Sequelae Of Trauma Research Articles

Conversion to Glaucoma After Ocular Trauma in Pediatric Patients

Background: The outcomes of pediatric glaucoma suspects with a history of ocular trauma remains unknown; we describe the rate of conversion to glaucoma of this population of patients at a research-intensive academic center. Methods: We conducted a retrospective case series of pediatric patients with a history of open- or closed-globe trauma who were being monitored as pediatric glaucoma suspects at the Wilmer Eye Institute between 2005 and 2016. Results: A total of 62 eyes from 62 patients with a history of ocular trauma were identified with a median age at presentation of 9.7 years (7.8 years) and a median follow-up of 2.7 (5.8 years). There were 29 eyes (46.8%) with open-globe injuries and 33 eyes (53.2%) with closed-globe injuries. A higher proportion of eyes that sustained closed-globe injuries were started on topical therapy for persistent ocular hypertension than eyes that sustained open-globe injuries (36.4% versus 10.3%, X2 = 5.6976, p = 0.017). Five eyes (8.1%) developed glaucoma during the follow-up period, all of which had a history of closed-globe injury (15.2%, X2 = 4.7794, p = 0.029). Four eyes of these eyes underwent glaucoma-related surgical intervention. Most eyes (3/5, 60%) that went on to develop post-traumatic glaucoma had undergone additional and/or concurrent intraocular surgical interventions to address sequelae of ocular trauma, such as traumatic cataract and retinal detachment. Conclusions: All eyes that developed glaucomatous damage or underwent glaucoma-related surgical intervention in this cohort of patients with a history of ocular trauma were those that had sustained close-globe injuries. No eyes that sustained open-globe injury progressed to glaucoma.

Indications for the Use of TMJ Prostheses in South America.

Since the 1960s, various surgical procedures have been developed to treat the temporomandibular joint (TMJ) disease, including stock or customized prostheses for severe TMJ diseases. Understanding the appropriate indications and timing for joint replacement is crucial for evaluating the prognosis of the treatment. This study sought to identify the indications for joint replacement surgery in three countries in Latin America and to determine characteristics associated with its surgical planning. The study was conducted by interviewing surgeons who performed surgery on patients using customized TMJ prostheses between 2022 and 2024 and who had surgical planning under the same protocol. Only preoperative information related to the indication and complementary procedures related to the customized prosthesis was used, comprising 133 subjects, 41 male subjects (30.82%) and 92 female subjects (69.17%), with significant differences. Degenerative TMJ disease presented the highest indication for replacement with 47 (35.33%) cases, followed by malformations with 26 (19.54%), ankylosis with 22 (16.54%), TMJ deformity by trauma sequelae with 20 (15.03%) and replacement by another joint prosthesis 18 (13.53%). We found a significant correlation between indications and the use of orthognathic surgery in some diseases (P<0.001). In 72.34% of subjects with degenerative disease, orthognathic surgery with bilateral prosthesis was indicated. In subjects with facial malformation, orthognathic surgery with unilateral prosthesis was indicated in 76.92%. We can conclude that female subjects are more common than male subjects in the treatment with TMJ replacement. TMJ prostheses presented the highest indication in degenerative TMJ disease, and they were significantly related to orthognathic surgery.

Blunt Force Trauma

Purpose. This case report describes the evidence-based work-up of blunt force ocular trauma that resulted in a zygomaticomaxillary fracture. Sequelae of blunt trauma, management, and referral for surgical consultation will be reviewed. Material and Methods. A patient presented for an eye examination following a referral from dentistry after receiving a computerized tomography (CT) scan that confirmed orbital fracture to rule out globe injury prior to maxillofacial surgery. The patient underwent a comprehensive dilated examination to evaluate vision, anterior and posterior segment structures. Results. The examination revealed a sub conjunctival hemorrhage and eyelid edema, with no other signs of ocular trauma. After the comprehensive examination, the patient was educated on the finding of a subconjunctival hemorrhage and was reassured regarding the self-limiting and benign nature of the condition. The patient was cleared for maxillofacial surgery and instructed to return to the clinic for refraction and to rule out any delayed sequelae of ocular trauma. Conclusion. Blunt force trauma to the eye can cause a host of ocular sequelae that may present as acute or delayed signs and symptoms. These sequelae can be managed by optometrists in hospital and outpatient settings. It is important to be aware of the potential long-term sequelae and how to treat, manage, or refer these patients. Reassurance is important when patients present with ocular signs that appear more alarming than they are. Education is imperative to preventing reoccurrence of trauma and to motivate the patient to remain compliant with the treatment plan.

Traumatic prepatellar quadriceps continuation injury in an elite cyclist

Injury to the prepatellar quadriceps continuation is a lesser recognized extensor mechanism injury when compared to the more commonly encountered quadriceps and patellar tendon injuries. We present a case of a traumatic injury to the prepatellar quadriceps continuation in an elite cyclist without injury to the adjacent patellar or quadriceps tendons. The magnetic resonance imaging findings depict the anatomy of the prepatellar structures in detail, as well as the sequelae of trauma. These include, but are not limited to partial or complete tearing, stripping and elevation of the anterior surface of the patella, and traumatic reactive prepatellar bursitis. Cyclists may be predisposed to injury to the prepatellar quadriceps continuation due to background overuse prepatellar friction syndrome, but as in our case, injury can also be the result of an acute traumatic insult. These injuries can be managed conservatively with physiotherapy and result in a good outcome.

American Football-associated Whiplash Maculopathy Presenting With Bilateral Bacillary Detachments: Case Report and Review of Literature.

Ocular trauma is a rare cause of bacillary layer detachments (BALAD). A case report was evaluated and a literature review was performed. A 15-year-old boy presented with bilateral scotomas after a routine American football tackle and was found to have bilateral BALADs. Inflammatory and infectious causes of BALAD were excluded, and he was diagnosed with whiplash maculopathy. Without intervention, the patient's visual acuity and macular anatomy rapidly improved. Novel indocyanine green angiography findings of this condition are reported. Bacillary detachments resulting from whiplash injuries generally resolve spontaneously with good visual outcomes. Even when other sequelae of trauma are not obvious, the presence of BALAD should prompt a targeted history around recent trauma including sports-associated whip-lash injuries. Patients with thicker choroids may be at increased risk of posterior segment sequalae from whiplash injury and choroidal status should be commented on in future reports. [Ophthalmic Surg Lasers Imaging Retina 2024;55:XX-XX.].

Abstract 171: A Hole In One: Using A Balloon Microcatheter To Delineate Rupture Point For High‐Flow Direct Carotid‐Cavernous Fistula, Followed By Scaffolding With Flow Diversion

Introduction Direct Carotid‐Cavernous fistulas (CC‐fistula) are a result of high flow arteriovenous shunt, typically sequelae of aneurysmal rupture, trauma or other etiologies. Numerous first line endovascular options exist, including vessel sacrifice and flow diversion. However, rupture/rent points in extremely high‐flow shunts may be difficult to characterize for treatment. We describe a case of a Barrow Type‐A Direct CC‐Fistula that arose secondary to ruptured ICA aneurysm and successfully treated with dual overlapping flow diverters as a scaffold for arterial access. Balloon microcatheter inflation was utilized to “roadmap” the point of rupture, allowing direct access to the cavernous sinus (CS) through this arterial defect. Case Report A 68‐year‐old woman with history of hereditary hemorrhagic telangiectasia and 7mm left cavernous ICA aneurysm presented with decreased alertness, inability to follow commands and left‐sided proptosis/chemosis. CTA revealed enlargement and intense enhancement of the left CS with prominence of adjacent venous structures concerning for CC‐fistula. Cerebral angiogram demonstrated brisk opacification of left greater than right CS with apparent wall defect of dorsal aspect of the genu at proximal left cavernous ICA in a blowout configuration. There was marked opacification of petrosal sinuses, internal jugular veins and reflux antegrade into cortical cyst/dilated superior ophthalmic veins with faint opacification of left MCA territory and even less opacification of left ACA‐A1 segment. 3‐D rotational angiography was performed with suboptimal visualization related to degree of arteriovenous shunting. To better accurately assess the source of extravasation, a balloon microcatheter was advanced and inflated under continuous fluoroscopy until adequate antegrade obstruction was noted followed by gentle hand‐injection through the proximal guide catheter. This revealed a carotid rent in the proximal carotid siphon at the site of known aneurysm. Using the roadmap imaging from the guide catheter, transvenous access was obtained through the rent/defect and transvenous coil embolization was performed until subsequent runs demonstrated increased intracranial arterial contrast transit. Persistent shunting warranted telescoping flow diversion over the defect after removal of the coiling catheter with 2x Pipeline Shield TM flow diverters (Medtronic). Subsequent angiogram revealed wide patency of overlapping pipeline embolization devices with significantly decreased CC‐fistula flow and preservation of intracranial artery circulation. The patient was eventually discharged to rehab and during follow‐up appointments noted no lasting neurologic symptoms. Follow up angiograms demonstrated successive occlusion and decreased shunting. Discussion Direct CC‐fistulas are often a consequence of traumatic tear in the carotid artery from skull base fracture, acceleration‐deceleration forces, iatrogenic injury from endovascular/trans‐sphenoidal interventions or cavernous carotid artery aneurysm rupture. This unique case illustrates a combination of techniques available to the practicing neurointerventionalist including the following: balloon microcatheter occlusion for angioarchitecture characterization, transarterial to venous access for cavernous sinus embolization, and final occlusion with scaffolding flow diverters.

Endolymphatic hydrops and cochlear synaptopathy after noise exposure are distinct sequelae of hair cell stereociliary bundle trauma

Endolymphatic hydrops, increased endolymphatic fluid within the cochlea, is the key pathologic finding in patients with Meniere’s disease, a disease of episodic vertigo, fluctuating hearing loss, tinnitus, and aural fullness. Endolymphatic hydrops also can occur after noise trauma and its presence correlates with cochlear synaptopathy, a form of hearing loss caused by reduced numbers of synapses between hair cells and auditory nerve fibers. Here we tested whether there is a mechanistic link between these two phenomena by using multimodal imaging techniques to analyze the cochleae of transgenic mice exposed to blast and osmotic challenge. In vivo cochlear imaging after blast exposure revealed dynamic increases in endolymph that involved hair cell mechanoelectrical transduction channel block but not the synaptic release of glutamate at the hair cell–auditory nerve synapse. In contrast, ex vivo and in vivo auditory nerve imaging revealed that synaptopathy requires glutamate release from hair cells but not endolymphatic hydrops. Thus, although endolymphatic hydrops and cochlear synaptopathy are both observed after noise exposure, one does not cause the other. They are simply co-existent sequelae that derive from the traumatic stimulation of hair cell stereociliary bundles. Importantly, these data argue that Meniere’s disease derives from hair cell transduction channel blockade.

Compensation for National Socialist Persecution as a Catalyst for a Paradigm Shift - A Contribution to the History of Psychiatry in the Early Federal Republic of Germany

After WW II, Holocaust survivors often faced negative assessments by German psychiatrists when claiming compensation for psychological damage, a fact that was met with criticism. This study examines how as a result the prevailing doctrine on trauma sequelae underwent a transformation. Academic contributions in German language from 1946 to 1969 are analyzed for their para-digmatic views on the etiology of mental disorders after war and Nazi persecution. Only a new generation of psychiatrists was able to develop more adequate psychotraumatological concepts by using anthropological and occasionally psychoanalytic theoretical elements. At the same time this also questioned the medically oriented concept of illness in psychiatry. Less the persistence of anti-Semitic sentiments but rather internal scientific reasons such as an unevidenced dogmatism obstructed the the advancement of science.

Recovery after neurologic injury in operative acetabular and pelvic fractures: Defining the natural history of foot drop

IntroductionDorsiflexion weakness, or footdrop, is a well-described sequela of high-energy acetabular and pelvic trauma, but little data exists describing the factors related to neurologic recovery and the timeline therein. An improved understanding of these factors would facilitate prognostication, patient education, and treatment decision-making. The aim of this study was to compare neurologic recovery between acetabular and pelvic fractures, delineate factors associated with recovery, and determine the expected timeline of recovery. MethodsA retrospective chart review was conducted at a level 1 tertiary referral center from 2000 to 2021 using CPT codes and keyword search functions to identify adult patients with neurologic injury in the setting of operative acetabular and/or pelvic ring trauma. Patients were included if they had documented, graded weakness not clearly explained by a concomitant injury (extremity or spine) following a pelvic/acetabular injury. Patients were followed to a minimum of 6 months follow-up or to neurologic recovery. Primary outcomes were the presence of motor recovery and time to initial and maximum recovery. The contributions of injury type and initial neurologic status were analyzed using logistic regression for impact on neurologic recovery. ResultsWe identified 121 patients with neurologic injury and resultant footdrop in the setting of an operative pelvic ring or acetabular fracture. From this cohort, 58 patients (47.9 %) demonstrated some degree of neurologic recovery in follow-up. There was no difference in recovery when comparing injury type (pelvis vs. acetabulum). Any motor function (including flicker) at time of initial evaluation was predictive of recovery (OR 6.18, [2.00 – 19.14]; p = 0.002). Initial neurologic function also correlated with more rapid recovery in comparison to patients with initial absent neurologic function both in time to initial recovery (56 days vs 107 days; p = 0.016) and time to maximum recovery (153 days vs 241 days; p = 0.027). ConclusionsThese results highlight the relatively poor prognosis for neurologic recovery in operative pelvic and acetabular injuries. Any initial neurologic function is predictive of likelihood of neurologic recovery and correlates with a more expedient neurologic recovery. Ultimately, this enables providers to better educate patients and facilitates decisions regarding further intervention.

Psychiatric Etiologies and Approaches in Altered Mental Status Presentations: Insights from Consultation Liaison Psychiatry.

Consultation liaison psychiatrists are frequently asked to evaluate patients with altered mental status (AMS). Psychiatrists have unique perspectives and approaches to care for confused patients, particularly optimizing facilitation of care and maintaining vigilance for diagnostic overshadowing. Psychiatrists also offer expertise in primary psychiatric illnesses that can overlap with AMS, and the most common etiology of AMS is delirium. In this article, we provide a consultation liaison psychiatrist perspective on AMS and related psychiatric conditions in addition to delirium. Manic and psychotic episodes have primary and secondary etiologies, with some symptoms that can overlap with delirium. Catatonia, neuroleptic malignant syndrome, and serotonin syndrome are potentially fatal emergencies, and require prompt index of suspicion to optimize clinical outcomes. Trauma sequelae, functional neurologic disorders, and dissociative disorders can present as puzzling cases that require psychiatric facilitation of care. Additionally, AMS is sometimes due to substance intoxication and withdrawal in the hospital. A nonstigmatizing approach to evaluation and management of delirium and AMS can ensure optimal patient care experiences and outcomes.

Secondary traumatization in refugee care—EMDR intervention for interpreters (STEIN): a study protocol for a quasi-randomized controlled trial

BackgroundBy the end of 2022, more than 100 million people worldwide fled their homes. Before, during and after their flight, refugees have high risk of experiencing traumatic events. Accordingly, around every third refugee is affected by posttraumatic stress disorder. For adequate mental health care, the service of interpreters is often urgently needed to overcome existing language barriers. However, repeated exposure with details of traumatic narratives, as experienced by interpreters, can be burdensome and can lead to trauma sequela symptoms in terms of secondary traumatic stress. Only few studies have examined the treatment of secondary traumatic stress to date. Based on the recommendations for the treatment of posttraumatic stress disorder with confrontational methods, this study was designed to evaluate the effectiveness of an eye movement desensitization and reprocessing (EMDR) intervention in a sample of interpreters working in refugee care suffering from secondary traumatic stress symptoms.MethodsTo evaluate the effectiveness of an EMDR intervention for the treatment of secondary traumatic stress symptoms, a quasi-randomized controlled trial using a waiting group design will be performed. Participants will be treated with a maximum of 6 sessions based on EMDR standard protocol. Primary outcome is the symptom load of secondary traumatic stress, assessed with the Questionnaire for Secondary Traumatization, while secondary outcomes comprise further symptom complexes such as PTSD due to self-experienced traumatic events, depression, anxiety, and somatization as well as quality of life, quality of professional life, and psychological wellbeing that will be assessed with the PDS, PHQ-9, GAD-7, SSD-12, SF-12, PROQOL-5, and WHO-5, respectively.DiscussionOur primary interest is to determine the efficacy of an EMDR intervention in interpreters affected by secondary traumatic stress, especially how many sessions are needed for significant symptom reduction. Change of associated symptom complexes and quality of life will be investigated. Reprocessing one’s own stressful experiences may also contribute to this, which is not the focus of the treatment but relevant to the EMDR protocol. This study aims to assess if EMDR could be an acceptable, effective, and time-efficient method for reducing work-related secondary traumatization.Trial registrationGerman Clinical Trials Register, DRKS00032092, registered 16 June 2023.

Calcific Myonecrosis of the Leg: A Clinical and Diagnostic Dilemma

Background: Calcific myonecrosis (CMN) is a rare condition, often considered to be a late sequela of antecedent trauma. Case Report: We describe here our experience in managing a 56-year-old male referred with a painless swelling on the lateral aspect of the left lower leg with a suspicion of a tumour. Results: Clinical and imaging features were classic of CMN. Conclusion: Clinical assessment, role of ultrasound scan in reaching a diagnosis and the management are highlighted.

SP7.6 - Incidence of hepatic pseudoaneurysm formation following blunt and penetrating abdominal trauma in the paediatric cohort: A 6-year retrospective analysis

Abstract Introduction Hepatic pseudoaneurysm (HPA) is a rare but potentially life-threatening sequelae of liver trauma. Little data exists in the literature in regards HPAs in paediatric patients. We aimed to determine the incidence and risk factors of HPA formation in children with blunt and penetrating liver trauma. Methods A retrospective analysis was performed on patients admitted to our institution under the age of 18, found to have liver injury on initial trauma protocoled CT imaging between 2017 &amp; 2022. Patients were identified from The Trauma Audit and Research Network (TARN) database. Data relevant to the study aims was collected. Results 34 patients were identified. (mean age 12 ± 5.4 years 76.5% male 23.5% female) 67.6% of patients suffered blunt injury (mean ISS 34.3 +/- 20.4 95% CI [25.4-43.1] median AAST 3) and 32.4% patients suffered penetrating liver injury (mean ISS 19.5 +/- 9.61 95% CI [12.6-26.4] median AAST 3) Four patients were excluded from further analysis due to loss of life from the primary injury. 18 patients (60%) underwent repeat CT. Of the 12 patients that did not have a repeat scan, 6 patients (50%) had a repeat USS at 6 weeks. follow up CT identified 4 HPAs (11.7%), of which two were treated with embolization. Conclusion HPA formation in paediatric liver trauma presents a significant clinical challenge. While the lack of standardised protocols poses a hurdle, a personalised approach informed by individual patient factors and the use of contrast enhanced ultrasound (CEUS) may optimise HPA detection while minimising radiation exposure.

Fears of stigma perceived from unit leaders for seeking psychological services for military sexual trauma sequelae is associated with suicide risk among male service members and veterans.

Fears of stigma perceived from unit leaders for seeking psychological services for military sexual trauma sequelae is associated with suicide risk among male service members and veterans.

Pilot Safety Study of a Microfabricated Device for Anterior Stromal Puncture to Treat Corneal Epithelial Disease in the Optical Axis.

Anterior stromal puncture is an inexpensive and widely used technique at the slit lamp to treat recurrent corneal erosions (RCE), common sequelae of corneal abrasions, trauma, and epithelial basement membrane dystrophies (EBMDs). The purpose of this study was to determine safety of a novel anterior stromal micropuncture device (termed a "plexitome") for use in the optical axis of the cornea. We performed an IRB-approved clinical pilot study on 45 patients with diverse corneal pathologies to determine the safety of the plexitome device and examined corneal healing responses clinically for a minimum of 30 days after treatment. Follow on efficacy data was collected for treated patients with RCE.Micropuncture treatment was performed either through loose epithelial tissue or after debridement using a cotton tip at the slit lamp. After "imprinting," patients were treated with topical medications including antibiotics, hypertonic saline/ointment, bandage contact lenses, and/or patching according to the treating physician's routine care for the condition. Micropuncture using the "plexitome" device did not create visible scars in the corneal stroma of the 45 patients treated and followed for at least 30 days. Photographic evidence of imprinting was seen at in 1 patient at 30 days. There were no significant adverse events associated with treatment. Micropuncture of the cornea using the "plexitome" device does not create optically evident anterior stromal scarring after treatment. Micropuncture using the device may be an effective way of treating RCE and other corneal manifestations of EBMD in the optical axis, which is not currently possible using standard anterior stromal puncture methods.

"Estuvimos en una hielera": Migration trauma and detainment among newcomer Latinx adolescents.

Exposure to migration-related traumatic events may increase the risk for immediate distress upon arrival and complex trauma following resettlement. Record numbers of Latinx immigrant youth are being held in detainment facilities at the border and around the country. However, little research examines the psychological sequelae of trauma among detained youth. Through addressing these gaps, this article can inform policies and best practices that adhere to human rights and foster acculturative adjustment. This article describes community collaborative research with newcomer Latinx adolescents enrolled in public high schools. Study 1 (n = 127) used quantitative data to examine whether time in detention and trauma exposure were associated with psychosocial adjustment. Study 2 (n = 46) used qualitative data to explore the lived experiences of detainment and related trauma. Study 1 results found that over a third of participants had been detained for at least 4 weeks (36%) and nearly half the participants witnessed or experienced a traumatic event (46%). Although time in detainment was not related to internalizing or externalizing symptoms, exposure to trauma was associated with more internalizing and more externalizing symptoms. Study 2 results illustrated specific detainment-related stressors, including multiple relocations, inhumane conditions, legal concerns, and family separation, as well as complex psychological sequelae, both during detainment and after resettlement, as well as some satisfactory experiences. Results contribute new understanding of the unique experiences of immigration detainment and its psychological sequelae and can inform legal, policy, and educational practices that directly impact recently resettled Latinx youth. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Esthetic reconstruction of traumatic defects by plastic surgery

The primary goal is preservation of the affected extremity, which can be associated with limitations in tasks relevant for daily life and adistorted body image caused by the original trauma. Therefore, asecondary goal is to reduce the trauma sequelae. For an esthetic outcome the choice of flap surgery is crucial. Factors such as tissue thickness, skin color, and hair covering need to be considered. The flap should blend seamlessly with the tissue surrounding the defect. The localization and closure of the defect are also important. The flaps undergo vascular, lymphatic and trophic postoperative changes caused by the so-called autonomization. Measures, such as compression therapy reshape the microcirculation and result in volume reduction of the transplant. It is important to preoperatively educate patients about this process. After completion of the conditioning surgical thinning procedures are available for persistent unattractive results, e.g., open surgical and liposuction techniques. Microsurgical defect coverage of traumatic skin and soft tissue defects is acompromise between limb preservation and functionality. In cases of missing local soft tissue, secure closure of the defect should be prioritized but initial esthetic considerations should also influence the choice of tissue transplant. Patients should be informed early about the development of the flap surgery and undergo postoperative compression therapy for conditioning. Secondary operative corrections are also possible.

I am the psychiatric patient and the psychiatric patient is me: Retelling a lived experience narrative of professional sexual misconduct.

WHAT IS KNOWN ON THE SUBJECT?: Professional sexual misconduct is the name given to the phenomenon of healthcare providers crossing sexual boundaries with their patients. It is comprised of a range of behaviors from comments to unwanted touching and even rape. The exact incidence is unknown, but estimates have been made. These abuses are thought to be underreported. The applicable reporting processes are problematic. Trauma-informed care presupposes knowledge of various types of trauma, and this is one type. Traua-informed care places emphasis on healthcare systems and healthcare providers' avoidance of retraumatizing patients who disclose any type of trauma, including sexual violence. WHAT THE PAPER ADDS TO EXISTING KNOWLEDGE?: This paper adds one narrative experience of a sexual assault perpetrated by the writer's colleague psychiatrist. It can be viewed as a cautionary tale about horizontal violence against nurses. This narrative discusses how one traumatic event can mushroom into chronic traumatic sequelae when disclosure re-traumatizes. WHAT ARE THE IMPLICATIONS FOR PRACTICE?: Increased knowledge of this type of sexual violence may help those who have suffered it. As psychiatry is among the healthcare fields who regularly screen patients for trauma, it is imperative that the psychiatric workforce gain familiarity with trauma-informed responses to avoid re-traumatizing patients who disclose sexual violence.

Treatment of sequelae of trauma

Treatment of sequelae of trauma

CD248 interacts with ECM to promote hypertrophic scar formation and development

Hypertrophic scar (HS) presents a significant clinical challenge, frequently arising as a fibrotic sequela of burn injuries and trauma. Characterized by the aberrant activation and proliferation of myofibroblasts, HS lacks a targeted therapeutic approach to effectively reduce this dysregulation. This study offers novel evidence of upregulated expression of CD248 in HS tissues compared to normal skin (NS) tissues. Specifically, the expression of CD248 was predominantly localized to α-SMA+-myofibroblasts in the dermis. To explain the functional role of CD248 in dermal myofibroblast activity, we employed a targeted anti-CD248 antibody, IgG78. Both CD248 intervention and IgG78 treatment effectively suppressed the proliferative, migratory, and ECM-synthesizing activities of myofibroblasts isolated from HS dermis. In addition, IgG78 administration significantly attenuated HS formation in an in vivo rabbit ear model. The LC/MS analysis coupled with co-immunoprecipitation of HS tissues indicated a direct interaction between CD248 and the ECM components Fibronectin (FN) and Collagen I (COL I). These findings collectively suggest that CD248 may function as a pro-fibrotic factor in HS development through its interaction with ECM constituents. The utilization of an anti-CD248 antibody, such as IgG78, represents a promising novel therapeutic strategy for the treatment of HS.