A13381 The relationship between blood pressure components of Ambulatory blood pressure monitoring and cystatin C in essential hypertensive patients

Abstract

Objectives: To investigate whether cystatin C, a marker of kidney function, is associated with 24 h mean systolic BP (24hSBP), 24 h mean diastolic BP (24 h DBP), 24 h mean pulse pressure (24 h PP) and pulse pressure index (PPI) obtained from ambulatory blood pressure monitoring (ABPM). Methods: A total of 270 patients with essential hypertension without overt proteinuria were enrolled. A 24 h ABPM was performed,serum levels of cystatin C were measured, and estimated glomerular filtration rate (eGFR) was estimated. Subjects were stratified into two categories: PPI above and below the median (0.437). Partial correlation and multiple stepwise regression analyses were performed to confirm determine the relationship between ABPM’ parameters and cystatin C. Results: A total of 270 patients with essential hypertension without overt proteinuria were enrolled. A 24 h ABPM was performed,serum levels of cystatin C were measured, and estimated glomerular filtration rate (eGFR) was estimated. Subjects were stratified into two categories: PPI above and below the median (0.437). Partial correlation and multiple stepwise regression analyses were performed to confirm determine the relationship between ABPM’ parameters and cystatin C. Conclusion: The 24hSBP, 24hPP, PPI had an independent relationship with cystatin C, and no significant correlation was observed 24hDBP and cystatin C.