Abstract
Effect of surgery on serum ferritin concentration in patients with breast cancer.
Highlights
Serum ferritin concentration usually reflects body iron stores in patients with iron deficiency and overload (Addison et at., 1972), the relationship is lost in a variety of pathological conditions
Blood was taken for measurement of serum ferritin concentration, no more than 3 days preoperatively, and postopertively on the 1st, 3rd, 5th, 8th and between the 21st and 35th days, samples for each postoperative sampling day were not obtained from every patient
Serum ferritin concentrations on each of the postoperative days were compared with the preoperative values using a t test for paired data
Summary
EFFECT OF SURGERY ON SERUM FERRITIN CONCENTRATION IN PATIENTS WITH BREAST CANCER. From the Departments of tHaematology and *Surgery, University of Liverpool, Royal Liverpool Hospital, Liverpool L69 3BX. Hyperferritinaemia without iron overload occurs with chronic inflammation (Zucker et al, 1974), in acute and chronic liver disease (Martin et al, 1971; Prieto et al, 1975) and in a variety of human malignancies including breast cancer (Buffe et al, 1968; Jones et al, 1973; Niitsu et al, 1975; Mori et al, 1975; Marcus & Zinberg, 1975), suggesting that serum ferritin may have a role as a tumour index substance In this respect, it has been suggested that measurement of serum ferritin concentration may be useful in the follow-up of patients with certain malignancies, to help assess residual tumour mass (Wahren et al, 1977).
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