The expression levels of TNF-α and IL-6 in tumor tissues and change of serum ferritin concentration in patients with intracranial aneurysm and its clinical significance

Abstract

Objective To investigate the expression levels of tumor necrosis factor alpha (TNF-α), interleukin-6(IL-6) and the change of serum ferritin in patients with intracranial aneurysm and its clinical significance. Methods 22 patients with intracranial aneurysm and 16 cases of traumatic brain injury who recevied operation in Department of Neurosurgery in Quzhou People's Hospital from Jan.2014 to Jan.2015 were enrolled as observation group and control group.The intracranial aneurysm tissues and normal cerebral vascular tissues were collected respectively to detect the situation of inflammatory cell infiltration, and the expression of TNF-α and IL-6 was detected by HE staining and immunohistochemical staining.The serum was collected on hospitalized, postoperative 3 days and postoperative 7 days to detect serum ferritin. Results The positive cells were observed in the observation group after immunohistochemical staining, in which the expression levels of TNF-α[(0.194±0.074) vs.(0.135±0.047), t=2.799]and IL-6[(0.152±0.057) vs.(0.103±0.028), t=3.494]were significantly higher than those in the control group(P=0.008, 0.001). The serum ferritin level in the observation group was significantly higher than that in the control group at postoperative 3d[(232.25±105.26)ng/mL vs.(169.51±66.24)ng/mL, t=2.097]and postoperative 7d[(263.39±114.73)ng/mL vs.(166.57±73.71)ng/mL, t=2.955](P=0.043, 0.005). The difference of serum ferritin on different day in the observation group also was statistically significant(F=8.625, P=0.003). Conclusion The expression levels of TNF-α and IL-6 in intracranial aneurysms were high, which may be one of the important factors in the formation of intracranial aneurysms, and it provides an important reference of early prevention and drug treatment for patients with intracranial aneurysm.The serum ferritin is related to the rupture and hemorrhage of intracranial aneurysm, which can be used to judge prognosis and guide rational treatment, and worth further study to confirm. Key words: Intracranial aneurysm; Tumor necrosis factor-α; Interleukin-6; Serum ferritin