Severe Depression Research Articles

The 2024-2025 Commonwealth Budget for Mental Health: Funding unproven initiatives and stings in the tail.

We discuss the ramifications of the Commonwealth of Australia Budget allocations for mental healthcare for 2024-2025. There is funding for population-based mental health initiatives for milder anxiety and depression but no direct funding of services for the most severe and disabling forms of mental illness, other than pre-existing state/territory disbursements from the Commonwealth for state-based health services. There are substantial concerns that the Commonwealth funding has potentially been misallocated to ineffective interventions that are unlikely to reduce the population prevalence of mild anxiety and depression in Australia. Funds may have been better allocated to provide effective care for those with the most severe and disabling illnesses including schizophrenia, bipolar disorder and severe depression.

Maternal Mental Health Spillovers From Child Illness and Disability: A Dynamic Panel Analysis

ObjectivesThere is growing recognition of the consequences of a person’s health and illness experience for the health and wider welfare of those close to them. However, estimation of these health spillovers is challenging. This study adopts a longitudinal approach to examine maternal mental health spillovers associated with various forms of child illness and disability. MethodsDynamic panel models are used in estimating maternal mental health spillovers related to 7 subcategories of chronic child illness and disability. In particular, we use longitudinal data from the Growing Up in Ireland study and a system generalized method of moments approach. We also consider heterogeneity in these spillovers by the severity of the child’s illness/disability and by household deprivation. ResultsWe find that a child’s experience of chronic nervous system conditions and chronic mental and behavioral disorders are associated with 10.8 and 5.1 percentage point increases in the probability of maternal depression, respectively. Similar associations were not observed for other health conditions. Spillover magnitude is also found to be strongly related to illness/disability severity. Finally, subsample analyses reveal a larger association between severe child illness and maternal depression among deprived households. ConclusionsThis analysis, in observing health spillovers related to certain disease categories but not others, draws further attention to their context specificity. Our findings also further corroborate calls for inclusion of caregiver and family member outcomes in the economic evaluation of child health services and support consensus guidelines for collection of these outcomes alongside patient outcomes in clinical trials.

Influence of Knee Osteoarthritis Severity, Knee Pain, and Depression on Physical Function: A Cross-Sectional Study.

Decreased physical function with increasing life expectancy is a public health concern worldwide. Knee osteoarthritis (KOA) is considered one of the primary illnesses causing decreased physical function. Depression affects decreased physical function and is closely related to knee pain in KOA. However, the effect of these interacting factors on physical function is not clear. We conducted a cross-sectional analysis of the baseline data of 1106 subjects of the 2009 Locomotive Syndrome and Health Outcome in Aizu Cohort Study (LOHAS). We determined the association between their Timed Up and Go test (TUG) scores and radiographic KOA, knee pain, and depression in a multivariate analysis. Severe knee pain was significantly associated with decreased physical function (the odds ratio [OR] was 2.13, 95% confidence interval [CI]: 1.32-4.89), as was depression (OR 2.64, 95% CI 1.61-4.33). Only Kellgren-Lawrence (KL) grade 4 was significantly associated with decreased physical function in the radiographic KOA severity (OR 6.58, 95% CI 1.75-24.68). Severe knee pain and depression were significantly associated with decreased physical function, but not radiographic KOA severity except for KL grade 4. The limitations of using radiographic KOA severity alone as the indicator of assessment for physical function were suggested. When assessing decreased physical function, the clinical focus tends to be on radiographic KOA severity, but it is important to consider the patient's knee pain and psychological factors.

Psychiatry Consultation in Primary Care: Examining Treatment Access for Adolescent Depression

PurposeYouth in the United States are experiencing mental health concerns at an unprecedented level. Child Psychiatry Access Programs offer an innovative approach to close the gap between the need for care and insufficient mental health workforce. This study examined whether primary care provider consultation with a Child Psychiatry Access Program, Michigan Clinical Consultation & Care (MC3), was associated with greater access to treatment for adolescents with moderate to severe depression symptoms. MethodsA retrospective chart review was conducted of primary care visits between 2017 and 2021 for adolescent patients with first-time positive scores on the Patient Health Questionnaire-9. Descriptive statistics and logistic regression were used to examine if patients whose primary care provider used MC3 psychiatric consultations had improved access to depression treatment compared to those who did not. ResultsFour hundred seventy nine patients reported Patient Health Questionnaire-9 scores indicating moderate to severe depression symptoms. Compared to non-MC3 consult patients (n = 409), MC3 consult patients (n = 70) had higher odds of being prescribed antidepressant medications (odds ratio [OR], 2.16; 95% confidence interval [CI] [1.11–4.22], p = .05), 4 times higher odds of having a primary care follow-up visit to monitor depression symptoms (OR, 4.56, 95% CI [2.56–8.14], p < .001), and higher odds of accessing mental health therapy (OR, 2.14; 95% CI [1.13–4.05], p = .05). DiscussionUse of MC3 consultations was associated with increased utilization of evidence-based depression treatments including medication, therapy, and follow-up care. Greater adoption of models such as MC3 may increase the capacity for addressing mental health needs in children.

The prevalence of depression among patients with diabetic foot ulcers at King Khalid University Hospital, Riyadh, Saudi Arabia

ABSTRACT Background and Aim: The prevalence rates of depression and anxiety among diabetic patients with diabetic foot ulcers (DFU) vary from one study to the other. We aimed to determine the prevalence of depression and the associated risk factors among patients with DFU. Methods: We conducted a cross-sectional study using a self-reported questionnaire on adult patients aged 18 years old and above with DFU at our institution. We used the 9-item Patient Health Questionnaire to evaluate the presence of depressive symptoms. Results: A total of 75 patients, 56 (74.7%) males and 19 (25.3%) females, participated in the study; 33 (44.0%) were more than 60 years old. The prevalence of moderate to severe depression among our patients was 35 (46.7%). Patients who had DFU for more than 1 year had a higher proportion of moderate to severe depression (P = 0.032). There were no significant differences in the proportion of patients who had depression according to age groups (P = 0.456), gender (P = 0.095), level of education (P = 0.145), employment (P = 0.514), type of diabetes (P = 0.561), duration of diabetes (P = 0.704), level of HbA1c (P = 0.525), smoking history (P = 0.163), and previous history of DFU (P = 0.713). Logistic regression analysis showed that patients who had DFU for more than 1 year were three times more at risk to have moderate to severe depression (P = 0.049). Conclusion: Patients with DFU have a high frequency of moderate to severe depression regardless of age, gender, or other sociodemographic characteristics, with patients with long-standing DFU having triple the risk of depression as those with freshly diagnosed DFU. Diabetic persons should be thoroughly assessed to reduce the diabetes result, and preventative actions and patient education about DFU are crucial.

The mediating role of subjective social status in the association between objective socioeconomic status and mental health status: evidence from Iranian national data.

Low socioeconomic status (SES) is identified as a pivotal risk factor for mental health. Objective socioeconomic status (OSS) is measured by tangible resources, whereas subjective social status (SSS) reflects an individual's perception of their OSS. A paucity of literature exists that elucidates the specific psychosocial mechanisms or pathways linking OSS with mental illness via SSS. This research aimed to explore the mediating role of SSS in the OSS-mental health association, utilizing data from the Iranian Mental Health Survey (IranMHS). This study is a secondary analysis of data from IranMHS, a national survey conducted in 2011 through face-to-face interviews with 7,886 Iranian adults aged 15-64. As part of the original survey, the General Health Questionnaire-28 (GHQ-28) was randomly administered to half of these participants. We focused our analysis on data from 3,759 participants who completed all items of the GHQ-28. OSS was evaluated using education, occupation, wealth, and a combined OSS index, while SSS was measured using the MacArthur Scale. We examined how SSS mediates the associations between OSS factors and GHQ scores, including its four dimensions-somatic symptoms, anxiety and insomnia, social dysfunction, and severe depression- while adjusting for demographic variables and conducting gender-stratified analyses. Among the 3759 respondents, 2157 (57.4%) were women, 2110 (56.1%) lived in urban areas, with an average age of 33.1 years (SD=12.1). SSS mediated the associations between wealth and the overall GHQ score (mediation percentage: 92.3%), education (75.4%), OSS index (66.7%), and occupation (34.0%) on the GHQ score. The most significant mediation effects were observed for wealth on the somatic symptoms, social dysfunction, and depression dimensions, with SSS accounting for more than 80% of these associations. The findings indicate a significant mediating role of SSS in the relationship between OSS and mental health. Enhancing our comprehension of the social determinants that moderate the relationship between objective and subjective socioeconomic status may contribute to a more nuanced understanding of the impact of SES on mental health outcomes.

The Impact of Endometriosis Diagnosis on Women's Mental Health-A Cross-Sectional Study

Endometriosis is a chronic condition where tissue similar to endometrium grows outside the uterus. It affects the social and psychological life of women. Objective: To evaluate the impact of endometriosis diagnosis on women's mental health. Methods: In this cross-sectional study basal data, Endometriosis Health Profile (EHP-30) statuses, and Hospital Anxiety and Depression scale scores were collected from 200 sub-fertile women who were sampled using a non-probability sampling technique. Frequency distribution and chi-square (X2) analysis were performed using IBM SPSS® version 26.0. Results: Out of 200 sub-fertile women 28 (14%) had endometriosis. Positive endometriosis significantly correlated with age (0.09&lt;0.1). The endometriosis-related health statuses significantly correlated with anxiety and depression with two-sided asymptomatic significances of 0.007 (&lt;0.05) and 0.000 (&lt; 0.05) respectively. The highest prevalence of severe anxiety and depression was present in women with bad possible health profiles related to endometriosis. Conclusions: It was concluded that endometriosis aggravates with age and its positive diagnosis has a strong negative impact on the social and psychological health of the patients.

Prevalence of Antidepressant Prescriptions for Community-Dwelling Adults Diagnosed with Depressive Disorder in the UK: A Systematic Review.

The UK National Institute for Health and Care Excellence (NICE) guidance for the treatment of depression is widely followed and has international influence. According to these guidelines, antidepressant medications are recommended for moderate to severe depression. Nonetheless, antidepressants are increasingly prescribed, including for cases of subthreshold and mild depression. This may indicate that a proportion of depressed patients uses pharmacological interventions with unclear evidence-base, though other factors such as physical and mental health comorbidities need to be accounted for. This study aims to investigate the prevalence and trends of antidepressant prescriptions among community-dwelling adults diagnosed with depression according to NICE recommendations. We conducted a systematic review of PsycInfo, PubMed/MEDLINE, and Scopus databases. Observational studies reporting on the prevalence of antidepressant treatments in UK adults diagnosed with depression were sought. Fifteen studies were included. The prevalence of antidepressants for depression treatment ranged from 30.8 to 95% and mainly concerned selective serotonin reuptake inhibitors (SSRIs) among classes of antidepressant drugs. Little information about depression severity as well as comorbid conditions was reported. High prevalence rates of antidepressant drug use highlight the widespread adoption of pharmacological interventions, while also raising concerns about compliance with NICE guidelines. Careful assessment of depressive illness severity and comorbidities is needed to ensure the delivery of adequate care to people with depression. Systematic Review Registration Number (PROSPERO) CRD42023448152.

Association of Depression With Handgrip Strength and Muscle Mass in Young and Middle-Aged American Adults From NHANES 2011-2014: A Cross-Sectional Study.

To investigate relationship between depression and handgrip strength (HGS) and appendicular lean mass (ALM) in Young and middle-aged adults. Cross-sectional study. Data from participants aged 20-59 from the 2011-2014 National Health and Nutrition Examination Survey. In a study of 4927 middle-aged Americans, 2564 (52.30%) were men and 2363 (47.7%) were women, with an average age of 38.57 ± 11.72. Among this group, 716 individuals (14.53%) experienced mild depression, while 385 individuals (7.81%) suffered from moderate to severe depression. Data of HGS and ALM were collected by handgrip test, and whole-body dual-energy X-ray absorptiometry scans. Depression was assessed using the Patient Health Questionnaire-9. Linear and logistic regression, restricted cubic spline regression analyses and subgroup analysis were conducted to evaluate the association. Following multivariate logistic regression analysis, the study showed that a 1-point increase in the depression score was associated with a 4% increase in the probability of reduced grip strength for both males (95% CI: 1.01-1.07) and females (95% CI: 1.01-1.06). Additionally, for males, there was a 5% increase in the likelihood of decreased muscle mass (95% CI: 1.01-1.09), whereas the decline in muscle mass for females did not exhibit statistical significance. Subgroup analysis indicated that the inverse relationship between depression and grip strength, along with the negative association between depression and muscle mass among males, remained consistent in the 40-59 age range. This research revealed an inverse relationship between depression and grip strength in middle-aged and young individuals, and a negative association between depression and ALM was only noted in males. Early intervention could be beneficial from age 40.

Single-dose psilocybin for U.S. military Veterans with severe treatment-resistant depression – A first-in-kind open-label pilot study

BackgroundThe enduring and severe depression often suffered by Veterans causes immense suffering and is associated with high rates of suicide and disability. This is the first study to evaluate the efficacy and safety of psilocybin in Veterans with severe treatment-resistant depression (TRD). Methods15 Veterans with severe TRD (major depressive episode failing to respond to ≥5 treatments, or lasting >2 years) received 25 mg of psilocybin. Primary outcome was change in Montgomery-Åsberg Depression Rating scale (MADRS) at 3 weeks posttreatment. Response was defined s ≥ 50 % reduction in MADRS, and remission as ≤10 MADRS score. Psychedelic experience was assessed using the Five-Dimensional Altered States of Consciousness scale (5D-ASC). Safety measures included assessment of suicidality and adverse events. Participants on antidepressants were tapered to avoid drug interactions. ResultsOf 15 participants, 60 % met response and 53 % met remission criteria at Week 3. At 12 weeks, 47 % maintained response, and 40 % remission. Co-morbid PTSD did not significantly influence study outcomes. The psychedelic experience reported in 5D-ASC did not correlate with response. Participants judged to need antidepressants were restarted and considered non-responders from that timepoint (n = 4). No unexpected adverse events occurred. LimitationsLimitations include the small sample size, and the uncontrolled and unblinded nature of the study. ConclusionsIn this first study on psilocybin for Veterans with severe TRD, a surprising response and remission was seen. Many Veterans had PTSD though no moderating impact of response was observed. The degree of psychedelic experience did not correlate with depression changes. Further study is warranted.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04433858.

Modified blepharoplasty combined with autologous fat transplantation into the orbital septum for the correction of dermatochalasis and sunken eyelids

BackgroundPeriorbital aging typically manifests with dermatochalasis and depression of the upper eyelid. Blepharoplasty is a popular choice for addressing upper eyelid skin laxity but is not suitable for sunken eyelids. This study introduces an innovative approach for periorbital rejuvenation by addressing dermatochalasis and sunken upper eyelids concurrently in aging Asian women. MethodThe study involved 45 patients with upper eyelid dermatochalasis accompanied by moderate to severe depression. Subbrow blepharoplasty was performed in conjunction with upper eyelid granular fat grafting in the orbital septum for these patients. Preoperative measurements of the depth and volume of the upper eyelid depression were taken and the surgical outcomes were assessed at 3 and 6 months postoperatively using the GAIS score and the Antera 3D camera. ResultThe average depth of the upper eyelid depression before surgery was 6.501±1.473mm, and the average volume was 0.579±0.144 cm3. There were significant improvements in the depth and volume of the depression at 3 and 6 months after surgery compared to the preoperative measurements. The GAIS scores were also improved and postoperative outcomes were deemed satisfactory. ConclusionFor patients with dermatochalasis accompanied by moderate to severe upper eyelid depression, a standard blepharoplasty was unable to improve the sunken eyelid. This novel technique combines autologous granular fat injection into the orbital septum and blepharoplasty to effectively address periorbital aging, thereby promoting facial rejuvenation.

Impact of dengue fever on depression, anxiety, and stress symptoms in Esmeraldas Province, Ecuador: a prospective cohort study

BackgroundPhysical symptoms of dengue have been documented extensively, but knowledge gaps on dengue-associated mental health hazards remain. We investigated the frequency of psychiatric symptoms (depression, anxiety, and stress) and neurocognitive performance during the first year after a dengue episode.MethodsUsing DASS-21 scores at 3, 6, and 12 months, we assessed depression, anxiety, and stress in anti-dengue IgM-positive adults and matched controls during the 2021 dengue season in Esmeraldas Province, Ecuador. Patients with DASS-21 scores ≤ 4 were considered normal; those with scores of 5–7, 8–10, and ≥ 11 indicated mild, moderate, and severe depression, respectively; cutoff scores for anxiety and stress were ≥ 5 and ≥ 9, respectively. We also assessed ‘delayed matching to sample’ (DMS) and ‘spatial working memory’ (SWM) using the Cambridge Neuropsychological Test Automated Battery.ResultsWe enrolled 102 cases and 78 controls. At 3 months, 90 cases and 70 controls were available for follow-up, among these 40/90 (44.4%) cases and 12/70 (17.1%) controls had DASS-21 scores ≥ 5 (RR 2.7, 95% CI [1.5–4.7]). Dengue remained a predictor for depression after adjusting for age, sex, and COVID-19 status. We observed no difference in anxiety between the groups, but stress scores increased at month 3 (RR 1.87, 95% CI [1.01–3.4]). DASS-21 scores normalized during follow-up. DMS and SWM did not differ between groups at 3 and 6 months. At month 12, cases had lower SWM than controls did (p value < 0.001).ConclusionsCare providers should be aware of dengue-associated mood disorders and facilitate timely referral to mental health services. Future longitudinal studies are warranted to validate our observations regarding the impact of dengue on mental health and neurocognitive status in affected patients.

Depression and inflammation in COVID-19 patients during and after hospitalisation – a systematic review and meta-analysis

Introduction: The severity of depression symptoms in COVID-19 patients differs among populations investigated and changes over time. Increasing evidence supports the hypothesis about the involvement of inflammation in the development of depression. Methods: A systematic review and a meta-analysis of the cross-sectional and cohort studies published between 2019 and 2023 were conducted according to the PRISMA criteria. The outcomes of interest were the proportions of mild, moderate, and severe depression symptoms during and after hospitalisation, and associations between depression and inflammation in COVID-19 patients. Results: Thirty articles were included in the systematic review. In the quantitative meta-analysis, the overall proportions of moderate-to-severe and mild-to-severe depression were estimated at 0.21 (95% CI: 0.13–0.31) and 0.35 (95% CI: 0.23–0.48), respectively. The fixed effects model of the meta-analysis of inflammatory markers showed a difference between COVID-19 patients with and without depression, with higher concentrations of both C-reactive protein and neutrophil-lymphocyte ratio detected among people suffering mood disturbances. However, in random effects models, findings for C-reactive protein lost significance, and for neutrophil-lymphocyte ratio were on the boundary of significance (p = 0.053). Conclusions: According to the study results, the proportion of depression decreases over time after a COVID-19 diagnosis. The relationship between depression and inflammation is still uncertain and requires further research.

Use of Electroconvulsive Therapy in a Patient with a Permanent Cardiac Pacemaker

Abstract There is limited information on the use of electroconvulsive therapy (ECT) in patients having a cardiac pacemaker. The aim of the study was to present a case of an older woman with an implanted permanent cardiac pacemaker who presented with recurrent catatonia in the background of recurrent depressive disorder, a current episode of severe depression with psychotic symptoms, and managed with ECT. A 65-year-old female patient presented with catatonia in the background of severe depression with psychotic symptoms and marked cachexia to the emergency services for management of catatonia. Initially, she was managed with lorazepam, with which she showed improvement in catatonia. However, after 2 weeks, there was a worsening of catatonia and resultantly she was considered for ECT. In addition, she was treated with venlafaxine 150 mg/day and olanzapine 5 mg/day. She maintained well for a year, she again developed depressive, psychotic symptoms, suicidal ideations, and catatonic symptoms in the form of mutism, rigidity, negativism, and staring. Her medications were increased to tablet escitalopram 20 mg/day and tablet olanzapine 10 mg/day, but her symptoms kept worsening. The lorazepam challenge test done during this time was negative, and she was readmitted to the inpatient unit. Her medications were changed to tablet dosulepin, and she again received 15 effective ECTs. The patient was discharged on tablet dosulepin 112.5 mg/day and olanzapine 10 mg/day and maintained well for the next 6 months, i.e., until the last follow-up. ECT can be given safely in patients with depression having cardiac pacemakers with close monitoring of the cardiac parameters during ECT.

Consensus-based recommendations for the diagnosis and treatment of anxiety and depression in children and adolescents with epilepsy: A report from the Psychiatric Pediatric Issues Task Force of the International League Against Epilepsy.

The Psychiatric Pediatric Issues Task Force of the International League Against Epilepsy (ILAE) aimed to develop recommendations for the diagnosis and treatment of anxiety and depression in children and adolescents with epilepsy. The Task Force conducted a systematic review and identified two studies that assessed the accuracy of four screening measures for depression and anxiety symptoms compared with a psychiatric interview. Nine studies met the eligibility criteria for treatment of anxiety and depressive disorders or symptoms. The risk of bias and certainty of evidence were assessed. The evidence generated by this review followed by consensus where evidence was missing generated 47 recommendations. Those with a high level of agreement (≥80%) are summarized. Diagnosis: (1) Universal screening for anxiety and depression is recommended. Closer surveillance is recommended for children after 12 years, at higher risk (e.g., suicide-related behavior), with subthreshold symptoms, and experiencing seizure worsening or therapeutic modifications. (2) Multiple sources of ascertainment and a formal screening are recommended. Clinical interviews are recommended whenever possible. The healthcare provider must always explain that symptom recognition is essential to optimize treatment outcomes and reduce morbidity. (3) Questioning about the relationship between symptoms of anxiety or depression with seizure worsening/control and behavioral adverse effects of antiseizure medications is recommended. Treatment: (1) An individualized treatment plan is recommended. (2) For mild depression, active monitoring must be considered. (3) Referral to a mental health care provider must be considered for moderate to severe depression and anxiety. (4) Clinical care pathways must be developed. (5) Psychosocial interventions must be tailored and age-appropriate. (6) Healthcare providers must monitor children with epilepsy who are prescribed antidepressants, considering symptoms and functioning that may not improve simultaneously. (7) Caregiver education is essential to ensure treatment adherence. (8) A shared-care model involving all healthcare providers is recommended for children and adolescents with epilepsy and mental health disorders. We identified clinical decisions in the management of depression and anxiety that lack solid evidence and provide consensus-based guidance to address the care of children and adolescents with epilepsy.

Depression severity and verbal comprehension in children and adolescents with a major depressive episode.

Severe depression is a prevalent psychiatric illness in children and adolescents associated with high levels of morbidity, disability, and a high risk of suicidal behavior. Cognitive factors associated with depression severity in juveniles have been poorly reported. We investigated the relationship between depression severity and intelligence quotient (IQ)with its subscales in 65 juveniles (aged 10-17 years) with a current major depressive episode evaluated at the Mood Disorder Program of Bambino Gesù Children's Hospital in Rome. Pearson's correlation analyses were followed by a Benjamini-Hochberg correction and linear multivariable regression model. Depression severity measured with the total score of the Children's Depression Rating Scale-Revised (CDRS-R) was positively associated with the Verbal Comprehension Index (VCI; Pearson's r = 0.309 [0.042-0.534]; p = 0.024). The CDRS-R subscales positively associated with VCI by Pearson's correlation were depressed feelings, suicidal ideation, excessive weeping, and reduced facial expressions. Suicidal ideation was the only factor independently and significantly associated with higher VCI in the multivariable linear regression model. Suicidal ideation was significantly and independently associated with higher verbal comprehension, indicating that depressed juveniles with better verbal ability may be at a greater risk of showing suicidal ideation.

Assessment of quality of life in IPF Patients: a multicenter observational study.

This study aimed to examine how dyspnea, cough, sleep disruption, anxiety, depression, and physiological factors affect the quality of life in newly diagnosed, untreated IPF patients. This study is a multicenter observational study. Patients not receiving antifibrotic treatment were included. To assess patients' quality of life, Leicester Cough Questionnaire (LCQ), St. George's Respiratory Questionnaire (SGRQ), Short Form-36 (SF-36), Hospital Anxiety and Depression Scale (HADS), Borg Dyspnea Index (BDI), Modified Medical Research Council Dyspnea Scale (MMRC) score, Composite Physiological Index (CPI), Gender Age and physiology (GAP) score, and Pittsburgh Sleep Quality Index (PSQI) were administered. Among 88 patients (mean age: 67.6±8.5 years), 81.9% were diagnosed with IPF through HRCT, 14.8% through surgery, and 3.4% via cryobiopsy. The average disease duration was 2.2±2.9 years. Over 50% experienced moderate to severe depression, and 40% had moderate to severe anxiety. In the IPF group, 13.6% had possible usual interstitial pneumonia (UIP), and 81.8% had definite UIP pattern. No significant differences were found between UIP groups in various scores. Anxiety and depression correlated negatively with respiratory function and positively with MMRC score and BDI. Sleep quality scores had similar correlations. Patients with good sleep quality had better respiratory parameters (p=0.013), lower MMRC (p=0.004), BDI (p=0.026), and CPI (p=0.047). -Conclusion: A notable number of IPF patients in follow-up show symptoms of anxiety and depression. Moreover, declining respiratory function not only diminishes sleep quality but also elevates dyspnea scores.

Quality of sleep after COVID-19 infection: a cross-sectional study in the Southern Italy.

This study investigated the quality of sleep in a sample of individuals from Southern Italy after the major waves of the COVID-19 pandemic, with the aim of evaluating how sleep patterns changed. A cross-sectional study was conducted between March 2022 and January 2023 and involved adults who had a COVID-19 infection, who were invited to complete a self-administered online questionnaire. A total of 408 individuals participated in the survey. Overall, 66.4% had a reduction in social relations; 72.1% had an increase in the use of social media; and 86%, 77.2%, and 71.1% reported an extremely severe level of anxiety, stress, and depression, respectively. Almost all of the respondents had a Pittsburgh Sleep Quality Index score (PSQI) ≥5, indicating poor sleep quality. Subjects with a severe or extremely severe depression score, a severe or extremely severe stress score, who had a job, and who had someone close who died because of a COVID-19 infection were more likely to have a high PSQI global score. The use of sleep medication in the past months was significantly higher in those who were older, who had a job, who had a COVID-19 infection in the first and second waves, who had someone close who died from COVID-19, and who did not have changes in social relationships during the pandemic. Moreover, participants with severe or extremely severe depression scores, with severe or extremely severe stress scores, who were women, and who were older had troubles staying awake while engaging in social activities during the past month. The results bring to light the high prevalence of poor sleep quality among individuals who were infected with SARS-CoV-2. Future research is needed to understand whether these disturbances are still present in the endemic period and whether it is necessary to investigate further determinants that have affected and/or are affecting sleep quality.

Beyond Force, Incapacitation, or Verbal Coercion: Rates and Outcomes of Sexual Assault without Warning

ABSTRACT To date, most sexual assault research has focused on specific perpetrator tactics, including verbal coercion, substance-related incapacitation, and force. Responding to recent calls to assess a broader range of nonconsensual sexual experiences, we examined the occurrence and outcomes of sexual assault without warning – when a perpetrator “just does” a behavior without giving a chance to say “no.” Participants were 850 college students (Mage = 19.70; 70% cisgender women, 28% cisgender men, 2% transgender/gender expansive), including 38% (n = 325) who reported sexual assault since age 14. Among these survivors, 72% reported sexual assault without warning, including 18% for whom this was the only tactic experienced. Sexual assault without warning was most often used to obtain nonconsensual sexual contact (23% of the sample) but also attempted (11%) and completed penetration (13%). Relative to no such experience, sexual assault without warning was associated with more severe posttraumatic stress, depression, and anxiety, but fewer past-month drinks per week. Although more alcohol use and related consequences were better predicted by incapacitated sexual assault, sexual assault without warning was consistently associated with mental health problems. Findings support the integration of this tactic into sexual assault assessments for college students of diverse gender and sexual identities.

Identifying depression, diabetes distress, and suicidality among adolescents with diabetes

ABSTRACT This study explored the frequency of adolescents with diabetes who endorse suicidality on the Patient Health Questionnaire (PHQ-9) with varying degrees of depression scores. Additionally, compared whether diabetes distress levels from the Problem Areas in Diabetes-Teen (PAID-T) assessment tool is associated with and without suicidal ideation. Χ2 analysis was used to assess differences in subjects with or without suicidal ideation based on depression severity. Since all the data were nonparametrically distributed (Shapiro–Wilk test, p < .05), Kruskal–Wallis test assessed differences in continuous variables. Overall, 27 of 355 adolescents screened endorsed suicidal ideation. Both PHQ-9 [13 (9–17.8) vs 1 (0–4.5)] and PAID-T [88 (61.8–104.5) vs 40 (30–58.8)] scores were significantly higher in patients with suicidal ideation. The frequency of suicidal ideation increased with the severity of depression. The frequency of severe depression was higher in adolescents with type 2 diabetes (n = 48) than in type 1, but there was no difference in suicidality. Adolescents with no demonstrable or minimal depression can still have potential suicidal ideation. Suicidality is a separate construct that should be screened routinely and apart from any measures screening for distress or adjustment disorders associated with adolescents experiencing life-long chronic conditions in a healthcare follow-up setting.