SESSION TITLE: Outcomes in Pneumonia and NTMSESSION TYPE: Rapid Fire Original InvPRESENTED ON: 10/17/2022 12:15 pm - 1:15 pmPURPOSE: Obstructive sleep apnea (OSA) has been shown to cause various cardiopulmonary complications. However, the effect of OSA on infectious processes is poorly documented. Our study sought to estimate the impact of OSA on clinical outcomes of hospitalizations for Aspiration pneumonia (AP) using the national database.METHODS: We queried the National Inpatient Sample (NIS) database from 2016 to 2019. The NIS is the largest inpatient hospitalization database in the United States. The NIS was searched for hospitalization of adult patients with AP as a principal diagnosis with and without OSA as a secondary diagnosis using ICD-10 codes. The primary outcome was inpatient mortality while the secondary outcomes were septic shock, ARDS, mechanical ventilation (MV), length of hospital stay (LOS) and total hospital charges (THC). Multivariate logistic and linear regression analysis was used accordingly to adjust for confounders.RESULTS: 602,024 patients were admitted for AP; 7.17% (43,194) had underlying OSA. Cohorts with OSA vs No OSA had a mean age of 69.5 years [CI 69.2 – 69.9] vs 73.8 years [CI 73.7 - 74.0]; male (63.4% vs 56.1%), female (36.6% vs 43.9%); white (82.9% vs 76.8%), black (8.7% vs 10.6%), and Hispanic (5.0% vs 6.9%). Compared to patients without OSA, patients admitted with coexisting OSA had a statistically significant decrease in mortality (4.9% vs 7.4%, AOR, 0.74, P<0.0001) and Septic shock (1.1% vs 1.5%, AOR 0.77, P= <0.020). OSA also had increased LOS (6.5 days vs 6.3 days, P<0.0001) and THC $64,024 vs $57,738, P<0.0001). There was no difference in ARDS (P=0.220) and mechanical ventilation (P=0.261) between both groups.CONCLUSIONS: In conclusion, OSA resulted in decreased inpatient mortality and septic shock, with increased length of stay and THC in patients hospitalized with AP. There was no difference in ARDS and use of mechanical ventilation in both groups.CLINICAL IMPLICATIONS: “Obesity paradox” may also affect outcomes in patients with co-existing OSA.DISCLOSURES: No relevant relationships by Po-Hua ChenNo relevant relationships by Aman DuttaNo relevant relationships by Jashan GillNo relevant relationships by Richard OrjiNo relevant relationships by Artem Sharko SESSION TITLE: Outcomes in Pneumonia and NTM SESSION TYPE: Rapid Fire Original Inv PRESENTED ON: 10/17/2022 12:15 pm - 1:15 pm PURPOSE: Obstructive sleep apnea (OSA) has been shown to cause various cardiopulmonary complications. However, the effect of OSA on infectious processes is poorly documented. Our study sought to estimate the impact of OSA on clinical outcomes of hospitalizations for Aspiration pneumonia (AP) using the national database. METHODS: We queried the National Inpatient Sample (NIS) database from 2016 to 2019. The NIS is the largest inpatient hospitalization database in the United States. The NIS was searched for hospitalization of adult patients with AP as a principal diagnosis with and without OSA as a secondary diagnosis using ICD-10 codes. The primary outcome was inpatient mortality while the secondary outcomes were septic shock, ARDS, mechanical ventilation (MV), length of hospital stay (LOS) and total hospital charges (THC). Multivariate logistic and linear regression analysis was used accordingly to adjust for confounders. RESULTS: 602,024 patients were admitted for AP; 7.17% (43,194) had underlying OSA. Cohorts with OSA vs No OSA had a mean age of 69.5 years [CI 69.2 – 69.9] vs 73.8 years [CI 73.7 - 74.0]; male (63.4% vs 56.1%), female (36.6% vs 43.9%); white (82.9% vs 76.8%), black (8.7% vs 10.6%), and Hispanic (5.0% vs 6.9%). Compared to patients without OSA, patients admitted with coexisting OSA had a statistically significant decrease in mortality (4.9% vs 7.4%, AOR, 0.74, P<0.0001) and Septic shock (1.1% vs 1.5%, AOR 0.77, P= <0.020). OSA also had increased LOS (6.5 days vs 6.3 days, P<0.0001) and THC $64,024 vs $57,738, P<0.0001). There was no difference in ARDS (P=0.220) and mechanical ventilation (P=0.261) between both groups. CONCLUSIONS: In conclusion, OSA resulted in decreased inpatient mortality and septic shock, with increased length of stay and THC in patients hospitalized with AP. There was no difference in ARDS and use of mechanical ventilation in both groups. CLINICAL IMPLICATIONS: “Obesity paradox” may also affect outcomes in patients with co-existing OSA. DISCLOSURES: No relevant relationships by Po-Hua Chen No relevant relationships by Aman Dutta No relevant relationships by Jashan Gill No relevant relationships by Richard Orji No relevant relationships by Artem Sharko