Serum Ferritin Concentration In Patients Research Articles

Serum Zinc Concentration Correlates With Ferritin Concentration in Patients Undergoing Peritoneal Dialysis: A Cross-Sectional Study.

Background: Zinc deficiency is common and is associated with erythropoietin resistant anemia, dysgeusia, and hypogonadism in patients undergoing hemodialysis. However, the prevalence and clinical effects of zinc deficiency in patients undergoing peritoneal dialysis (PD) have not been determined.Methods: This was a retrospective, cross-sectional study. The prevalence of serum zinc deficiency and the clinical factors related to serum zinc concentration were determined in 49 patients undergoing PD [mean age 59.5 years (±14.8 years), 38/49 were men (78.6%), median PD period 24.0 months (12.5–45.0 months)]. A serum zinc concentration <60 μg/dL was defined as serum zinc deficiency, and a serum zinc concentration between 60 and 80 μg/dL as possible serum zinc deficiency.Results: Serum zinc deficiency was present in 51% (25/49) of the patients, and possible serum zinc deficiency was present in 45% (22/49) of patients undergoing PD. Multivariate analysis showed that serum zinc concentration significantly correlated with serum ferritin concentration (β = 0.357, P < 0.01).Conclusions: The prevalences of serum zinc deficiency and possible serum deficiency are high and serum zinc concentration correlates with serum ferritin concentration in patients undergoing PD.

Estimation of Serum Iron and Ferritin in Patients with Chronic Renal Failure

Background: The incidence of renal failure, and potentially of CRF, is increasing steadily in Sudan. Anaemia is an accompaniment and independent risk factor for the development of cardiac dysfunction along with other complications. It is also responsible for 40-50% deaths in CRF patients. For this reason, the quick and accurate diagnosis of anaemia should help in decreasing the morbidity caused by CRF. The correction of anaemia, e.g. by the administration of iron supplements and/or erythropoietin, should help improving the general outcome of CRF.&#x0D; methods: Fifty patients with chronic renal failure, already diagnosed clinically and on laboratory basis were selected as a sample group. Another 50 healthy individuals not known to have renal disease were selected as a control group. 5 ml of venous blood was collected in lithium heparin container for iron and ferritin. Concentration of iron was measured by colorimetric method by using SPINREACT™ and serum ferritin by Turbilatex-Ferritin kit. The data obtained were analyzed by using statistical package for social science (SPSS) on programmed computer. Results: The mean ± SD of serum ferritin was calculated in patients and controls and it was found 72 μg/L ± 16.2 for patients and 96 μg/L ± 19.7 for controls the (p-value 0.000). Also the mean ± SD of serum iron was obtain from patients and controls and was found 41μg/dL ± 29.2 and 87 μg/dL ± 47.5 respectively with (p-value = 0.000). There were a weak negative correlation between serum iron and serum ferritin concentrations in patients and controls (R -0.161). Conclusion: The study concludes that serum iron and ferritin levels in CRF patients are significantly low in comparison to healthy controls.

The expression levels of TNF-α and IL-6 in tumor tissues and change of serum ferritin concentration in patients with intracranial aneurysm and its clinical significance

Objective To investigate the expression levels of tumor necrosis factor alpha (TNF-α), interleukin-6(IL-6) and the change of serum ferritin in patients with intracranial aneurysm and its clinical significance. Methods 22 patients with intracranial aneurysm and 16 cases of traumatic brain injury who recevied operation in Department of Neurosurgery in Quzhou People's Hospital from Jan.2014 to Jan.2015 were enrolled as observation group and control group.The intracranial aneurysm tissues and normal cerebral vascular tissues were collected respectively to detect the situation of inflammatory cell infiltration, and the expression of TNF-α and IL-6 was detected by HE staining and immunohistochemical staining.The serum was collected on hospitalized, postoperative 3 days and postoperative 7 days to detect serum ferritin. Results The positive cells were observed in the observation group after immunohistochemical staining, in which the expression levels of TNF-α[(0.194±0.074) vs.(0.135±0.047), t=2.799]and IL-6[(0.152±0.057) vs.(0.103±0.028), t=3.494]were significantly higher than those in the control group(P=0.008, 0.001). The serum ferritin level in the observation group was significantly higher than that in the control group at postoperative 3d[(232.25±105.26)ng/mL vs.(169.51±66.24)ng/mL, t=2.097]and postoperative 7d[(263.39±114.73)ng/mL vs.(166.57±73.71)ng/mL, t=2.955](P=0.043, 0.005). The difference of serum ferritin on different day in the observation group also was statistically significant(F=8.625, P=0.003). Conclusion The expression levels of TNF-α and IL-6 in intracranial aneurysms were high, which may be one of the important factors in the formation of intracranial aneurysms, and it provides an important reference of early prevention and drug treatment for patients with intracranial aneurysm.The serum ferritin is related to the rupture and hemorrhage of intracranial aneurysm, which can be used to judge prognosis and guide rational treatment, and worth further study to confirm. Key words: Intracranial aneurysm; Tumor necrosis factor-α; Interleukin-6; Serum ferritin

Serum prohepcidin and other iron metabolism parameters in elderly patients with anemia of chronic disease and with iron deficiency anemia

The diagnosis of iron deficiency anemia (IDA) in the context of the anemia of chronic disease (ACD) in elderly patients is often difficult due to the existence of many disorders. Recent studies have shown that hepcidin measurement (combined with the existing diagnostic methods) may possibly help in the differential diagnosis of IDA and ACD. The aim of the study was to evaluate the differential diagnostic value of serum prohepcidin in elderly patients with IDA and ACD. The study included 65 individuals aged 65 years or more: 26 patients with ACD, 13 patients with IDA, and 26 age-matched controls. Prohepcidin, ferritin, soluble transferrin receptor, erythropoietin, and interleukin 6 (IL-6) were measured using the commercially available enzyme-linked immunosorbent assay kits. Complete blood count, total iron-binding capacity (TIBC), and iron, transferrin, and C-reactive protein (CRP) levels were assayed using the standard laboratory methods. Prohepcidin concentrations were similar in patients with ACD (196.59 ng/ml) compared with those with IDA (230.16 ng/ml) (P = 0.35). Patients with ACD had significantly lower levels of TIBC compared with those with IDA (P <0.0001). Serum ferritin concentration in patients with ACD was almost 20-fold higher compared with those observed in patients with IDA (P <0.0001). CRP and IL-6 concentrations in patients with ACD were significantly higher compared with those with IDA. The results of the study indicate that serum prohepcidin has limited value in the differential diagnosis of IDA and ACD in elderly patients.

Maternal serum ferritin concentration in patients with preterm labor and intact membranes

Objective. To determine the relationship between maternal serum ferritin concentrations in the second trimester and the risk of preterm delivery (PTD).Methods. A prospective observational study was conducted. Fifty consecutive women with singleton pregnancies, who were admitted to the Maternal Fetal Medicine Unit due to preterm labor in the second trimester, were included. Maternal serum samples for determination of ferritin concentrations were obtained. Multiple logistic regression analysis was performed to control for confounders.Results. Out of fifty patients enrolled in the study, 38% (19/50) delivered prematurely. Eight women (16%) had maternal serum ferritin concentrations above 30 ng/ml in the second trimester. Among them, 75% (n = 6) subsequently presented with preterm delivery (odds ratio (OR) = 6.7 with 95% confidence interval (CI) 1.1–56.2, p = 0.04). Only two patients with increased maternal ferritin concentrations delivered at term. However, 13 patients with second trimester ferritin concentrations below 30 ng/ml had preterm delivery. No significant differences in mean maternal ferritin concentrations were found between patients who delivered preterm and those that delivered at term, 31.9 ± 50.6 vs. 13.6 ± 15.2, respectively (p = 0.064). Using a multivariable analysis, controlling for anemia, leucocytosis and maternal age, increased serum ferritin concentrations were found to be an independent risk factor for PTD (OR = 8.6; 95% CI 1.4–52.5; p < 0.019). No significant correlation was found between serum ferritin concentrations and gestational age at birth (Pearson correlation coefficient r = –0.093; p = 0.522).Conclusions. Maternal ferritin concentrations above 30 ng/ml in the second trimester can serve as a marker for preterm delivery. However, since no correlation was found between serum ferritin concentrations and gestational age at birth, the routine use of serum ferritin as a marker for preterm delivery warrants further investigation.

Hepatic iron deposition on MR imaging in patients with chronic liver disease: correlation with serial serum ferritin concentration.

To evaluate the relationship between magnetic resonance (MR) imaging grading of iron deposition and serial serum ferritin concentration in patients with chronic viral liver diseases. In 80 patients with viral hepatitis and cirrhosis, MR images including T2*-weighted gradient echo images (echo time > or = 6.5 ms) were reviewed. The grades of parenchymal iron deposition and iron-containing nodules in the liver and spleen and the liver-to-muscle and spleen-to-muscle signal intensity ratios were compared with the most recent, the mean, the lowest, and the highest values from all available serum ferritin levels. The serum ferritin concentration was significantly correlated with the grades of iron deposition in liver and spleen and with the grades of iron-containing nodules seen on MR images (p < 0.05). Liver-to-muscle signal intensity ratio was weakly correlated with the ferritin concentrations. Among categories of ferritin concentration, correlation with MR grades was highest for mean ferritin concentration (r = 0.487, p < 0.001). MR imaging grades of hepatic iron and siderotic nodules correlate with serum ferritin, especially with the mean levels.

Changes in serum ferritin and other 'acute phase' proteins following major surgery.

We have measured ferritin concentrations in healthy women, and ferritin, C-reactive protein, iron and total iron-binding capacity in patients undergoing hysterectomy or major gastrointestinal surgery. Pre-operative serum ferritin concentrations in patients awaiting hysterectomy were significantly lower than those for patients awaiting gastrointestinal surgery and also lower than those for healthy women of similar age. Healthy women aged between 51 and 60 years had significantly higher ferritin levels than women aged 35-50 years. All patients studied showed large increases in serum ferritin and C-reactive protein concentrations after surgery and approximately similar decreases in iron and in total iron-binding capacity.

Effect of ascorbic acid deficiency on serum ferritin concentration in patients with beta-thalassaemia major and iron overload.

The incidence of ascorbic acid (AA) deficiency and its effect on serum ferritin concentration relative to body iron stores was studied in 61 unchelated patients with beta-thalassaemia major. Thirty-nine (64%) of patients had subnormal leucocyte ascorbate concentrations without clinical evidence of scurvy. The lowest leucocyte ascorbate concentrations tended to occur in the most transfused patients. No correlation was found between the units transfused and serum ferritin concentration in the AA-deficient patients but a close correlation (r = +0.82; p less than 0.005) existed for the AA-replete group. Similarly a close correlation (r = +0.77; p less than 0.005) was obtained between liver iron concentration and serum ferritin in AA-replete patients but only a weak correlation (r = +0.385; p less than 0.025) existed for the AA-deficient group. When AA-deficient patients were treated with ascorbic acid, serum iron and percentage saturation of iron binding capacity rose significantly; serum ferritin rose in 13 of 21 patients despite the simultaneous commencement of desferrioxamine therapy. In contrast all three measurements tended to fall in AA-replete patients with ascorbic acid and desferrioxamine therapy. Thus, AA deficiency is commonly present in beta-thalassaemia patients with iron overload and may give rise to inappropriate serum ferritin concentrations in relation to body iron stores.

Hepatic and serum ferritin concentrations in patients with idiopathic hemochromatosis

Hepatic iron and ferritin concentrations have been measured in needle biopsy specimens from patients with idiopathic hemochromatosis and from patients with other liver diseases. There was an excellent correlation between liver iron and ferritin concentrations in patients with miscellaneous liver diseases, but this was not found for the patients with hemochromatosis either before or after treatment. The proportion of liver iron bound to ferritin was lower in treated and untreated hemochromatosis than in the other patients. This probably reflects the formation of increasing amounts of hemosiderin with increasing iron deposition. Three patients in the early stage of idiopathic hemochromatosis were studied. These patients had high concentrations of hepatic iron and ferritin, but had serum ferritin concentrations within, or just above, the normal range. These results suggest that, in the early stage of hemochromatosis, there is no failure of ferritin synthesis in the liver and that normal levels of serum ferritin are present either because the total body iron content is within the normal range or because the liver parenchymal cells are not, in the absence of liver damage, an important source of plasma ferritin.

Effect of surgery on serum ferritin concentration in patients with breast cancer.

Effect of surgery on serum ferritin concentration in patients with breast cancer.