Electrochemical disinfection is characterized by its simple operation and maintenance, along with effective sterilization capabilities, making it ideal for decentralized wastewater treatment in rural areas. As a bimetallic oxide, spinel ferrite exhibits excellent catalytic activity for the oxygen reduction reaction (ORR). Herein, a novel cathode was fabricated from nickel foam modified with spinel ferrite and multi-way carbon nanotubes (CoFe2O4-MWCNTs@NF). The modification successfully strengthens the electrochemical cathode reaction to generate strong oxidants such as hydrogen peroxide and Hydroxyl radical, enabling the disinfection of water bodies with low chloride concentrations. Compared to other influencing factors (including current density, aeration rate, and electrode spacing), the impact of conductivity on hydrogen peroxide generation is relatively minor. Modified electrodes still exhibited effective disinfection capabilities in water with low conductivity. At a current density of 2 mA/cm², the CoFe2O4-MWCNTs@NF electrode achieved 4.00 log removal of E.coli in real treated sewage within 15 minutes, with an energy consumption of 1.038 kWh/m³. Electrochemical disinfection also had a certain degradation ability for sulfonamides and quinolones antibiotics in water. The disinfection and antibiotic removal effects of the modified electrode demonstrated its potential for practical applications.