Sigma-point Kalman filtering (SPKF) uses a set of sigma points to completely capture the first and second order moments of the a priori random variable. Using the SPKF, a tightly-coupled GPS/INS integration can be designed in either the navigation state space or the error state space. This paper uses the error state space. This approach blends the INS error model with the nonlinear range and range-rate equations, and can avoid the time-consuming unscented transformation on the strapdown computation which is needed when the implementation occurs through the navigation state space. The SPKF demonstrated its ability to track INS errors in the field test. The comparison between SPKF and EKF was conducted in terms of accuracy and time consumption. The results show that for the pseudorange-based tightly-coupled GPS/INS integration, the SPKF design provides little performance benefit compared to the EKF.