This study aimed to examine the mediating effect of meaning in life in the relationship between self-efficacy for managing chronic disease and compliance of patient role behavior in hemodialysis patients. Participants included 149 hemodialysis patients. Data were collected from July, 3 to July, 21, 2023 using self-reported questionnaires. Data were analyzed using descriptive statistics, t-test, ANOVA, Scheffé test, Pearson’s correlation coefficient, multiple regression. Mediation analysis was performed using the Baron and Kenny method and Sobel test. The higher the self-efficacy for managing chronic disease, the higher the meaning in life(r=.61, p<.001), and the higher the compliance patient role behavior(r=.59, p<.001). In addition, a significant positive correlation was found that the higher the awareness of the meaning in life, the higher the compliance of patient role behavior(r=.65, p<.001). Meaning in life showed partial mediating effects in the relationship between self-efficacy for managing chronic disease and compliance of patient role behavior. Thus, it is required to develop interventions to enhance self-efficacy for managing chronic disease and to strengthen meaning in life. It is necessary also to prepare programs and strategies to improve compliance of patient role behavior.