Objective: Rosacea, a chronic inflammatory skin disease, is known to be associated with various systemic disorders. However, limited data are available on the association between rosacea and renal diseases. The objective of this study was to evaluate serum creatinine, cystatin C and neutrophil gelatinase-associated lipocalin (NGAL) levels in patients with rosacea without any systemic diseases. Material and Methods: A prospective, case-control study was planned to investigate the relationship between rosacea and renal involvement by evaluating serum creatinine, cystatin C and NGAL levels. Results: A total of 38 patients with rosacea and 45 healthy controls were included. Statistically significant differences in serum creatinine and cystatin C levels were noted between the patient and control groups (respectively p=0.012, p<0.001). No statistically significant difference was shown in the values of NGAL between the two groups (p=0.235). A positive correlation was noted between serum creatinine and serum cystatin C levels (r=0.434; p<0.001). The serum levels of cystatin C were positively correlated with disease duration (r=0.511, p<0.001). Conclusion: Serum creatinine and cystatin C levels may provide early detection of renal dysfunction in rosacea.