Feeling stress and anxious is a common experience among elderly people. These feelings are part of “defense mechanism” to better combat unusual situations or “adaptive behavior. There are many reasons triggered elderly people to be unrest and stressful such as losing a loved one which leads to chronic grief, ongoing illness, chronic pain, loneliness, adverse drugs reactions, physical or mental abuse or neglect, new social interactions, relocation, physical deficiency (e.g., poor vision or hearing) and nutritional deficiency. But when feeling stress and anxious becomes chronic and overwhelming it might affects daily activities, cognitive impairment and memory interferences, poor sleep, lack of energy or motivation, changes in appetite (weight loss or gain), and quality of life. These outcomes can end up with depression, self care neglect and losing social interest. Yet, older adults with anxiety disorders often undiagnosed and untreated. Moreover, in many cases older adults may not seek treatment because they do not feel comfortable to reveal or to admit this feeling. Physical exercises as treatment option: It is probably impossible to eliminate stress and anxiety, but one can learn to manage them. While there are variety of treatments for stress and anxiety reduction such as medication, cognitive behavior therapy, relaxation techniques, coping skills, recreational activities and family support, physical exercises may be the one most recommended by health care professionals and very successful to deal and to relieve stress and anxiety symptoms. In recent investigation done in my lab we measured the effects of exercise training on spatial behavior among old mice. Previously, anxiety as a function of insecurity or lack of self-control has been evaluated using various laboratory measures such as chemical changes in saliva, cortisol [1], blood levels of serotonin and norepinephrine, using physiological parameters of blood pressure, heart rate, cholesterol, oxidative stress and free radicals [2], or using behavioral factors such as sleeping and eating [3,4]. In our study the results indicated the beneficial effects of moderate exercise training on reducing anxiety-related behavior and triggering spatial behaviors in an Open Field Test (OFT). Rodents that lack a sense of security prefer markedly prolonged stays at the edges or corners of the open field arena [5] while staying in or moving to the center of the arena indicates confidence and less anxiety [6]. Increase in the amount and speed of locomotion in the OFT and the number of times the running mice entered the center of the arena indicate a sense of security and higher “sensory-motor inner pressure” [7] to