This research investigates the effects of heat transfer on the stagnation-point flow of a non-Newtonian Casson fluid in a two-dimensional magnetohydrodynamic (MHD) boundary layer over a stretched sheet, considering thermal radiation impacts. By employing similarity transformations, the governing partial differential equations are transformed into nonlinear ordinary differential equations. The obtained self-similar equations are numerically solved using the Optimal Homotopy Analysis Method (OHAM). The numerical results are graphically represented, showcasing the influence of various parameters on fluid flow and heat transfer characteristics. The study uncovers important dynamics in transport phenomena. Examining and illustrating the effects of dimensionless parameters on velocity, temperature, and concentration profiles reveal significant insights. Moreover, skin friction and Nusselt number results for Casson fluids are analyzed and presented. The findings indicate that the Casson parameter and Hartman number act in opposition to fluid momentum, while the thermal conductivity parameter enhances fluid temperature. Thus, this research provides valuable insights into MHD boundary layer flows of non-Newtonian Casson fluids with thermal radiation effects, and the OHAM solution method proves effective in predicting flow transport properties.