This study aims to assess the trends of dengue incidence and socio-demographic characteristics of reported dengue cases in Seremban district, Malaysia during the last decade. Secondary data on reported dengue cases during 2003-2011 were collected from the District Health Office, Seremban. Trend analysis was conducted to assess the status of dengue incidence and demographic distribution of the disease in the district. Annual incidence rates of the disease were also calculated and compared. The district experienced a total of 11,936 dengue infections during 2003-2011. It was found that majority of the reported cases were among the Malays (62%), followed by Chinese (17%) and Indians (15%). The age-specific incidence rate was highest in young adult and adult group (15-44 years), followed by middle-age group (45-59 years). The analysis also revealed that majority of the reported cases (on average, 79% per year) came from urban areas of the district which highlights the fact that dengue is still an urban public health problem in Seremban. The study findings provide the critical data and information on trends of dengue incidence and socio-demographic characteristics of reported dengue cases which might assist the public health authorities to achieve dengue mortality and morbidity reduction goals in the district.