Sensitive Periods Of Development Research Articles

Fear learning, avoidance, and generalization are more context-dependent for adults than adolescents

This study examined developmental differences in contextual and perceptual generalization of fear and avoidance learning. Adults (N = 39) and adolescents (N = 44) completed differential fear acquisition wherein each conditional stimulus (CS) appeared in a background context. In the dangerous context, one stimulus (CS+) predicted an aversive sound, and the other stimulus (CS-) did not. In the safe context, the aversive sound was never administered with either CS. During fear generalization, participants were presented with three generalization stimuli (GSs), ranging on a perceptual continuum from threat to safety stimuli, in both contexts. Participants then completed avoidance conditioning and avoidance generalization phases, allowing them to actively avoid the upcoming aversive sound by pressing an avoidance button. Developmental differences emerged in threat perception, physiological arousal, avoidance behavior, and eye movements during contextual fear learning and generalization. Adolescents showed less discrimination between stimuli and contexts than adults, resulting primarily from their elevated fear responses to safety and generalized stimuli. Developmental differences in fear learning should be further explored in future research, as they could explain why adolescence is a sensitive developmental period for anxiety.

DNA methylation changes induced by prenatal toxic metal exposure: An overview of epidemiological evidence.

Accumulating evidence suggests that exposure to unfavorable conditions early in life can substantially contribute to the risk of chronic disorders later in life (‘developmental programming’ phenomenon). The mechanistic basis for this phenomenon remains poorly understood so far, although epigenetic mechanisms such as DNA methylation, histone modifications and microRNA-mediated gene regulation apparently play a crucial role. The key role of epigenetic modifications triggered by unfavorable environmental cues during sensitive developmental periods in linking adverse early-life events to later-life health outcomes is evident from a large body of studies, including methylome-wide association studies and research of candidate genes. Toxic metals (TMs), such as heavy metals, including lead, chromium, cadmium, arsenic, mercury, etc., are among environmental contaminants currently most significantly impacting human health status. Since TMs can cross the placental barrier and accumulate in fetal tissues, exposure to high doses of these xenobiotics early in development is considered to be among important factors contributing to the developmental programming of adult-life diseases in modern societies. In this mini-review, we summarize epidemiological findings indicating that prenatal TM exposure can induce epigenetic dysregulation, thereby potentially affecting adult health outcomes.

Соматометрическая оценка недоношенных детей в сенситивный период развития

Aim. To establish the features of somatometric maturity of premature infants in the sensitive period of development. Material and methods. The somatometric method of the study was used to examine 124 children aged 7 years, who were divided into control and main groups. The control group included boys and girls with a history of traditional gestation periods. Boys and girls of the main group had all the signs of anatomical and physiological prematurity. Somatometric studies were carried out according to the traditional method, which included measurements of the overall dimensions of the body. On the basis of somatometric indicators, the indices of proportionality and harmony of the physique were calculated. The body types of children were determined according to the recommendations of V. G. Nikolaev (2007). To perform calculations of individual components of body weight, the manual of E. G. Martirosov (2010). Results. Somatometric studies have established sexual and intergroup differences in the physique of children aged 7 years. The analysis of the obtained data revealed the following feature: the longitudinal, transverse and girth dimensions in children of the control group are characterized by a significantly high increase by the age of 7. In children of the main group, the value of somatometric indicators is significantly lower, which is reflected in the lower massiveness and strength of the body of children of this group. It can be assumed that somatometric measurements revealed the features of growth processes in the physical development of children of the main and control groups. Somatometric studies can serve as objective criteria for the physical health of children and allow a more differentiated approach to the assessment of growth processes, as well as to predict possible deviations in a timely manner. Our study showed that the component composition of body weight has a significant impact on the formation of somatotypological features that reflect the degree of reactivity and resistance of the body of children at certain stages of development. The magnitude of endomorphy, mesomorphy and ectomorphy is characterized by sexual and intergroup differences that have a significant impact on the body shape and strength of the physique. Conclusion. Somatometric studies of the body of children aged 7 years allowed us to establish the features of growth processes in children of the main and control groups, which represent the norm of a biological reaction aimed at the optimal development of the child’s body. The revealed features in the morphofunctional status of children have established the mechanisms of compensatory and adaptive reactions that contribute to the formation of a certain morphotype. The structural and functional specificity of children is determined, which provides a certain reactivity and resistance of the body at the age of 7 years. Somatometric differences in the physical status of children are an objective criterion for the sanitary and hygienic well-being of the younger generation, and the data obtained allow us to identify deviations in a timely manner and carry out corrective measures.

Penggunaan Gadget pada Anak: Hubungan Pengawasan dan Interaksi Orang Tua terhadap Perkembangan Bicara dan Bahasa Anak

Lack of supervision on gadgets can affect children's speech and language development, especially without interaction with parents. This study aimed to analyze the relationship between parental supervision and interaction with gadgets in children aged 4-5 years with the risk of speech and language development delays. The method used in this research is observational analytic. In analyzing the data, this study uses non-parametric statistical test Chi Square. The results of this study found that most respondents with speech and language development results are at risk of being late, rarely get supervision from their parents when using gadgets, namely, 23 respondents (79.31%), and most of the respondents' parents also said they did not interact when their children were using gadgets. gadgets as many as 23 respondents (79.31%). So that we get the results that there is a relationship between supervision (p value 0.001 < 0.05) and interaction (p value 0.000 < 0.05) of parents and children when using gadgets with children's speech and language development. Supervision and parental interaction on the use of gadgets in children are very important, considering the age of 4-5 years is included in the golden age where this period is a very sensitive developmental period because it will affect the future development of children. The findings in this study are expected to provide implications for parents to be able to increase supervision and interact with the use of gadgets in children.

Perineuronal nets in HVC and plasticity in male canary song.

Songbirds learn their vocalizations during developmental sensitive periods of song memorization and sensorimotor learning. Some seasonal songbirds, called open-ended learners, recapitulate transitions from sensorimotor learning and song crystallization on a seasonal basis during adulthood. In adult male canaries, sensorimotor learning occurs each year in autumn and leads to modifications of the syllable repertoire during successive breeding seasons. We previously showed that perineuronal nets (PNN) expression in song control nuclei decreases during this sensorimotor learning period. Here we explored the causal link between PNN expression in adult canaries and song modification by enzymatically degrading PNN in HVC, a key song control system nucleus. Three independent experiments identified limited effects of the PNN degradation in HVC on the song structure of male canaries. They clearly establish that presence of PNN in HVC is not required to maintain general features of crystallized song. Some suggestion was collected that PNN are implicated in the stability of song repertoires but this evidence is too preliminary to draw firm conclusions and additional investigations should consider producing PNN degradations at specified time points of the seasonal cycle. It also remains possible that once song has been crystallized at the beginning of the first breeding season, PNN no longer play a key role in determining song structure; this could be tested by treatments with chondroitinase ABC at key steps in ontogeny. It would in this context be important to develop multiple stereotaxic procedures allowing the simultaneous bilateral degradation of PNN in several song control nuclei for extended periods.

Complex Housing, but Not Maternal Deprivation Affects Motivation to Liberate a Trapped Cage-Mate in an Operant Rat Task.

Early life environment influences the development of various aspects of social behavior, particularly during sensitive developmental periods. We studied how challenges in the early postnatal period or (early) adolescence affect pro-social behavior. To this end, we designed a lever-operated liberation task, to be able to measure motivation to liberate a trapped conspecific (by progressively increasing required lever pressing for door-opening). Liberation of the trapped rat resulted either in social contact or in liberation into a separate compartment. Additionally, a condition was tested in which both rats could freely move in two separate compartments and lever pressing resulted in social contact. When partners were not trapped, rats were more motivated to press the lever for opening the door than in either of the trapped configurations. Contrary to our expectations, the trapped configuration resulted in a reduced motivation to act. Early postnatal stress (24 h maternal deprivation on postnatal day 3) did not affect behavior in the liberation task. However, rearing rats from early adolescence onwards in complex housing conditions (Marlau cages) reduced the motivation to door opening, both in the trapped and freely moving conditions, while the motivation for a sucrose reward was not affected.

Possible Consequences of Social Isolation For Children During The Pandemic Process: A Model Proposal

The aim of the present study is to review the existing literature on possible consequences of social isolation for children and propose a model that supports preschool children’s cognitive, social, emotional and physical development, who have been living their daily lives under social isolation conditions for a period of around 3 months in Turkey and who are likely to be exposed to new conditions of the normalization process where social distancing is recommended by health authorities. To help achieve this goal, a mobile application with a software feature such as a mobile timer and model reminder, a functional website and activities are designed to be integrated into the model by treating them as components of a systematic process called PEDAM (Pedagogical Support Assistance Model). The primary limitation of this study is that the proposed model has not yet been tested in an experimental, pre-test/post-test control group design or in a large sample. The main reason why it has not been applied experimental or long-term empirical research design in this study is that there is still a risk of transmission of COVID-19 for both children and adults. A second reason has to do with the necessity and responsibility to taking immediately initiative and action for the children who are in critical and sensitive periods of development. PEDAM is a model to ensure that parents have access to appropriate content and to control the content systematically, using only materials and physical activities whose positive effects are supported by existing researches.It is believed that PEDAM can give researchers from different disciplines an idea to design other applications for the planning of the Covid 19 pandemic process. Keywords: Covid 19, Social Isolation, Preschool Children, Model Suggestion

Testing whether implicit emotion regulation mediates the association between discrimination and symptoms of psychopathology in late childhood: An RDoC perspective.

Discrimination has been associated with adverse mental health outcomes, though it is unclear how early in life this association becomes apparent. Implicit emotion regulation, developing during childhood, is a foundational skill tied to a range of outcomes. Implicit emotion regulation has yet to be tested as an associated process for mental illness symptoms that can often emerge during this sensitive developmental period. Youth aged 9-11 were recruited for the Adolescent Brain Cognitive Development (ABCD) study. Associations between psychotic-like experiences, depressive symptoms, and total discrimination (due to race, ethnicity, nationality, weight, or sexual minority status) were tested, as well as associations with implicit emotion regulation measures (emotional updating working memory and inhibitory control). Analyses examined whether associations with symptoms were mediated by implicit emotion regulation. Discrimination related to decreased implicit emotion regulation performance, and increased endorsement of depressive symptoms and psychotic-like experiences. Emotional updating working memory performance partially mediated the association between discrimination and psychotic-like experiences, while emotional inhibitory control did not. Discrimination and implicit emotion regulation could serve as putative transdiagnostic markers of vulnerability. Results support the utility of using multiple units of analysis to improve understanding of complex emerging neurocognitive functions and developmentally sensitive periods.

Within-person changes in basal cortisol and caregiving modulate executive attention across infancy.

One pathway by which environments of socioeconomic risk are thought to affect cognitive development is through stress physiology. The biological systems underpinning stress and attention undergo a sensitive period of development during infancy. Psychobiological theory emphasizes a dynamic pattern of context-dependent development, however, research has yet to examine how basal cortisol and attention dynamically covary across infancy in ecologically valid contexts. Thus, to address these gaps, we leveraged longitudinal, multilevel analytic methods to disentangle between- from within-person associations of hypothalamic-pituitary-adrenal (HPA) axis activity and executive attention behaviors across infancy. We use data from a large longitudinal sample (N = 1,292) of infants in predominantly low-income, nonurban communities at 7-, 15-, and 24-months of age. Using multilevel models, we investigated longitudinal associations of infant attention and basal cortisol levels and examined caregiving behaviors as moderators of this relationship. Results indicated a negative between- and within-person association between attention and cortisol across infancy and a within-person moderation by caregiver responsiveness. In other words, on the within-person level, higher levels of cortisol were concomitantly associated with lower infant attention across the first 2 years of life. However, variation in the caregiver's level of responsiveness either buffered or sensitized the executive attention system to the negative effects of physiological stress.

Tendency towards violence and social roles: a descriptive study among high school students in Turkey

Background: Violence affects more than half of women worldwide and the perception of social roles has a significant role in this. Adolescence is a sensitive developmental period in the life of an individual. It is therefore important to understand the perception of violence and change the acceptance of violence among adolescents. Aims: To address the experiences that adolescents had with violence and its relationship with attitudes towards women. Methods: This descriptive study, comprising 2321 high school students, was conducted in Izmir, Turkey, between May and August 2015. We used a questionnaire to collect data on sociodemographic information and the perceptions that adolescents have of violence. The Violence Tendency and Attitudes Towards Women Scales were applied to show the perceptions of adolescents of social roles. Results: One third of the adolescents reported that they were exposed to some kind of violence. More than half had witnessed violence against their family members, relatives, or close friends. Conservative and traditional attitudes towards women were associated with a higher tendency towards violence among adolescents. Conclusions: To end violence against women, public health actions should focus on the young population and their representation of social roles

Racial and Economic Adversity Differences in Stress Markers and Immune Function Among Urban Adolescents.

Exposure to racism and associated adversities, such as poverty, is hypothesized to contribute to racial inequities in health via stress and immune pathways. Furthermore, the effects of adversity may be more salient during sensitive developmental periods. Our study examined racial differences in stress and immune biomarkers during adolescence and the effects of exposure to economic adversity at distinct developmental time periods and cumulatively in accounting for potential racial differences. Secondary analysis of the Adolescent Health and Development in Context study was conducted. Data were derived from self-administered surveys; interviews; smartphone-based, geographic-explicit ecological momentary assessment; stress biomarkers (evening salivary cortisol over six nights and hair cortisol); and immune biomarkers (salivary shedding of Epstein-Barr virus [EBV] DNA among EBV-positive adolescents). Current socioeconomic status measures included annual household income and caregiver education. Caregivers also reported experiences of bankruptcy, difficulty paying bills, receipt of food stamps/Supplemental Nutrition Assistance Program/electronic benefit transfer, and job loss when the child was of ages birth-5 years, 6-10 years, and 11 years or older. An affirmative response to any item was defined as exposure to economic adversity for that developmental time period (yes/no). A cumulative economic adversity measure was calculated as the sum of exposures across developmental periods (0 = never exposed to 3 = exposed across all time periods). Descriptive and multivariable regression analyses were conducted, accounting for covariates. Black/African American adolescents had higher salivary cortisol concentration, higher hair cortisol concentration, and an increased odd of salivary shedding of EBV DNA compared to White adolescents. Racial differences were not attenuated by the current socioeconomic status or economic adversity (developmental period or cumulatively). Our study provides evidence that stress and immune biomarkers differ by race as early as adolescence and may be one pathway through which racism and associated adversities contribute to racial health inequities. Further research on the contribution of multiple adversities beyond poverty to racial inequities in physiological stress and health is critical for informing effective prevention and intervention efforts.

Prenatal androgen influences on the brain: A review, critique, and illustration of research on congenital adrenal hyperplasia.

Sex hormones, especially androgens, contribute to sex and gender differences in the brain and behavior. Organizational effects are particularly important because they are thought to be permanent, reflecting hormone exposure during sensitive periods of development. In human beings, they are often studied with natural experiments in which sex hormones are dissociated from other biopsychosocial aspects of development, such as genes and experiences. Indeed, the greatest evidence for organizational effects on sex differences in human behavior comes from studies of females with congenital adrenal hyperplasia (CAH), who have heightened prenatal androgen exposure, female-typical rearing, and masculinized toy play, activity and career interests, spatial skills, and some personal characteristics. Interestingly, however, neuroimaging studies of females with CAH have revealed few neural mechanisms underlying these hormone-behavior links, with the exception of emotion processing; studies have instead shown reduced gray matter volumes and reduced white matter integrity most consistent with other disease-related processes. The goals of this narrative review are to: (a) describe methods for studying prenatal androgen influences, while offering a brief overview of behavioral outcomes; (b) provide a critical methodological review of neuroimaging research on females with CAH; (c) present an illustrative analysis that overcomes methodological limitations of previous work, focusing on person-specific neural reward networks (and their associations with sensation seeking) in women with CAH and their unaffected sisters in order to inform future research questions and approaches that are most likely to reveal organizational hormone effects on brain structure and function.

The effects of early-life immune activation on microglia-mediated neuronal remodeling and the associated ontogeny of hippocampal-dependent learning in juvenile rats

Many neurodevelopmental disorders and associated learning deficits have been linked to early-life immune activation or ongoing immune dysregulation (Laskaris et al., 2016; O’Connor et al., 2014; Frick et al., 2013). Neuroscientists have begun to understand how the maturation of neural circuits allows for the emergence of cognitive and learning behaviors; yet we know very little about how these developing neural circuits are perturbed by certain events, including risk-factors such as early-life immune activation and immune dysregulation. To answer these questions, we examined the impact of early-life immune activation on the emergence of hippocampal-dependent learning in juvenile male and female rats using a well-characterized hippocampal-dependent learning task and we investigated the corresponding, dynamic multicellular interactions in the hippocampus that may contribute to these learning deficits. We found that even low levels of immune activation can result in hippocampal-depedent learning deficits days later, but only when this activation occurs during a sensitive period of development. The initial immune response and associated cytokine production in the hippocampus resolved within 24 h, several days prior to the observed learning deficit, but notably the initial immune response was followed by altered microglial-neuronal communication and synapse remodeling that changed the structure of hippocampal neurons during this period of juvenile brain development. We conclude that immune activation or dysregulation during a sensitive period of hippocampal development can precipitate the emergence of learning deficits via a multi-cellular process that may be initiated by, but not the direct result of the initial cytokine response. Significance StatementMany neurodevelopmental disorders have been linked to early-life immune activation or immune dysregulation; however, very little is known about how dynamic changes in neuroimmune cells mediate the transition from normal brain function to the early stages of cognitive disorders, or how changes in immune signaling are subsequently integrated into developing neuronal networks. The current experiments examined the consequences of immune activation on the cellular and molecular changes that accompany the emergence of learning deficits during a sensitive period of hippocampal development. These findings have the potential to significantly advance our understanding of how early-life immune activation or dysregulation can result in the emergence of cognitive and learning deficits that are the largest source of years lived with disability in humans.

Evidence and Implications From a Natural Experiment of Prenatal Androgen Effects on Gendered Behavior

Sex and gender are key to people’s lives, and are the focus of scientific and popular interest and controversy. Sex-related psychological characteristics reflect more than socialization; they are influenced by sex hormones present during sensitive periods of development, particularly androgens that are present prenatally. Studies of females with congenital adrenal hyperplasia (CAH) show how prenatal androgens affect behavior across the life span; these hormones have large effects on interest and engagement in gendered activities, moderate effects on spatial abilities, and relatively small (or no) effects on gender identity, gender cognitions, and gendered peer involvement. In addition to showing the complexity of androgens’ effects on gendered behavior, studies of females with CAH provide an opportunity to test theories of gender development, gain insight into how nature and nurture work together, and examine mechanisms of development. The implications of this work have often been misunderstood, so we consider what it means—and does not mean—for biology to influence gender-related behavior.

Applicability of the German Food Based Dietary Guidelines for Infancy to Estimate Exposure to Substances in Food – The Example of Erucic Acid

ObjectivesThe objective of this study was to use the recommended total daily food amounts of the German ‘Dietary Scheme for the first year of life’ (for the first time) to calculate the potential exposure of substances in the infant diet from a public health perspective. Erucic acid was taken as a concrete example, because the European Food Safety Agency (EFSA) recently issued a Tolerable Daily Intake (TDI) for erucic acid with a special note that vulnerable groups, especially young children, may be particularly at risk of exceeding the TDI. MethodsThe age of about 1 month with the highest consumption per kg body weight was chosen for scenarios for the phase of exclusive milk feeding, the age of about 8 months for the CF phase. Principle of calculation was: erucic acid exposure = food consumption volume per kg bodyweight per day x erucic acid concentration in food (from European studies for breastmilk, EFSA food samples for formula, current German market analysis for rapeseed oil, EU food law). We calculated 6 scenarios for the milk phase (4 formula-feeding, 2 breastfeeding) and 8 scenarios for the CF phase (5 CF + formula-feeding, 3 CF + breastfeeding). ResultsOut of the 14 scenarios, only 3 resulted in exposures in the safe range below the TDI (range 4.4.– 6.0 mg/kg BW). All scenarios assuming either high consumption (p95) or high concentration led to high exceedances of the TDI (range 7.5–26.2 mg/kg BW), especially when using maximum values of EU law for formula or vegetable oils (33.6 and 43.2 mg/kg BW respectively). ConclusionsThe Dietary Scheme proved to be a suitable frame to calculate the potential exposure of substances in foods forming the daily infant diet. The results give cause for concern, as the calculated high exposure to erucic acid in the scenarios occurs during infancy as a particularly sensitive developmental period and results from the food-based recommendations as public health guidelines. Considering the scarcity of data, in addition to the proven low erucic acid concentrations in rapeseed oil in Germany, it is imperative to analyze the erucic acid content of mature breast milk and formula as well. Funding SourcesUnion for the Promotion of Oil and Protein Plants (UFOP, Berlin, Germany).

Digital Phenotyping of Emotion Dysregulation Across Lifespan Transitions to Better Understand Psychopathology Risk.

Ethical and consensual digital phenotyping through smartphone activity (i. e., passive behavior monitoring) permits measurement of temporal risk trajectories unlike ever before. This data collection modality may be particularly well-suited for capturing emotion dysregulation, a transdiagnostic risk factor for psychopathology, across lifespan transitions. Adolescence, emerging adulthood, and perinatal transitions are particularly sensitive developmental periods, often marked by increased distress. These participant groups are typically assessed with laboratory-based methods that can be costly and burdensome. Passive monitoring presents a relatively cost-effective and unobtrusive way to gather rich and objective information about emotion dysregulation and risk behaviors. We first discuss key theoretically-driven concepts pertaining to emotion dysregulation and passive monitoring. We then identify variables that can be measured passively and hold promise for better understanding emotion dysregulation. For example, two strong markers of emotion dysregulation are sleep disturbance and problematic use of Internet/social media (i.e., use that prompts negative emotions/outcomes). Variables related to mobility are also potentially useful markers, though these variables should be tailored to fit unique features of each developmental stage. Finally, we offer our perspective on candidate digital variables that may prove useful for each developmental transition. Smartphone-based passive monitoring is a rigorous method that can elucidate psychopathology risk across human development. Nonetheless, its use requires researchers to weigh unique ethical considerations, examine relevant theory, and consider developmentally-specific lifespan features that may affect implementation.

Naringin Supplementation during Pregnancy Induces Sex and Region-Specific Alterations in the Offspring's Brain Redox Status.

Research has shown the beneficial effects of naringin supplementation to adult rodents, which can ameliorate oxidative stress in disease models. However, evidence has demonstrated that polyphenol supplementation induced detrimental effects when consumed during sensitive periods of development, such as pregnancy. Therefore, we investigated the effect of maternal naringin supplementation during pregnancy on the offspring’s cerebral redox status. Pregnant Wistar rats were divided into control and naringin groups and supplemented from gestational day 15 to gestational day 21. On postnatal days 1, 7, and 21, offspring were euthanized, and the prefrontal cortex, hippocampus, striatum, and cerebellum dissected. On postnatal day 1, maternal naringin supplementation positively modulated the pups’ brain redox status. On postnatal day 7, a pro-oxidative milieu was observed in the offspring’s striatum and cerebellum in a sex-dependent manner, even though the prefrontal cortex and hippocampus were not negatively affected. Besides, the alterations observed on postnatal day 7 did not persist up to weaning. Our findings demonstrated that the effect induced by naringin supplementation in the brain redox status differed according to the period of development in which naringin was consumed since the beneficial effects usually found in the adult rodents became detrimental when the supplementation was applied during pregnancy.

Shift-&-Persist and discrimination predicting depression across the life course: An accelerated longitudinal design using MIDUSI-III.

Life course theorists posit that sensitive periods exist during life span development where risk and protective factors may be particularly predictive of psychological outcomes relative to other periods in life. While there have been between-cohort studies trying to examine differences in discrimination and depressive symptoms, these studies have not been designed to identify these sensitive periods, which are best modeled by examining intra-individual change across time. To identify sensitive periods where discrimination and shift-&-persist (S&P) - a coping strategy that may protect against the negative impact of discrimination - are most strongly predictive of depressive symptoms, we employed latent growth curve modeling using an accelerated longitudinal design to track intra-individual change in depressive symptoms from ages 20-69. Participants were 3,685 adults measured at three time points ~10 years apart from the Midlife in the United States study (Mage = 37.93, SD = 6.948 at Wave I). Results identified two sensitive periods in development where high levels of S&P interacted with discrimination to protect against depressive symptoms; during the 30s and a lagged effect where 40's S&P protected against depressive symptoms when participants were in their 50s. Implications for the life course study of discrimination, coping, and depression are discussed.

Partner Emotional Support and Child Problem Behaviors: The Indirect Role of Harsh Parenting for Young Mothers and Their Children.

Emotionally supportive partners promote the well-being of teenage mothers and their children as they navigate sensitive developmental periods. Yet, having focused on young parents' relationship dissolution, we know very little about benefits of partner supportiveness for the development of children's psychological adjustment or processes that may explain this association. Using five waves of Fragile Families and Child Well-being Study data (N = 771) and parallel process latent growth curve modeling, this study tested whether trajectories of partner supportiveness (measured by maternal reports of fathers' emotional support) directly mitigated trajectories of children's externalizing and internalizing problem behaviors (measured by maternal reports of problem behaviors) and/or whether such effects were indirectly linked through lower levels of maternal harsh parenting (measured by observational ratings of mother-child interactions). Results suggest that higher levels of partner supportiveness at birth were associated with child externalizing and internalizing trajectories that started at lower levels and demonstrated slower improvements across time. Lower starting levels of maternal harsh parenting when children were three years old partially explained associations between partner supportiveness at birth and lower levels of child externalizing symptoms at age three. Lessons gleaned from this study are discussed in context of young families' strengths and applied to practice-based settings.

Resilience to anhedonia-passive coping induced by early life experience is linked to a long-lasting reduction of Ih current in VTA dopaminergic neurons

Exposure to aversive events during sensitive developmental periods can affect the preferential coping strategy adopted by individuals later in life, leading to either stress-related psychiatric disorders, including depression, or to well-adaptation to future adversity and sources of stress, a behavior phenotype termed “resilience”.We have previously shown that interfering with the development of mother-pups bond with the Repeated Cross Fostering (RCF) stress protocol can induce resilience to depression-like phenotype in adult C57BL/6J female mice. Here, we used patch-clamp recording in midbrain slice combined with both in vivo and ex vivo pharmacology to test our hypothesis of a link between electrophysiological modifications of dopaminergic neurons in the intermediate Ventral Tegmental Area (VTA) of RCF animals and behavioral resilience. We found reduced hyperpolarization-activated (Ih) cation current amplitude and evoked firing in VTA dopaminergic neurons from both young and adult RCF female mice. In vivo, VTA-specific pharmacological manipulation of the Ih current reverted the pro-resilient phenotype in adult early-stressed mice or mimicked behavioral resilience in adult control animals.This is the first evidence showing how pro-resilience behavior induced by early events is linked to a long-lasting reduction of Ih current and excitability in VTA dopaminergic neurons.