Surface-enhanced Raman scattering (SERS), an offshoot of Raman spectroscopy, has emerged as a popular detection/diagnostic technique that enhances Raman signal significantly when the analyte is placed in the vicinity of plasmonic structures. The design of a resilient SERS-active substrate constituted of gold polygonal nano-patterns with varying number of corners on SiO2 substrate has been proposed in this work. Different polygonal structures (n = 3 to n = 10) have been optimized in this study, yielding high electric field enhancement; ≈ 109in near sidedmode and≈1010 in far sided mode. In terms of design parameters, the proposed SERS substrates are robust with a high degree of tolerance. In addition, it has been established that the proposed SERS-active substrates are reproducible, such that experimental findings can be replicated owing to the precise positioning of hot-spots. The proposed SERS substrate responds to several analytes, such as rhodamine B, nicotine with a high degree of sensitivity. The suggested SERS substrate can be fabricated employing contemporary nano-lithography techniques such as e-beam lithography (EBL), focused ion beam (FIB) lithography, etc. The proposed structures can be used in various applications including detection of explosive, biomolecules, narco-analysis, detection of food and water adulterants etc.