In this paper, two different computational methodologies are implemented to predict the behavior of a strain sensor based on a microstrip antenna. The first approach attributes changes in resonance frequency only to variations in patch length produced by an applied axial tensile loading. In the second approach, a Multiphysics model has used to couple the mechanical and electromagnetic phenomena. Thus, this model considers the characteristics of the variations in the antenna structure and the dielectric substrate that is used. Additionally, this study describes the fabrication of such a sensor and an experimental validation in which the rectangular microstrip antenna was subjected to tensile forces. The obtained results gave a good convergence between simulation results and measurements, so the proposed models clearly describe the behavior of the strain sensor. Nevertheless, the sensor analyzed here achieves a sensitivity of −2.847 kHz/ <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${\mu } {\varepsilon }$ </tex-math></inline-formula> , high repeatability, and its resolution depends on the implemented vector network analyzer. Moreover, the proposed sensor operates in an ISM band and, as a result, it can be integrated with commercial electronic devices. This article aims to lay the foundation for the future use of patch antenna sensors for structural health monitoring by introducing a computational methodology that can predict the behavior of this kind of sensor.