In this paper, we introduce and study the notion of quasi-multipliers on a semi-topological semigroup [Formula: see text]. The set of all quasi-multipliers on [Formula: see text] is denoted by [Formula: see text]. First, we study the problem of extension of quasi-multipliers on topological semigroups to its Stone–Čech compactification. Indeed, we prove if [Formula: see text] is a topological semigroup such that [Formula: see text] is pseudocompact, then [Formula: see text] can be regarded as a subset of [Formula: see text] Moreover, with an extra condition we describe [Formula: see text] as a quotient subsemigroup of [Formula: see text] Finally, we investigate quasi-multipliers on topological semigroups, its relationship with multipliers and give some concrete examples.