Abstract
Preclinical ELS models (e.g., maternal separation) have been extensively used to investigate biomolecular changes underlying the behavioral outcomes in response to stress exposure during early postnatal period. However, it still unclear how the reprograming effects of these early stress experiences could interact with the exposure to a second stressor during later periods of development, such as adolescence. To address that, this study investigated how maternal separation would interact with chronic adolescence stress exposure on anxiety-like response, gene and protein expression of GR and FKBP5 in the hippocampus.
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