95% CI 48.8-87.9) in Côte d'Ivoire. Sensitivity analyses suggest infertility estimates are particularly sensitive to adjustments around pregnancy recognition timing and sexual activity, with little impact of adjustments for recent injectable contraceptive use, infertility treatment, and underreporting of traditional and coital dependent contraceptive use. There was substantial digit preference in responses at 12 months, particularly among the tryers, which could introduce bias. Data quality concerns in the reproductive calendar may impact the accuracy of the CD approach among the broader sample of women exposed to unprotected sex, particularly with regard to underreported contraceptive use, induced and spontaneous abortions, and unrecognized pregnancies. Lastly, we lacked information on postpartum amenorrhea or abstinence. Understanding the inconsistencies in definition and analytic approach and their implications for infertility estimation is important for reliably monitoring population-level infertility trends, identifying factors influencing infertility, improving prevention programs, and ensuring access to quality treatment and services. This study was supported by grants from the Bill & Melinda Gates Foundation (INV009639) and the National Institute of Child Health and Human Development (K01HD107172). The funders were not involved in the study design, analyses, manuscript writing, or the decision to publish. The authors have no conflicts of interest to declare. N/A.

When a Partner Supports Your Sexual Autonomy: Perceived Partner Sexual Autonomy Support, Need Fulfillment, and Satisfaction in Romantic Relationships.

Sexual need fulfillment is central to well-being in romantic relationships. Self-determination theory suggests that perceiving a romantic partner as autonomously supportive is linked with greater well-being through supporting the fulfillment of basic psychological needs. The current research examines whether there are unique associations with need fulfillment and sexual and relationship satisfaction when people perceive their partner as autonomously supportive in the sexual domain. Across three multi-method studies (N = 786), we developed a measure of perceived partner sexual autonomy support and demonstrated that perceiving sexual autonomy support from a partner in general, during sex, and over time were associated with greater sexual need fulfillment as well as sexual and relationship satisfaction for both partners over and above the association with general perceived autonomy support and perceived partner responsiveness during sex. Sexual need fulfillment also accounted for the positive associations between perceived partner sexual autonomy support and satisfaction across studies.

A retrospective study of sexual minority women’s gendered sexuality: Butch and femme sex at the turn of the 21st century

This study is a retrospective examination of how sexual minority women have experienced their sexuality. The analysis examined a national archival dataset that was collected online in the US and Canada to examine the relationship between gender and sexuality in 1084 sexual minority women in 2003, with a focus on butch and femme identities. It provided an understanding of how gender and sexuality interacted at the turn of the last century when the gender identity landscape differed from that of today. While this study collected data from butch and femme women approximately 20-years ago, the results have implications for how we develop situated understandings of the relationship between gender and sexuality. Findings indicated gendered patterns in sexual preferences and attraction that can shed light on how gender and sexuality have evolved in connection. At the same time, there were no differences in sexual satisfaction, which suggests that the enactment of gendered sexuality (in which attraction is structured by a gender dynamic) was experienced as empowering rather than oppressive. We examine our findings in relation to current scholarship on gendered sexuality to consider how sexuality is constructed and reconstructed across time. The findings support a view of gendered sexuality as a source of pleasure, affirmation, and positive embodiment. We theorize gendered sexuality as functioning to enhance experiences of authenticity and resist heteronormativity. The study holds implications for research on the interaction of gender and sexuality.

Evaluation of polymer combinations in vaginal mucoadhesive tablets for the extended release of acyclovir

Genital herpes, caused by herpes simplex virus type 2 (HSV-2), affects nearly 500 million people, mostly women. Since the main route of transmission is sexual contact, the development of an acyclovir extended-release vaginal microbicide would be a suitable tool for the prevention of virus transmission. In this work, we evaluated the potential of three polymers with different characteristics (chitosan, xanthan gum and ethyl cellulose) for obtaining acyclovir extended-release vaginal tablets. By combining the polymers, certain useful synergies were observed to modify their mucoadhesive capacity and control drug release. In the swelling studies, it observed that a polyelectrolyte complex with more moderate swelling and sustained gelation was formed between chitosan and xanthan gum exclusively in acidic medium (simulated vaginal fluid). This complex allowed prolonging the mucoadhesion of the tablets in ex vivo studies performed with vaginal mucosa, which would translate into better retention in the vagina after administration. In addition, the combination of chitosan and xanthan gum allowed obtaining a controlled release of acyclovir for 5 days, regardless of the pH of the medium, which would guarantee that drug release continues even in the presence of seminal fluid.

CHILDHOOD SEXUAL ABUSE IMPACT ON ADULTHOOD

Introduction – Child sexual abuse (CSA) occurs when a kid or younger person is forced or persuaded to engage in sexual activity, whether the child is conscious of what is taking place. According to global databases, in one-third of countries in the world, at least 5% of young women reported experiences of sexual abuse in childhood. Mental health issues, behavioral manifestations, and interpersonal outcomes are a few impacts of CSA. This study aims to discuss the CSA's impact on adulthood. Methods – The researcher used a total of 13 works of literature, articles, and journals that discuss CSA and its correlation with some mental health issues impact on an adult. Results – Adults with a history of CSA are more likely to suffer from early onset depression, borderline personality disorder, and suicidal tendencies than someone without a history, that is why emotional support seems very important to the CSA survivors. Discuss – As children are sexually abused, it may lead to a variety of difficulties with relationships in general, as well as a host of poor intimate relationship consequences such as adult sexual assault, intimate partner violence, and reduced happiness in romantic relationships. Conclusion – Childhood sexual abuse is still a major problem among children and has several psychological impacts on adulthood, and emotional support is one of the great therapies. Keywords: childhood, sexual, abuse.

Laparoscopy Supports Implementation of Primary Infertility Diagnosis and Treatment: Case Reports

Background: Infertility is defined as conception failure in couples who have had sexual activity without regular contraception for one year and are still not pregnant. Abnormalities in the fallopian tube have the highest percentage of 30-45% as a cause of infertility. Hydrosalping is a condition where one or both fallopian tubes have fluid-containing clots and is the cause of 25–30% of all infertility cases. The condition of the fallopian tube and its patency can be detected with a hysterosalpingogram (HSG). Although a HSG examination can give a picture of the uterine cavity and tubes, other abnormalities such as adhesion and endometriosis are sometimes not detected. So, laparoscopy can be used to solve this problem. Results: We reported that a 27-year-old woman, Para 0, Abortus 0, came to the gynecology department with a major complaint of infertility. At the HSG examination, an unpatented right fallopian tube was found. So, the patient underwent laparoscopy, but both fallopian tubes were found in a patent state, and there was a tubal attachment on the omentum and a paratuba cyst, so adhesionolysis and cystectomy were performed. It can be concluded that tubal abnormalities can be detected more clearly with laparoscopy than with HSG. Conclusions: Laparoscopic is more recommended in cases of primary infertility, but further research to compare or combine these two modalities is still imperative.

The Movement: Reproductive Health and Rights in 2024

Women’s sexual and reproductive health (SRH) encompasses several topics, including but not limited to sexual expression, pregnancy, childbirth, contraception, and diseases of the reproductive system. The use of legal authority and power, as well as political influence, have long been factors used to regulate women’s SRH. In the United States (U.S.), examples of state and national legislation have been undertaken to impact SRH and medical treatment and decision-making related to SRH. Several national and international organizations engage in sexual and reproductive health rights (SRHR) activities. The activities of these national and international organizations in SRH often include policy formulation, data collection, monitoring, reporting, and other functions. While definitions of sexual and reproductive health rights vary, there are commonalities and core issues that can be identified. These include issues related to the LGBTQ population, immigration, and reproductive health rights among minoritized groups, which are leading topics wrapped around SRHR and of debate in recent history. This article aims to discuss sexual and reproductive health in promoting population health and societal well-being, recent policy decisions impacting SRH, and the role nurses play in shaping research, practice, and policies. For this paper, sexual and reproductive health rights (SRHR) are defined as an extension of human rights relating to an individual’s autonomy, sexuality, sexual expression, reproduction, and access to information and resources on SRH. SRHR also includes freedom from violence, discrimination, and mistreatment. While a comprehensive review of these areas is beyond this article's scope, historical and recent examples are illustrated.

PARAPHILIA AND MAJOR DEPRESSIVE DISORDERS: PREVALENCE AND PATHOGENESIS

Introduction - Paraphilia disorders are defined as an abnormal intense sexual deviant followed by behaviors to fulfill fierce sexual erotic activities. Major depressive disorder (MDD) is a mood disorder marked by the appearance of a depressed mood, decreased interest, poor cognitive function, and vegetative symptoms including sleep or eating disorders. There is a study about the prevalence of paraphilia in the US, 15,9%. Meanwhile, there is about 6,1% of the prevalence of depressive disorders in Indonesia. According to DSM-5, Paraphilias, and paraphilia-related disorders, depressive disorders are the most frequent comorbid axis I diagnoses with a lifetime prevalence of life by 56%. Based on these case numbers, this study aims to discuss the correlation between these two events. Methods - Researchers used several journals and textbooks discussing the prevalence and pathogenesis of paraphilia and major depressive disorders; and the correlation between these two disorders. Results - Paraphilias are rarely diagnosed in clinical settings because many cases of paraphilia are related to illegal and criminal acts (such as sexual harassment), and reporting methods are unreliable, meanwhile depression is ubiquitous in both high and low-income countries. This shows that any government needs to be aware of the effects of depressive disorders. Those who have not sought treatment are still high, amounting to 87 to 91% of depressive disorders that have not sought treatment. Discuss - There is a significant correlation between paraphilia and major depressive disorder, MDD is one of the paraphilia-related disorders comorbid axis I diagnosis with a lifespan prevalence of 56%. From the pathogenesis, monoamine neurotransmitters dopamine, norepinephrine, and serotonin serve a modulatory role in human sexual motivation, appetitive, and consummatory behavior. Conclusion - In pathogenesis, there's a degradation in function, amount, and production of neurotransmitter monoamine, dopamine, norepinephrine, and serotonin that cause the person with paraphilia usually show symptoms such as mood changes, decreased interest, depression, decreased cognitive function, and the appearance of vegetative-related symptoms such as impaired appetite or sleep activity. Keywords: paraphilias, depression, pathogenesis.

Prevalence of Erectile Dysfunction among Sudanese Patients at Gezira Hospital for Renal Disease and Surgery

Background: Erectile dysfunction (ED) is a disorder that makes it hard or impossible to keep or get an erection that is good enough for sexual activity. ED can be caused by physical, mental, or combined factors, and it is usually associated with a long-term health issue. Methods: The study is a prospective and cross-sectional research conducted in a hospital setting. It took place from December 2019 to December 2022 at Gezira Hospital for Renal Disease and Surgery. The study sample consisted of 246 patients. Results: The most frequently affected age groups were 30–40 years and 50–60 years, accounting for 26% and 25.2% of the sample, respectively, while the least affected age groups were >20 years and >70 years, representing 1.2% and 3.7% of the sample, respectively. The most common symptoms reported by the patients were ED alone (74%) and ED with penile curvature (22%). The most prevalent causes were psychogenic, Peyronie’s disease, and venogenic, affecting 54.1%, 24.4%, and 16.3% of patients, respectively. The most frequent comorbidities associated with ED were diabetes mellitus (DM) and hypertension, occurring in 12.2% and 4.1% of the patients, respectively. There was a statistically significant correlation between age and etiology (P-value = 0.00), age and symptom (P-value = 0.012), and symptom and cause (P-value = 0.000). Conclusion: The age group of 30–40 years was the most affected by ED, and ED alone was the most frequent symptom. Psychological factors were the main cause of ED, and DM was the most common comorbidity associated with ED.

Human Immunodeficiency Virus - a Review of the clinical aspects and detection of the infection

Introduction: Currently, many people are infected with the human immunodeficiency virus (HIV). Transmission is primarily through sexual contact, with additional routes including mother-infant exposure to needles and needle sharing. Since the HIV/AIDS pandemic was first identified in 1981, more than 75 million people have been infected. Numerous new cases continue to be reported, and infection can become the starting point for the development of HIV. Clinical manifestations include acute retroviral syndrome, opportunistic infections, and dermatological, neuromuscular, and other complications. Despite advances in antiretroviral therapy (ART), challenges remain, including drug resistance, opportunistic infections, and persistent HIV reservoirs in some cell types. Early and accurate diagnosis is essential, and recommended testing protocols include fourth-generation serological tests and point-of-care (POC) testing. ART, which includes combinations of antiretroviral drugs, is the standard treatment, and ongoing research into gene therapy shows promise for the future. Purpose of the work: The aim of this study is to review and characterize the clinical aspects and detection of human immunodeficiency virus infection. Materials and methods: A comprehensive analysis of research papers available on PubMed, Google Scholar, Web of Science, Embase and Scopus was undertaken using the searchterms encompassing the following keywords: HIV, human immunodeficiency virus, ART, HIV manifestation, HIV detection, HIV diagnosis, HIV treatment.

A Theory on the Nonlinear Relationship of Sexual Behavior and Aggression

Objective: Claims have been made that more sexual liberalism in society than what generally existed in human history is necessary to promote societal tranquility and reduce violence. This research was conducted to investigate the real relationship between sexual behavior and aggression based on scientific data especially from the perspective of physiological psychology. Method: This study was a narrative review and utilized evidence-based findings from neuropsychology, psychophysiology, laboratory research, and field studies. Databases were explored for related terms until sufficiency was reached. The findings were categorized and analyzed descriptively and interpretively to establish connections between the findings. Ultimately, a comprehensive conceptualization was developed to conclude a theory on the relationship between sexual behavior, sexual satiety, and aggression. Results: The study indicated that unrestrained sexual behavior leads to an escalation of the behavior, rather than satiation, and aggression rather than calmness. This may be due to positive feedback in the nervous and hormonal systems, specifically mediated by the medial preoptic area (MPA) and testosterone, leading to aggressive behavior. However, since sexual deprivation can potentially lead to aggression, it is advisable to view the relationship between sexual activity and violence as a non-linear one. Conclusion: This paper establishes that the intensification of sexual behaviors leads to increased violence and aggression in society, ultimately elevating levels of public insecurity. Therefore, limiting sexual behavior within the framework of the relationship of married couples may serve as a moderating factor for this phenomenon.

Sexual Satisfaction in a Sample of Italian Women during the COVID-19 Lockdown Period

This study explored the relationships among psychological, relational, and sexual factors and their impact on sexual satisfaction among Italian women during the COVID-19 lockdown. Data were collected via an online survey with 3803 participants. The survey assessed mental health, relationship quality, frequency of sexual intercourse, frequency of masturbation, body awareness, and sexual satisfaction. Correlation analyses revealed positive relationships among all the variables and negative relationships with low mental health. A network analysis showed that sexual satisfaction was the most central variable, strongly linked to relationship quality, frequency of sexual intercourse, and body awareness. An exploratory mediation model examined the indirect effects of mental health and frequency of masturbation on sexual satisfaction through the other variables as mediators. The results indicated that mental health negatively influenced sexual satisfaction both directly and indirectly through relationship quality and body awareness, while frequency of masturbation had a positive indirect effect through body awareness. These findings highlight the complex interplay among mental health, body awareness, relational factors, and sexual satisfaction, emphasizing the importance of holistic approaches in enhancing sexual well-being. Future research should focus on longitudinal studies to establish causality and explore interventions that promote positive body awareness and relationship quality.